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    COMPOUNDS AND METHODS FOR DIAGNOSIS AND TREATMENT OF LEISHMANIASIS
    53.
    发明申请
    COMPOUNDS AND METHODS FOR DIAGNOSIS AND TREATMENT OF LEISHMANIASIS 有权
    用于诊断和治疗感染的化合物和方法

    公开(公告)号：US20110280902A1

    公开(公告)日：2011-11-17

    申请号：US12901961

    申请日：2010-10-11

    申请人： Yasuyuki Goto ,  Steven G. Reed

    发明人： Yasuyuki Goto ,  Steven G. Reed

    IPC分类号： A61K38/17 ,  A61P37/02 ,  A61P33/02 ,  A61K38/10 ,  C07K14/435 ,  C40B60/12

    CPC分类号： G01N33/56905 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/5091 ,  G01N33/6854 ,  G01N2500/00

    摘要： Compounds and methods are provided for diagnosing, preventing, treating and detecting leishmaniasis infection and stimulating immune responses in patients are disclosed. The compounds disclosed are include polypeptides and fusion proteins that contain at least one immunogenic portion of one or more Leishmania antigens, or a variant thereof. Additionally, methods of screening a screening library for tandem repeat proteins that have immunogenic properties are disclosed. Vaccines and pharmaceutical compositions comprising polynucleotides, polypeptides, fusion proteins and variants thereof that may be used for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmaniasis infection are described.

    摘要翻译： 提供了用于诊断，预防，治疗和检测利什曼病感染和刺激患者免疫应答的化合物和方法。 所公开的化合物包括含有一种或多种利什曼原虫抗原或其变体的至少一种免疫原性部分的多肽和融合蛋白。 另外，公开了筛选具有免疫原性的串联重复蛋白的筛选文库的方法。 描述了可用于预防和治疗利什曼病以及利什曼病感染检测的包含多核苷酸，多肽，融合蛋白及其变体的疫苗和药物组合物。

    Methods and Materials for the Detection of Leishmania Infection
    54.
    发明申请
    Methods and Materials for the Detection of Leishmania Infection 有权
    检测利什曼原虫感染的方法和材料

    公开(公告)号：US20110159528A1

    公开(公告)日：2011-06-30

    申请号：US13012398

    申请日：2011-01-24

    申请人： Raymond L. Houghton ,  Steven G. Reed ,  Syamal Raychaudhuri

    发明人： Raymond L. Houghton ,  Steven G. Reed ,  Syamal Raychaudhuri

    IPC分类号： G01N33/569

    CPC分类号： G01N33/56905 ,  Y02A50/55

    摘要： The present invention provides rapid diagnostic assays for the detection of Leishmania which can readily be used in the field, leading to more rapid treatment. In certain embodiments, the inventive assays, including ELISA and lateral flow assays, employ antibodies that may be effectively employed to detect the Leishmania major antigen TSA, which is present in both promastigotes grown in culture and in amastigotes. Such assays may be employed to detect the presence of cutaneous leishmaniasis in a subject using scrapings, biopsies, and/or aspirates taken from cutaneous lesions.

    摘要翻译： 本发明提供了用于检测利什曼原虫的快速诊断测定法，其可以容易地用于该领域，导致更快速的治疗。 在某些实施方案中，本发明的测定法，包括ELISA和侧向流动测定，采用可有效地用于检测在培养物中生长的两种前鞭毛体中存在的利什曼原虫主要抗原TSA的抗体。 可以使用这种测定法来检测受试者中使用刮皮，活组织检查和/或从皮肤病变获取的吸出物中皮肤利什曼病的存在。

    Compounds and methods for therapy of lung cancer
    59.
    发明授权
    Compounds and methods for therapy of lung cancer 失效
    用于治疗肺癌的化合物和方法

    公开(公告)号：US06312695B1

    公开(公告)日：2001-11-06

    申请号：US09123912

    申请日：1998-07-27

    申请人： Steven G. Reed ,  Tong Tong Wang

    发明人： Steven G. Reed ,  Tong Tong Wang

    IPC分类号： A61K3900

    CPC分类号： C12Q1/6809 ,  A61K38/00 ,  C07K14/47

    摘要： Compounds and methods for treating lung cancer are provided. The inventive compounds include polypeptides containing at least a portion of a lung tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of lung cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.

    摘要翻译： 提供了治疗肺癌的化合物和方法。 本发明化合物包括含有至少一部分肺肿瘤蛋白的多肽。 还提供包含这种多肽的肺癌免疫治疗用疫苗和药物组合物，或编码这些多肽的DNA分子，以及用于制备本发明多肽的DNA分子。