公开(公告)号：US20110014274A1

公开(公告)日：2011-01-20

申请号：US12843395

申请日：2010-07-26

申请人： Steven G. Reed ,  Darrick Carter

发明人： Steven G. Reed ,  Darrick Carter

IPC分类号： A61K9/127 ,  A61K39/245 ,  A61P31/22 ,  A61P37/04 ,  A61P39/06

CPC分类号： A61K39/39 ,  A61K39/0005 ,  A61K39/008 ,  A61K39/04 ,  A61K39/145 ,  A61K45/06 ,  A61K2039/53 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/57 ,  C12N7/00 ,  C12N2760/16034 ,  C12N2760/16071 ,  Y02A50/41 ,  Y02A50/412

摘要： Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.

公开(公告)号：US07695925B2

公开(公告)日：2010-04-13

申请号：US12092562

申请日：2006-11-02

申请人： Raymond L. Houghton ,  Steven G. Reed ,  Syamal Raychaudhuri

发明人： Raymond L. Houghton ,  Steven G. Reed ,  Syamal Raychaudhuri

IPC分类号： G01N33/53

CPC分类号： C07K14/44 ,  A61K39/00 ,  C07K2319/40 ,  G01N2333/44 ,  Y02A50/414 ,  Y10S435/975

摘要： Compositions comprising fusion polypeptides of T. cruzi epitopes are provided, together with methods for the use of such compositions in the diagnosis of T. cruzi infection and in screening blood supplies. Diagnostic kits comprising such compositions are also provided.

摘要翻译： 提供了包含克氏锥虫表位的融合多肽的组合物，以及用于诊断克氏锥虫感染和筛选血液供应的方法。 还提供了包含这种组合物的诊断试剂盒。

公开(公告)号：US20100008924A1

公开(公告)日：2010-01-14

申请号：US12497178

申请日：2009-07-02

申请人： Ajay Bhatia ,  Steven G. Reed

发明人： Ajay Bhatia ,  Steven G. Reed

IPC分类号： A61K39/395 ,  C07K14/00 ,  C07H21/04 ,  C07K16/00 ,  A61K31/7088 ,  A61K39/008 ,  A61K38/16 ,  A61P1/16 ,  A61P3/04 ,  G01N33/53

CPC分类号： C07K14/44 ,  A61K38/00 ,  A61K39/00 ,  C07K16/20 ,  G01N33/56905 ,  G01N33/6893 ,  Y10S435/81 ,  Y10S435/975

摘要： The present invention relates generally to a fusion protein made from a synthetic gene construct comprising of elements derived from the Leishmania antigens K26, K39, and K9. The fusion protein is particularly useful in the diagnosis of leishmaniasis, particularly visceral leishmaniasis in animals such as humans and dogs.

摘要翻译： 本发明一般涉及由包含源自利什曼原虫抗原K26，K39和K9的元件的合成基因构建体制成的融合蛋白。 融合蛋白特别可用于诊断利什曼病，特别是动物如人和狗中的内脏利什曼病。

公开(公告)号：US06569433B1

公开(公告)日：2003-05-27

申请号：US09569098

申请日：2000-05-10

申请人： Steven G. Reed ,  Michael J. Lodes ,  Raymond L. Houghton ,  Paul R. Sleath ,  Patricia D. McNeill ,  Mary J. Homer ,  Heather Secrist

发明人： Steven G. Reed ,  Michael J. Lodes ,  Raymond L. Houghton ,  Paul R. Sleath ,  Patricia D. McNeill ,  Mary J. Homer ,  Heather Secrist

IPC分类号： A61K39002

CPC分类号： C07K14/44 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/51 ,  C07K2319/00 ,  Y10S530/822

摘要： Compounds and methods for the diagnosis and treatment of B. microti infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a B. microti antigen and DNA sequences encoding such polypeptides. Antigenic epitopes of such antigens are also provided, together with pharmaceutical compositions and vaccines comprising such polypeptides, DNA sequences or antigenic epitopes. Diagnostic kits containing such polypeptides, DNA sequences or antigenic epitopes and a suitable detection reagent may be used for the detection of B. microti infection in patients and biological samples. Antibodies directed against such polypeptides and antigenic epitopes are also provided.

摘要翻译： 公开了用于诊断和治疗微生物感染的化合物和方法。 提供的化合物包括含有微生物抗原的至少一个抗原部分和编码这种多肽的DNA序列的多肽。 还提供了这样的抗原的抗原表位以及包含这种多肽，DNA序列或抗原表位的药物组合物和疫苗。 含有此类多肽，DNA序列或抗原表位的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的微生物感染。 还提供了针对这种多肽和抗原表位的抗体。

公开(公告)号：US06312695B1

公开(公告)日：2001-11-06

申请号：US09123912

申请日：1998-07-27

申请人： Steven G. Reed ,  Tong Tong Wang

发明人： Steven G. Reed ,  Tong Tong Wang

IPC分类号： A61K3900

CPC分类号： C12Q1/6809 ,  A61K38/00 ,  C07K14/47

摘要： Compounds and methods for treating lung cancer are provided. The inventive compounds include polypeptides containing at least a portion of a lung tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of lung cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.

摘要翻译： 提供了治疗肺癌的化合物和方法。 本发明化合物包括含有至少一部分肺肿瘤蛋白的多肽。 还提供包含这种多肽的肺癌免疫治疗用疫苗和药物组合物，或编码这些多肽的DNA分子，以及用于制备本发明多肽的DNA分子。

公开(公告)号：US06228372B1

公开(公告)日：2001-05-08

申请号：US08993674

申请日：1997-12-18

申请人： Steven G. Reed ,  Yasir A. W. Skeiky ,  Michael J. Lodes ,  Raymond L. Houghton ,  John M. Smith ,  Patricia D. McNeill

发明人： Steven G. Reed ,  Yasir A. W. Skeiky ,  Michael J. Lodes ,  Raymond L. Houghton ,  John M. Smith ,  Patricia D. McNeill

IPC分类号： A61K39002

CPC分类号： G01N33/56905 ,  A61K38/00 ,  A61K39/00 ,  C07K14/44 ,  G01N2333/44 ,  Y02A50/414

摘要： Compounds and methods are provided for diagnosing Trypanosoma cruzi infection. The disclosed compounds are polypeptides, or antibodies thereto, that contain one or more epitopes of T. cruzi antigens. The compounds are useful in a variety of immunoassays for detecting T. cruzi infection. The polypeptide compounds are further useful in vaccines and pharmaceutical compositions for inducing protective immunity against Chagas' disease in individuals exposed to T. cruzi.

摘要翻译： 提供化合物和方法用于诊断克氏锥虫感染。 所公开的化合物是含有一个或多个克氏锥虫抗原表位的多肽或其抗体。 该化合物可用于各种用于检测克氏锥虫感染的免疫测定。 多肽化合物还可用于疫苗和药物组合物，用于在暴露于克氏锥虫的个体中诱导针对恰加斯氏病的保护性免疫。

公开(公告)号：US06013268A

公开(公告)日：2000-01-11

申请号：US989370

申请日：1997-12-12

申请人： Steven G. Reed

发明人： Steven G. Reed

IPC分类号： A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61P33/02 ,  C07K14/44 ,  C12N15/30 ,  A61K31/70 ,  C07K14/00

CPC分类号： C07K14/44 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00

摘要： Methods for eliciting or enhancing immune responses to antigens, including tumor antigens, and/or DNA vaccines are provided. The methods employ polypeptides or nucleic acid compositions that contain at least a biologically active portion of a Leishmania braziliensis or Leishmania major homologue of the eukaryotic initiation factor 4A, or a variant thereof. Such polypeptides and compositions are useful for enhancing or eliciting a patient's cellular and/or humoral immune response, for instance within methods for treating tumors.

公开(公告)号：US5916572A

公开(公告)日：1999-06-29

申请号：US557309

申请日：1995-11-14

申请人： Steven G. Reed ,  Yasir A. W. Skeiky ,  Michael J. Lodes ,  Raymond L. Houghton

发明人： Steven G. Reed ,  Yasir A. W. Skeiky ,  Michael J. Lodes ,  Raymond L. Houghton

IPC分类号： G01N33/53 ,  A61K39/002 ,  A61K39/005 ,  A61P33/02 ,  C07K14/44 ,  C07K16/20 ,  C07K19/00 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/30 ,  C12Q1/68 ,  C12R1/19 ,  G01N33/569

CPC分类号： G01N33/56905 ,  C07K14/44 ,  C07K2319/00

摘要： Compounds and methods are provided for diagnosing Trypanosoma cruzi infection. The disclosed compounds are polypeptides, or antibodies thereto, that contain one or more epitopes of T. cruzi antigens. The compounds are useful in a variety of immunoassays for detecting T. cruzi infection. The polypeptide compounds are further useful in vaccines and pharmaceutical compositions for inducing protective immunity against Chagas' disease in individuals exposed to T. cruzi.

公开(公告)号：US5879687A

公开(公告)日：1999-03-09

申请号：US634642

申请日：1996-04-18

申请人： Steven G. Reed

发明人： Steven G. Reed

IPC分类号： C12N15/09 ,  A61K9/50 ,  A61K38/00 ,  A61K39/00 ,  A61K39/39 ,  A61K48/00 ,  A61P35/00 ,  A61P37/04 ,  A61P43/00 ,  C07K14/44 ,  C07K19/00 ,  C12N15/30 ,  C12Q1/02 ,  A61K39/008

CPC分类号： C07K14/44 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00

摘要： Methods for eliciting or enhancing immune responses to antigens, including tumor antigens, and/or DNA vaccines are provided. The methods employ polypeptides or nucleic acid compositions that contain at least a biologically active portion of a Leishmania braziliensis or Leishmania major homologue of the eukaryotic initiation factor 4A, or a variant thereof. Such polypeptides and compositions are useful for enhancing or eliciting a patient's cellular and/or humoral immune response, for instance within methods for treating tumors.

公开(公告)号：US20140193459A1

公开(公告)日：2014-07-10

申请号：US13886666

申请日：2013-05-03

申请人： Steven G. Reed ,  Darrick Carter

发明人： Steven G. Reed ,  Darrick Carter

IPC分类号： A61K39/39 ,  A61K39/04 ,  A61K39/145 ,  A61K39/008

CPC分类号： A61K39/39 ,  A61K39/0005 ,  A61K39/008 ,  A61K39/04 ,  A61K39/145 ,  A61K45/06 ,  A61K2039/53 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/57 ,  C12N7/00 ,  C12N2760/16034 ,  C12N2760/16071 ,  Y02A50/41 ,  Y02A50/412

摘要： Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.