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80 条记录 (耗时 0.049 秒)

    Process for the stereoselective preparation of (−)-halofenate and derivatives thereof
    52.
    发明授权
    Process for the stereoselective preparation of (−)-halofenate and derivatives thereof 失效
    （ - ） - 卤代苯甲酸酯及其衍生物的立体选择性制备方法

    公开(公告)号：US07714131B2

    公开(公告)日：2010-05-11

    申请号：US11525200

    申请日：2006-09-20

    申请人： Yan Zhu ,  Peng Cheng ,  Xin Chen ,  Jingyuan Ma ,  Zuchun Zhao

    发明人： Yan Zhu ,  Peng Cheng ,  Xin Chen ,  Jingyuan Ma ,  Zuchun Zhao

    IPC分类号： C07D295/16 ,  C07D207/06

    CPC分类号： C07D295/185

    摘要： The present invention provides a compounds the formula (IV): and methods for producing an α-(phenoxy)phenylacetic acid compound of the formula: wherein R1 is a member selected from the group consisting of: each R2 is a member independently selected from the group consisting of (C1-C4)alkyl, halo, (C1-C4)haloalkyl, amino, (C1-C4)aminoalkyl, amido, (C1-C4)amidoalkyl, (C1-C4)sulfonylalkyl, (C1-C4)sulfamylalkyl, (C1-C4)alkoxy, (C1-C4)heteroalkyl, carboxy and nitro; the subscript n is 1 when R1 has the formula (a) or (b) and 2 when R1 has the formula (c) or (d); the subscript m is an integer of from 0 to 3; * indicates a carbon which is enriched in one stereoisomeric configuration; and the wavy line indicates the point of attachment of R1; and compounds.

    摘要翻译： 本发明提供式（Ⅳ）化合物及其制备下式所示的α-（苯氧基）苯乙酸化合物的方法：其中R 1为选自以下的成员：每个R 2为独立地选自 由（C 1 -C 4）烷基，卤素，（C 1 -C 4）卤代烷基，氨基，（C 1 -C 4）氨基烷基，酰胺基，（C 1 -C 4）酰氨基烷基，（C 1 -C 4）磺酰基烷基，（C 1 -C 4） ，（C 1 -C 4）烷氧基，（C 1 -C 4）杂烷基，羧基和硝基; 当R1具有式（a）或（b）时，下标n为1，当R1具有式（c）或（d））时，下标n为1; 下标m为0〜3的整数; *表示富含一种立体异构构型的碳; 波浪线表示R1的连接点; 和化合物。

    Die casting process incorporating computerized pattern recognition techniques
    55.
    发明授权
    Die casting process incorporating computerized pattern recognition techniques 有权
    包含计算机化模式识别技术的压铸工艺

    公开(公告)号：US07363957B2

    公开(公告)日：2008-04-29

    申请号：US10887767

    申请日：2004-07-09

    申请人： Arnie Fulton ,  Yan Zhu ,  Michael Bomar

    发明人： Arnie Fulton ,  Yan Zhu ,  Michael Bomar

    IPC分类号： B22D46/00

    CPC分类号： B22D17/32 ,  B22D46/00

    摘要： A die casting process using pattern recognition techniques to identify those die castings manufactured under conditions likely to produce a die casting which would subsequently prove unacceptable for use. By promptly identifying such die castings, they may be discarded before being shipped to a remote facility for further processing. As a result, the rejection rate of die castings at the remote facility may be reduced and the raw materials used to form the discarded die castings may be more readily recycled.

    摘要翻译： 使用模式识别技术的压铸方法来识别在可能产生压铸件的条件下制造的那些压铸件，随后将被证明是不可接受的。 通过及时识别这种压铸件，在运送到远程设备进行进一步处理之前，可将其丢弃。 结果，可以减少远程设备的压铸件的排出率，并且用于形成废弃压铸件的原材料可以更容易地再循环。

    Substituted triazoles as modulators of PPAR and methods of their preparation
    56.
    发明授权
    Substituted triazoles as modulators of PPAR and methods of their preparation 有权
    取代三唑作为PPAR的调节剂及其制备方法

    公开(公告)号：US07323480B2

    公开(公告)日：2008-01-29

    申请号：US11137678

    申请日：2005-05-24

    申请人： Yan Zhu ,  Jingyuan Ma ,  Peng Cheng ,  Zuchun Zhao ,  Francine M. Gregoire ,  Vera A. Rakhmanova

    发明人： Yan Zhu ,  Jingyuan Ma ,  Peng Cheng ,  Zuchun Zhao ,  Francine M. Gregoire ,  Vera A. Rakhmanova

    IPC分类号： A61K31/4192 ,  A61K31/501 ,  C07D249/06 ,  C07D257/04

    CPC分类号： C07D249/06 ,  C07D409/10

    摘要： The present invention is directed to certain novel triazole compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity, and eating disorders.

    摘要翻译： 本发明涉及由式I表示的某些新颖的三唑化合物及其药学上可接受的盐，溶剂合物，水合物和前药。 本发明还涉及制备和使用这些化合物和含有这些化合物的药物组合物的方法，以治疗或控制PPAR介导的许多疾病，例如葡萄糖代谢，脂质代谢和胰岛素分泌，特别是2型糖尿病，高胰岛素血症，高脂血症 高尿酸血症，高胆固醇血症，动脉粥样硬化，心血管疾病的一个或多个危险因素，X综合征，高甘油三酯血症，高血糖症，肥胖症和进食障碍。

    BICYCLIC, SUBSTITUTED TRIAZOLES AS MODULATORS OF PPAR AND METHODS OF THEIR PREPARATION
    58.
    发明申请
    BICYCLIC, SUBSTITUTED TRIAZOLES AS MODULATORS OF PPAR AND METHODS OF THEIR PREPARATION 审中-公开
    作为PPAR的调节剂的双相，取代三唑类及其制备方法

    公开(公告)号：US20060014785A1

    公开(公告)日：2006-01-19

    申请号：US11137679

    申请日：2005-05-24

    申请人： Yan Zhu ,  Jingyuan Ma ,  Peng Cheng ,  Zuchun Zhao ,  Francine Gregoire ,  Vera Rakhmanova

    发明人： Yan Zhu ,  Jingyuan Ma ,  Peng Cheng ,  Zuchun Zhao ,  Francine Gregoire ,  Vera Rakhmanova

    IPC分类号： A61K31/4709 ,  C07D403/02

    CPC分类号： C07D403/12 ,  C07D403/06 ,  C07D403/14 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12

    摘要： The present invention is directed to certain novel triazole compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity, and eating disorders.

    摘要翻译： 本发明涉及由式I表示的某些新颖的三唑化合物及其药学上可接受的盐，溶剂合物，水合物和前药。 本发明还涉及制备和使用这些化合物和含有这些化合物的药物组合物的方法，以治疗或控制PPAR介导的许多疾病，例如葡萄糖代谢，脂质代谢和胰岛素分泌，特别是2型糖尿病，高胰岛素血症，高脂血症 高尿酸血症，高胆固醇血症，动脉粥样硬化，心血管疾病的一个或多个危险因素，X综合征，高甘油三酯血症，高血糖症，肥胖症和进食障碍。

    System for manufacturing die castings
    59.
    发明授权
    System for manufacturing die castings 有权
    压铸件制造系统

    公开(公告)号：US06772821B1

    公开(公告)日：2004-08-10

    申请号：US10208424

    申请日：2002-07-30

    申请人： Arnie Fulton ,  Yan Zhu ,  Michael Bomar

    发明人： Arnie Fulton ,  Yan Zhu ,  Michael Bomar

    IPC分类号： B22C1904

    CPC分类号： B22D17/32

    摘要： A die casting system for manufacturing die castings configured for measuring plural physical parameters during the forming of each die casting and to associate the measured physical parameters with the specific die casting manufactured under those conditions and any defect information subsequently acquired for that die casting. By enabling a die casting manufacturing system to associate such types of information, control over the manufacturing process may be enhanced.

    摘要翻译： 一种用于制造压铸件的压铸系统，其被配置用于在形成每个压铸件期间测量多个物理参数，并将测量的物理参数与在这些条件下制造的特定压铸件和随后为该压铸获得的任何缺陷信息相关联。 通过使压铸制造系统能够将这种类型的信息相关联，可以增强对制造过程的控制。

    Mosquito lamp
    60.
    外观设计
    Mosquito lamp 有权

    公开(公告)号：USD870233S1

    公开(公告)日：2019-12-17

    申请号：US29637199

    申请日：2018-02-14

    申请人： Yan Zhu

    设计人： Yan Zhu