公开(公告)号：US20230249182A1

公开(公告)日：2023-08-10

申请号：US17929099

申请日：2022-09-01

申请人： NANTONG UNIVERSITY

发明人： Yuling QIN ,  Huanhuan CHEN ,  Tianzhi MAO ,  Wenqi HU ,  Lvyang ZHU ,  Qu TANG

IPC分类号： B01L3/00

CPC分类号： B01L3/50273 ,  B01L3/502761 ,  B01L2200/0652 ,  B01L2300/0816 ,  B01L2300/0867

摘要： A microfluidic chip device based on a magnetic field-controlled fluorescently labeled cell sorting method and a use method are disclosed. The microfluidic chip comprises a sample channel, two sheath fluid channels, a first fluorescence detection area, a second fluorescence detection area, a magnetic field control system, a magnetic field-controlled cell sorting area, a target cell channel, and a waste fluid channel. Based on fluorescence signals labeled on the cells, the FACS system is combined with a magnetic field-controlled sorting system to achieve automated cell sorting, which not only miniaturizes and automates the sorting detection integration, but also has the advantages of easy and economical operation. The device sorts both a large number of cell samples and a small number of cell samples, thus overcoming the defects of a flow cytometer.

公开(公告)号：US20230151065A1

公开(公告)日：2023-05-18

申请号：US17303273

申请日：2019-04-10

申请人： NANTONG UNIVERSITY ,  DALIAN INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCES

发明人： Xiaozhe ZHANG ,  Fei DING ,  Qiong CHENG ,  Xiaosong GU ,  Xinmiao LIANG ,  Yunpeng BAI ,  Dengbing YAO ,  Ying YUAN ,  Caiping WANG ,  Jian YANG ,  Shu YU

IPC分类号： C07K14/415 ,  A61K38/00

CPC分类号： C07K14/415 ,  A61K38/00

摘要： A multi-disulfide-bond long-chain peptide with neuroprotective activity can reduce cellular calcium influx by inhibiting glutamate receptors to protect cortical neurons from excitotoxicity induced by glutamate. It can be an effective neuroprotective agent.

公开(公告)号：US20230144643A1

公开(公告)日：2023-05-11

申请号：US17633950

申请日：2020-07-24

申请人： NANTONG UNIVERSITY

发明人： Yan LIU ,  Mei LIU ,  Xiaosong GU ,  Tuchen GUAN

IPC分类号： A61L27/22

CPC分类号： A61L27/227 ,  A61L2430/32

摘要： A silk fibroin nerve graft fused with NT3 and a preparation method therefor is provided. The method includes the steps of: synthesizing a gene fragment containing a silk fibroin light chain and NT-3, connecting the fragment to a pET-30 expression vector, and transferring the obtained recombinant expression vector into BL21 Escherichia coli to obtain a fusion protein; placing a silk fibroin fiber web in a mold, mixing the fusion protein and a silk fibroin solution, and performing freeze drying to enable the silk fibroin to be crosslinked with the fusion protein to form a nerve conduit; and after deformation processing, finally obtaining a silk fibroin nerve graft having NT-3 activity. The silk fibroin nerve graft can provide a mechanical support, exert nerve protection and nerve regeneration promotion functions in a long term, and adjust the proportion of NT-3 bioactive peptides in the nerve conduit, facilitating repair of nerve injuries.

公开(公告)号：US20220414857A1

公开(公告)日：2022-12-29

申请号：US17288558

申请日：2020-10-28

申请人： NANTONG UNIVERSITY

发明人： Liang HUA ,  Hongkun ZHU ,  Yuqing LIU ,  Ling JIANG ,  Ran CHEN ,  Kexin SHI

IPC分类号： G06T7/00 ,  G06V10/82 ,  G06V10/74

摘要： Disclosed is a quaternion multi-degree-of-freedom neuron-based multispectral welding image recognition method, comprising: using three cameras having different wavebands to obtain multispectral weld pool images, and respectively performing pre-processing and edge extraction on the weld pool images having the different wavebands obtained at a same moment by the three cameras; establishing a quaternion-based multispectral weld pool image edge model; extracting low-frequency features after a quaternion discrete cosine transform; using a quaternion-based multi-degree-of-freedom neuron network to perform classification, training and recognition on edge features of the multispectral weld pool images. Compared to traditional means, the present invention has multiple recognition information sources, strong anti-interference capabilities and high recognition accuracy.

公开(公告)号：US20220267297A1

公开(公告)日：2022-08-25

申请号：US17633898

申请日：2021-08-25

申请人： NANTONG UNIVERSITY

发明人： Hong Dai ,  Ruijian Yan ,  Heyi Miao ,  Zhipeng Wang ,  Dandan Zheng ,  Yan Zhang ,  Zichan Zhang ,  Lei Shi ,  Jianhua Li ,  Haijun Zhang

IPC分类号： C07D401/06 ,  A01N51/00 ,  A01P7/04

摘要： The present disclosure relates to a 2-substituted imidazolidine derivative containing an aryl bipyridyloxy structure, and a preparation method and use thereof, which is obtained by the reaction of 2-substituted imidazolidine and aryl bipyridyloxy compound. The 2-substituted imidazolidine derivative containing an aryl bipyridyloxy structure has a good insecticidal effect on harmful insects, and the compound can be used to prepare insecticides in the fields of agriculture, horticulture, etc.

公开(公告)号：US20220213437A1

公开(公告)日：2022-07-07

申请号：US17596647

申请日：2020-06-19

申请人： NANTONG UNIVERSITY

发明人： Xin TANG ,  Cheng SUN ,  Xiaosong GU ,  Youlang ZHOU ,  Chunkang TANG

IPC分类号： C12N5/0793 ,  A61L27/26 ,  B82Y5/00 ,  C07K14/78

摘要： A protein-modified PLGA microsphere can be used to construct tissue-engineered nerve. The microspheres are loaded with active substances for treating peripheral nerve injury and are bound to tissue-engineered nerves. It has been shown that the prepared tissue-engineered nerve effectively promotes nerve regeneration after peripheral nerve injury.

公开(公告)号：US08854161B2

公开(公告)日：2014-10-07

申请号：US13239426

申请日：2011-09-22

申请人： Jian Xin Chen ,  Li Heng Zhou ,  Hui Tang ,  Zhi Hua Bao ,  Yong Jie Yang ,  Quan Xue

发明人： Jian Xin Chen ,  Li Heng Zhou ,  Hui Tang ,  Zhi Hua Bao ,  Yong Jie Yang ,  Quan Xue

IPC分类号： H01P7/08

CPC分类号： H01P7/088

摘要： The present invention provides a wideband frequency tunable ring resonator, wherein, comprises a closed λg/2 transmission line and two variable capacitors with tunable capacitance, the λg/2 transmission line is axisymmetric around a central line, first ends of the two variable capacitors are respectively connected to two intersection points of the λg/2 transmission line and the central line, the second ends of the two variable capacitors are respectively grounded. By implementing the technical solution of present invention, following technical effects are obtained. The fundamental resonant frequency (ffund) can be shifted up and down by controlling the respective values of the two loading capacitors, resulting in a bi-directional tuning of ffund. As a result, the tuning range of this invention can be approximately doubled as compared with the conventional tunable ring resonator.

摘要翻译： 本发明提供一种宽带频率可调环形谐振器，其中包括一个闭合的λg/ 2传输线和两个具有可调电容的可变电容器，λg/ 2传输线围绕中心线是轴对称的，两个可变电容器的第一端 分别连接到λg/ 2传输线和中心线的两个交点，两个可变电容器的第二端分别接地。 通过实施本发明的技术方案，获得以下技术效果。 通过控制两个负载电容器的相应值，基本谐振频率（ffund）可以上下移动，从而导致ffund的双向调谐。 结果，与传统的可调环谐振器相比，本发明的调谐范围可以大致加倍。

公开(公告)号：US08766739B2

公开(公告)日：2014-07-01

申请号：US13483047

申请日：2012-05-30

申请人： Jian Xin Chen ,  Hui Tang ,  Li Heng Zhou ,  Jin Shi ,  Zhi Hua Bao

发明人： Jian Xin Chen ,  Hui Tang ,  Li Heng Zhou ,  Jin Shi ,  Zhi Hua Bao

IPC分类号： H01P5/10 ,  H01P1/203 ,  H01P7/08

CPC分类号： H01P5/10 ,  H01P1/20381 ,  H01P7/082

摘要： A microwave frequency tunable filtering balun is provided. The microwave frequency tunable filtering balun comprises a first microwave split ring transmission line resonator and a second microwave split ring transmission line resonator arranged in a bilaterally symmetrical manner, a fourth variable capacitor and a fifth variable capacitor of same parameters. It combines two functions of balun and tunable bandpass filter (BPF) into one circuit, resulting in a compact design. The balun characteristic and frequency-tuning mechanism are investigated, and the design equations are derived.

摘要翻译： 提供微波频率可调滤波平衡 - 不平衡转换器。 微波频率可调滤波平衡 - 不平衡变换器包括第一微波裂环传输线谐振器和以双向对称布置的第二微波裂环传输线谐振器，第四可变电容器和具有相同参数的第五可变电容器。 它将巴伦和可调带通滤波器（BPF）的两个功能组合成一个电路，从而实现了紧凑的设计。 研究了平衡 - 不平衡转换特性和调频机制，得出了设计方程。

公开(公告)号：US20090112286A1

公开(公告)日：2009-04-30

申请号：US12159776

申请日：2006-12-25

申请人： Zhigong Wang ,  Xiaosong Gu ,  Xiaoying Lv

发明人： Zhigong Wang ,  Xiaosong Gu ,  Xiaoying Lv

IPC分类号： A61N1/36 ,  A61N1/18

CPC分类号： A61N1/372 ,  A61N1/0551 ,  A61N1/36014 ,  A61N1/37205

摘要： Methods and equipment used to regenerate sensory, motorial, or visceral signals of injured, broken or diseased nerves of mammalia, such as humans, are provided. In some embodiments, a lineup of downward and upward channels to bridge injured neural channels is disclosed. The downward or upward channels can be connected to electrodes which are in contact with upper or lower nerve stumps. The channels can be used to detect, amplify, and recognize the motorial or sensory signals, to generate related Functional Electrical Stimulation (FES) signals, and to supply the FES signals to the electrodes on the lower or upper nerve stumps. Neural signals can thus be regenerated and the injured motorial or sensory channels can be bridged.

摘要翻译： 提供了用于再生哺乳动物（例如人）的受伤，断裂或患病神经的感觉，运动或内脏信号的方法和设备。 在一些实施例中，公开了用于桥接受损神经通道的向下和向上通道的阵列。 向下或向上的通道可以连接到与上部或下部神经残骸接触的电极。 通道可用于检测，放大和识别动力或感觉信号，以产生相关的功能性电刺激（FES）信号，并将FES信号提供给下部或上部神经根的电极。 因此可以再生神经信号，并且可以桥接损伤的运动或感觉通道。

公开(公告)号：US12131474B2

公开(公告)日：2024-10-29

申请号：US18571258

申请日：2023-05-24

申请人： NANTONG UNIVERSITY

发明人： Weiping Ding ,  Ying Sun ,  Tao Hou ,  Xinjie Shen ,  Hengrong Ju ,  Jiashuang Huang ,  Haipeng Wang ,  Tingzhen Qin ,  Yu Geng ,  Ming Li ,  Haowen Xue ,  Zhongyi Wang

IPC分类号： G06T7/00 ,  G06T5/30 ,  G06T7/12 ,  G16H15/00

CPC分类号： G06T7/0012 ,  G06T7/12 ,  G16H15/00 ,  G06T5/30 ,  G06T2207/10024 ,  G06T2207/20081 ,  G06T2207/20084 ,  G06T2207/30041

摘要： The present disclosure is a three-way U-Net method for accurately segmenting an uncertain boundary of a retinal blood vessel, includes: describing an uncertainty of a blood vessel boundary label, constructing an upper bound and a lower bound of the uncertain boundary based on the dilation operator and the erosion operator respectively to obtain a maximum value and a minimum value for the blood vessel boundary, and mapping the boundary with uncertain information into one range; combining an uncertainty representation of the boundary with a loss function, and designing a three-way loss function; training network parameters by adopting a stochastic gradient descent algorithm and utilizing a total loss of the three-way loss function; and designing and implements an auxiliary diagnosis application system for intelligently segmenting the retinal blood vessel with functions of the fundus data acquisition, the intelligent accurate segmentation and the auxiliary diagnosis for the retinal blood vessel.