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57 条记录 (耗时 0.051 秒)

    .beta.-adrenergic agonists
    53.
    发明授权
    .beta.-adrenergic agonists 失效
    β-肾上腺素能激动剂

    公开(公告)号：US5859044A

    公开(公告)日：1999-01-12

    申请号：US892381

    申请日：1997-07-14

    申请人： Robert L. Dow ,  Kristin M. Lundy

    发明人： Robert L. Dow ,  Kristin M. Lundy

    IPC分类号： A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61P3/00 ,  A61P3/04 ,  A61P3/08 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D209/42

    CPC分类号： C07D209/42

    摘要： The present invention relates to certain compounds of the formula (I) the racemic-enantiomeric mixtures and optical isomers of said compounds, prodrugs thereof and the pharmaceutically acceptable salts, depicted below, which are .beta.-adrenergic receptor agonists and accordingly have utility as, inter alia, hypoglycemic and antiobesity agents. The invention also relates to methods of use for the compounds and to compositions containing them. The compounds of the present invention also possess utility for increasing lean meat deposition and/or improving the lean meat to fat ratio in animals, e.g., ungulate animals, companion animals, especially dogs, and poultry. The compounds of formula (I) have the following structure ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as defined in the specification.

    摘要翻译： 本发明涉及某些式（I）化合物，所述化合物的外消旋对映异构体混合物和旋光异构体，其前药和下文描述的药学上可接受的盐，其是β-肾上腺素能受体激动剂，因此具有效用 尤其是低血糖和抗肥胖剂。 本发明还涉及用于化合物的方法和含有它们的组合物。 本发明的化合物还具有用于增加动物，例如有蹄动物，伴侣动物，特别是狗和家禽的瘦肉沉积和/或改善瘦肉与脂肪比例的效用。 式（I）化合物具有以下结构，其中R1，R2，R3，R4和R5如说明书中所定义。

    4-aminopyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors
    54.
    发明授权
    4-aminopyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors 失效
    4-氨基吡咯并[2,3-d]嘧啶作为酪氨酸激酶抑制剂

    公开(公告)号：US5639757A

    公开(公告)日：1997-06-17

    申请号：US448248

    申请日：1995-05-23

    申请人： Robert L. Dow ,  Kevin Koch

    发明人： Robert L. Dow ,  Kevin Koch

    IPC分类号： A61K31/519 ,  A61K31/505 ,  A61K31/52

    CPC分类号： A61K31/519

    摘要： Certain 4-aminopyrrolo[2,3-d]pyrimidine compounds, and their pharmaceutically-acceptable salts, are inhibitors of tyrosine kinase enzymes, and are useful for immunoregulation and for the treatment of cancer, angiogenesis and atherosclerosis.

    摘要翻译： 某些4-氨基吡咯并[2,3-d]嘧啶化合物及其药学上可接受的盐是酪氨酸激酶的抑制剂，可用于免疫调节和治疗癌症，血管生成和动脉粥样硬化。

    Combined EED igniter means and means for protecting the EED from inadvertent extraneous electricity induced firing
    57.
    发明授权
    Combined EED igniter means and means for protecting the EED from inadvertent extraneous electricity induced firing 失效
    组合的EED点火器装置和装置，用于保护EED免于无意的外部电力触发

    公开(公告)号：US5355800A

    公开(公告)日：1994-10-18

    申请号：US868249

    申请日：1992-04-14

    申请人： Robert L. Dow ,  Paul W. Proctor

    发明人： Robert L. Dow ,  Paul W. Proctor

    IPC分类号： A61N1/37 ,  F42B3/188 ,  F42B3/18

    CPC分类号： A61N1/37 ,  F42B3/188

    摘要： The precision ignition device disclosed in U.S. Pat. No. 4,708,060 is combined with the device disclosed in U.S. Pat. No. 5,036,768, and U.S. Ser. No. 07/584,045 to provide accurate control over the ignition of an EED while also protecting that EED from inadvertent firing caused by exposure to extraneous electricity, such as RF energy or electrostatic energy. The combined device can be connected to a source of power and/or to an external sequential timer for further control over the firing process. A method of fabricating the means for protecting the EED from inadvertent extraneous electricity induced firing is also disclosed.

    摘要翻译： 美国专利公开的精密点火装置 美国专利No.4,708,060与美国专利No. 美国专利No.5,036,768， 以提供对EED的点火的精确控制，同时还保护EED免于由暴露于诸如RF能量或静电能量的外部电力引起的无意烧毁。 组合的设备可以连接到电源和/或外部顺序定时器，以进一步控制点火过程。 还公开了一种制造用于保护EED免于无意的外部电力引发的烧制的方法。