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公开(公告)号:US20230226376A1
公开(公告)日:2023-07-20
申请号:US18110304
申请日:2023-02-15
申请人: DALHOUSIE UNIVERSITY
发明人: James Leonard ROBAR
IPC分类号: A61N5/10 , A61B5/11 , A61N7/02 , A61B90/18 , A61B5/05 , A61B34/20 , A61B90/14 , G01V3/08 , A61B5/053 , A61B5/00
CPC分类号: A61N5/1049 , A61B5/1126 , A61N7/02 , A61B90/18 , A61B5/05 , A61B34/20 , A61B90/14 , G01V3/08 , G01V3/088 , A61B5/053 , A61B5/746 , A61N5/1039 , A61B2562/0214 , A61B34/30
摘要: Systems and methods are described for the monitoring of patient motion via the detection of changes in capacitance, as measured using a capacitance position sensing electrode array. The changes in capacitance may be processed to determine a corresponding positional offset, for example, using a calibration data set relating capacitance to offset for each electrode of the array. The detected positional offset may be employed to provide feedback to a surgeon or operator of a medical device, or directly to the medical device for the control thereof. A medical procedure may be interrupted when the positional offset is detected to exceed a threshold. Alternatively, the detected positional offset may be employed to manually or automatically reconfigure a medical device to compensate for the detected change in position. Various configurations of capacitive position sensing devices are disclosed, including embodiment in incorporating capacitive sensing electrodes with a mask or other support structure.
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公开(公告)号:US11612763B2
公开(公告)日:2023-03-28
申请号:US17092129
申请日:2020-11-06
申请人: DALHOUSIE UNIVERSITY
发明人: James Leonard Robar
IPC分类号: A61N5/10 , A61B5/11 , A61N7/02 , A61B90/18 , A61B5/05 , A61B34/20 , A61B90/14 , G01V3/08 , A61B5/053 , A61B5/00 , A61B34/30 , A61N5/06 , A61B90/00
摘要: Systems and methods are described for the monitoring of patient motion via the detection of changes in capacitance, as measured using a capacitance position sensing electrode array. The changes in capacitance may be processed to determine a corresponding positional offset, for example, using a calibration data set relating capacitance to offset for each electrode of the array. The detected positional offset may be employed to provide feedback to a surgeon or operator of a medical device, or directly to the medical device for the control thereof. A medical procedure may be interrupted when the positional offset is detected to exceed a threshold. Alternatively, the detected positional offset may be employed to manually or automatically reconfigure a medical device to compensate for the detected change in position. Various configurations of capacitive position sensing devices are disclosed, including embodiment in incorporating capacitive sensing electrodes with a mask or other support structure.
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53.
公开(公告)号:US11426602B2
公开(公告)日:2022-08-30
申请号:US16427444
申请日:2019-05-31
申请人: Dalhousie University
发明人: James Robar , Shiqin Su
摘要: Disclosed herein are systems, methods, and computer-readable storage devices for manufacturing patient-specific bolus for use in targeted radiotherapy treatment. Based on dose calculations without a bolus and based on three-dimensional scan data of a patient, the example system generates a model of a bolus for targeting radiotherapy treatment to a planning target volume or target region within the patient. The system can perform several iterations to generate a resulting model for the bolus. Then, the system can generate instructions for controlling a three-dimensional printer to generate the bolus that conforms to the patient's skin surface while also specifically targeting the planning target volume for the radiotherapy treatment. In this way, the amount of radiotherapy treatment administered to other tissue is reduced, while the costs, time, and human involvement in creating the bolus are significantly reduced.
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公开(公告)号:US20210244970A1
公开(公告)日:2021-08-12
申请号:US17054141
申请日:2019-04-18
申请人: DALHOUSIE UNIVERSITY
摘要: Methods and systems for radiation treatment planning and delivery apply a CODA cube. Cost values in the CODA cube may be used in the optimization of couch, collimator, and gantry angles simultaneously. Trajectories generated using the CODA cube show significant benefits when compared to conventional VMAT. A statistically significant sparing to OAR maximum radiation doses was seen. CODA plans resulted in a reduction to maximum radiation dose in OARs of 20.6% (p
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公开(公告)号:US10989810B2
公开(公告)日:2021-04-27
申请号:US15544778
申请日:2016-01-22
申请人: DALHOUSIE UNIVERSITY
摘要: The present disclosure provides systems and methods for ultrasound imaging using a modified variable sampling beamforming technique. Unlike conventional methods of variable sampling beamforming, in which in-phase and quadrature samples are obtained for each pixel location, in various example embodiments of the present disclosure, the pixel locations are quadrature-spaced such that for each 5 sample point, an adjacent sample point along an A-line is employed as the quadrature sample. The samples at each array element may be triggered according to the time of flight between a first pixel location and the location of the array element, such that successive samples, corresponding to successive pixel locations along the selected A-line, are obtained such that adjacent samples are spaced by a 10 time interval corresponding to a quarter of an odd number of wavelenghths of the beamformed transmit pulse, and such that only one sample is acquired per pixel.
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公开(公告)号:US10857390B2
公开(公告)日:2020-12-08
申请号:US15767325
申请日:2016-10-13
申请人: DALHOUSIE UNIVERSITY
发明人: James Leonard Robar
IPC分类号: A61N5/10 , A61B5/11 , A61N7/02 , A61B90/18 , A61B5/05 , A61B34/20 , A61B90/14 , G01V3/08 , A61B5/053 , A61B5/00 , A61B34/30 , A61N5/06 , A61B90/00
摘要: Systems and methods are described for the monitoring of patient motion via the detection of changes in capacitance, as measured using a capacitance position sensing electrode array. The changes in capacitance may be processed to determine a corresponding positional offset, for example, using a calibration data set relating capacitance to offset for each electrode of the array. The detected positional offset may be employed to provide feedback to a surgeon or operator of a medical device, or directly to the medical device for the control thereof. A medical procedure may be interrupted when the positional offset is detected to exceed a threshold. Alternatively, the detected positional offset may be employed to manually or automatically reconfigure a medical device to compensate for the detected change in position. Various configurations of capacitive position sensing devices are disclosed, including embodiment in incorporating capacitive sensing electrodes with a mask or other support structure.
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公开(公告)号:US20200347058A1
公开(公告)日:2020-11-05
申请号:US16930039
申请日:2020-07-15
申请人: DALHOUSIE UNIVERSITY
发明人: Christopher McMaster , Gordon Simms
IPC分类号: C07D471/04 , A61K31/444 , C07C317/48 , C07C229/24 , C07F9/38 , C07J31/00 , A61P27/02 , A61P9/10 , A61P25/28 , A61P9/00 , A61P3/10 , A61P9/12 , A61P11/00 , A61P15/00 , A61P25/00 , A61P19/10
摘要: Methods and compositions are provided for the treatment of familial exudative vitreoretinopathy (FEVR) through the administration of a therapeutically effective amount of a sphingosine-1-phosphate receptor type 2 (S1PR2) antagonist. Also provided herein are compounds which contain bioisosteric replacements of the urea group of JTE-013 and analogs thereof, and their use in treating retinopathies and diseases characterized by insufficient angiogenesis.
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公开(公告)号:US10300055B2
公开(公告)日:2019-05-28
申请号:US15302930
申请日:2015-04-10
申请人: Dalhousie University
发明人: Michel Roberge , Chris McMaster , Carla Zimmerman , Pak Poon
IPC分类号: A61K31/381 , A61K31/495 , A61K31/4402 , C07D213/61 , C07D213/74 , C07D295/073 , A61K31/496 , A61K31/4425
摘要: Methods are provided for the treatment of Parkinson's disease (PD) in patients bearing mutations in the LRRK2 gene. A therapeutically effective amount of piperazine derivative compounds are employed to inhibit the biological activity of ArfGAP1, inhibition that counteracts the deleterious effects of mutations in, or increased expression of, the LRRK2 protein.
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公开(公告)号:US10058543B2
公开(公告)日:2018-08-28
申请号:US15316072
申请日:2015-06-01
申请人: DALHOUSIE UNIVERSITY
发明人: Christopher McMaster
IPC分类号: A61K31/444
CPC分类号: A61K31/444 , A61K9/0051 , A61K31/00 , A61K31/437 , A61K31/505 , A61K31/661
摘要: Methods and compositions are provided for the treatment of familial exudative vitreoretinopathy (FEVR) and retinopathy of prematurity (ROP) through the administration of a therapeutically effective amount of a Sphingosine-1-phosphate receptor type 2 (S1PR2) inhibitor.
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公开(公告)号:US20170065598A1
公开(公告)日:2017-03-09
申请号:US15232788
申请日:2016-08-09
发明人: Mark Firman Bear , Kevin R. Duffy , Donald E. Mitchell , Ming-Fai Fong , Arnold Heynen , Jeffrey P. Gavornik
IPC分类号: A61K31/529 , A61K9/00
CPC分类号: A61K31/529 , A61K9/0048 , A61K31/137 , A61K31/167 , A61K31/216 , A61K31/245 , A61K31/381 , A61K31/4168 , A61K31/4174 , A61K31/4409 , A61K31/445 , A61K31/46 , A61K31/47 , A61K38/4893 , A61K45/06 , A61K2300/00
摘要: Amblyopia is a prevalent form of visual impairment that generally arises during infancy and early childhood when inputs to the visual cortex form the two eyes are poorly balanced. Disclosed herein are methods involving retinal inactivation of at least one retina to treat visual impairment in the form of amblyopia or other conditions.
摘要翻译: 弱视是视觉障碍的一种普遍形式,通常在婴儿期和幼儿时期出现,因为双眼视觉皮层的输入差距很小。 本文公开了涉及至少一种视网膜的视网膜失活以以弱视或其他状况的形式治疗视力损害的方法。
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