公开(公告)号：US10018630B2

公开(公告)日：2018-07-10

申请号：US14343364

申请日：2012-09-07

申请人： Tatsumi Yamazaki ,  Hisafumi Okabe ,  Shinta Kobayashi ,  Takeshi Watanabe ,  Koichi Matsubara ,  Atsuhiko Kato ,  Masami Suzuki

发明人： Tatsumi Yamazaki ,  Hisafumi Okabe ,  Shinta Kobayashi ,  Takeshi Watanabe ,  Koichi Matsubara ,  Atsuhiko Kato ,  Masami Suzuki

IPC分类号： G01N33/574 ,  G01N33/50 ,  G01N33/569 ,  C12N5/095 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/555 ,  A61K31/7088 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  C07K16/18 ,  A61K31/7105 ,  A61K31/713 ,  C07K16/30

CPC分类号： G01N33/574 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/555 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  A61K39/0011 ,  A61K39/3955 ,  A61K45/06 ,  C07K16/18 ,  C07K16/30 ,  C12N5/0695 ,  G01N33/5073 ,  G01N33/56966 ,  G01N2500/04

摘要： An objective of the present invention is to provide: a cancer stem cell isolated using a cell marker; a substantively homogeneous cancer stem cell population including said cancer stem cell; and a method of preparing said cancer stem cell population. Another objective of the present invention is to provide: a method for separating cancer stem cells with a high proliferative potential and those with a low proliferative potential; a method for inducing cancer stem cells to have a different proliferative potential; and cancer stem cells separated or induced by these separation or induction methods. A further objective of the present invention is to provide: a method of screening for pharmaceuticals using said cancer stem cell or cancer stem cell population; a method for detecting the presence of said cancer stem cell or cancer stem cell population and for identifying or quantifying the same. The present inventors discovered that highly pure colon cancer stem cells (CSC) can be obtained in a large quantity, and identified two types of states of colon CSCs distinguishable through Lgr5 expression.

公开(公告)号：US09086697B2

公开(公告)日：2015-07-21

申请号：US14234244

申请日：2012-07-04

申请人： Masami Suzuki

发明人： Masami Suzuki

IPC分类号： G06F7/00 ,  G05B19/418 ,  H01L21/67 ,  H01L21/677

CPC分类号： G05B19/41895 ,  G05B2219/31013 ,  H01L21/67276 ,  H01L21/67727 ,  H01L21/6773 ,  H01L21/67733 ,  H01L21/67736 ,  Y02P90/20 ,  Y02P90/285 ,  Y02P90/60

摘要： A processing facility includes transport management means for managing a transport vehicle which transports a processing target object by traveling along a transporting route which extends along a plurality of processing devices and a storage device for storing the processing target objects. The transport managing means: monitors process advancement information which is transmitted from the processing device to the primary managing means; selects, as advance transport origin and before the transport command information is transmitted from the primary managing means, a processing device, among the plurality of processing devices, in which a process performed on the processing target object has been completed, or is nearly completed; and performs advance transport control in which the transport vehicle is caused to travel to the processing device selected as the advance transport origin in order to carry out the processing target object from the processing device.

摘要翻译： 一种处理设备包括：运输管理装置，用于管理沿着沿着多个处理装置延伸的运送路线行进运送处理对象物体的运送车辆和用于存储处理对象物体的存储装置。 传输管理装置：监视从处理装置发送到主管理装置的进程提前信息; 选择作为提前传送原点，并且在从主要管理装置发送传输命令信息之前，在对处理目标对象执行的处理已经完成或接近完成的多个处理装置中的处理装置; 并且执行使运输车辆行进到选择为先进运输原点的处理装置的前进运输控制，以便从处理装置执行处理对象物体。

公开(公告)号：US08548700B2

公开(公告)日：2013-10-01

申请号：US12946443

申请日：2010-11-15

申请人： Go Endo ,  Masami Suzuki

发明人： Go Endo ,  Masami Suzuki

IPC分类号： B60K15/00

CPC分类号： F16H61/08 ,  F16H61/061 ,  F16H2059/385 ,  F16H2061/0087 ,  F16H2061/0227

摘要： A control system for controlling an automatic transmission that is capable of establishing a given speed stage by engaging a given frictional element. The control system comprises an actual time lag measuring section that measures an actual time lag from the time when a speed change instruction for the given speed stage is issued to the time when a gear ratio of the automatic transmission starts to change for the purpose of establishing the given speed stage, a torque detecting section that detects a torque from an engine, a time lag map that provides a suitable time lag in accordance with the detected torque from the engine, a learning correction section that corrects, by learning control, an instruction value for the hydraulic pressure led to the frictional element in a manner to cause the actual time lag to have the same value as the suitable time lag; and a time lag map correcting section that corrects the suitable time lag in accordance with an operation condition of an associated motor vehicle.

摘要翻译： 一种用于控制能够通过接合给定的摩擦元件来建立给定速度级的自动变速器的控制系统。 控制系统包括：实时时滞测量部，其测量从发出给定速度级的变速指令到自动变速器的变速比开始变化时为了建立目的的时间的实际时间差 给定速度级，检测来自发动机的转矩的转矩检测部，根据来自发动机的检测转矩提供合适的时间延迟的时间延迟图;学习校正部，其通过学习控制来修正指令; 液压值导致摩擦元件以使实际时滞具有与合适时间延迟相同的值; 以及时差图校正部，其根据相关联的机动车辆的运行状况来校正合适的时滞。

公开(公告)号：US08267836B2

公开(公告)日：2012-09-18

申请号：US12486981

申请日：2009-06-18

申请人： Masami Suzuki

发明人： Masami Suzuki

IPC分类号： F16H61/40 ,  F16H59/48 ,  F16H61/26 ,  B60W10/00 ,  B60W10/04 ,  B60W10/10

CPC分类号： F16H61/0437 ,  B60W10/06 ,  B60W10/115 ,  F16H61/061 ,  F16H63/50 ,  F16H63/502 ,  Y10T477/636 ,  Y10T477/6403 ,  Y10T477/675 ,  Y10T477/692 ,  Y10T477/69367 ,  Y10T477/6939

摘要： A control system for an automatic transmission includes a downshift control section configured to increase an engaging capacity of an engaging-side engaging element to engage the engaging-side engaging element and decrease a first engaging capacity of a disengaging-side engaging element to disengage the disengaging-side engaging element when a parameter representing a progressing condition of the downshift reaches a value, thereby carrying out the downshift in a power-on condition. Additionally, the downshift control section is configured to decrease the engaging capacity of the disengaging-side engaging element to a second engaging capacity smaller than the first engaging capacity to continue the downshift which is currently progressing and to cause the engine control section to continue controlling the engine speed when a power-off condition is detected upon an accelerator pedal being returned to a position representing an operating amount during the downshift.

摘要翻译： 一种用于自动变速器的控制系统包括降档控制部分，其被配置为增加接合侧接合元件的接合能力以接合接合侧接合元件并降低分离侧接合元件的第一接合能力以脱离接合 当表示降档的进行状态的参数达到一个值时，从而在通电状态下执行降档。 此外，降挡控制部被构造成将分离侧接合元件的接合能力降低到小于第一接合能力的第二接合能力，以继续正在进行的降档，并且使发动机控制部分继续控制 当在加速踏板返回到代表降档期间的操作量的位置时检测到关闭状态时的发动机转速。

公开(公告)号：US08192862B2

公开(公告)日：2012-06-05

申请号：US12242420

申请日：2008-09-30

申请人： Hiroyuki Yamada ,  Fumihata Yamamoto ,  Hiroshi Seino ,  Masami Suzuki ,  Masayuki Kageyama

发明人： Hiroyuki Yamada ,  Fumihata Yamamoto ,  Hiroshi Seino ,  Masami Suzuki ,  Masayuki Kageyama

IPC分类号： H01M2/02 ,  H01M2/08

CPC分类号： H01M2/0275 ,  H01M2/0212 ,  H01M2/0215 ,  H01M2/0287 ,  Y10T29/4911

摘要： A battery pack including a battery cell, a circuit board electrically connected to the battery cell, a first cover, and a second cover. The battery cell includes a battery element, a rectangular first packaging component, a recess, and a rectangular second packaging component. The battery element is housed in the recess, the first packaging component and the second packaging component are stacked so that the second packaging component covers the opening of the recess, the periphery of the opening is sealed, both ends of the second packaging component are abutted at the outer bottom surface of the recess of the first packaging component, and the first outer resin layer and the second inner resin layer are bonded by heat seal adhesive layer.

摘要翻译： 一种电池组，包括电池单元，电连接到电池单元的电路板，第一盖和第二盖。 电池单体包括电池元件，矩形第一包装部件，凹部和矩形第二包装部件。 电池元件容纳在凹部中，第一包装部件和第二包装部件被堆叠，使得第二包装部件覆盖凹部的开口，开口的周边被密封，第二包装部件的两端被抵接 在第一包装部件的凹部的外底表面处，并且第一外树脂层和第二内树脂层通过热封粘合剂层接合。

公开(公告)号：US07932289B2

公开(公告)日：2011-04-26

申请号：US11658450

申请日：2005-07-26

申请人： Nobuhiro Suzuki ,  Masami Suzuki ,  Tomoko Asakawa ,  Osamu Kataoka

发明人： Nobuhiro Suzuki ,  Masami Suzuki ,  Tomoko Asakawa ,  Osamu Kataoka

IPC分类号： A61K31/19

CPC分类号： A61K31/192 ,  A61K31/00 ,  Y10S514/866

摘要： The present invention relates to a therapeutic agent for diabetes with sulfonylurea secondary failure, which contains a GPR40 agonist. According to the present invention, a therapeutic agent for diabetes with sulfonylurea secondary failure that affords a superior insulin secretion effect and a superior hypoglycemic effect even in diabetic patients for whom a sulfonylurea compound or a fast-acting insulin secretagogue fails to provide an insulin secretion effect and therefore, fails to provide a sufficient hypoglycemic effect can be provided.

摘要翻译： 本发明涉及含有GPR40激动剂的磺酰脲类二级衰竭的糖尿病治疗剂。 根据本发明，即使在磺酰脲类化合物或速效胰岛素促分泌素不能提供胰岛素分泌作用的糖尿病患者中，也可提供具有优异的胰岛素分泌效果和优异的降血糖作用的具有磺酰脲类二次衰竭的糖尿病治疗剂 因此不能提供足够的降血糖作用。

公开(公告)号：US20110091907A1

公开(公告)日：2011-04-21

申请号：US12736180

申请日：2009-03-16

申请人： Hiroaki Kataoka ,  Hirotake Takai ,  Atsuhiko Kato ,  Masami Suzuki ,  Masamichi Sugimoto

发明人： Hiroaki Kataoka ,  Hirotake Takai ,  Atsuhiko Kato ,  Masami Suzuki ,  Masamichi Sugimoto

IPC分类号： G01N33/574

CPC分类号： G01N33/57438 ,  A61K2039/505 ,  C07K16/303

摘要： The present invention relates to an in-vitro immunoassay method for detecting the presence of liver cancer cells in a subject. In the method of the present invention, antigen retrieval treatment based on heat-induced epitope retrieval method and antigen retrieval treatment based on protease-induced epitope retrieval method can be combined in the detection of glypican 3 antigen expression in liver cancer tissues to thereby detect the difference in the expression level or expression pattern of the glypican 3 antigen by immunohistochemical staining method. This enables samples, which has been determined by the conventional HIER method as highly expressing glypican 3, to be graded according to the expression level of glypican 3.

摘要翻译： 本发明涉及用于检测受试者中肝癌细胞存在的体外免疫测定方法。 在本发明的方法中，基于热诱导表位检索方法和基于蛋白酶诱导表位检索方法的抗原恢复处理的抗原恢复处理可以结合在肝癌组织中检测磷脂酰肌醇蛋白聚糖3抗原表达，从而检测 通过免疫组织化学染色法观察磷脂酰肌醇蛋白聚糖3抗原的表达水平或表达模式差异。 这使得通过常规HIER方法确定的高度表达磷脂酰肌醇蛋白聚糖3的样品根据磷脂酰肌醇蛋白聚糖3的表达水平被分级。

公开(公告)号：US20090298361A1

公开(公告)日：2009-12-03

申请号：US12468121

申请日：2009-05-19

申请人： Daisuke Nakamura ,  Yoshihiko Okabe ,  Yoshihito Fukuoka ,  Masami Suzuki

发明人： Daisuke Nakamura ,  Yoshihiko Okabe ,  Yoshihito Fukuoka ,  Masami Suzuki

IPC分类号： B63H20/14

CPC分类号： B63H20/20

摘要： A boat propulsion unit has a construction that prevents a structure near a drive shaft from becoming complicated and increased in size. The boat propulsion unit preferably in the form of an outboard motor includes a front propeller that is rotated together with a front propeller drive shaft during both forward travel and reverse travel of the boat, a rear propeller that is rotated together with a rear propeller drive shaft in an opposite direction of the front propeller during both of the forward travel and the reverse travel of the boat, and a forward-reverse drive that is arranged on an axis of the front propeller drive shaft and the rear propeller drive shaft, and that can be switched between a direction in which the front propeller drive shaft and the rear propeller drive shaft are rotated during the forward travel of the boat and a direction in which the front propeller drive shaft and the rear propeller drive shaft are rotated during the reverse travel of the boat.

摘要翻译： 船推进单元具有防止驱动轴附近的结构变得复杂和尺寸增加的结构。 优选为舷外马达形式的船推进单元包括在船的向前行进和反向行进期间与前螺旋桨驱动轴一起旋转的前螺旋桨，与螺旋桨传动轴一起旋转的后推进器 在船的前进行驶和反向行驶期间在前螺旋桨的相反方向上，以及布置在前螺旋桨传动轴和后螺旋桨驱动轴的轴线上的前后倒档驱动器，并且可以 在前轮驱动轴和后推进器驱动轴在船的向前行进期间旋转的方向与前推进器驱动轴和后螺旋桨驱动轴在逆向行驶期间旋转的方向之间切换 小舟。

公开(公告)号：US07595333B2

公开(公告)日：2009-09-29

申请号：US10717738

申请日：2003-11-20

申请人： Hiroyuki Odaka ,  Masami Suzuki

发明人： Hiroyuki Odaka ,  Masami Suzuki

IPC分类号： A61K31/425 ,  A61K38/28 ,  A61K31/41

CPC分类号： A61K31/427 ,  A61K31/422 ,  A61K31/426 ,  A61K31/4439 ,  Y10S514/866

摘要： An agent for improving ketosis which comprises an insulin sensitizer, which has an excellent action and low toxicity.

摘要翻译： 用于改善酮症的药剂，其包含胰岛素敏化剂，其具有优异的作用和低毒性。

公开(公告)号：US20080319077A1

公开(公告)日：2008-12-25

申请号：US11658450

申请日：2005-07-26

申请人： Nobuhiro Suzuki ,  Masami Suzuki ,  Tomoko Asakawa ,  Osamu Kataoka

发明人： Nobuhiro Suzuki ,  Masami Suzuki ,  Tomoko Asakawa ,  Osamu Kataoka

IPC分类号： A61K31/192 ,  A61P3/10

CPC分类号： A61K31/192 ,  A61K31/00 ,  Y10S514/866

摘要： The present invention relates to a therapeutic agent for diabetes with sulfonylurea secondary failure, which contains a GPR40 agonist. According to the present invention, a therapeutic agent for diabetes with sulfonylurea secondary failure that affords a superior insulin secretion effect and a superior hypoglycemic effect even in diabetic patients for whom a sulfonylurea compound or a fast-acting insulin secretagogue fails to provide an insulin secretion effect and therefore, fails to provide a sufficient hypoglycemic effect can be provided.

摘要翻译： 本发明涉及含有GPR40激动剂的磺酰脲类二级衰竭的糖尿病治疗剂。 根据本发明，即使在磺酰脲类化合物或速效胰岛素促分泌素不能提供胰岛素分泌作用的糖尿病患者中，也可提供具有优异的胰岛素分泌效果和优异的降血糖作用的具有磺酰脲类二次衰竭的糖尿病治疗剂 因此不能提供足够的降血糖作用。