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135 条记录 (耗时 0.049 秒)

    Quinoline compounds
    51.
    发明授权
    Quinoline compounds 失效
    喹啉化合物

    公开(公告)号：US5650415A

    公开(公告)日：1997-07-22

    申请号：US487090

    申请日：1995-06-07

    申请人： Peng Cho Tang ,  Gerald McMahon ,  Li Sun

    发明人： Peng Cho Tang ,  Gerald McMahon ,  Li Sun

    IPC分类号： A61K31/47 ,  A61K31/4706 ,  C07D215/54 ,  C07D213/80 ,  A61K31/44

    CPC分类号： C07D215/54 ,  A61K31/47 ,  A61K31/4706

    摘要： A method of inhibiting cell proliferation or differentiation by exposing a cell to a compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof. Q is selected from the group consisting of NH and S, n is 0 or 1; and R.sub.1-9 are independently selected from the group consisting of halo, trihalomethyl, alkyl, nitro, hydroxy, alkoxy, sulphoxy, sulphonyl, amide, sulfonamide, carboxamide, amino, and hydrogen. Also provided is a compound of the structure ##STR2##

    摘要翻译： 一种通过将细胞暴露于式IMA化合物或其药学上可接受的盐来抑制细胞增殖或分化的方法。 Q选自NH和S，n为0或1; 卤素，三卤代甲基，烷基，硝基，羟基，烷氧基，磺酰氧基，磺酰基，酰胺，磺酰胺，甲酰胺，氨基和氢。 还提供了结构的化合物

    Methods of modulating tyrosine protein kinase function with indolinone compounds
    52.
    发明授权
    Methods of modulating tyrosine protein kinase function with indolinone compounds 失效
    用吲哚啉酮化合物调节酪氨酸蛋白激酶功能的方法

    公开(公告)号：US06514981B1

    公开(公告)日：2003-02-04

    申请号：US09283657

    申请日：1999-04-01

    申请人： Peng Cho Tang ,  Li Sun

    发明人： Peng Cho Tang ,  Li Sun

    IPC分类号： A61K31404

    CPC分类号： C07D403/06 ,  C07D209/34 ,  C07D209/86 ,  C07D409/06

    摘要： The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds. The invention also relates to methods of modulating the function of protein tyrosine kinases using indolinone compounds and methods of treating diseases by modulating the function of protein tyrosine kinases and related signal transduction pathways.

    摘要翻译： 本发明涉及某些吲哚啉酮化合物，其合成方法和由吲哚啉酮化合物组成的组合文库。 本发明还涉及使用吲哚酮化合物调节蛋白酪氨酸激酶的功能的方法以及通过调节蛋白酪氨酸激酶和相关信号转导途径的功能来治疗疾病的方法。

    Indolinone combinatorial libraries and related products and methods for the treatment of disease
    55.
    发明申请
    Indolinone combinatorial libraries and related products and methods for the treatment of disease 有权
    吲哚酮组合文库及相关产品及治疗方法

    公开(公告)号：US20050197382A1

    公开(公告)日：2005-09-08

    申请号：US10784917

    申请日：2004-02-24

    申请人： Peng Tang ,  Li Sun ,  Gerald McMahon ,  Klaus Hirth ,  Laura Shawver

    发明人： Peng Tang ,  Li Sun ,  Gerald McMahon ,  Klaus Hirth ,  Laura Shawver

    IPC分类号： C07D209/34 ,  A61K31/404 ,  G01N33/53 ,  G01N33/543

    CPC分类号： C07D209/34

    摘要： The present invention relates to organic molecules capable of modulating, regulating and/or inhibiting protein kinase signal transduction. Such compounds are useful for the treatment of diseases related to unregulated protein kinase signal transduction, including cell proliferative diseases such as cancer, atherosclerosis, arthritis and restenosis and metabolic diseases such as diabetes. The present invention features indolinone compounds that potently inhibit protein kinases and related products and methods. Inhibitors specific to the FLK protein kinase can be obtained by adding chemical substituents to the 3-[(indole-3-yl)methylene]-2-indolinone, in particular at the 1′ position of the indole ring. Indolinone compounds that specifically inhibit the FLK and platelet derived growth factor protein kinases can harbor a tetrahydroindole or cyclopentano-b-pyrrol moiety. Indolinone compounds that are modified with substituents, particularly at the 5 position of the oxindole ring, can effectively activate protein kinases. This invention also features novel hydrosoluble indolinone compounds that are tyrosine kinase inhibitors and related products and methods.

    摘要翻译： 本发明涉及能够调节，调节和/或抑制蛋白激酶信号转导的有机分子。 这些化合物可用于治疗与未调节的蛋白激酶信号转导相关的疾病，包括细胞增殖性疾病如癌症，动脉粥样硬化，关节炎和再狭窄以及诸如糖尿病的代谢疾病。 本发明具有抑制蛋白激酶及相关产物和方法的吲哚啉酮化合物。 可以通过向3 - [（吲哚-3-基）亚甲基] -2-二氢吲哚酮，特别是在吲哚环的1'位置添加化学取代基来获得对FLK蛋白激酶特异性的抑制剂。 特异性抑制FLK和血小板衍生生长因子蛋白激酶的吲哚酮化合物可以含有四氢吲哚或环戊基-b-吡咯部分。 被取代基修饰的吲哚啉酮化合物，特别是在羟吲哚环的5位，可以有效地激活蛋白激酶。 本发明还具有酪氨酸激酶抑制剂和相关产物和方法的新型水溶性吲哚啉酮化合物。

    Solution based polymer nanofiller-composites synthesis
    56.
    发明授权
    Solution based polymer nanofiller-composites synthesis 有权
    基于溶液的聚合物纳米填料 - 复合材料的合成

    公开(公告)号：US09228065B2

    公开(公告)日：2016-01-05

    申请号：US14274111

    申请日：2014-05-09

    申请人： Li Sun ,  Anil Pitta ,  Hung Duong

    发明人： Li Sun ,  Anil Pitta ,  Hung Duong

    IPC分类号： C08F2/46 ,  C08G61/04 ,  C07F7/18 ,  C08F8/00 ,  C08J3/215 ,  C08J5/00 ,  C08K7/24

    CPC分类号： C08J5/005 ,  C08J3/215 ,  C08J5/042 ,  C08J2315/00 ,  C08K3/041 ,  C08K3/046 ,  C08K7/24 ,  C08K9/02 ,  C08K2201/011

    摘要： A solution based polymer nanofiller composite processing method to improve mechanical, electrical, thermal and/or chemical properties. The solution based synthesis method may include the steps of surface functionalizing carbon nanomaterials and dissolving a polymer in a solvent. The functionalized carbon nanomaterials and dissolved polymer may be mixed until the mixture is homogenous. The mixture may be cured to form the polymer carbon nano-composite material, which provides significant improvements in modulus, hardness, strength, fracture toughness, wear, fatigue, creep, and damping performance.

    摘要翻译： 一种基于溶液的聚合物纳米填料复合加工方法，以改善机械，电气，热和/或化学性质。 基于溶液的合成方法可以包括表面官能化碳纳米材料并将聚合物溶解在溶剂中的步骤。 官能化的碳纳米材料和溶解的聚合物可以混合直到混合物是均匀的。 混合物可以固化以形成聚合物碳纳米复合材料，其提供模量，硬度，强度，断裂韧性，磨损，疲劳，蠕变和阻尼性能方面的显着改进。

    Amorphous oxide thin film transistor, method for manufacturing the same, and display panel
    57.
    发明授权
    Amorphous oxide thin film transistor, method for manufacturing the same, and display panel 有权
    无定形氧化物薄膜晶体管，其制造方法和显示面板

    公开(公告)号：US09112040B2

    公开(公告)日：2015-08-18

    申请号：US13428422

    申请日：2012-03-23

    申请人： Xiaodi Liu ,  Li Sun ,  Haijing Chen

    发明人： Xiaodi Liu ,  Li Sun ,  Haijing Chen

    IPC分类号： H01L29/786 ,  H01L29/66

    CPC分类号： H01L29/78693 ,  H01L21/02565 ,  H01L21/02592 ,  H01L21/02631 ,  H01L21/0273 ,  H01L21/441 ,  H01L21/467 ,  H01L21/477 ,  H01L29/66969 ,  H01L29/78618

    摘要： Embodiments of the disclosed technology provide an amorphous oxide thin film transistor (TFT), a method for preparing an amorphous oxide TFT, and a display panel. The amorphous oxide thin film transistor includes: a gate electrode, a gate insulating layer, a semiconductor active layer, a source electrode and a drain electrode. The semiconductor active layer comprises a channel layer and an ohmic contact layer, and the channel layer has a greater content of oxygen than the ohmic contact layer; the channel layer contacts the gate insulating layer, and the ohmic contact layer comprises two separated ohmic contact regions, one of which contacts the source electrode and the other of which contacts the drain electrode.

    摘要翻译： 所公开技术的实施例提供无定形氧化物薄膜晶体管（TFT），制备无定形氧化物TFT的方法和显示面板。 无定形氧化物薄膜晶体管包括：栅极，栅极绝缘层，半导体有源层，源极和漏极。 半导体有源层包括沟道层和欧姆接触层，并且沟道层具有比欧姆接触层更大的氧含量; 沟道层接触栅极绝缘层，欧姆接触层包括两个分离的欧姆接触区域，其中一个接触源极电极，另一个接触漏极电极。

    SOLUTION BASED POLYMER NANOFILLER-COMPOSITES SYNTHESIS
    58.
    发明申请
    SOLUTION BASED POLYMER NANOFILLER-COMPOSITES SYNTHESIS 有权
    基于溶液的聚合物纳米复合材料的合成

    公开(公告)号：US20140336299A1

    公开(公告)日：2014-11-13

    申请号：US14274111

    申请日：2014-05-09

    申请人： Li Sun ,  Anil Pitta ,  Hung Duong

    发明人： Li Sun ,  Anil Pitta ,  Hung Duong

    IPC分类号： C08J3/20 ,  C08J3/28

    CPC分类号： C08J5/005 ,  C08J3/215 ,  C08J5/042 ,  C08J2315/00 ,  C08K3/041 ,  C08K3/046 ,  C08K7/24 ,  C08K9/02 ,  C08K2201/011

    摘要： A solution based polymer nanofiller composite processing method to improve mechanical, electrical, thermal and/or chemical properties. The solution based synthesis method may include the steps of surface functionalizing carbon nanomaterials and dissolving a polymer in a solvent. The functionalized carbon nanomaterials and dissolved polymer may be mixed until the mixture is homogenous. The mixture may be cured to form the polymer carbon nano-composite material, which provides significant improvements in modulus, hardness, strength, fracture toughness, wear, fatigue, creep, and damping performance.

    摘要翻译： 一种基于溶液的聚合物纳米填料复合加工方法，以改善机械，电气，热和/或化学性质。 基于溶液的合成方法可以包括表面官能化碳纳米材料并将聚合物溶解在溶剂中的步骤。 官能化的碳纳米材料和溶解的聚合物可以混合直到混合物是均匀的。 混合物可以固化以形成聚合物碳纳米复合材料，其提供模量，硬度，强度，断裂韧性，磨损，疲劳，蠕变和阻尼性能方面的显着改进。