公开(公告)号：US20120265278A1

公开(公告)日：2012-10-18

申请号：US13255102

申请日：2009-12-22

申请人： Michael Fourkas ,  Ronald Williams ,  Punit Govenji ,  Byron Reynolds

发明人： Michael Fourkas ,  Ronald Williams ,  Punit Govenji ,  Byron Reynolds

IPC分类号： A61F7/12 ,  A61F7/00

CPC分类号： A61B18/02 ,  A61B2018/00041 ,  A61B2018/0281 ,  A61B2018/0293 ,  A61F2007/0052 ,  A61F2007/0056

摘要： A system for treating tissue in a patient includes a body having a cooling fluid supply path and a tissue piercing probe in fluid communication with the cooling fluid supply path. The probe extends distally from the body and is insertable into the tissue through the patient's skin. A cooling fluid source is fluidly coupled with the probe such that when cooling is initiated, cooling fluid flows in the probe thereby cooling the probe and any adjacent tissue. A heater element is in thermal engagement with the cooling fluid source and a power source provides power to the heater element thereby heating the cooling fluid. The power source has sufficient power to heat the cooling fluid to at least a desired temperature but has insufficient power to heat the cooling fluid above a critical temperature which results in rupture of the cooling fluid source.

摘要翻译： 用于治疗患者组织的系统包括具有冷却流体供应路径和与冷却流体供应路径流体连通的组织刺穿探针的主体。 探头从身体向远端延伸，并通过病人的皮肤插入组织。 冷却流体源与探针流体耦合，使得当冷却开始时，冷却流体在探针中流动，从而冷却探针和任何相邻组织。 加热器元件与冷却流体源热接合，并且电源为加热器元件提供电力，从而加热冷却流体。 电源具有足够的功率以将冷却流体加热到至少所需温度，但是具有不足以将冷却流体加热到高于导致冷却流体源破裂的临界温度以上的功率。

公开(公告)号：US20120265187A1

公开(公告)日：2012-10-18

申请号：US13325004

申请日：2011-12-13

申请人： Francis R. Palmer, III ,  Michael Hsu ,  Kristine Tatsutani

发明人： Francis R. Palmer, III ,  Michael Hsu ,  Kristine Tatsutani

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B2018/00434 ,  A61B2018/00458 ,  A61B2018/0047 ,  A61B2018/0293

摘要： A method for cryogenically treating a target tissue comprises providing a cryogenic device having one or more tissue penetrating needle probes, and advancing the one or more tissue penetrating needle probes through skin disposed above the target tissue into the target tissue. The target tissue comprises a motor nerve. The method also includes cooling the target tissue with the one or more tissue penetrating needle probes, and temporarily disrupting signal conduction from the motor nerve thereby preventing contraction of a muscle operably coupled to the motor nerve. This reduces or eliminates hyperdynamic wrinkles of a patient's face.

摘要翻译： 用于低温处理靶组织的方法包括提供具有一个或多个组织穿刺针探针的低温装置，以及使一个或多个组织穿刺针探针穿过设置在靶组织上方的皮肤进入靶组织。 目标组织包括运动神经。 该方法还包括用一个或多个组织穿刺针探针冷却目标组织，并暂时扰乱来自运动神经的信号传导，从而防止可操作地耦合到运动神经的肌肉的收缩。 这减少或消除了患者脸部的高动态皱纹。

公开(公告)号：US08048066B2

公开(公告)日：2011-11-01

申请号：US12485697

申请日：2009-06-16

申请人： Daniel M. Lafontaine

发明人： Daniel M. Lafontaine

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B18/0218 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2018/0293

摘要： Cryotreatment devices and methods of ablating tissue within the body are disclosed. A cryotreatment device in accordance with an exemplary embodiment of the present invention includes an elongated member having one or more needle-like ablation tips configured to induce necrosis at a target site within the heart. A cooling fluid such as a cryogen may be injected through a lumen extending into the distal portion of the device. The ablation tips can be configured to pierce and ablate surrounding tissue, blocking electrical stimuli that can cause fibrillations or other arrhythmias of the heart. The device may also include means for controlling the transmural depth at which the ablation tips are inserted into the cardiac tissue. Methods of forming a contiguous line of conduction block in accordance with the present invention are also disclosed.

摘要翻译： 公开了冷冻处理装置和消融体内组织的方法。 根据本发明的示例性实施例的冷冻处理装置包括细长构件，其具有被配置为在心脏内的靶部位处诱导坏死的一个或多个针状消融尖端。 诸如冷冻剂的冷却流体可以通过延伸到装置的远端部分的管腔注射。 消融尖端可以被配置为刺穿和消融周围组织，阻止可引起心脏纤维化或其他心律失常的电刺激。 该装置还可以包括用于控制消融尖端插入到心脏组织中的透壁深度的装置。 还公开了形成根据本发明的连续导电阻挡线的方法。

公开(公告)号：US20110144631A1

公开(公告)日：2011-06-16

申请号：US12948659

申请日：2010-11-17

申请人： Lisa Elkins ,  Ronald Williams

发明人： Lisa Elkins ,  Ronald Williams

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B18/14 ,  A61B2017/00747 ,  A61B2018/00041 ,  A61B2018/0262 ,  A61B2018/0293

摘要： Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve/muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.

摘要翻译： 装置，系统和方法处理化妆品缺陷，并且经常使用插入穿过患者皮肤的至少一个组织穿透探针施加冷却。 冷却可以改变一个或多个靶组织，以便实现靶组织的组合物的期望变化和/或其行为的改变。 冷却处理的示例性实施方案将干扰神经/肌肉收缩功能链，以减轻皮肤的皱纹。 相关治疗可用于治疗背部和其它肌肉痉挛，慢性疼痛等。 一些实施方案可改变皮下脂肪组织以改变皮肤表面的形状或外观。

公开(公告)号：US20090118722A1

公开(公告)日：2009-05-07

申请号：US11933066

申请日：2007-10-31

申请人： Edward A. Ebbers ,  Mitchell E. Levinson ,  Jessica Preciado ,  Nathan R. Every ,  John W. Allison

发明人： Edward A. Ebbers ,  Mitchell E. Levinson ,  Jessica Preciado ,  Nathan R. Every ,  John W. Allison

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B18/0218 ,  A61B2017/00084 ,  A61B2018/0262 ,  A61B2018/0293 ,  A61F7/10 ,  A61F2007/029 ,  A61F2007/126

摘要： A system for reducing subcutaneous lipid-rich cells or tissue of a subject is disclosed. The system may include a fluid supply, a probe in fluid communication with the fluid supply, and a coolant circulated between the fluid supply and the probe. The probe may be configured to be inserted into the subject to be at least proximate to the subcutaneous lipid rich cells. The coolant may be at a temperature such that the subcutaneous lipid-rich cells or tissue proximate to the inserted probe are cooled.

摘要翻译： 公开了用于减少皮下富含脂质的细胞或受试者组织的系统。 该系统可以包括流体供应源，与流体供应源流体连通的探针以及在流体供应源和探针之间循环的冷却剂。 探针可以被配置成插入到受试者中至少接近皮下富含脂质的细胞。 冷却剂可以处于使得接近插入的探针的皮下富含脂质的细胞或组织被冷却的温度。

公开(公告)号：US20080183164A1

公开(公告)日：2008-07-31

申请号：US11770185

申请日：2007-06-28

申请人： Lisa Elkins ,  Ronald Williams

发明人： Lisa Elkins ,  Ronald Williams

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B18/14 ,  A61B2017/00747 ,  A61B2018/00041 ,  A61B2018/0262 ,  A61B2018/0293

摘要： Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve/muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.

摘要翻译： 装置，系统和方法处理化妆品缺陷，并且经常使用插入穿过患者皮肤的至少一个组织穿透探针施加冷却。 冷却可以改变一个或多个靶组织，以便实现靶组织的组合物的期望变化和/或其行为的改变。 冷却处理的示例性实施方案将干扰神经/肌肉收缩功能链，以减轻皮肤的皱纹。 相关治疗可用于治疗背部和其它肌肉痉挛，慢性疼痛等。 一些实施方案可改变皮下脂肪组织以改变皮肤表面的形状或外观。

公开(公告)号：US20080125775A1

公开(公告)日：2008-05-29

申请号：US11605905

申请日：2006-11-28

申请人： David L. Morris

发明人： David L. Morris

IPC分类号： A61B18/14

CPC分类号： A61B18/1477 ,  A61B18/02 ,  A61B18/08 ,  A61B18/18 ,  A61B18/1815 ,  A61B18/20 ,  A61B2017/320069 ,  A61B2017/32007 ,  A61B2017/320071 ,  A61B2018/00011 ,  A61B2018/0016 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00702 ,  A61B2018/00755 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/0212 ,  A61B2018/0293 ,  A61B2018/1425 ,  A61B2018/143 ,  A61B2018/1472 ,  A61B2018/1475 ,  A61B2090/3966 ,  A61B2218/002 ,  A61B2218/007

摘要： A tissue treatment apparatus is described that includes a housing having a proximal end and a distal end including a tissue contacting surface having a plurality of apertures. The housing defines an interior. An electrode array is positionable in the housing interior. The electrode array includes a plurality of bipolar electrodes. The electrode array is configured to be advanced from the housing interior so a first spacing between a deployed pair of electrodes of the plurality of electrodes is different relative to a second spacing between at least one other deployed pair of electrodes. An advancement device is configured to selectively advance the plurality of electrodes from the housing interior into a target tissue site and withdraw advanced electrodes into the housing interior.

摘要翻译： 描述了一种组织处理装置，其包括具有近端和远端的壳体，该远端包括具有多个孔的组织接触表面。 外壳定义一个内部。 电极阵列可定位在壳体内部。 电极阵列包括多个双极电极。 电极阵列被配置为从壳体内部前进，使得多个电极中部署的电极对之间的第一间隔相对于至少一个其它部署的电极对之间的第二间隔是不同的。 推进装置被配置为选择性地将多个电极从壳体内部推进到目标组织部位，并将先进的电极撤回到壳体内部。

公开(公告)号：US20080103411A1

公开(公告)日：2008-05-01

申请号：US11964244

申请日：2007-12-26

申请人： Kevin Van Bladel ,  Shigeru Tanaka ,  Daren Stewart

发明人： Kevin Van Bladel ,  Shigeru Tanaka ,  Daren Stewart

IPC分类号： A61B10/02

CPC分类号： A61B10/0266 ,  A61B18/02 ,  A61B2010/0208 ,  A61B2018/0262 ,  A61B2018/0293 ,  H04L41/147 ,  H04L47/11 ,  H04L47/14

摘要： A device and method of use for securing and coring of tumors within the body during a biopsy of the tumor, specifically breast tumors. An adhesion probe for securing the tumor is described. The probe secures the tumor by piercing the tumor and providing a coolant to the distal tip to cool the tip. The cooled tip adheres to the tumor. A coring instrument adapted for cutting a core sample of the tumor is described. The instrument is provided with a cannula that can cut a core sample of the tumor. The instrument is adapted for use with the probe with the probe fitting within the cannula. The instrument can be used in conjunction with the probe to secure and core a sample of the tumor for biopsy.

摘要翻译： 用于在肿瘤活检期间，特别是乳腺肿瘤中用于确保和取出体内肿瘤的装置和方法。 描述了用于固定肿瘤的粘附探针。 探针通过刺穿肿瘤固定肿瘤，并向​​远端提供冷却剂以冷却末端。 冷却的尖端附着于肿瘤。 描述适于切割肿瘤的核心样本的取芯器械。 该仪器设置有可以切割肿瘤的核心样本的套管。 该仪器适用于带探头接头的探头与套管内的接头。 该仪器可以与探头一起使用，以固定和核心肿瘤样本进行活检。

公开(公告)号：US07144394B2

公开(公告)日：2006-12-05

申请号：US10653692

申请日：2003-09-02

申请人： Allen Carl

发明人： Allen Carl

IPC分类号： A61B18/18

CPC分类号： A61B18/02 ,  A61B2017/00092 ,  A61B2017/00261 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2018/0293 ,  A61B2090/378

摘要： The present invention relates to devices and methods for altering the tissue in and around an intervertebral disc through localized hypothermia therapy to restore function of the disc and reduce pain. Hypothermia therapy is defined as the reduction of tissue temperature to below that of the equilibrium temperature. Target therapeutic temperatures and times are varied according to the desired treatment effect. Intended effects of hypothermia of the intervertebral disc include cellular disruption leading to cell death and or structural and chemical denaturation within the anulus fibrosus, nucleus pulposus, or nerve fibers, temporary or permanent deadening of the nerves within or surrounding the disc, induction of a healing response, angiogenesis, or accelerated degeneration and/or drying of the nucleus pulposus and/or anulus fibrosus. Various effects can be achieved by reaching different temperatures for differing periods of time or by the proximity of the hypothermia therapy device to the treatment target. Accordingly, it is an object of one or more the embodiments of the invention to provide hypothermic therapy to selected locations within an intervertebral disc utilizing a flexible and guidable cryogenic device.

公开(公告)号：US20050043725A1

公开(公告)日：2005-02-24

申请号：US10954433

申请日：2004-09-30

申请人： Thach Duong ,  James Dinh

发明人： Thach Duong ,  James Dinh

IPC分类号： A61B17/00 ,  A61B18/02 ,  F25B9/02 ,  F28D7/10

CPC分类号： F25B9/02 ,  A61B18/02 ,  A61B2017/0046 ,  A61B2018/00041 ,  A61B2018/0262 ,  A61B2018/0293 ,  F28D7/106 ,  F28F2255/18

摘要： The threaded cryostat for a cryosurgical probe system includes an outer tube and a hollow elongated threaded element positioned within the outer tube. The threaded element has integral, external threads that extend from on an outer surface thereof. During operation a working fluid is transported in a first direction between a fluid supply line and a distal end of a cryosurgical probe within a first space defined within the threaded element. Working fluid is transported in a second direction between the distal end of the cryosurgical probe and the fluid supply line within a second space defined between the outer tube and the threaded element.

摘要翻译： 用于冷冻手术探针系统的螺纹低温恒温器包括外管和位于外管内的中空细长螺纹元件。 螺纹元件具有从其外表面延伸的整体的外螺纹。 在操作期间，工作流体在限定在螺纹元件内的第一空间内的流体供应管线和冷冻手术探针的远端之间沿第一方向输送。 在外管和螺纹元件之间限定的第二空间内，工作流体沿第二方向输送在冷冻外科探针的远端和流体供应管线之间。