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公开(公告)号:US06270991B1
公开(公告)日:2001-08-07
申请号:US08916481
申请日:1997-08-22
申请人: Nicola Gail Wallis
发明人: Nicola Gail Wallis
IPC分类号: C12N1500
CPC分类号: C12N9/1223 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/3156 , C12N9/1205 , G01N2500/04
摘要: The invention provides histidine kinase polypeptides and DNA (RNA) encoding histidine kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidine kinase polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供组氨酸激酶多肽和编码组氨酸激酶多肽的DNA(RNA),以及通过重组技术产生此类多肽的方法。 还提供了利用组氨酸激酶多肽筛选抗菌化合物的方法。
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公开(公告)号:US6136556A
公开(公告)日:2000-10-24
申请号:US771321
申请日:1996-12-20
IPC分类号: C12N15/02 , A61K31/00 , A61K38/00 , A61K39/085 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/00 , A61P31/04 , C07K14/195 , C07K14/31 , C07K16/12 , C12N1/21 , C12N15/00 , C12N15/09 , C12N15/31 , C12P21/02 , C12P21/08 , C12R1/445 , C12D21/00 , C12N15/63 , C12N15/85
CPC分类号: C07K14/31 , A61K2039/51 , C07K2319/00
摘要: Novel response regulator polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides and polypeptides for the treatment of infection, particularly bacterial infections. Antagonists against such the polypeptides of the invention and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence the nucleic acid sequences and the polypeptides of the invention in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding response regulators and for detecting the polypeptide in a host.
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公开(公告)号:US6120771A
公开(公告)日:2000-09-19
申请号:US398165
申请日:1999-09-17
申请人: Nicola Gail Wallis
发明人: Nicola Gail Wallis
IPC分类号: G01N33/50 , A61K31/00 , A61K38/00 , A61K39/395 , A61K48/00 , A61P31/00 , A61P31/04 , C07K2/00 , C12N1/21 , C12N9/00 , C12N15/00 , C12N15/09 , C12Q1/00 , C12R1/46 , G01N33/15 , G01N33/566 , G01N33/68 , A61K39/00 , A61K38/51 , A61K39/02
摘要: The invention provides MurE polypeptides and DNA (RNA) encoding MurE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurE polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供了编码MurE多肽的MurE多肽和DNA(RNA),以及通过重组技术产生此类多肽的方法。 还提供了利用MurE多肽筛选抗菌化合物的方法。
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公开(公告)号:US6084086A
公开(公告)日:2000-07-04
申请号:US771110
申请日:1996-12-20
IPC分类号: G01N33/50 , A61K39/00 , A61K39/085 , C07K14/31 , C12N15/00 , C12N15/09 , C12R1/445 , G01N33/15 , G01N33/566 , G01N33/569 , C07H21/00 , C07H21/04 , C12P21/06
CPC分类号: C07K14/31 , A61K2039/51 , A61K39/00 , C07K2319/00 , Y10S435/883
摘要: Novel response regulator polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides and polypeptides for the treatment of infection, particularly bacterial infections. Antagonists against such the polypeptides of the invention and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence the nucleic acid sequences and the polypeptides of the invention in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding response regulators and for detecting the polypeptide in a host.
摘要翻译: 公开了新型的响应调节剂多肽和编码这种多肽的DNA(RNA)以及通过重组技术产生此类多肽的方法。 还公开了利用这种多核苷酸和多肽治疗感染,特别是细菌感染的方法。 还公开了抗这些本发明多肽的拮抗剂及其作为治疗感染,特别是细菌感染的治疗剂的用途。 还公开了用于检测与宿主中本发明的核酸序列和多肽相关的疾病的诊断测定法。 还公开了用于检测编码响应调节剂的多核苷酸和用于在宿主中检测多肽的诊断测定。
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公开(公告)号:US5910572A
公开(公告)日:1999-06-08
申请号:US8253
申请日:1998-01-16
申请人: Nicola Gail Wallis
发明人: Nicola Gail Wallis
IPC分类号: A61K39/00 , C07K14/315 , C12N15/31 , C07K1/00 , C12N15/75
CPC分类号: C07K14/3156 , A61K39/00
摘要: The invention provides Response regulator polypeptides and DNA (RNA) encoding Response regulator polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Response regulator polypeptides to screen for antibacterial compounds.
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