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公开(公告)号:US06201005B1
公开(公告)日:2001-03-13
申请号:US09411630
申请日:1999-10-01
申请人: Masakuni Okuhara , Hirokazu Tanaka , Toshio Goto , Tohru Kino , Hiroshi Hatanaka
发明人: Masakuni Okuhara , Hirokazu Tanaka , Toshio Goto , Tohru Kino , Hiroshi Hatanaka
IPC分类号: A01N4338
CPC分类号: C07D498/18 , C07H19/01 , C12P17/188 , C12P19/44 , C12R1/465 , C12R1/55 , Y02P20/55 , Y10S435/886 , Y10S435/898
摘要: This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.
摘要翻译: 本发明涉及可用于治疗和预防移植抵抗力的三环化合物,通过髓质骨移植自身免疫性疾病,传染病等的移植物抗宿主病,其可以由下式表示: 制备成含有该组合物的药物组合物及其用途。
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公开(公告)号:US06174839B1
公开(公告)日:2001-01-16
申请号:US09255959
申请日:1999-02-23
申请人: Akihiko Yanagi , Shin-ichi Narabu , Toshio Goto , Seishi Ito , Natsuko Minegishi , Tatsuya Yamaoka , Chieko Ueno
发明人: Akihiko Yanagi , Shin-ichi Narabu , Toshio Goto , Seishi Ito , Natsuko Minegishi , Tatsuya Yamaoka , Chieko Ueno
IPC分类号: A01N43647
CPC分类号: C07D231/38 , A01N43/54 , A01N43/56 , A01N43/713 , A01N43/82 , A01N47/20 , A01N55/00 , C07D239/22 , C07D239/54 , C07D257/04 , C07D271/113 , C07D405/04 , C07F7/0812
摘要: The invention is related to a novel phenylacetylene derivates of formula: wherein X represents hydrogen, halogen, optionally substituted C1-6 alkyl; Y represents hydrogen, halogen, cyano, nitro, optionally substituted C1-6 alkyl, C1-6 alkoxy, C3-8 cycloalkoxy, optionally substituted C1-6 alkylthio, C3-8 cycloalkylthio, C1-6 alkylsulfinyl, optionally substituted C1-6 alkylsulfonyl, C3-8 cycloalkylsulfonyl, C1-6 alkylsulfonyloxy, optionally substituted sulfonamide, optionally substituted carboxamide, etc., or Y may form together with Z which is bonded to the vicinal carbon atom a 5- or 6-membered ring; n is 0 or 1; Z represents hydrogen or halogen; m is 1 or 2; R represents hydrogen, halogen, C1-6 alkyl, tri(C1-6 alkyl)silyl, COORc or CONRdRe; Q represents a heterocyclic group, and their use as herbicid.
摘要翻译: 本发明涉及下式的新型苯乙炔衍生物:其中X表示氢,卤素,任选取代的C 1-6烷基; Y代表氢,卤素,氰基,硝基,任选取代的C 1-6烷基,C 1-6烷氧基,C 3-8环烷氧基,任选取代的C 1-6烷硫基,C 3-8环硫基,C 1-6烷基亚磺酰基,任选取代的C 1-6烷基磺酰基 ,C 3-8环烷基磺酰基,C 1-6烷基磺酰氧基,任选取代的磺酰胺,任选取代的羧酰胺等,或Y可以与连接在邻位碳原子上的5或6元环一起形成; n为0或1; Z表示氢或卤素; m为1或2; R表示氢,卤素,C 1-6烷基,三(C 1-6烷基)甲硅烷基,COOR c或CONR d Re; Q表示杂环基,它们用作除草剂。
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公开(公告)号:US5935907A
公开(公告)日:1999-08-10
申请号:US47260
申请日:1998-03-24
申请人: Akihiko Yanagi , Shin-ichi Narabu , Toshio Goto , Seishi Ito , Natsuko Minegishi , Tatsuya Yamaoka , Chieko Ueno
发明人: Akihiko Yanagi , Shin-ichi Narabu , Toshio Goto , Seishi Ito , Natsuko Minegishi , Tatsuya Yamaoka , Chieko Ueno
IPC分类号: C07D249/12 , A01N43/08 , A01N43/36 , A01N43/38 , A01N43/50 , A01N43/54 , A01N43/56 , A01N43/58 , A01N43/653 , A01N43/707 , A01N43/713 , A01N43/76 , A01N43/78 , A01N43/82 , A01N43/824 , A01N43/88 , A01N43/90 , A01N47/20 , A01N55/00 , C07D207/24 , C07D207/27 , C07D207/277 , C07D207/38 , C07D207/40 , C07D209/48 , C07D231/20 , C07D231/38 , C07D233/76 , C07D237/14 , C07D239/22 , C07D239/54 , C07D253/06 , C07D257/04 , C07D263/18 , C07D263/44 , C07D271/10 , C07D271/113 , C07D273/04 , C07D277/20 , C07D277/42 , C07D277/60 , C07D285/12 , C07D307/66 , C07D307/90 , C07D405/04 , C07D471/04 , C07D487/04 , C07D513/04 , C07F7/08 , C07D413/04 , A01N43/80 , C07D417/04
CPC分类号: C07D231/38 , A01N43/54 , A01N43/56 , A01N43/713 , A01N43/82 , A01N47/20 , A01N55/00 , C07D239/22 , C07D239/54 , C07D257/04 , C07D271/113 , C07D405/04 , C07F7/0812
摘要: The invention is related to a novel phenylacetylene derivates of formula: ##STR1## wherein X represents hydrogen, halogen, optionally substituted C.sub.1-6 alkyl; Y represents hydrogen, halogen, cyano, nitro, optionally substituted C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.3-8 cycloalkoxy, optionally substituted C.sub.1-6 alkylthio, C.sub.3-8 cycloalkylthio, C.sub.1-6 alkylsulfinyl, optionally substituted C.sub.1-6 alkylsulfonyl, C.sub.3-8 cycloalkylsulfonyl, C.sub.1-6 alkylsulfonyloxy, optionally substituted sulfonamide, optionally substituted carboxamide, etc., or Y may form together with Z which is bonded to the vicinal carbon atom a 5- or 6-membered ring; n is 0 or 1; Z represents hydrogen or halogen; m is 1 or 2; R represents hydrogen, halogen, C.sub.1-6 alkyl, tri(C.sub.1-6 alkyl)silyl, COOR.sup.c or CONR.sup.d R.sup.e ; Q represents a heterocyclic group, and their use as herbicid.
摘要翻译: 本发明涉及下式的新型苯乙炔衍生物:其中X表示氢,卤素,任选取代的C 1-6烷基; Y代表氢,卤素,氰基,硝基,任选取代的C 1-6烷基,C 1-6烷氧基,C 3-8环烷氧基,任选取代的C 1-6烷硫基,C 3-8环硫基,C 1-6烷基亚磺酰基,任选取代的C 1-6烷基磺酰基 ,C 3-8环烷基磺酰基,C 1-6烷基磺酰氧基,任选取代的磺酰胺,任选取代的羧酰胺等,或Y可以与连接在邻位碳原子上的5或6元环一起形成; n为0或1; Z表示氢或卤素; m为1或2; R表示氢,卤素,C 1-6烷基,三(C 1-6烷基)甲硅烷基,COOR c或CONR d Re; Q表示杂环基,它们用作除草剂。
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公开(公告)号:US5747420A
公开(公告)日:1998-05-05
申请号:US552900
申请日:1995-11-03
申请人: Toshio Goto , Seishi Ito , Kazuhiro Ukawa , Yukiyoshi Watanabe , Shin-ichi Narabu , Akihiko Yanagi
发明人: Toshio Goto , Seishi Ito , Kazuhiro Ukawa , Yukiyoshi Watanabe , Shin-ichi Narabu , Akihiko Yanagi
IPC分类号: A01N47/38 , C07D257/04 , C07D401/06 , C07D403/06 , C07D257/06 , C07D295/104 , C07D413/06
CPC分类号: C07D257/04 , A01N47/38 , C07D401/06
摘要: Novel herbicidal tetrazolinone derivatives of the formula ##STR1## and intermediates therefor of the formula ##STR2## wherein R.sup.1 is alkyl substituted by halogen, and R.sup.2 and R.sup.3 each independently is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl or substituted phenyl, or R.sup.2 and R.sup.3 together with the N-atom to which they are attached, which may form a 5- or 6-membered heterocyclic ring.
摘要翻译: 式(Ⅰ)的新型除草四唑啉酮衍生物及其中R 1为被卤素取代的烷基,R 2和R 3各自独立地为烷基,烯基,炔基,环烷基,苯基或 取代的苯基,或者R 2和R 3与它们所连接的N-原子一起形成5-或6-元杂环。
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公开(公告)号:US5668087A
公开(公告)日:1997-09-16
申请号:US616674
申请日:1996-03-15
申请人: Toshio Goto , Yoshinori Kitagawa , Seishi Ito , Katsuhiko Shibuya , Kazuhiro Ukawa , Yoshiko Kyo , Natsuko Minegishi
发明人: Toshio Goto , Yoshinori Kitagawa , Seishi Ito , Katsuhiko Shibuya , Kazuhiro Ukawa , Yoshiko Kyo , Natsuko Minegishi
IPC分类号: C07D401/06 , A01N47/38 , C07D257/04 , C07D403/06 , A01N43/713
CPC分类号: C07D257/04 , A01N47/38
摘要: Herbicidal 1-alkenyltetrazolinones of the formula: ##STR1## wherein R.sup.1 represents the group: ##STR2## or the group: ##STR3## R.sup.2 and R.sup.3, independently of one another, represent C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl which may optionally be substited by methyl, C.sub.2-4 alkenyl, C.sub.2-5 alkynyl, phenyl which may optionally be substituted or aralkyl which may optionally be substituted, orR.sup.2 and R.sup.3 may optionally form, together with the N-atom to which they are bonded, a heterocyclic ring which may optionally be substituted, and novel intermediates therefor.
摘要翻译: 下式的除草1-烯基四唑啉酮:彼此独立地表示C 1-6烷基,可以任选地被甲基,C 2-4烯基,C 2-5炔基,可任选被取代的苯基或任选被取代的芳基烷基的C 3-7环烷基 可以任选地被取代,或者R 2和R 3可以任选地与它们所键合的N-原子一起形成可以任选被取代的杂环,以及其新颖的中间体。
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公开(公告)号:US5654257A
公开(公告)日:1997-08-05
申请号:US601748
申请日:1996-02-15
申请人: Toshio Goto , Yoshinori Kitagawa , Seishi Ito , Katsuhiko Shibuya , Tatsuya Yamaoka , Chieko Ueno , Yoshiko Kyo
发明人: Toshio Goto , Yoshinori Kitagawa , Seishi Ito , Katsuhiko Shibuya , Tatsuya Yamaoka , Chieko Ueno , Yoshiko Kyo
IPC分类号: C07D401/06 , A01N47/38 , C07D257/04 , C07D403/06 , A01N43/713
CPC分类号: C07D257/04 , A01N47/38
摘要: 1-cycloalkenyltetrazolinone derivatives of the following herbicidal formula ##STR1## R.sup.1 is cycloalkenyl which may optionally be substituted by halogen C.sub.1-4 alkyl, or bicycloalkenyl which may optionally be substituted by halogen or C.sub.1-4 alkyl, andR.sup.2 and R.sup.3 each independently is alkyl, cycloalkyl, phenyl (optionally substituted by a member selected from the group consisting of nitro, cyano, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy and alkylthio), alkenyl and alkynyl,orR.sup.2 and R.sup.3 together with the N-atom to which they are bonded form, a 5- or 6-membered heterocyclic ring which may optionally contain a further hetero atom, said heterocyclic ring optionally being benzo-condensed, or a C-.sub.1-4 alkyl,and intermediates therefore of the formula ##STR2##
摘要翻译: 以下除草式R 1的1-环烯基四唑啉酮衍生物是可任选被卤素C 1-4烷基取代的环烯基,或可任意被卤素或C 1-4烷基取代的双环烯基,R 2和R 3各自独立地为烷基 ,环烷基,苯基(任选被选自硝基,氰基,卤素,烷基,卤代烷基,烷氧基,卤代烷氧基和烷硫基的成员取代),烯基和炔基,或者R 2和R 3与它们的N-原子一起 键合形式,可任选地含有另外的杂原子的所述5或6元杂环,所述杂环任选地被苯并稠合,或C 1-4烷基,因此具有下式的中间体:
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公开(公告)号:US5652198A
公开(公告)日:1997-07-29
申请号:US611580
申请日:1996-03-06
IPC分类号: A01N47/38 , C07D257/04
CPC分类号: C07D257/04 , A01N47/38
摘要: Selective herbicidal tetrazolinones of the formula ##STR1## wherein X is hydrogen or halogen,Y is hydrogen or C.sub.1-4 alkyl,R.sup.1 is C.sub.1-4 alkyl, andR.sup.2 is cycloheptyl or cyclooctyl.and synergistic mixtures thereof.
摘要翻译: 选择性除草四唑啉酮,Y是氢或C 1-4烷基,R 1是C 1-4烷基,R 2是环庚基或环辛基。 及其协同混合物。
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公开(公告)号:US5624842A
公开(公告)日:1997-04-29
申请号:US450412
申请日:1995-05-25
申请人: Masakuni Okuhara , Hirokazu Tanaka , Toshio Goto , Tohru Kino , Hiroshi Hatanaka
发明人: Masakuni Okuhara , Hirokazu Tanaka , Toshio Goto , Tohru Kino , Hiroshi Hatanaka
IPC分类号: A01N43/38 , A61K31/00 , A61K31/33 , A61K31/40 , A61K31/407 , A61K31/435 , A61K31/4353 , A61K31/436 , A61K31/445 , A61K31/4465 , A61K31/4523 , A61K31/453 , A61K31/4745 , A61P31/00 , A61P31/04 , A61P37/00 , A61P37/06 , C07D491/14 , C07D498/04 , C07D498/14 , C07D498/18 , C07D519/00 , C07H19/01 , C12N1/20 , C12P17/16 , C12P17/18 , C12P19/44 , C12R1/465 , C12R1/55
CPC分类号: C07D498/18 , C07H19/01 , C12P17/188 , C12P19/44 , C12R1/465 , C12R1/55 , Y02P20/55 , Y10S435/886 , Y10S435/898
摘要: This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: ##STR1## to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.
摘要翻译: 本发明涉及可用于治疗和预防移植抵抗的三环类化合物,通过髓质移植移植物抗宿主病,自身免疫性疾病,感染性疾病等,其可以由下式表示:
( I)涉及其制备方法,含有该方法的药物组合物及其用途。 -
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公开(公告)号:US5496727A
公开(公告)日:1996-03-05
申请号:US450639
申请日:1995-05-25
申请人: Masakuni Okuhara , Hirokazu Tanaka , Toshio Goto , Tohru Kino , Hiroshi Hatanaka
发明人: Masakuni Okuhara , Hirokazu Tanaka , Toshio Goto , Tohru Kino , Hiroshi Hatanaka
IPC分类号: A01N43/38 , A61K31/00 , A61K31/33 , A61K31/40 , A61K31/407 , A61K31/435 , A61K31/4353 , A61K31/436 , A61K31/445 , A61K31/4465 , A61K31/4523 , A61K31/453 , A61K31/4745 , A61P31/00 , A61P31/04 , A61P37/00 , A61P37/06 , C07D491/14 , C07D498/04 , C07D498/14 , C07D498/18 , C07D519/00 , C07H19/01 , C12N1/20 , C12P17/16 , C12P17/18 , C12P19/44 , C12R1/465 , C12R1/55
CPC分类号: C07D498/18 , C07H19/01 , C12P17/188 , C12P19/44 , C12R1/465 , C12R1/55 , Y02P20/55 , Y10S435/886 , Y10S435/898
摘要: This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: ##STR1## to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.
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公开(公告)号:US5466660A
公开(公告)日:1995-11-14
申请号:US230949
申请日:1994-04-21
IPC分类号: A01N47/38 , C07D257/04 , A01N43/713
CPC分类号: C07D257/04 , A01N47/38
摘要: Compositions comprising herbicidal tetrazolinones of the formula (I) ##STR1## wherein X is chlorine or bromine, Y is hydrogen, chlorine, bromine, methyl or ethyl, andR.sup.1 and R.sup.2 are the same or different C.sub.2-4 alkyl,and at least one additional herbicide.
摘要翻译: 包含式(I)的除草四唑啉酮的组合物其中X是氯或溴,Y是氢,氯,溴,甲基或乙基,R1和R2是相同或不同的C2-4烷基,和 至少一种额外的除草剂。
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