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公开(公告)号：US20120190628A1
公开(公告)日：2012-07-26
申请号：US12910015
申请日：2010-10-22
CPC分类号： C07K14/47 , C07K14/4748
摘要： The present application provides novel human genes RNF43 whose expression is markedly elevated in colorectal cancers, as well as CXADRL1 and GCUD1 whose expression is markedly elevated in gastric cancers compared to corresponding non-cancerous tissues. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.
摘要翻译： 本申请提供了在结肠直肠癌中表达显着升高的新型人基因RNF43，以及与相应的非癌组织相比，胃癌中其表达显着升高的CXADRL1和GCUD1。 由该基因编码的基因和多肽可用于例如细胞增殖性疾病的诊断，以及用于开发针对该疾病的药物的靶分子。
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公开(公告)号：US07705141B2
公开(公告)日：2010-04-27
申请号：US12180204
申请日：2008-07-25
IPC分类号： C07H21/04
CPC分类号： C07K14/47 , C07K14/4748
摘要： The present application provides novel human genes RNF43 whose expression is markedly elevated in colorectal cancers, as well as CXADRL1 and GCUD1 whose expression is markedly elevated in gastric cancers compared to corresponding non-cancerous tissues. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.
摘要翻译： 本申请提供了在结肠直肠癌中表达显着升高的新型人基因RNF43，以及与相应的非癌组织相比，胃癌中其表达显着升高的CXADRL1和GCUD1。 由该基因编码的基因和多肽可用于例如细胞增殖性疾病的诊断，以及用于开发针对该疾病的药物的靶分子。
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公开(公告)号：US20050069930A1
公开(公告)日：2005-03-31
申请号：US10916064
申请日：2004-08-10
CPC分类号： C07K14/47 , C07K14/4748
摘要： The present application provides novel human genes RNF43 whose expression is markedly elevated in colorectal cancers, as well as CXADRL1 and GCUD1 whose expression is markedly elevated in gastric cancers compared to corresponding non-cancerous tissues. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.
摘要翻译： 本申请提供了在结肠直肠癌中表达显着升高的新型人基因RNF43，以及与相应的非癌组织相比，胃癌中其表达显着升高的CXADRL1和GCUD1。 由该基因编码的基因和多肽可用于例如细胞增殖性疾病的诊断，以及用于开发针对该疾病的药物的靶分子。
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公开(公告)号：US07425612B2
公开(公告)日：2008-09-16
申请号：US10916064
申请日：2004-08-10
CPC分类号： C07K14/47 , C07K14/4748
摘要： The present application provides novel human genes RNF43 whose expression is markedly elevated in colorectal cancers, as well as CXADRL1 and GCUD1 whose expression is markedly elevated in gastric cancers compared to corresponding non-cancerous tissues. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.
摘要翻译： 本申请提供了在结肠直肠癌中表达显着升高的新型人基因RNF43，以及与相应的非癌组织相比，胃癌中其表达显着升高的CXADRL1和GCUD1。 由该基因编码的基因和多肽可用于例如细胞增殖性疾病的诊断，以及用于开发针对该疾病的药物的靶分子。
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公开(公告)号：US08674059B2
公开(公告)日：2014-03-18
申请号：US11913228
申请日：2006-07-21
IPC分类号： A61K38/00
CPC分类号： G01N33/57419 , C07K16/18 , C07K16/3046 , G01N2500/00
摘要： Objective methods for detecting and diagnosing colon cancer are described herein. In one embodiment, the diagnostic method involves determining the expression level of TOM34 that discriminates between colon cancer cells and normal cells. Finally, the present invention provides methods of screening for therapeutic agents useful in the treatment of colon cancer, methods of treating colon cancer and method for vaccinating a subject against colon cancer.
摘要翻译： 本文描述了用于检测和诊断结肠癌的客观方法。 在一个实施方案中，诊断方法包括确定区分结肠癌细胞和正常细胞的TOM34的表达水平。 最后，本发明提供筛选可用于治疗结肠癌的治疗剂，治疗结肠癌的方法和接种个体对结肠癌的方法。
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公开(公告)号：US08642724B2
公开(公告)日：2014-02-04
申请号：US11913228
申请日：2006-07-21
IPC分类号： A61K38/00
摘要： Objective methods for detecting and diagnosing colon cancer are described herein. In one embodiment, the diagnostic method involves determining the expression level of TOM34 that discriminates between colon cancer cells and normal cells. Finally, the present invention provides methods of screening for therapeutic agents useful in the treatment of colon cancer, methods of treating colon cancer and method for vaccinating a subject against colon cancer.
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公开(公告)号：US07847065B2
公开(公告)日：2010-12-07
申请号：US12175092
申请日：2008-07-17
IPC分类号： C07K14/435 , C07K7/00
CPC分类号： C07K14/47 , C07K14/4748
摘要： The present application provides novel human genes RNF43 whose expression is markedly elevated in colorectal cancers, as well as CXADRL1 and GCUD1 whose expression is markedly elevated in gastric cancers compared to corresponding non-cancerous tissues. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.
摘要翻译： 本申请提供了在结肠直肠癌中表达显着升高的新型人基因RNF43，以及与相应的非癌组织相比，胃癌中其表达显着升高的CXADRL1和GCUD1。 由该基因编码的基因和多肽可用于例如细胞增殖性疾病的诊断，以及用于开发针对该疾病的药物的靶分子。
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公开(公告)号：US20100016220A1
公开(公告)日：2010-01-21
申请号：US12175092
申请日：2008-07-17
IPC分类号： A61K38/16 , C07K14/435 , A61P35/04
CPC分类号： C07K14/47 , C07K14/4748
摘要： The present application provides novel human genes RNF43 whose expression is markedly elevated in colorectal cancers, as well as CXADRL1 and GCUD1 whose expression is markedly elevated in gastric cancers compared to corresponding non-cancerous tissues. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.
摘要翻译： 本申请提供了在结肠直肠癌中表达显着升高的新型人基因RNF43，以及与相应的非癌组织相比，胃癌中其表达显着升高的CXADRL1和GCUD1。 由该基因编码的基因和多肽可用于例如细胞增殖性疾病的诊断，以及用于开发针对该疾病的药物的靶分子。
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公开(公告)号：US20090012032A1
公开(公告)日：2009-01-08
申请号：US12180204
申请日：2008-07-25
CPC分类号： C07K14/47 , C07K14/4748
摘要： The present application provides novel human genes RNF43 whose expression is markedly elevated in colorectal cancers, as well as CXADRL1 and GCUD1 whose expression is markedly elevated in gastric cancers compared to corresponding non-cancerous tissues. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.
摘要翻译： 本申请提供了在结肠直肠癌中表达显着升高的新型人基因RNF43，以及与相应的非癌组织相比，胃癌中其表达显着升高的CXADRL1和GCUD1。 由该基因编码的基因和多肽可用于例如细胞增殖性疾病的诊断，以及用于开发针对该疾病的药物的靶分子。
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10.发明申请PEPTIDE VACCINES FOR LUNG CANCERS EXPRESSING TTK, URLC10 OR KOC1 POLYPEPTIDES 有权用于表达TTK，URLC10或KOC1多肽的肺癌患者的抗生素疫苗公开(公告)号：US20110027302A1
公开(公告)日：2011-02-03
申请号：US12903961
申请日：2010-10-13
CPC分类号： C12N9/1211 , C12Q1/6886
摘要： The present invention provides peptides comprising the amino acid sequence of SEQ ID NO: 8, 67, 89, as well as peptides comprising the above-mentioned amino acid sequences in which 1, 2, or several amino acids are substituted, deleted, or added, and having cytotoxic T cell inducibility. The present invention also provides drugs for treating or preventing tumors comprising these peptides. The peptides of the present invention can also be used as vaccines.
摘要翻译： 本发明提供了包含SEQ ID NO：8,67,89的氨基酸序列的肽以及包含上述氨基酸序列的肽，其中1,2或几个氨基酸被取代，缺失或添加 ，并具有细胞毒性T细胞诱导性。 本发明还提供了用于治疗或预防包含这些肽的肿瘤的药物。 本发明的肽也可以用作疫苗。
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