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124 条记录 (耗时 0.072 秒)

    Human Chemotactic Cytokine I Polypeptides
    51.
    发明申请
    Human Chemotactic Cytokine I Polypeptides 审中-公开
    人类趋化细胞因子I多肽

    公开(公告)号：US20090062510A1

    公开(公告)日：2009-03-05

    申请号：US11737622

    申请日：2007-04-19

    申请人： Jian Ni ,  Guo-Liang Yu ,  Pedro Alfonso ,  Reiner L. Gentz ,  Jeffrey Y. Su

    发明人： Jian Ni ,  Guo-Liang Yu ,  Pedro Alfonso ,  Reiner L. Gentz ,  Jeffrey Y. Su

    IPC分类号： C07K14/52

    CPC分类号： C07K14/52 ,  C07H21/04

    摘要： Human chemotactic cytokine I polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.

    摘要翻译： 公开了人类趋化性细胞因子I多肽和编码这种趋化性细胞因子的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫，慢性和急性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。

    Pancreas-derived plasminogen activator inhibitor
    55.
    发明授权
    Pancreas-derived plasminogen activator inhibitor 失效
    胰腺来源的纤溶酶原激活物抑制剂

    公开(公告)号：US06893870B2

    公开(公告)日：2005-05-17

    申请号：US10628395

    申请日：2003-07-29

    申请人： Jian Ni ,  Reiner L. Gentz ,  Steven M. Ruben ,  Y. Eric Shi

    发明人： Jian Ni ,  Reiner L. Gentz ,  Steven M. Ruben ,  Y. Eric Shi

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/81 ,  C12N15/12 ,  C12N5/02

    CPC分类号： C07K14/81 ,  A61K38/00 ,  A61K48/00 ,  C07K14/8132 ,  C07K2319/00 ,  Y02A50/463

    摘要： The present invention relates to a novel member of the plasminogen activator inhibitor protein family. In particular, isolated nucleic acid molecules are provided encoding the pancreas-derived plasminogen activator inhibitor protein. Pancreas-derived plasminogen activator inhibitor polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to methods for treating physiologic and pathologic disease conditions and diagnostic methods for detecting pathologic disorders.

    摘要翻译： 本发明涉及纤溶酶原激活物抑制剂蛋白家族的新成员。 特别地，提供编码胰腺衍生的纤溶酶原激活物抑制蛋白的分离的核酸分子。 还提供了胰腺来源的纤溶酶原激活物抑制剂多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于治疗生理和病理疾病状况的方法以及用于检测病理学疾病的诊断方法。

    Polynucleotides encoding T1 receptor like ligand II
    57.
    发明授权
    Polynucleotides encoding T1 receptor like ligand II 失效
    编码T1受体的多核苷酸，如配体II

    公开(公告)号：US06586210B1

    公开(公告)日：2003-07-01

    申请号：US08916442

    申请日：1997-08-22

    申请人： Jian Ni ,  Reiner L. Gentz ,  Steven M. Ruben

    发明人： Jian Ni ,  Reiner L. Gentz ,  Steven M. Ruben

    IPC分类号： C12N510

    CPC分类号： C07K14/54

    摘要： The present invention concerns a novel T1R-like ligand II protein. In particular, isolated nucleic acid molecules are provided encoding the T1R-like ligand II protein. T1R-like ligand II polypeptides are also provided, as are recombinant vectors and host cells for expressing the same.

    摘要翻译： 本发明涉及一种新的T1R样配体II蛋白。 特别地，提供编码T1R样配体II蛋白质的分离的核酸分子。 还提供了T1R样配体II多肽，重组载体和用于表达它们的宿主细胞也是如此。

    Mammary transforming protein
    59.
    发明授权
    Mammary transforming protein 失效
    乳腺转化蛋白

    公开(公告)号：US06482922B2

    公开(公告)日：2002-11-19

    申请号：US09263811

    申请日：1999-03-08

    申请人： Jian Ni ,  Guo-Liang Yu ,  Reiner L. Gentz

    发明人： Jian Ni ,  Guo-Liang Yu ,  Reiner L. Gentz

    IPC分类号： C07K100

    CPC分类号： C07K14/82 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026 ,  C12Q1/6886 ,  C12Q2600/136

    摘要： A human mammary transforming protein and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for inhibiting such polypeptide for preventing and/or treating neoplasia. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.

    摘要翻译： 公开了一种编码这种多肽的人类乳腺转化蛋白和DNA（RNA），以及通过重组技术产生这种多肽的方法。 还公开了抑制这种多肽以预防和/或治疗瘤形成的方法。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。

    Galectin 9 and 10SV polynucleotides
    60.
    发明授权
    Galectin 9 and 10SV polynucleotides 失效
    半乳凝素9和10SV多核苷酸

    公开(公告)号：US06468768B1

    公开(公告)日：2002-10-22

    申请号：US09656450

    申请日：2000-09-06

    申请人： Jian Ni ,  Reiner L. Gentz ,  Steven M. Ruben

    发明人： Jian Ni ,  Reiner L. Gentz ,  Steven M. Ruben

    IPC分类号： C12N1500

    CPC分类号： C07K14/4726 ,  A61K38/00 ,  C07K2319/00 ,  G01N33/68 ,  G01N2333/4724

    摘要： The present invention relates to novel galectin 8, 9, 10 and 10SV proteins which are members of the galectin superfamily. In particular, isolated nucleic acid molecules are provided encoding the human galectin 8, 9, 10 and 10SV proteins. Galectin 8, 9, 10 and 10SV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of galectin 8, 9, 10 or 10SV activity. Also provided are diagnostic and therapeutic methods.

    摘要翻译： 本发明涉及作为半乳凝素超家族成员的新型半乳凝素8,9,10和10SV蛋白。 特别地，提供了编码人半乳凝素8,9,10和10SV蛋白的分离的核酸分子。 还提供了Galectin 8,9,10和10SV多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定半乳凝素8,9,10或10SV活性的激动剂和拮抗剂的筛选方法。 还提供诊断和治疗方法。