Biodegradable oxidized cellulose esters and their uses as microspheres
    54.
    发明授权
    Biodegradable oxidized cellulose esters and their uses as microspheres 失效
    可生物降解的氧化纤维素酯及其用作微球体

    公开(公告)号:US07649089B2

    公开(公告)日:2010-01-19

    申请号:US10975248

    申请日:2004-10-28

    CPC classification number: A61K9/1652 A61K9/5042 C08B3/00 C08B15/00

    Abstract: A new cellulose excipient, OCCAE, suitable for use as a binder, filler, and/or disintegrant in the development of solid dosage forms and as a bodying agent or a drug carrier in the preparation of topical formulations is described. The cellulose excipient is formed by reacting an oxidized cellulose ester with an alcohol in the presence of a catalyst. The invention also describes the formation of controlled release microspheres using OCCAE and/or oxidized cellulose esters that may be used to control the release of drug in a patient over a time period of several hours to several days.

    Abstract translation: 描述了一种新的纤维素赋形剂OCCAE,其适于在制备固体剂型中作为粘合剂,填充剂和/或崩解剂,以及作为局部制剂制剂中的保护剂或药物载体。 纤维素赋形剂通过在催化剂存在下使氧化的纤维素酯与醇反应而形成。 本发明还描述了使用OCCAE和/或氧化的纤维素酯形成控制释放微球,其可以用于在数小时至数天的时间段内控制药物释放。

    Biodegradable oxidized cellulose esters

    公开(公告)号:US07595392B2

    公开(公告)日:2009-09-29

    申请号:US10007866

    申请日:2001-12-06

    CPC classification number: C08B3/00 C08B15/00

    Abstract: The present invention relates to the preparation of a series of oxidized cellulose esters suitable for use as a drug carrier in the development of biodegradable controlled and/or sustained release pharmaceutical, agricultural, and veterinary compositions, such as films, compacts, microspheres, and pellets. The esters are prepared by acylation of oxidized cellulose having at least 3% carboxyl groups. The resulting oxidized cellulose esters are soluble in aqueous alkaline solutions, water, and a variety of organic solvents.

    Method
    56.
    发明申请
    Method 审中-公开
    方法

    公开(公告)号:US20090098589A1

    公开(公告)日:2009-04-16

    申请号:US11920074

    申请日:2006-05-15

    CPC classification number: C12Q1/42 C07F9/12

    Abstract: There is provided a method for the detection of phytase activity in a sample, which comprises bringing into association a phytase substrate and said sample, and measuring the level of an organic metabolite of said phytase substrate.

    Abstract translation: 提供了一种用于检测样品中植酸酶活性的方法,其包括使植酸酶底物和所述样品结合,并测量所述植酸酶底物的有机代谢物的水平。

    Biodegradable oxidized cellulose esters

    公开(公告)号:US20060093672A1

    公开(公告)日:2006-05-04

    申请号:US11301900

    申请日:2005-12-13

    CPC classification number: C08B3/00 C08B15/00

    Abstract: The present invention relates to the preparation of a series of oxidized cellulose esters suitable for use as a drug carrier in the development of biodegradable controlled and/or sustained release pharmaceutical, agricultural, and veterinary compositions, such as films, compacts, microspheres, and pellets. The esters are prepared by acylation of oxidized cellulose having at least 3% carboxyl groups. The resulting oxidized cellulose esters are soluble in aqueous alkaline solutions, water, and a variety of organic solvents.

    Regenerated cellulose and oxidized cellulose membranes as potential biodegradable platforms for drug delivery and tissue engineering
    60.
    发明授权
    Regenerated cellulose and oxidized cellulose membranes as potential biodegradable platforms for drug delivery and tissue engineering 失效
    再生纤维素和氧化再生纤维素膜作为药物递送和组织工程的潜在可生物降解支架

    公开(公告)号:US06800753B2

    公开(公告)日:2004-10-05

    申请号:US10234276

    申请日:2002-09-04

    Applicant: Vijay Kumar

    Inventor: Vijay Kumar

    Abstract: The present invention describes the use of regenerated celluloses (RC) and (ORC) oxidized regenerated celluloses in the manufacture of scaffolds for drug delivery and tissue engineering. The RC and ORC are biodegradable and biocompatible. The carboxyl, aldehyde, or ketone groups present on the ORC scaffold serve as sites for cell, drug, protein and/or peptide attachment or further chemical modification to induce cell adhesion and subsequent proliferation. The method of manufacture of these membrane structures is simple, and produces flexible structures that maintain their strength when hydrated.

    Abstract translation: 本发明描述了再生纤维素(RC)和(ORC))氧化再生纤维素在制备用于药物递送和组织工程的支架中的用途。 RC和ORC是可生物降解和生物相容的。 存在于ORC支架上的羧基,醛或酮基用作细胞,药物,蛋白质和/或肽附着或进一步化学修饰的位点,以诱导细胞粘附和随后的增殖。 这些膜结构的制造方法简单,并且产生柔软的结构,在水合时保持其强度。

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