Abstract:
The invention is directed to indole amide derivatives as EP4 receptor antagonists useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, osteoarthritis, rheumatoid arthritis and cancer. Pharmaceutical compositions and methods of use are also included.
Abstract:
A display for measured quantities can include a gauge with a set of indicia spaced around the gauge to indicate the measured quantities. A window can be formed in the gauge that extends along the set of indicia. An elliptical reflector can be positioned such that a first focus of the elliptical reflector is on the same axis as the center of the gauge with this axis perpendicular to the axis connecting the foci. An optical device can be mounted on a shaft and be arranged to redirect a light beam from a second foci of the elliptical reflector onto the elliptical reflector to generate a virtual pointer in the window. Means can be provided for turning the shaft to rotate the optical device. A light source can project the light beam onto the optical device. Rotation of the optical device can enable the virtual pointer to be selectively aimed at the set of indicia.
Abstract:
This invention relates to class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis. They have the following structure: Formula (I)
Abstract:
A composition comprising a substantially purified compound of the formula: in combination with at least one additional therapeutic agent, and methods of preventing or treating cancer and a condition treatable by the inhibition of vacuolar-type (H+)-ATPase.
Abstract:
This invention relates to class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis. They have the following structure: Formula (I).
Abstract:
A wireless device, such as a remote control unit, may include an internal fingerprint identification unit. The fingerprint identification unit may be arranged to capture the user's fingerprint when the user's finger is positioned over a button that is substantially radiation transmissive. Radiation directed at the user's finger through the button may be captured for image analysis and ultimately for fingerprint identification. Thus, the device may be used to identify users who wish to access a processor-based system such as a processor-based television receiver.