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公开(公告)号：US09390900B2
公开(公告)日：2016-07-12
申请号：US13574788
申请日：2011-01-21
CPC分类号： H01J49/105 , H01J27/16 , H05H1/2406 , H05H2001/2443
摘要： A mass spectrometer of ionizing a sample by a dielectric barrier discharge under a reduced pressure. An ionization with inconsiderable fragmentation can be carried out highly sensitively by the present invention.
摘要翻译： 一种质谱仪，其通过介电阻挡放电在减压下离子化样品。 通过本发明可以高度敏感地进行具有不可忽视的碎裂的电离。
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公开(公告)号：US09076638B2
公开(公告)日：2015-07-07
申请号：US13365355
申请日：2012-02-03
CPC分类号： H01J49/0031 , H01J49/0045
摘要： A variation in an ionization efficiency and the amount of sample which is introduced into an ion trap is corrected and quantified. Ions of an internal standard and ions of a sample are trapped in the ion trap at the same time, and a concentration of the sample is quantified according to an intensity of the ions of the internal standard which are mass-selectively ejected, and an intensity of fragment ions of the sample.
摘要翻译： 电离效率的变化和引入离子阱的样品量被校正和量化。 将内标的离子和样品的离子同时捕获在离子阱中，并且根据质量选择性地喷射的内标的离子的强度来量化样品的浓度，强度 的样品的碎片离子。
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公开(公告)号：US08680464B2
公开(公告)日：2014-03-25
申请号：US13085761
申请日：2011-04-13
CPC分类号： H01J49/0422 , H01J49/0013 , H01J49/0495 , H01J49/24
摘要： A mass spectrometer having a resolution improved by introducing ions into a mass spectrometry part with a high efficiency is provided with a small-sized, simple configuration. The mass spectrometer includes an opening/closing mechanism provided between a sample introducing piping part for introducing a sample into the mass spectrometry part and the mass spectrometry part to conduct gas introduction intermittently and control sample passage. The mass spectrometer further includes a pump mechanism to evacuate a high pressure side of the sample introducing piping part, that is, an opposite side of the opening/closing mechanism to the mass spectrometry part to have a pressure in a range of 100 to 10,000 Pa.
摘要翻译： 具有小型，简单的结构，提供通过以高效率将离子引入质谱部分而提高分辨率的质谱仪。 该质谱仪包括设置在用于将样品引入质谱部分的样品导入管道部分和质谱部分间歇地导入气体引入并控制样品通道的开/关机构。 质谱仪还包括泵机构，用于将样品导入管道部分的高压侧排出，即，将质量分析部件的开闭机构的相反侧压力为100〜10000Pa 。
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公开(公告)号：US08164053B2
公开(公告)日：2012-04-24
申请号：US12039306
申请日：2008-02-28
IPC分类号： B01D59/44
CPC分类号： H01J49/0045
摘要： There has been a problem that both detection sensitivity and throughput cannot be improved simultaneously by a conventional MS/MS analysis method.A mass analyzer having an ion trap for ejecting ions in a specific mass range, a collisional dissociation part for causing ions ejected from the ion trap to be dissociated, a mass analyzing part for performing a mass analysis of ions ejected from the collisional dissociation part, and a control part including a list in which measurement conditions for each ion are stored selectively resonance-ejects ions introduced into and accumulated in the ion trap based on masses. A scanning operation is a repetition of an operation of ejecting specific precursor ions in a direction of the collisional dissociation part and an operation of ejecting nothing, and each ion can be measured under optimal measurement conditions by controlling an output voltage of each part with reference to list information, realizing a mass analyzer that can perform an MS/MS measurement with high throughput and high sensitivity.
摘要翻译： 存在通过常规MS / MS分析方法不能同时改善检测灵敏度和通过量的问题。 1.一种质量分析装置，具有用于将特定质量范围的离子排出的离子阱，用于使从离子阱排出的离子离解的碰撞解离部，用于进行从碰撞解离部喷出的离子的质量分析的质量分析部， 以及包括其中存储每个离子的测量条件的列表的控制部分选择性地基于质量共振 - 喷射引入和积聚在离子阱中的离子。 扫描操作是重复在碰撞解离部分的方向上排出特定的前体离子的操作和不喷射的操作，并且可以在最佳测量条件下测量每个离子，通过参考每个部分的输出电压 列表信息，实现能够以高吞吐量和高灵敏度执行MS / MS测量的质量分析器。
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公开(公告)号：US07982182B2
公开(公告)日：2011-07-19
申请号：US12472899
申请日：2009-05-27
CPC分类号： H01J49/4295
摘要： The present invention relates to an ion trap with a large trap capacity. A mass spectrometer comprises a first linear ion trap that performs mass selective ejection, and a second linear ion trap that accumulates and then mass selectively ejects ions ejected from the first linear ion trap. Directions of resonant excitation of ions of the first linear ion trap and of the second linear ion trap are orthogonal. Compared to conventional art, sensitivity is significantly improved.
摘要翻译： 本发明涉及具有大的捕集能力的离子阱。 质谱仪包括执行质量选择性喷射的第一线性离子阱和积累然后大量选择性地喷射从第一线性离子阱排出的离子的第二线性离子阱。 第一线性离子阱和第二线性离子阱的离子的共振激发方向是正交的。 与传统技术相比，灵敏度显着提高。
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56.发明授权Ion mobility spectrometer and ion-mobility-spectrometry/mass-spectrometry hybrid spectrometer 有权离子迁移光谱仪和离子迁移光谱/质谱混合光谱仪公开(公告)号：US07718960B2
公开(公告)日：2010-05-18
申请号：US12149737
申请日：2008-05-07
CPC分类号： G01N27/622
摘要： A low-cost and high-ion-transmission-ratio ion-mobility spectrometry filter, including an ion source, a first drift region in which a gas flow direction and a DC electric-field direction are opposite to each other, a second drift region in which a gas flow direction is provided, the gas flow direction being different from the gas flow direction in the first drift region, and being opposite to a DC electric-field application direction in the second drift region, an intermediate region having an electric field for causing ions to travel between the first drift region and the second drift region, and a detector for detecting ions which have passed through the first drift region and the second drift region.
摘要翻译： 一种低成本和高离子透射率的离子迁移谱分析滤光器，包括离子源，气流方向和DC电场方向彼此相反的第一漂移区，第二漂移区 其中设置有气体流动方向，气体流动方向与第一漂移区域中的气体流动方向不同，并且与第二漂移区域中的直流电场施加方向相反，具有电场的中间区域 用于使离子在第一漂移区域和第二漂移区域之间行进;以及检测器，用于检测已经通过第一漂移区域和第二漂移区域的离子。
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公开(公告)号：US20090065688A1
公开(公告)日：2009-03-12
申请号：US12037148
申请日：2008-02-26
IPC分类号： B01D59/44
CPC分类号： H01J49/0036
摘要： The present invention achieves accurate quantitative determination without reducing measurement throughput and also without having to add a multi-component reference standard. An analytical instrument of the present invention for determining the concentration of a target compound contained in a target sample includes: a means for ionizing a mixture having a specific compound added to the target sample; a means for performing mass analysis on resulting ions; and a database that stores dependence of signal intensity on the concentration of a specific matrix component for each of the target compound and the addition compound, wherein the database is used to calibrate the concentration of the target compound from a signal derived from the target compound and a signal derived from the addition compound, each signal obtained by the mass analysis means. The present invention achieves a multi-component analyzer using low-cost, high-throughput mass analysis, as compared to conventional technique.
摘要翻译： 本发明可以在不降低测量吞吐量的情况下实现准确的定量测定，而且不必添加多组分参考标准。 本发明的用于测定目标样品中包含的目标化合物浓度的分析仪包括：将具有特定化合物的混合物电离于目标样品的装置; 对所得离子进行质量分析的手段; 以及数据库，其存储信号强度对于每种目标化合物和加成化合物的特定基质成分的浓度的依赖性，其中所述数据库用于从源自目标化合物的信号校准目标化合物的浓度，以及 来自加成化合物的信号，通过质量分析装置得到的各信号。 与现有技术相比，本发明实现了使用低成本，高吞吐量质量分析的多分量分析仪。
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公开(公告)号：US20090032697A1
公开(公告)日：2009-02-05
申请号：US12039306
申请日：2008-02-28
IPC分类号： B01D59/44
CPC分类号： H01J49/0045
摘要： There has been a problem that both detection sensitivity and throughput cannot be improved simultaneously by a conventional MS/MS analysis method.A mass analyzer having an ion trap for ejecting ions in a specific mass range, a collisional dissociation part for causing ions ejected from the ion trap to be dissociated, a mass analyzing part for performing a mass analysis of ions ejected from the collisional dissociation part, and a control part including a list in which measurement conditions for each ion are stored selectively resonance-ejects ions introduced into and accumulated in the ion trap based on masses. A scanning operation is a repetition of an operation of ejecting specific precursor ions in a direction of the collisional dissociation part and an operation of ejecting nothing, and each ion can be measured under optimal measurement conditions by controlling an output voltage of each part with reference to list information, realizing a mass analyzer that can perform an MS/MS measurement with high throughput and high sensitivity.
摘要翻译： 存在通过常规MS / MS分析方法不能同时改善检测灵敏度和通过量的问题。 1.一种质量分析装置，具有用于在特定质量范围内排出离子的离子阱，用于使从离子阱排出的离子离解的碰撞解离部，对从碰撞解离部喷出的离子进行质量分析的质量分析部， 以及包括其中存储每个离子的测量条件的列表的控制部分选择性地基于质量共振 - 喷射引入和积聚在离子阱中的离子。 扫描操作是重复在碰撞解离部分的方向上排出特定的前体离子的操作和不喷射的操作，并且可以在最佳测量条件下测量每个离子，通过参考每个部分的输出电压 列表信息，实现能够以高吞吐量和高灵敏度执行MS / MS测量的质量分析器。
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59.发明授权Mass spectrometer and mass analyzing method for efficiently ionizing a sample with less carry-over 有权质谱分析方法，用于有效地离子化样品，携带较少公开(公告)号：US09543135B2
公开(公告)日：2017-01-10
申请号：US13562435
申请日：2012-07-31
申请人： Shun Kumano , Masuyuki Sugiyama , Yuichiro Hashimoto , Hideki Hasegawa , Masuyoshi Yamada , Kazushige Nishimura , Hidetoshi Morokuma
发明人： Shun Kumano , Masuyuki Sugiyama , Yuichiro Hashimoto , Hideki Hasegawa , Masuyoshi Yamada , Kazushige Nishimura , Hidetoshi Morokuma
CPC分类号： H01J49/0431
摘要： A mass spectrometer for efficiently ionizing a sample with less carry-over. The ratio of the amount of sample gas to that of a whole headspace gas is increased by decreasing the pressure inside of a sample vessel in which the sample is sealed thereby efficiently ionizing the sample.
摘要翻译： 一种用于有效地电离样品的质谱仪，其携带较少。 样品气体与整个顶部空间气体的比例通过降低样品容器的内部压力而增加，其中样品被密封，从而有效地使样品电离。
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公开(公告)号：US09184037B2
公开(公告)日：2015-11-10
申请号：US13527627
申请日：2012-06-20
申请人： Shun Kumano , Masuyuki Sugiyama , Yuichiro Hashimoto , Hideki Hasegawa , Masuyoshi Yamada , Hidetoshi Morokuma , Shuhei Hashiba
发明人： Shun Kumano , Masuyuki Sugiyama , Yuichiro Hashimoto , Hideki Hasegawa , Masuyoshi Yamada , Hidetoshi Morokuma , Shuhei Hashiba
CPC分类号： H01J49/0409 , H01J49/0495
摘要： A mass spectrometer including a sample attaching member of attaching a sample, an ionizing chamber including an introductory port of the sample attaching member and an ionization source of generating a sample ion, a vacuumed chamber having a mass analyzer of analyzing the sample ion, and an opening/closing mechanism provided between the ionizing chamber and the vacuumed chamber, in which the opening/closing mechanism is controlled from a closed state to an open state after introducing the sample attaching member into the ionizing chamber to thereby enable to perform ionization with inconsiderable fragmentation at a high sensitivity with a high throughput.
摘要翻译： 一种质谱仪，包括附着样品的样品附着构件，包括样品附着构件的入口的电离室和产生样品离子的离子源，具有分析样品离子的质量分析器的真空室，以及 设置在离子化室和真空室之间的开/关机构，其中将样品附着构件引入电离室之后，将开/关机构从关闭状态控制到打开状态，从而能够以不可分割的碎片进行电离 灵敏度高，吞吐量高。
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