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    Topical glycopyrrolate formulations
    51.
    发明授权
    Topical glycopyrrolate formulations 有权
    局部格隆溴铵制剂

    公开(公告)号：US08618160B2

    公开(公告)日：2013-12-31

    申请号：US12738168

    申请日：2008-10-17

    申请人： Michael Johnston ,  Robert James Houlden

    发明人： Michael Johnston ,  Robert James Houlden

    IPC分类号： A61Q15/00

    CPC分类号： A61K8/0208 ,  A61K8/4913 ,  A61K9/0014 ,  A61K31/40 ,  A61K47/10 ,  A61K47/32 ,  A61Q15/00

    摘要： Individually packaged topical formulations comprising about 0.25 to about 6% w/w of glycopyrrolate for the treatment of hyperhidrosis, wherein said wipe is contained within a pouch resistant to leakage. The formulations may further comprise ethanol, a buffering agent and water. In addition, the formulations may further comprise a polymer system comprising a hydrophobic polymer in combination with a hydrophilic polymer.

    摘要翻译： 包含约0.25至约6％w / w的格隆溴铵的单独包装的局部制剂用于治疗多汗症，其中所述擦拭物包含在抵抗渗漏的小袋内。 制剂还可以包含乙醇，缓冲剂和水。 此外，制剂还可包含包含与亲水性聚合物组合的疏水性聚合物的聚合物体系。

    Microemulsion process and composition
    53.
    发明授权
    Microemulsion process and composition 有权
    微乳液工艺及组成

    公开(公告)号：US08460641B2

    公开(公告)日：2013-06-11

    申请号：US11216668

    申请日：2005-08-31

    申请人： Maria Graziella Larm ,  Ronald Harding ,  Michael Johnston ,  Albert Zorko Abram ,  Prema Vijayakumar ,  Phoebe Sun

    发明人： Maria Graziella Larm ,  Ronald Harding ,  Michael Johnston ,  Albert Zorko Abram ,  Prema Vijayakumar ,  Phoebe Sun

    IPC分类号： A61K9/00 ,  A61K8/02 ,  A61K8/00 ,  A61K31/59 ,  A61K31/56 ,  A01N45/00

    CPC分类号： A61K31/56 ,  A61K8/062 ,  A61K8/068 ,  A61K9/0014 ,  A61K9/107 ,  A61K9/1075 ,  A61K9/12 ,  A61K31/59 ,  A61Q19/00

    摘要： An oil-in-water microemulsion or sub-micron emulsion composition for dermal delivery of at least one pharmaceutically active ingredient, comprising: a first part including at least one occlusive agent and one or more lipophilic surfactants dispersed throughout a second part including water and at least one hydrophilic surfactant, and a non-surfactant amphiphilic type compound, pharmaceutically active ingredient, and water. It has been found that if a non-surfactant amphiphilic type compound is added together with the second part as would conventionally be the case, a microemulsion or sub-micron emulsion is not formed, by adding the so called third part, phase assembly occurs at a lower temperature than would be expected and moreover, this phase appears to assist in maintaining the microemulsion or sub-micron emulsion characteristics of the formulation during storage at normal temperatures.

    摘要翻译： 一种用于皮肤递送至少一种药物活性成分的水包油微乳液或亚微米乳液组合物，其包含：第一部分，其包含至少一种封闭剂和一种或多种分散在包括水的第二部分和在 至少一种亲水性表面活性剂和非表面活性剂两亲型化合物，药物活性成分和水。 已经发现如果将非表面活性剂两亲型化合物与常规情况下的第二部分一起加入，则不形成微乳液或亚微米级乳液，通过加入所谓的第三部分，相组合发生在 比预期的温度更低，此外，该阶段似乎有助于在常温下储存期间维持制剂的微乳液或亚微米乳液特性。

    Systems, Methods, and Computer Program Products for Location Salience Modeling for Multimodal Search
    54.
    发明申请
    Systems, Methods, and Computer Program Products for Location Salience Modeling for Multimodal Search 有权
    系统，方法和计算机程序产品用于多模态搜索的位置显式建模

    公开(公告)号：US20120117112A1

    公开(公告)日：2012-05-10

    申请号：US12941312

    申请日：2010-11-08

    申请人： Michael Johnston ,  Patrick Ehlen

    发明人： Michael Johnston ,  Patrick Ehlen

    IPC分类号： G06F7/00 ,  G06F17/30

    CPC分类号： G06F17/3087 ,  G01C21/3608

    摘要： Computational models of dialog context have often focused on unimodal spoken dialog or text, using the language itself as the primary locus of contextual information. But as spoken unimodal interaction is replaced by situated multimodal interaction on mobile platforms supporting a combination of spoken dialog with graphical interaction, touch-screen input, geolocation, and other non-linguistic contextual factors, a need arises for more sophisticated models of context that capture the influence of these factors on semantic interpretation and dialog flow. The systems, methods, and computer program products disclosed herein address this need. A method for multimodal search includes, in part, determining an intended location of search query based upon information received from a remote mobile device that issued the search query.

    摘要翻译： 对话语境的计算模型往往侧重于单语口语对话或文本，使用语言本身作为语境信息的主要场所。 但是，由于口头单模互动被移动平台上的定位多模态交互所取代，支持语音对话与图形交互，触摸屏输入，地理位置和其他非语言背景因素的组合，需要出现更复杂的上下文模型 这些因素对语义解释和对话流程的影响。 本文所公开的系统，方法和计算机程序产品满足了这一需求。 用于多模式搜索的方法部分地包括基于从发出搜索查询的远程移动设备接收的信息来确定搜索查询的预期位置。

    Customized Interface Based on Viewed Programming
    55.
    发明申请
    Customized Interface Based on Viewed Programming 有权
    基于浏览编程的定制界面

    公开(公告)号：US20120030709A1

    公开(公告)日：2012-02-02

    申请号：US13252563

    申请日：2011-10-04

    申请人： David Gibbon ,  Michael Johnston ,  Behzad Shahraray

    发明人： David Gibbon ,  Michael Johnston ,  Behzad Shahraray

    IPC分类号： H04N5/445

    CPC分类号： H04H60/65 ,  H04N7/17318 ,  H04N21/26603 ,  H04N21/2668 ,  H04N21/4331 ,  H04N21/4667 ,  H04N21/6582 ,  H04N21/84

    摘要： In one embodiment, a system generates a customized interface based on displayed programming. The system stores a program that a user displayed through a media device; searches through a network for information related to the displayed program; and extracts data associated with the information related to the displayed program. A custom interface is generated based substantially on the data associated with the information related to the displayed program.

    摘要翻译： 在一个实施例中，系统基于显示的程序生成定制界面。 系统存储用户通过媒体设备显示的节目; 通过网络搜索与显示的节目有关的信息; 并提取与所显示的程序相关的信息相关联的数据。 基于与与所显示的程序相关的信息相关联的数据生成定制界面。

    SYSTEMS AND METHODS FOR FAST STATE MODIFICATION OF AT LEAST A PORTION OF NON-VOLATILE MEMORY
    57.
    发明申请
    SYSTEMS AND METHODS FOR FAST STATE MODIFICATION OF AT LEAST A PORTION OF NON-VOLATILE MEMORY 有权
    至少一个非易失性存储器部分进行快速状态修改的系统和方法

    公开(公告)号：US20090172280A1

    公开(公告)日：2009-07-02

    申请号：US11966826

    申请日：2007-12-28

    申请人： Sanjeev N. Trika ,  Debra Hensgen ,  Han H. Chau ,  Michael Johnston

    发明人： Sanjeev N. Trika ,  Debra Hensgen ,  Han H. Chau ,  Michael Johnston

    IPC分类号： G06F12/00

    CPC分类号： G06F12/0246 ,  G06F2212/7207 ,  G06F2212/7211

    摘要： A method is provided for reducing the number of writes in a non-volatile memory (122). The method involves writing data in the non-volatile memory and determining a set of data from the data in the non-volatile memory to be written to a removable memory (126) that is operatively coupled to the non-volatile memory (e.g., a NAND memory). The method also involves writing the set of data to the removable memory (e.g., a hard disk) from the non-volatile memory. The method further involves writing a delineation marker (e.g., a sequence number) to the non-volatile memory specifying that the set of data has been written to the removable memory. Notably, the metadata of the data in the non-volatile memory comprises at least one marker set as a specific marker type (e.g., a valid marker and a dirty marker).

    摘要翻译： 提供了一种用于减少非易失性存储器（122）中的写入数量的方法。 该方法涉及在非易失性存储器中写入数据并且从非易失性存储器中的数据确定一组数据以写入可操作地耦合到非易失性存储器的可移除存储器（126），例如， NAND存储器）。 该方法还涉及从非易失性存储器将该组数据写入可移动存储器（例如，硬盘）。 该方法还包括将描述标记（例如，序列号）写入非易失性存储器，指定该数据集已被写入可移动存储器。 值得注意的是，非易失性存储器中的数据的元数据包括设置为特定标记类型的至少一个标记（例如，有效标记和脏标记）。

    System and method of handling problematic input during context-sensitive help for multi-modal dialog systems
    58.
    发明授权
    System and method of handling problematic input during context-sensitive help for multi-modal dialog systems 有权
    在多模式对话系统的上下文相关帮助过程中处理问题输入的系统和方法

    公开(公告)号：US07451088B1

    公开(公告)日：2008-11-11

    申请号：US11619325

    申请日：2007-01-03

    申请人： Patrick Ehlen ,  Helen Hastie ,  Michael Johnston

    发明人： Patrick Ehlen ,  Helen Hastie ,  Michael Johnston

    IPC分类号： G10L11/00 ,  G10L21/00

    CPC分类号： G10L15/22 ,  G10L2015/221 ,  G10L2015/228

    摘要： A method of presenting a multi-modal help dialog move to a user in a multi-modal dialog system is disclosed. The method comprises presenting an audio portion of the multi-modal help dialog move that explains available ways of user inquiry and presenting a corresponding graphical action performed on a user interface associated with the audio portion. The multi-modal help dialog move is context-sensitive and uses current display information and dialog contextual information to present a multi-modal help move that is currently related to the user. A user request or a problematic dialog detection module may trigger the multi-modal help move.

    摘要翻译： 公开了一种向多用户对话系统中的用户呈现多模式帮助对话框的方法。 该方法包括呈现多模式帮助对话移动的音频部分，其解释用户查询的可用方式并呈现在与音频部分相关联的用户界面上执行的对应图形动作。 多模式帮助对话框移动是上下文相关的，并使用当前显示信息和对话框上下文信息来呈现当前与用户相关的多模式帮助移动。 用户请求或有问题的对话检测模块可以触发多模式帮助移动。

    Customized interface based on viewed programming
    59.
    发明申请
    Customized interface based on viewed programming 有权
    基于浏览编程的定制界面

    公开(公告)号：US20080109850A1

    公开(公告)日：2008-05-08

    申请号：US11592469

    申请日：2006-11-02

    申请人： David Gibbon ,  Michael Johnston ,  Behzad Shahraray

    发明人： David Gibbon ,  Michael Johnston ,  Behzad Shahraray

    IPC分类号： G06F3/00

    CPC分类号： H04H60/65 ,  H04N7/17318 ,  H04N21/26603 ,  H04N21/2668 ,  H04N21/4331 ,  H04N21/4667 ,  H04N21/6582 ,  H04N21/84

    摘要： In one embodiment, a system generates a customized interface based on viewed programming. The system stores a program that a user viewed through a media device; searches through a network for information related to the viewed program; and extracts data associated with the information related to the viewed program. A custom interface is generated based substantially on the data associated with the information related to the viewed program.

    摘要翻译： 在一个实施例中，系统基于所查看的节目生成定制界面。 系统存储用户通过媒体设备观看的节目; 通过网络搜索与所查看的节目有关的信息; 并提取与所查看的程序相关的信息相关联的数据。 基于与与所查看的程序相关的信息相关联的数据生成定制界面。

    Method and apparatus for filling a space between a sloping roof of a building and a peaked roof of an adjoining extension
    60.
    发明申请
    Method and apparatus for filling a space between a sloping roof of a building and a peaked roof of an adjoining extension 审中-公开
    用于填充建筑物的倾斜屋顶和相邻延伸部的顶峰之间的空间的方法和装置

    公开(公告)号：US20080005978A1

    公开(公告)日：2008-01-10

    申请号：US11820644

    申请日：2007-06-20

    申请人： Alexis Spyrou ,  Michael Johnston

    发明人： Alexis Spyrou ,  Michael Johnston

    IPC分类号： E04B7/02

    CPC分类号： E04B7/063 ,  E04D2003/0868

    摘要： An assembly of prefabricated metal extrusions is utilized to secure roof plates in a construction to fill a void or space between a sloped roof of a building such as one family house and a peaked roof of an adjoining extension such as a sunroom. The extrusions have angularly adjustable channels for adjustably receiving the roof plates.

    摘要翻译： 使用预制金属挤压件的组件来将屋顶板固定在一个结构中，以填充诸如一个家庭房屋的建筑物的倾斜屋顶与相邻延伸部例如日光室的顶峰屋顶之间的空隙或空间。 挤压件具有角度可调节的通道，用于可调节地接收屋顶板。