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57 条记录 (耗时 0.033 秒)

    Solder ball allocation on a chip and method of the same
    53.
    发明授权
    Solder ball allocation on a chip and method of the same 有权
    焊球分配芯片和方法相同

    公开(公告)号：US06696763B2

    公开(公告)日：2004-02-24

    申请号：US09990920

    申请日：2001-11-13

    申请人： Shu-Hui Chen ,  Hsiu-Tzu Chen

    发明人： Shu-Hui Chen ,  Hsiu-Tzu Chen

    IPC分类号： H01L2348

    CPC分类号： H01L23/49816 ,  H01L23/50 ,  H01L2924/0002 ,  H01L2924/00

    摘要： A solder ball allocation on a chip, and a method of the same are provided. The chip has a substrate, first solder balls and second solder balls. The first solder balls are located on a periphery of the substrate and arranged outwardly. The second solder balls are located in a central part of the substrate and arranged with several first geometric patterns that construct a second geometric pattern. The first geometric patterns are also arranged to divide the chip into several power source blocks. The conflict between the second solder balls and the power source blocks are analyzed to remove the second solder balls with conflicts. The power line can go through the middle directly to avoid the power source bypass, or other reasons that cause the chip unable to work stable. The invention divides the chip into several power source blocks without increase the chip volume and cost.

    摘要翻译： 提供了芯片上的焊球分配及其方法。 芯片具有基板，第一焊球和第二焊球。 第一焊球位于衬底的周边并且向外布置。 第二焊球位于基板的中心部分，并布置成构成第二几何图案的几个第一几何图案。 第一几何图案也被布置成将芯片分成几个电源块。 分析第二焊球和电源块之间的冲突，以冲出第二焊球。 电源线可以直接通过中间，避免电源旁路，或导致芯片工作不稳定的其他原因。 本发明将芯片分成几个电源块，而不增加芯片的体积和成本。

    Method of recovering adipic acid and 6-hydroxycaproic acid from waste solution of alkali metal salts of organic acids coming from the process of cyclohexane oxidation
    54.
    发明授权
    Method of recovering adipic acid and 6-hydroxycaproic acid from waste solution of alkali metal salts of organic acids coming from the process of cyclohexane oxidation 有权
    从环己烷氧化过程的有机酸碱金属盐的废溶液中回收己二酸和6-羟基己酸的方法

    公开(公告)号：US06063958A

    公开(公告)日：2000-05-16

    申请号：US218613

    申请日：1998-12-22

    申请人： Kuang-Ruei Chen ,  Jih-Dar Hwang ,  Shu-Hui Chen

    发明人： Kuang-Ruei Chen ,  Jih-Dar Hwang ,  Shu-Hui Chen

    IPC分类号： C07C51/215 ,  C07B61/00 ,  C07C51/31 ,  C07C51/44 ,  C07C51/48 ,  C07C55/14 ,  C07C59/105 ,  C07C51/42

    CPC分类号： C07C51/44 ,  C07C51/313 ,  C07C51/48

    摘要： A method of recovering adipic acid and 6-hydroxycaproic acid from the waste solution of alkali metal salts of organic acids coming from the process of cyclohexane oxidation, which comprises:(i) basifying the reaction mixture coming from cyclohexane oxidation with an aqueous solution of an alkali-metal base so that the organic acids essentially comprising adipic acid and 6-hydroxycaproic acid therein, are saponified, extracting the formed alkali metal salts of organic acids from the mixture with water, then acidifying the aqueous extract comprising the alkali metal salts of organic acids to a pH value of 3 or lower with an aqueous solution of a protic inorganic acid, as a result, said aqueous extract is separated into an oily layer and an aqueous layer;(ii) extracting the organic acid from said oily layer obtained from the step (i) with an aqueous solution of a protic inorganic acid, to obtain an aqueous extract;(iii) extracting the organic acid from the aqueous layer obtained from the step (i) with an organic solvent selected from alcohols, ketones, esters or the mixtures thereof, to obtain an oily extract;(iv) extracting the organic acid from the aqueous extract obtained from the step (ii) with an organic solvent selected from alcohols, ketones, esters or mixtures thereof, to obtain an oily extract; and(v) combining and distilling the oily extracts obtained from the steps (iii) and (iv), to recover the organic acid essentially comprising adipic acid and 6-hydroxycaproic acid.

    摘要翻译： 从环己烷氧化方法的有机酸的碱金属盐的废溶液中回收己二酸和6-羟基己酸的方法，该方法包括：（i）将来自环己烷氧化的反应混合物用 碱金属碱，使得其中主要含有己二酸和6-羟基己酸的有机酸被皂化，从水中与混合物中提取形成的有机酸碱金属盐，然后酸化含有机碱的碱金属盐的含水提取物 酸与酸性无机酸的水溶液的pH值为3以下，结果将所述含水提取物分离成油层和水层; （ii）用质子性无机酸的水溶液从所述步骤（i）得到的所述油层中提取有机酸，得到水提取物; （iii）使用选自醇，酮，酯或其混合物的有机溶剂从由步骤（ⅰ）获得的水层萃取有机酸，得到油状提取物; （iv）用选自醇，酮，酯或其混合物的有机溶剂从步骤（ii）获得的水提取物中萃取有机酸，得到油状提取物; 和（v）合并并蒸馏由步骤（iii）和（iv）得到的油状提取物，以回收基本上包含己二酸和6-羟基己酸的有机酸。

    Processes for high-yield diastereoselective synthesis of dideoxynucleosides
    55.
    发明授权
    Processes for high-yield diastereoselective synthesis of dideoxynucleosides 失效
    用于高产率非对映选择性合成双脱氧核苷的方法

    公开(公告)号：US6005097A

    公开(公告)日：1999-12-21

    申请号：US663674

    申请日：1996-06-14

    申请人： Shu-Hui Chen ,  Xiuyan Li

    发明人： Shu-Hui Chen ,  Xiuyan Li

    IPC分类号： C07D307/33 ,  C07F7/18 ,  C07H19/00 ,  C07H19/048 ,  C07H19/06 ,  C07H19/16 ,  C07H19/22 ,  C07H19/04

    CPC分类号： C07H19/06 ,  C07F7/1892 ,  C07H19/16

    摘要： The present invention relates to methods for substantially enhancing the stereoselective synthesis of .beta.-anomeric nucleoside analogs. In methods according to the present invention, the introduction of a phenylseleno group onto a blocked lactone sugar precursor may be selected so that the desirable phenylseleno substituent is introduced on the side of the blocked lactone away from the blocking group. This stereospecific introduction of the phenylseleno group in sugar precursor allows the synthesis of nucleoside analogs and in particular, 2',3',-dideoxy- and 2',3'-dideoxy-2',3'-didehydronucleoside analogs in very high yield. In certain preferred embodiments, the preferred phenylseleno blocked lactone is obtained in an amount representing approximately 90% or more of the total amount of the stereoisomers obtained. In even more preferred embodiments, the amount of the preferred stereoisomer is at least 95%, even more preferably at least about 97% of the total amount of phenylseleno blocked lactone produced.

    摘要翻译： 本发明涉及用于基本上增强β-异头核苷类似物的立体选择性合成的方法。 在根据本发明的方法中，可以选择在封端的内酯糖前体上引入苯基硒基团，使得所需的苯基硒取代基被引入封闭的内酯的远离阻断基团的一侧。 苯基硒基团在糖前体中的这种立体特异性引入允许以非常高的产率合成核苷类似物，特别是2'，3'， - 二脱氧-2'，3'-二脱氧-2'，3'-二脱氢核苷类似物 。 在某些优选的实施方案中，以所获得的立体异构体总量的约90％或更多的量获得优选的苯基硒封闭的内酯。 在甚至更优选的实施方案中，优选的立体异构体的量为所产生的苯基硒嵌段内酯的总量的至少95％，甚至更优选至少约97％。

    Deoxy taxols
    56.
    发明授权
    Deoxy taxols 失效
    脱氧紫杉醇

    公开(公告)号：US5478854A

    公开(公告)日：1995-12-26

    申请号：US212447

    申请日：1994-03-10

    申请人： Vittorio Farina ,  Shu-Hui Chen ,  David Langley ,  Mark D. Wittman ,  Joydeep Kant ,  Dolatrai M. Vyas

    发明人： Vittorio Farina ,  Shu-Hui Chen ,  David Langley ,  Mark D. Wittman ,  Joydeep Kant ,  Dolatrai M. Vyas

    IPC分类号： C07D305/14 ,  C07D407/12 ,  C07D409/12 ,  C07F7/18 ,  C07F9/655 ,  C07F9/6558 ,  H01L21/48 ,  A61K31/33 ,  A61K31/34 ,  A61K31/38

    CPC分类号： C07D407/12 ,  C07D305/14 ,  C07D409/12 ,  C07F7/1856 ,  C07F9/65512 ,  C07F9/65586 ,  H01L21/4839

    摘要： R.sup.g is C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-6 cycloalkyl, or a radical of the formula --W--R.sup.x in which W is a bond, C.sub.2-6 alkenediyl, or --(CH.sub.2).sub.t --, in which t is one to six; and R.sup.x is naphthyl, phenyl, or heteroaryl, and furthermore R.sup.x can be optionally substituted with one to three same or different C.sub.1-6 alkyl, C.sub.1-6 alkoxy, halogen or --CF.sub.3 groups;R.sup.2 is --OCOR, H, OH, --OR, --OSO.sub.2 R, --OCONR.sup.o R, --OCONHR, --OCOO(CH.sub.2).sub.t R, or --OCOOR; andR and R.sup.o are independently C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.3-6 cycloalkyl, C.sub.2-6 alkynyl, or phenyl, optionally substituted with one to three same or different C.sub.1-6 alkyl, C.sub.1-6 alkoxy, halogen or --CF.sub.3 groups.Further provided by this invention are pharmaceutical formulations and intermediates for the the preparation of deoxy taxols of formula I. A method of treating mammalian tumors using a compound of formula I is also provided.

    摘要翻译： 其中R 1是-COR z，其中R z是RO-或R; R 8为C 1-6烷基，C 2-6烯基，C 2-6炔基，C 3-6环烷基或W-Rx基团，W为键，C 2-6亚烯基或 - （CH 2）t - 其中t为1至6; 并且Rx是萘基，苯基或杂芳基，此外Rx可任选地被一至三个相同或不同的C 1-6烷基，C 1-6烷氧基，卤素或-CF 3基团取代; R2是-OCOR，H，OH，-OR，-OSO2R，-OCONRoR，-OCONHR，-OCOO（CH2）tR或-OCOOR; 并且R和R 4独立地是C 1-6烷基，C 2-6烯基，C 3-6环烷基，C 2-6炔基或苯基，任选地被一至三个相同或不同的C 1-6烷基，C 1-6烷氧基，卤素或 -CF3组。 本发明进一步提供了用于制备式I的脱氧紫杉醇的药物制剂和中间体。还提供了使用式I化合物治疗哺乳动物肿瘤的方法。