Genes and polypeptides relating to human colon cancers
    53.
    发明授权
    Genes and polypeptides relating to human colon cancers 有权
    与人结肠癌相关的基因和多肽

    公开(公告)号:US07705141B2

    公开(公告)日:2010-04-27

    申请号:US12180204

    申请日:2008-07-25

    IPC分类号: C07H21/04

    CPC分类号: C07K14/47 C07K14/4748

    摘要: The present application provides novel human genes RNF43 whose expression is markedly elevated in colorectal cancers, as well as CXADRL1 and GCUD1 whose expression is markedly elevated in gastric cancers compared to corresponding non-cancerous tissues. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.

    摘要翻译: 本申请提供了在结肠直肠癌中表达显着升高的新型人基因RNF43,以及与相应的非癌组织相比,胃癌中其表达显着升高的CXADRL1和GCUD1。 由该基因编码的基因和多肽可用于例如细胞增殖性疾病的诊断,以及用于开发针对该疾病的药物的靶分子。

    IMP-3 OLIGOPEPTIDES AND VACCINES INCLUDING THE SAME
    57.
    发明申请
    IMP-3 OLIGOPEPTIDES AND VACCINES INCLUDING THE SAME 审中-公开
    IMP-3寡核苷酸和疫苗,包括它们

    公开(公告)号:US20120308590A1

    公开(公告)日:2012-12-06

    申请号:US13513120

    申请日:2010-11-30

    摘要: Oligopeptides having cytotoxic T cell inducibility and suitable for use in the context of cancer immunotherapy, more particularly cancer vaccines are described herein. Notable examples include oligopeptides having the amino acid sequence of SEQ ID NO: 1, 3, 5 or 6, wherein 1, 2, or several amino acids are optionally substituted, deleted, inserted or added so long as they retain the cytotoxic T cell inducibility of the original oligopeptides. Pharmaceutical formulations or “drugs” related to such oligopeptides suitable for treating or preventing cancers or tumors, as well as the post-operative recurrence thereof, are also described.

    摘要翻译: 本文描述了具有细胞毒性T细胞诱导能力并且适用于癌症免疫治疗,尤其是癌症疫苗的背景下的寡肽。 值得注意的实例包括具有SEQ ID NO:1,3,5或6的氨基酸序列的寡肽,其中1,2或几个氨基酸任选被取代,缺失,插入或加入,只要它们保留细胞毒性T细胞诱导性即可 的原始寡肽。 还描述了与适用于治疗或预防癌症或肿瘤的这种寡肽相关的药物制剂或药物,以及其术后复发。