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公开(公告)号:US08481037B2
公开(公告)日:2013-07-09
申请号:US13007211
申请日:2011-01-14
申请人: Jennifer Lynne Reed , Herren Wu , Ying Tang , Julian Davies , Jeffry Watkins
发明人: Jennifer Lynne Reed , Herren Wu , Ying Tang , Julian Davies , Jeffry Watkins
IPC分类号: A61K39/395
CPC分类号: C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C07K2317/92 , G01N33/6869
摘要: The present invention provides novel antibodies that immunospecifically bind to an IL-9 polypeptide and compositions comprising said antibodies. The present invention also provides methods and compositions preventing, treating, managing, and/or ameliorating diseases and disorders associated with aberrant expression and/or activity of IL 9 or IL-9 receptor or subunits thereof, autoimmune diseases, inflammatory diseases, proliferative diseases, and infections comprising administration of one or more antibodies thereof that immunospecifically bind to an IL-9 polypeptide. The invention also encompasses methods and compositions for diagnosing, monitoring, and prognosing these disorders. The present invention further relates to articles of manufacture and kits comprising antibodies that immunospecifically bind to an IL-9 polypeptide.
摘要翻译: 本发明提供免疫特异性结合IL-9多肽的新型抗体和包含所述抗体的组合物。 本发明还提供了预防,治疗,治疗和/或改善与IL 9或IL-9受体或其亚基的异常表达和/或活性相关的疾病和病症的方法和组合物,自身免疫性疾病,炎性疾病,增殖性疾病, 以及感染,其包括施用一种或多种免疫特异性结合IL-9多肽的抗体。 本发明还包括用于诊断,监测和预测这些疾病的方法和组合物。 本发明还涉及包含免疫特异性结合IL-9多肽的抗体的制品和试剂盒。
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公开(公告)号:US08183346B2
公开(公告)日:2012-05-22
申请号:US12628263
申请日:2009-12-01
申请人: Donmienne Doen Mun Leung , Peng Luan , Joseph Vincent Manetta , Ying Tang , Derrick Ryan Witcher
发明人: Donmienne Doen Mun Leung , Peng Luan , Joseph Vincent Manetta , Ying Tang , Derrick Ryan Witcher
CPC分类号: C07K16/2869 , A61K38/1816 , A61K39/3955 , C07K16/28 , C07K2317/34 , C07K2317/70 , C07K2317/76 , C07K2317/77 , C07K2317/90
摘要: Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of human FPN1, and which are effective in maintaining or increasing the transport of iron out of mammalian cells and/or maintaining or increasing the level of serum iron, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a subject in vivo.
摘要翻译: 提供了结合并抑制人FPN1的活性的单克隆抗体和其抗原结合片段,并且其有效维持或增加铁离开哺乳动物细胞的运输和/或维持或提高血清铁的水平, 网织红细胞计数,红细胞计数,血红蛋白和/或体内血细胞比容。
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公开(公告)号:US20110253055A1
公开(公告)日:2011-10-20
申请号:US12998257
申请日:2009-11-10
申请人: Ying Tang , Igor Sokolik , Adam Winkleman , Seth Johnson , Brian Mayers , Patrick Reust , Wendell Ray Guffey , Yimin Zhang , Regina Pratt
发明人: Ying Tang , Igor Sokolik , Adam Winkleman , Seth Johnson , Brian Mayers , Patrick Reust , Wendell Ray Guffey , Yimin Zhang , Regina Pratt
CPC分类号: A01K1/0152 , A01K1/0154 , A01K1/0155
摘要: The invention provides animal litters and methods of making and using such litters. The animal litters comprise (a) a plurality of absorbent particles comprising (i) a non-swelling particle and (ii) a clumping material coated on the non-swelling particle and (b) a plurality of one or more filler particles that are not associated with the absorbent particles. The filler particles provide additional functionality to the litters, e.g., controlling odor, absorbing moisture, releasing fragrance, controlling microorganisms, controlling dust, reducing density, reducing weight, and combinations thereof. The litters are made by producing the absorbent particles using conventional means and combining the absorbent particles with one or more filler particles that impart the desired characteristic to the litters.
摘要翻译: 本发明提供了动物窝和制造和使用这种窝的方法。 动物窝包括(a)多个吸收性粒子,其包含(i)非溶胀性颗粒和(ii)涂覆在非溶胀性颗粒上的聚集材料,以及(b)多个一个或多个不是 与吸收性颗粒相关联。 填料颗粒提供了额外的功能,例如控制气味,吸收水分,释放香味,控制微生物,控制粉尘,降低密度,减轻重量及其组合。 通过使用常规方法制备吸收性颗粒来制造衣物,并将吸收性颗粒与赋予衣物赋予期望特性的一种或多种填料颗粒结合。
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公开(公告)号:US20110189190A1
公开(公告)日:2011-08-04
申请号:US13055201
申请日:2009-07-29
CPC分类号: C07K16/26 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/92 , G01N33/74
摘要: Monoclonal antibodies are provided that bind to the N-terminus of human hepcidin-25 and are characterized as having high affinity and selectivity for the polypeptide. The antibodies of the invention are useful for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment of various disorders, such as anemia, in a human subject. The antibodies of the invention are also useful as analytical tools, such as in sandwich ELISA.
摘要翻译: 提供结合人hepcidin-25的N末端的单克隆抗体,其特征在于对多肽具有高亲和力和选择性。 本发明的抗体可用于增加人类血清铁水平,网织红细胞计数,红细胞计数,血红蛋白和/或血细胞比容,以及用于治疗人类受试者中的各种疾病如贫血。 本发明的抗体也可用作分析工具,例如夹心ELISA。
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公开(公告)号:US20110129480A1
公开(公告)日:2011-06-02
申请号:US12628263
申请日:2009-12-01
申请人: Donmienne Doen Mun Leung , Peng Luan , Joseph Vincent Manetta , Ying Tang , Derrick Ryan Witcher
发明人: Donmienne Doen Mun Leung , Peng Luan , Joseph Vincent Manetta , Ying Tang , Derrick Ryan Witcher
IPC分类号: A61K39/395 , C07K16/00 , C07H21/00 , C12N15/63 , C12N5/07 , C12P21/08 , A61P7/00 , A61P35/00
CPC分类号: C07K16/2869 , A61K38/1816 , A61K39/3955 , C07K16/28 , C07K2317/34 , C07K2317/70 , C07K2317/76 , C07K2317/77 , C07K2317/90
摘要: Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of human FPN1, and which are effective in maintaining or increasing the transport of iron out of mammalian cells and/or maintaining or increasing the level of serum iron, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a subject in vivo.
摘要翻译: 提供了结合并抑制人FPN1的活性的单克隆抗体和其抗原结合片段,并且其有效维持或增加铁离开哺乳动物细胞的运输和/或维持或提高血清铁的水平, 网织红细胞计数,红细胞计数,血红蛋白和/或体内血细胞比容。
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公开(公告)号:US07763247B2
公开(公告)日:2010-07-27
申请号:US12070146
申请日:2008-02-15
申请人: Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
发明人: Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
IPC分类号: A61K39/00
CPC分类号: C07K16/30 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K16/18 , C07K2317/24 , C07K2317/55 , C07K2317/565
摘要: The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.
摘要翻译: 本发明提供了接枝抗体或其功能片段,其包含一个或多个在重链CDR的一个或多个CDR中具有至少一个氨基酸取代的互补决定区(CDR),其中所述接枝抗体或其功能片段具有特异性 隐形胶原表位的结合活性。 本发明还提供了使用具有对神经胶原表位具有特异性结合活性的抗体的方法,包括抑制血管生成,肿瘤生长和转移的方法。
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公开(公告)号:US07619069B2
公开(公告)日:2009-11-17
申请号:US11874952
申请日:2007-10-19
申请人: Julian Davies , Craig Duane Dickinson , David Matthew Marquis , Ying Tang , Peter Edward Vaillancourt
发明人: Julian Davies , Craig Duane Dickinson , David Matthew Marquis , Ying Tang , Peter Edward Vaillancourt
IPC分类号: C07K16/00 , A61K39/395
CPC分类号: C07K16/22 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K2317/55 , C07K2317/74 , C07K2317/92
摘要: TGF-beta 1 binding compositions and reagents related thereto are provided. Methods of using such compositions for therapeutic purpose are also provided.
摘要翻译: 提供与其相关的TGF-β1结合组合物和试剂。 还提供了将这些组合物用于治疗目的的方法。
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公开(公告)号:US07575747B2
公开(公告)日:2009-08-18
申请号:US10544050
申请日:2004-02-06
申请人: Julian Davies , Ying Tang , Jeffry Dean Watkins
发明人: Julian Davies , Ying Tang , Jeffry Dean Watkins
IPC分类号: A61K39/395 , C07K16/18
CPC分类号: C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要: The present invention encompasses isolated antibodies, or fragments thereof, that are humanized variants of murine antibody 266 which employ complementarity determining regions derived from murine antibody 266. The variant antibodies are useful for treatment or prevention of conditions and diseases associated with Aβ, including Alzheimer's disease, Down's syndrome, cerebral amyloid angiopathy, mild cognitive impairment, and the like.
摘要翻译: 本发明包括使用衍生自鼠抗体266的互补决定区的鼠抗体266的人源化变体的分离的抗体或其片段。变体抗体可用于治疗或预防与Aβ相关的病症和疾病,包括阿尔茨海默氏病 唐氏综合征,脑淀粉样血管病,轻度认知障碍等。
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公开(公告)号:US20080260733A1
公开(公告)日:2008-10-23
申请号:US12117642
申请日:2008-05-08
申请人: Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
发明人: Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
IPC分类号: A61K39/395 , C07K16/00 , A61P9/00 , G01N33/68 , C07H21/00
CPC分类号: C07K16/30 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565
摘要: The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.
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公开(公告)号:US07390885B2
公开(公告)日:2008-06-24
申请号:US10011250
申请日:2001-12-06
申请人: Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
发明人: Jeffry D. Watkins , William D. Huse , Ying Tang , Daniel Broek , Peter Brooks
IPC分类号: C12P21/08
CPC分类号: C07K16/30 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565
摘要: The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.
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