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51.发明申请BACTERIUM PRODUCING A PRODUCT OF A REACTION CATALYZED BY A PROTEIN HAVING 2-OXOGLUTARATE-DEPENDENT ENZYME ACTIVITY AND A METHOD FOR MANUFACTURING THE PRODUCT 有权生产由具有2-羟基脂肪酸依赖性酶活性的蛋白质催化的反应产物的细菌和制造该产品的方法公开(公告)号：US20100330622A1
公开(公告)日：2010-12-30
申请号：US12819485
申请日：2010-06-21
申请人： Sergey Vasilievich Smirnov , Natalia Nikolaevna Samsonova , Veronika Aleksandrovna Kotliarova , Natalia Yurievna Rushkevich , Olga Sergeevna Beznoschenko , Tatyana Aleksandrovna Bachina , Yuki Imabayashi , Masakazu Sugiyama , Shunichi Suzuki
发明人： Sergey Vasilievich Smirnov , Natalia Nikolaevna Samsonova , Veronika Aleksandrovna Kotliarova , Natalia Yurievna Rushkevich , Olga Sergeevna Beznoschenko , Tatyana Aleksandrovna Bachina , Yuki Imabayashi , Masakazu Sugiyama , Shunichi Suzuki
CPC分类号： C12P13/06 , C12N9/0069 , C12N9/0071 , C12P13/24
摘要： A method for manufacturing a product of a reaction catalyzed by a protein having 2-oxoglutarate-dependent enzyme activity such as (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof using a bacterium transformed with a DNA fragment containing a gene coding for a protein having 2-oxoglutarate-dependent enzyme activity such as L-isoleucine dioxygenase activity; and wherein said bacterium has the ability to produce a product such as (2S,3R,4S)-4-hydroxy-L-isoleucine.
摘要翻译： 使用由DNA片段转化的细菌制造由具有2-氧戊二酸依赖性酶活性的蛋白质（例如（2S，3R，4S）-4-羟基-L-异亮氨酸或其盐）催化的反应产物的方法 含有编码具有2-氧戊二酸依赖性酶活性的蛋白质的基因，例如L-异亮氨酸双加氧酶活性; 并且其中所述细菌具有产生如（2S，3R，4S）-4-羟基-L-异亮氨酸的产物的能力。
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公开(公告)号：US07816541B2
公开(公告)日：2010-10-19
申请号：US12028360
申请日：2008-02-08
IPC分类号： C07D209/04
CPC分类号： C07D209/18 , C07D209/20
摘要： The present invention provides a process for selectively producing an enantiomer at position 4 of an optically active compound in the cross aldol reaction of pyruvic acid and indole-3-pyruvic acid. The process comprises the step of reacting pyruvic acid with indole-3-pyruvic acid in the presence of an optically active α-amino acid containing a secondary amine and a metal ion.
摘要翻译： 本发明提供了在丙酮酸和吲哚-3-丙酮酸的交叉醛醇反应中选择性地在光学活性化合物的第4位产生对映异构体的方法。 该方法包括在含有仲胺和金属离子的光学活性α-氨基酸存在下使丙酮酸与吲哚-3-丙酮酸反应的步骤。
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公开(公告)号：US20080207920A1
公开(公告)日：2008-08-28
申请号：US12028360
申请日：2008-02-08
IPC分类号： C07D209/04
CPC分类号： C07D209/18 , C07D209/20
摘要： The present invention provides a process for selectively producing an enantiomer at position 4 of an optically active compound in the cross aldol reaction of pyruvic acid and indole-3-pyruvic acid. The process comprises the step of reacting pyruvic acid with indole-3-pyruvic acid in the presence of an optically active α-amino acid containing a secondary amine and a metal ion.
摘要翻译： 本发明提供了在丙酮酸和吲哚-3-丙酮酸的交叉醛醇反应中选择性地在光学活性化合物的第4位产生对映异构体的方法。 该方法包括在含有仲胺和金属离子的光学活性α-氨基酸存在下使丙酮酸与吲哚-3-丙酮酸反应的步骤。
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公开(公告)号：US20060154343A1
公开(公告)日：2006-07-13
申请号：US11317308
申请日：2005-12-27
IPC分类号： C12P13/22 , C07D209/18
CPC分类号： C12P17/10 , C07D209/20
摘要： A solution to be treated containing monatin and impurities is treated with a nonpolar resin having aromatic rings, whereby monatin is separated from the solution. Treatment with the nonpolar resin having aromatic rings results in efficient separation of monatin under a mild pH condition.
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公开(公告)号：US06303353B1
公开(公告)日：2001-10-16
申请号：US09509547
申请日：2000-04-12
IPC分类号： C12P718
CPC分类号： C12P7/18
摘要： Xylitol is produced by contacting D-arabitol with a microorganism that belongs to the genus Gluconobacter, Acetobacter, Achromobacter, Agrobacterium, Arthrobacter, Azotobacter, Brevibacterium, Corynebacterium, Erwinia, Flavobacterium, Micrococcus, Nocardia, Planococcus, Pseudomonas, Rhodococcus, Morganella, Actinomadura, Actinomyces, or Streptomyces and is capable of converting D-arabitol to xylitol, and recovering xylitol thus produced.
摘要翻译： 通过使D-阿拉伯糖醇与属于葡萄糖酸杆菌属，醋杆菌属，无色杆菌属，农杆菌属，节杆菌属，固氮菌属，短杆菌属，棒状杆菌属，欧文氏菌属，黄杆菌属，微球菌属，诺卡氏菌属，普兰克菌属，假单胞菌属，红球菌属，摩根氏菌属，放线菌属， 放线菌或链霉菌，能够将D-阿拉伯糖醇转化为木糖醇，并回收如此生产的木糖醇。
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公开(公告)号：US6127174A
公开(公告)日：2000-10-03
申请号：US371008
申请日：1999-08-10
CPC分类号： C12N15/74
摘要： A shuttle vector autonomously replicable in bacteria belonging to the genera Gluconobacter and Escherichia is constructed from an endogenous plasmid of Gluconobacter oxydans IF03171 strain, which has a size of about 5.6 kb, or a part thereof, and a plasmid autonomously replicable in bacteria belonging to the genus Escherichia or a part thereof. The present invention provides a novel plasmid useful for gene manipulation of Gluconobacter bacteria, and a shuttle vector utilizing the plasmid.
摘要翻译： 在属于葡萄糖酸杆菌属和埃希氏杆菌属的细菌中自主复制的穿梭载体由氧化葡糖杆菌IF03171菌株的内源质粒构建，其具有约5.6kb的大小或其一部分，以及可以在属于 属埃希氏菌属或其一部分。 本发明提供了可用于葡萄糖杆菌属细菌的基因操作的新型质粒和利用该质粒的穿梭载体。
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公开(公告)号：US20110194398A1
公开(公告)日：2011-08-11
申请号：US13016464
申请日：2011-01-28
IPC分类号： G11B9/08
CPC分类号： G11B9/1436 , G11B9/1409
摘要： According to one embodiment, a MEMS memory microprobe includes a probe tip, a lever, and a base. The probe tip is arranged to oppose a recording medium and is brought into contact with the recording medium to perform recording or reproduction of information when a current or voltage is applied between them. In the probe tip, a plurality of electrodes used in the recording or reproduction and a plurality of support portions which form the probe tip together with the electrodes are alternately arranged, and the electrodes and the support portions form a single plane which opposes the recording medium.
摘要翻译： 根据一个实施例，MEMS存储器微探针包括探针尖端，杠杆和基部。 探针尖端被布置为与记录介质相对，并且当在其之间施加电流或电压时与记录介质接触以执行信息的记录或再现。 在探针尖端中，用于记录或再现的多个电极和与电极一起形成探针尖端的多个支撑部分交替布置，并且电极和支撑部分形成与记录介质相对的单个平面 。
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58.发明申请ALPHA-AMINO ACID DERIVATIVES AND MEDICAMENTS CONTAINING THE SAME AS AN ACTIVE INGREDIENT 有权ALPHA-氨基酸衍生物和含有其作为活性成分的药物公开(公告)号：US20090275623A1
公开(公告)日：2009-11-05
申请号：US12306901
申请日：2007-06-29
申请人： Kazuhiko Ohrai , Michiaki Adachi , Koji Toyama , Takanori Shimizu , Keishi Hayashi , Masataka Minami , Yoshiyuki Suzuki , Masakazu Sugiyama , Masateru Ohta , Shojiro Kadono , Takuya Shiraishi , Haruhiko Sato , Yoshiaki Watanabe , Nobuya Ishii , Masahiro Sakaitani , Masami Hasegawa
发明人： Kazuhiko Ohrai , Michiaki Adachi , Koji Toyama , Takanori Shimizu , Keishi Hayashi , Masataka Minami , Yoshiyuki Suzuki , Masakazu Sugiyama , Masateru Ohta , Shojiro Kadono , Takuya Shiraishi , Haruhiko Sato , Yoshiaki Watanabe , Nobuya Ishii , Masahiro Sakaitani , Masami Hasegawa
IPC分类号： A61K31/429 , C07D513/04 , A61P9/04 , A61P35/00
CPC分类号： C07D513/04
摘要： The present invention provides novel α-amino acid derivatives of formula (1): (wherein, R1, R2, R3, R4, X and Y are as defined in the claims) or pharmaceutically acceptable salts, prodrugs or solvates thereof. The derivatives of formula (1) have βARK1 inhibitory activity and are useful for preventing or treating heart failure. Moreover, the derivatives of formula (1) also have antitumor activity, particularly dual inhibitory activity on Aurora kinase and CDK, and are useful for cell proliferative diseases such as cancer.
摘要翻译： 本发明提供新的式（1）的α-氨基酸衍生物：（其中，R 1，R 2，R 3，R 4，X和Y如权利要求中所定义）或其药学上可接受的盐，前药或溶剂合物。 式（1）的衍生物具有βARK1抑制活性，可用于预防或治疗心力衰竭。 此外，式（1）的衍生物还具有抗肿瘤活性，特别是对Aurora激酶和CDK的双重抑制活性，并且可用于细胞增殖性疾病如癌症。
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公开(公告)号：US07534590B2
公开(公告)日：2009-05-19
申请号：US11317308
申请日：2005-12-27
IPC分类号： C12P13/04 , C12P13/12 , C12P13/22 , C12P17/10 , C07D209/18
CPC分类号： C12P17/10 , C07D209/20
摘要： A solution to be treated containing monatin and impurities is treated with a nonpolar resin having aromatic rings, whereby monatin is separated from the solution. Treatment with the nonpolar resin having aromatic rings results in efficient separation of monatin under a mild pH condition.
摘要翻译： 用含有莫纳甜和杂质的待处理溶液用具有芳环的非极性树脂处理，由此将莫纳甜与溶液分离。 用具有芳香环的非极性树脂进行处理导致莫纳甜在温和的pH条件下有效分离。
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公开(公告)号：USD281139S
公开(公告)日：1985-10-29
申请号：US555956
申请日：1983-11-29
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