公开(公告)号：US4389419A

公开(公告)日：1983-06-21

申请号：US205340

申请日：1980-11-10

Applicant: Franklin Lim ,  Richard D. Moss

Inventor： Franklin Lim ,  Richard D. Moss

IPC: A61K9/16 ,  A61K9/50 ,  A61K9/66 ,  B01J13/08 ,  A23L1/30 ,  B01J13/02

CPC classification number: A61K9/1652 ,  A61K9/5036 ,  B01J13/08

Abstract: Disclosed is a process for encapsulating oils and oil-soluble substances in multi-compartmentalized, mechanically stable microcapsules. The process comprises the steps of first forming an emulsion consisting of a continuous phase comprising an aqueous solution of an alkali metal alginate and optionally a water-soluble, alcohol-insoluble filler such as a polysaccharide, and a dispersed phase of an oleophilic substance such as one or more vitamins dissolved in an oil. The emulsion is then formed into droplets which are thereafter immersed in an alcoholic solution of multivalent cations, to produce a shape-retaining alginate matrix filled with precipitated polysaccharide and enclosing plural oil droplets. The vitamins are thereby protected from oxidative degradation and can be handled like conventional crystalline solids.

Abstract translation: 公开了一种将油和油溶性物质包封在多室化机械稳定的微胶囊中的方法。 该方法包括以下步骤：首先形成由包含碱金属藻酸盐的水溶液和任选的水溶性，不溶于醇的填料如多糖的连续相组成的乳液，以及亲油性物质如 溶解在油中的一种或多种维生素。 然后将乳液形成液滴，然后将其浸入多价阳离子的醇溶液中，以产生填充有沉淀多糖并包围多个油滴的形状保持藻酸盐基质。 因此，维生素被保护免受氧化降解，并且可像常规结晶固体一样处理。

公开(公告)号：US4269729A

公开(公告)日：1981-05-26

申请号：US59733

申请日：1979-07-23

Applicant: Hitoshi Maruyama ,  Koichi Kajitani ,  Makoto Shiraishi

Inventor： Hitoshi Maruyama ,  Koichi Kajitani ,  Makoto Shiraishi

IPC: B41M5/165 ,  B01J13/08 ,  B01J13/02

CPC classification number: B01J13/08 ,  Y10S428/914 ,  Y10T428/2987 ,  Y10T428/2989

Abstract: Microcapsules having walls formed from polyvinyl alcohol are prepared by dispersing a substantially water insoluble nuclear material in an aqueous solution of a polyvinyl alcohol polymer, which solution has a cloud point, phase separating and depositing a concentrated aqueous solution of the polyvinyl alcohol polymer as a separated phase around said nuclear material from the bulk continuous phase by maintaining the temperature of the system above the cloud point of the aqueous polyvinyl alcohol polymer solution, and subjecting the phase separated solution to conditions which substantially solidify or gel said polyvinyl alcohol polymer in said concentrated aqueous solution of said separated phase around said nuclear material but which do not substantially solidify or gel the polyvinyl alcohol in the diluted aqueous solution of the continuous phase.

Abstract translation: 通过将基本上不溶于水的核材料分散在聚乙烯醇聚合物的水溶液中制备具有由聚乙烯醇形成的壁的微胶囊，该溶液具有浊点，相分离和沉积作为分离的聚乙烯醇聚合物的浓缩水溶液 通过将系统的温度保持在聚乙烯醇聚合物水溶液的浊点以上，并使相分离的溶液进行基本上固化或凝胶化所述聚乙烯醇聚合物在所述浓缩水溶液中的条件 所述分离相在所述核材料周围的溶液，但是在连续相的稀释水溶液中基本上不固化或凝胶化聚乙烯醇。

公开(公告)号：US4107072A

公开(公告)日：1978-08-15

申请号：US364222

申请日：1973-05-25

Applicant: Lewis D. Morse ,  Melvin J. Boroshok ,  Roy W. Grabner

Inventor： Lewis D. Morse ,  Melvin J. Boroshok ,  Roy W. Grabner

IPC: A61K9/50 ,  B01J13/08 ,  B01J13/20 ,  B01J13/02

CPC classification number: B01J13/08 ,  A61K9/5047 ,  B01J13/20 ,  Y10T428/2989

Abstract: Ethylcellulose walled microcapsules, obtained from cyclohexane medium are heavily solvated with cyclohexane and tend to form lumps even after drying. Displacements of cyclohexane by pentane, hexane, heptane or octane or mixtures thereof during the isolation of the microcapsules gives a dry product which is essentially all discrete dry microcapsules.

Abstract translation: 由环己烷介质获得的乙基纤维素膜微胶囊用环己烷进行高度溶剂化，甚至在干燥后也会形成团块。 在分离微胶囊期间，通过戊烷，己烷，庚烷或辛烷或其混合物的环己烷的位移产生干燥的产物，其基本上都是离散的干燥微胶囊。

公开(公告)号：US4016099A

公开(公告)日：1977-04-05

申请号：US238528

申请日：1972-03-27

Applicant: Russel E. Wellman ,  Robert W. Brown

Inventor： Russel E. Wellman ,  Robert W. Brown

IPC: A61K8/11 ,  A61Q19/00 ,  B01J13/08 ,  B01J13/12 ,  G03G9/093 ,  B01J13/02

CPC classification number: A61K8/11 ,  A61Q19/00 ,  B01J13/08 ,  B01J13/12 ,  G03G9/09392 ,  A61K2800/412 ,  Y10T428/2984 ,  Y10T428/2987

Abstract: A method is provided for forming encapsulated particles comprising forming a dispersion of core material in a solution of wall material in a solvent; drowning said dispersion in at least one liquid which is miscible with the solvent and in which at least the wall material is substantially insoluble, to effect phase-separation of said wall material, whereby said wall material deposits about said core material forming a dilute dispersion of particles comprising said core material encapsulated with said wall material in said liquid, and recovering said encapsulated particles from said liquid.

Abstract translation: 提供了一种用于形成包封颗粒的方法，包括在壁材料在溶剂中的溶液中形成核心材料的分散体; 将至少一种与溶剂混溶的液体中的分散体浸没在其中至少壁材料基本上不溶于其中，以实现所述壁材料的相分离，由此所述壁材料围绕所述芯材料沉积形成稀释分散体 所述颗粒包括用所述液体中的所述壁材料包封的所述芯材料，并从所述液体中回收所述包封颗粒。

公开(公告)号：US3878121A

公开(公告)日：1975-04-15

申请号：US31293272

申请日：1972-12-07

Applicant: POUDRES & EXPLOSIFS STE NALE

Inventor： ROCHE GERARD ,  DUMAS BERNARD

IPC: C22B26/10 ,  B01J13/08 ,  B01J13/10 ,  C08G18/00 ,  C08G18/48 ,  C09K3/00 ,  B01J13/02 ,  B44D1/02 ,  B44D1/44

CPC classification number: C08G18/4879 ,  B01J13/10 ,  C08G18/00 ,  Y10T428/2989 ,  Y10T428/2998

Abstract: The present invention relates to a method of encapsulation by coacervation of fine particles of a very reactive substance such as an alkali metal or a very powerful reducing agent. The said substance is suspended in a polyurethane resin solution made up of constituents which do not react with the substance, the coacervate is obtained by adding more of one of the constituents of the solution, the resulting mixture is dispersed in a slightly polar liquid which does not mix with the mixture and contains in solution an agent for cross-linking polyurethane resin, and the encapsulated substance is then separated from the liquid and dried.

Abstract translation: 本发明涉及通过凝聚诸如碱金属或非常强大的还原剂的非常反应性物质的微粒的包封的方法。 所述物质悬浮在由与物质不反应的成分组成的聚氨酯树脂溶液中，通过加入更多的溶液成分获得凝聚体，所得混合物分散在稍微极性的液体中 不与混合物混合，并在溶液中含有交联聚氨酯树脂的试剂，然后将包封的物质与液体分离并干燥。

公开(公告)号：US3822181A

公开(公告)日：1974-07-02

申请号：US24608172

申请日：1972-04-20

Applicant: CHAMPION INT CORP

Inventor： VASSILIADES A ,  NAUMAN E ,  SHROFF S

IPC: B01J13/08 ,  B29D7/01 ,  D21H19/38 ,  D21H19/42 ,  D21H3/82

CPC classification number: D21H19/42 ,  B01J13/08 ,  B29D7/01 ,  D21H19/385 ,  Y10T428/268 ,  Y10T428/2984 ,  Y10T428/2987 ,  Y10T428/2989

Abstract: OPACIFIERS COMPRISING AIR-CONTAINING MICROCAPSULES, HAVING AN AVERAGE PARTICLE DIAMETER BELOW ABOUT 2 MICRONS WITH PIGMENT PARTICLES INCORPORATED IN THE MICROCAPSULAR STRUCTURE PROVIDED HIGHLY OPAQUE SURFACES WHEN INCORPORATED INTO FIBROUS SUBSTRATES. THE OPACIFIERS ARE PRODUCED BY HEATING LIQUID-CONTAINING PRECURSOR MICROCAPULES, WHICH CONTAIN THE PIGMENT PARTICLES IN THEIR STRUCTURE, AT TEMPERATURES SUFFICIENT TO EXPEL THE LIQUID AND PROVIDE AIR IN THE MICROCAPSULES.

公开(公告)号：US3804775A

公开(公告)日：1974-04-16

申请号：US20756871

申请日：1971-12-13

Applicant: KANZAKI PAPER MFG CO LTD

Inventor： SHIOZAKI T ,  KONO J

IPC: B01J13/06 ,  B01J13/08 ,  B41M5/165 ,  B44D1/02 ,  B01J13/02

CPC classification number: B41M5/165 ,  B01J13/08 ,  Y10T428/2984 ,  Y10T428/2985 ,  Y10T428/2989

Abstract: A MICROENCAPSULATION PROCESS IS DISCLOSED USING A MIXTURE OF SOLUTIONS OF POLYMER MATERIALS USEFUL OVER A WIDE PH RANGE WHICH INCLUDES BRINGING CORE PARTICLES, EITHER OF A WATER-IMMISIBLE LIQUID OR PARTICULATE SOLID, INTO CONTACT WITH AN AQUEOUS SOLUTION OF GELATIN AND POLYVINYL ALCOHOL, OR THEIR WATER SOLUBLE DERIVATIVES, CAUSING THE GELATING COMPOUND TO UNDERGO PHASE SEPARATION FORMING AN ENCAPSULATING SHELL COMPOSED PRIMARILY OF THE GELATING COMPONENT IS FOMED AROUND THE INDIVIDUAL CORE PARTICLES, THEN LOWERING THE TEMPERATURE OF THE MIXTURE TO CAUSE THE GELATIN COMPONENT THAT SURROUNDS THE INDIVIDUAL CORE PARTICLES TO GEL. SUBSTANTIALLY UNIFORM NONAGGLOMERATED MICROCAPSULES SO FORMED ARE USEFUL AS SURFACE COATINGS ON A SUBSTRATE MATERIAL SUCH AS A PRESSURE SENSITIVE RECORDING PAPER.

公开(公告)号：US3779957A

公开(公告)日：1973-12-18

申请号：US3779957D

申请日：1972-04-20

Applicant: CHAMPION INT CORP

Inventor： VASSILIADES A ,  NAUMAN E ,  SHROFF S

IPC: B01J13/08 ,  B29D7/01 ,  D21H19/42 ,  B44D1/02 ,  B01J13/02 ,  C09D5/00

CPC classification number: D21H19/42 ,  B01J13/08 ,  B29D7/01 ,  Y10T428/249974 ,  Y10T428/2984 ,  Y10T428/2987 ,  Y10T428/2989

Abstract: TAINING PRECURSOR MICROCAPSULES, WHICH CONTAIN THE PIGMENT PARTICLES IN THEIR STRUCTURE, AT TEMPERATURES SUFFICIENT TO EXPEL THE LIQUID AND PROVIDE AIR IN THE MICROCAPSULES.

OPACIFIERS COMPRISING AIR-CONTAINING MICROCAPSULES HAVING AN AVERAGE PARTICLE DIAMETER OF PREDETERMINED SIZE WITH PIGMENT PARTICLES INCORPORATED IN THE MICROCAPSULAR STRUCTURE PROVIDE HIGHLY OPAQUE SURFACES WHEN COATED ONTO AND/OR INCORPORATED INTO FIBROUS AND NON-FIBROUS SUBSTRATES. THE OPACIFIERS ARE PRODUCED BY HEATING LIQUID-CON-

公开(公告)号：US3737337A

公开(公告)日：1973-06-05

申请号：US3737337D

申请日：1971-02-09

Applicant: BAYER AG

Inventor： SCHNORING H ,  PAMPUS G ,  SCHON N ,  WITTE J

IPC: A61K9/16 ,  A61K9/50 ,  B01J13/08 ,  B01J13/12 ,  B44D1/02 ,  B01J13/02

CPC classification number: A61K9/5047 ,  A61K9/1652 ,  A61K9/1694 ,  A61K9/5089 ,  B01J13/08 ,  B01J13/12 ,  Y10T428/2984 ,  Y10T428/2989

Abstract: A PROCESS FOR THE PRODUCTION OF SOLID, FREE-FLOWING SPHERICAL MICROGRANULATES FROM A POLYMER MATRIX CONTAINING SOLID OR LIQUID PARTICLES OF A CORE MATERIAL EMBEDDED THEREIN, WHEREIN IN A SOLVENT SOLUBLE TO AT MOST 15% BY WEIGHT IN WATER AT 20*C., (2) A SOLID OR LIQUID CORE MATERIAL IS DISSOLVED OR DISPERSED IN THIS SOLUTION, (3) THE RESULTING SOLUTION OR DISPERSION ("ORGANIC PHASE A") IS SUSPENDED IN AN AQUEOUS LIQUID (AQUEOUS PHASE B) THAT IS IMMISCIBLE WITH THE ORGANIC SOLVENT, (4) THE ORGANIC SOLENT IS ALLOWED TO MIGRATE SLOWLY AND UNDER CONTROL OUT OF THE ORGANIC PHASE A SO THAT THE DISSOLVED POLYMER IS DEPOSITED ONTO THE SURFACE OF THE PRTICLES DISPERSED IN AQUEOUS PHASE B, AND (5) THE SOLIDIFIED PARTICLES, I.E. THE MICROGRANULATE, ARE SEPARATED OFF.

公开(公告)号：US3703474A

公开(公告)日：1972-11-21

申请号：US3703474D

申请日：1967-08-21

Applicant: NCR CO

Inventor： HUBER HANS F

IPC: B01J13/08 ,  B01J13/02 ,  B44D1/02

CPC classification number: B01J13/08 ,  Y10T428/2987

Abstract: A PROCESS IS PROVIDED FOR PREPARATION OF MINUTE CAPSULES WHEREIN PARTICLES OF INTENDED INTERNAL PHASE MATERIAL WHICH HAVE BEEN DISPERSED INDIVIDUALLY IN A LIQUID MANUFACTURING VEHICLE ARE COATED BY A SOLID POLYMERIC FILMFORMING MATERIAL. POLYMERIC MATERIAL IS PRECIPITATED FROM SOLUTION IN THE MANUFACTURING VEHICLE OR FROM SOLUTION IN THE INTENDED INTERNAL PHASE MATERIAL DUE TO A "ZONE OF INSOLUBILITY" ESTABLISHED AT THE INTERFACE BETWEEN THE PARTICLES AND THE MANUFACTURING VEHICLE. THE PARTICLES ARE EITHER LIQUID DROPLETS OR SOLID PARTICLES HAVING AN ASSOCIATED LIQUID THEREWITH. THE NOVEL PROCESS IS UTILIZED TO ENCAPSULATE PARTICLES WHICH ARE, TO SOME DEGREE, MISCIBLE WITH THE MANUFACTURING VEHICLE.