公开(公告)号：US4322311A

公开(公告)日：1982-03-30

申请号：US143932

申请日：1980-04-25

申请人： Franklin Lim ,  Richard D. Moss

发明人： Franklin Lim ,  Richard D. Moss

IPC分类号： A61K9/50 ,  B01J13/16 ,  G01N33/537 ,  G01N33/549 ,  G01N33/74 ,  B01J13/02

CPC分类号： A61K9/5089 ,  A61K9/5031 ,  B01J13/16 ,  G01N33/5375 ,  G01N33/549 ,  G01N33/74 ,  Y10S424/07

摘要： A process for producing microcapsules of controlled porosity containing a chemically active core material. A core material such as a biologically active material and a first monomer in aqueous solution are emulsified in a hydrophobic solvent. A monomer complementary to the first and soluble in the continuous, hydrophobic phase of the emulsion is added to initiate interfacial polymerization about the aqueous droplets. During the course of the reaction, the affinity of the continuous phase for the first monomer is varied by adding a solvent to the continuous phase to vary its polarity. The continuous phase may be relatively nonpolar at the outset and a polar solvent may be added to increase its affinity for the first monomer, or it may be relatively polar at the outset and a nonpolar (or less polar) solvent may be added. This technique allows production of microcapsules having a selected pore size so that, for example, encapsulated material cannot escape, yet lower molecular weight materials can diffuse through the capsule wall.

摘要翻译： 一种用于生产含有化学活性芯材料的受控孔隙微胶囊的方法。 核心材料如生物活性材料和水溶液中的第一单体在疏水性溶剂中乳化。 添加与第一种互补并且可溶于乳液的连续疏水相的单体以引发关于水滴的界面聚合。 在反应过程中，连续相对第一单体的亲和力通过向连续相中加入溶剂以改变其极性来改变。 连续相可以在开始时相对非极性，并且可以加入极性溶剂以增加其对第一单体的亲和力，或者其可以在开始时相对极性并且可以加入非极性（或更小的极性）溶剂。 该技术允许生产具有选定孔径的微胶囊，使得例如包封的材料不能逸出，但较低分子量的材料可以扩散通过胶囊壁。

公开(公告)号：US5120648A

公开(公告)日：1992-06-09

申请号：US199229

申请日：1988-05-26

申请人： Franklin Lim ,  William H. Bingham ,  Richard D. Moss ,  Lloyd T. Hall, III

发明人： Franklin Lim ,  William H. Bingham ,  Richard D. Moss ,  Lloyd T. Hall, III

IPC分类号： G01N22/00

CPC分类号： G01N22/00

摘要： A chemical analyzer in which the measurement of the change in attenuation of RF radiation propagated through a sample is used as the basis for calculating the change in concentration of a given chemical in the sample. Also disclosed are various probe and system designs which facilitate the use of RF attenuation as a basis for measurement of certain chemical characteristics of a sample.

摘要翻译： 使用通过样品传播的RF辐射的衰减变化的测量作为计算样品中给定化学品的浓度变化的基础的化学分析仪。 还公开了促进使用RF衰减作为测量样品的某些化学特性的基础的各种探针和系统设计。

公开(公告)号：US4251387A

公开(公告)日：1981-02-17

申请号：US30847

申请日：1979-04-17

申请人： Franklin Lim ,  Richard D. Moss

发明人： Franklin Lim ,  Richard D. Moss

IPC分类号： A61K9/50 ,  B01J13/16 ,  G01N33/537 ,  G01N33/74 ,  B01J13/02

CPC分类号： A61K9/5089 ,  A61K9/5031 ,  B01J13/16 ,  G01N33/537 ,  G01N33/5375 ,  G01N33/74 ,  Y10S424/07 ,  Y10T428/2989

摘要： Techniques for producing semipermeable microcapsules by interfacial polymerization are disclosed. The material to be encapsulated and a hydrophilic monomer are emulsified within a hydrophobic continuous phase. Polymerization is initiated by dissolving a second monomer in the continuous phase, and occurs only at the interface of the emulsion to result in the formation of macroporous, poorly defined capsule membranes. Next, the affinity of the continuous phase for the hydrophilic monomer is varied by altering the polarity of the continuous phase. This step is accomplished either by isolating and resuspending the raw capsules in a fresh continuous phase of different polar character, or by mixing a second solvent with the continuous phase. By controlling the affinity and the concentration of the second monomer, it is possible to produce microcapsules having uniform capsule membranes and a selected upper limit of permeability.

摘要翻译： 公开了通过界面聚合生产半透性微胶囊的技术。 待包被的材料和亲水性单体在疏水性连续相中乳化。 通过将第二单体溶解在连续相中而引发聚合，仅在乳液的界面处发生，从而导致形成大孔性差的胶囊膜。 接下来，通过改变连续相的极性来改变连续相对亲水性单体的亲和力。 该步骤通过将生胶囊分离并重新悬浮在不同极性特征的新鲜连续相中，或通过将第二溶剂与连续相混合来实现。 通过控制第二单体的亲和力和浓度，可以制备具有均匀的胶囊膜和所选择的渗透性上限的微胶囊。

公开(公告)号：US4389419A

公开(公告)日：1983-06-21

申请号：US205340

申请日：1980-11-10

申请人： Franklin Lim ,  Richard D. Moss

发明人： Franklin Lim ,  Richard D. Moss

IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K9/66 ,  B01J13/08 ,  A23L1/30 ,  B01J13/02

CPC分类号： A61K9/1652 ,  A61K9/5036 ,  B01J13/08

摘要： Disclosed is a process for encapsulating oils and oil-soluble substances in multi-compartmentalized, mechanically stable microcapsules. The process comprises the steps of first forming an emulsion consisting of a continuous phase comprising an aqueous solution of an alkali metal alginate and optionally a water-soluble, alcohol-insoluble filler such as a polysaccharide, and a dispersed phase of an oleophilic substance such as one or more vitamins dissolved in an oil. The emulsion is then formed into droplets which are thereafter immersed in an alcoholic solution of multivalent cations, to produce a shape-retaining alginate matrix filled with precipitated polysaccharide and enclosing plural oil droplets. The vitamins are thereby protected from oxidative degradation and can be handled like conventional crystalline solids.

摘要翻译： 公开了一种将油和油溶性物质包封在多室化机械稳定的微胶囊中的方法。 该方法包括以下步骤：首先形成由包含碱金属藻酸盐的水溶液和任选的水溶性，不溶于醇的填料如多糖的连续相组成的乳液，以及亲油性物质如 溶解在油中的一种或多种维生素。 然后将乳液形成液滴，然后将其浸入多价阳离子的醇溶液中，以产生填充有沉淀多糖并包围多个油滴的形状保持藻酸盐基质。 因此，维生素被保护免受氧化降解，并且可像常规结晶固体一样处理。

公开(公告)号：US4255411A

公开(公告)日：1981-03-10

申请号：US963932

申请日：1978-11-27

申请人： Franklin Lim ,  Richard D. Moss

发明人： Franklin Lim ,  Richard D. Moss

IPC分类号： A61K9/50 ,  F02B75/02 ,  G01N33/537 ,  G01N33/74 ,  A61K43/00 ,  B01J13/00 ,  G01N33/48 ,  G01T1/00

CPC分类号： A61K9/5089 ,  G01N33/537 ,  G01N33/5375 ,  G01N33/743 ,  F02B2075/025 ,  Y10S436/804 ,  Y10S436/805 ,  Y10S436/815 ,  Y10S436/817 ,  Y10S436/829

摘要： A process for determining an immunogenic substance present in a sample wherein the immunogenic substance in the sample competes with a distinguishable analog of such substance for available binding sites on an antibody which is highly specific for the immunogenic substance in the sample. The antibody is encapsulated in a semi-permeable microcapsule.A specific example of the foregoing procedure is the determination of digoxin present in serum wherein the digoxin in the serum competes with radioiodine labeled digoxin for available binding sites on an antibody which is highly specific for digoxin and has been previously encapsulated in semi-permeable microcapsules. The concentration of digoxin in the sample is determined from a standard curve by relating digoxin concentration inversely to the percent of radioiodine labeled digoxin that is complexed to the antibody.

摘要翻译： 用于确定样品中存在的免疫原性物质的方法，其中样品中的免疫原性物质与对所述样品中的免疫原性物质高度特异性的抗体上的可获得的结合位点的可区别类似物进行竞争。 将抗体包封在半透性微胶囊中。 上述步骤的具体实例是测定血清中存在的地高辛，其中血清中的地高辛与放射性碘标记的地高辛竞争抗体上的可用结合位点，该抗体对地高辛具有高度特异性，并且已经预先包封在半渗透性微胶囊中。 通过将地高辛浓度与与抗体复合的放射性碘标记的地高辛的百分比相反地从标准曲线确定样品中地高辛的浓度。

公开(公告)号：US4911556A

公开(公告)日：1990-03-27

申请号：US324676

申请日：1989-03-17

申请人： Franklin Lim ,  William H. Bingham ,  Richard D. Moss

发明人： Franklin Lim ,  William H. Bingham ,  Richard D. Moss

IPC分类号： B01F11/00 ,  B01F13/08

CPC分类号： B01F11/0082 ,  B01F13/0818

摘要： Efficient mixing is promoted in a turbulent stirring unit by providing an agitator with flexible finger-like appendages and by varying the rate of rotation of a rotating magnetic field such that the fingers execute an undulatory motion, disrupting laminar flow and tending to collapse the liquid vortex. Motor control for controlling the fluctuation of the rotating magnetic field may provided by simple and economical electronic or electromechanical means. The control unit may be separately configured to control a number of other pieces of equipment, either in common or independently. The controller also may be integrated into stirrers, vortexers or shaker tables or externally provided to control existing units.

摘要翻译： 通过提供具有柔性指状附属物的搅拌器和通过改变旋转磁场的旋转速率使得手指执行波动运动，扰乱层流并倾向于使液体涡流折叠来在湍流搅拌单元中促进高效混合 。 用于控制旋转磁场波动的电动机控制可以通过简单和经济的电子或机电装置来提供。 控制单元可以被单独地配置成控制多个设备的共同或独立的数量。 控制器还可以集成到搅拌器，涡旋器或振动台中，或者外部设置以控制现有的单元。

公开(公告)号：US4324683A

公开(公告)日：1982-04-13

申请号：US606166

申请日：1975-08-20

申请人： Franklin Lim ,  Richard D. Moss

发明人： Franklin Lim ,  Richard D. Moss

IPC分类号： A61K9/50 ,  A61K38/16 ,  A61K38/42 ,  A61K38/43 ,  B01D67/00 ,  B01D69/02 ,  B01D69/14 ,  B01J13/02 ,  B01J13/16 ,  C08G69/26 ,  C08G69/28 ,  C12N11/04

CPC分类号： B01D67/0006 ,  A61K38/42 ,  A61K38/443 ,  A61K38/45 ,  A61K38/47 ,  A61K38/50 ,  A61K9/5031 ,  A61K9/5089 ,  B01D67/0088 ,  B01D69/02 ,  B01D69/141 ,  B01J13/16 ,  C08G69/26 ,  C08G69/28 ,  C12N11/04 ,  Y10T428/2989

摘要： A two step interfacial polymerization process for encapsulating operative chemically active substances in high quality semipermeable membranes. An emulsion is formed wherein the discontinuous phase contains the substance to be encapsulated and a first monomer. When a second monomer is added to the continuous phase, an imperfect membrane forms about the droplets of the discontinuous phase. Removal of the continuous phase, followed by resuspension of the raw microcapsules and addition of a second portion of second monomer, causes further polymerization strengthening the membranes and "patching" macroporous defects in them. The choice of solvents and control of reaction conditions such as pH, maximize the yield of operable labile substance encapsulated. A method of encapsulating a very high concentration of hemoglobin is also disclosed. Adaption of the two step process provides a method for forming and controlling the pore sizes in the membranes of a number of known prior art encapsulation processes.

摘要翻译： 用于在高质量半透膜中包封有效的化学活性物质的两步界面聚合方法。 形成乳液，其中不连续相含有待包被的物质和第一单体。 当将第二单体加入到连续相中时，不连续的膜围绕不连续相的液滴形成。 连续相的去除，然后重悬悬浮原始微胶囊并加入第二部分第二单体，进一步聚合加强膜并“修补”其中的大孔缺陷。 溶剂的选择和反应条件如pH的控制，使包封的可操作不稳定物质的产率最大化。 还公开了一种封装非常高浓度的血红蛋白的方法。 两步法的适应提供了一种用于形成和控制多种已知现有技术封装方法的膜中的孔径的方法。

公开(公告)号：US5226257A

公开(公告)日：1993-07-13

申请号：US899891

申请日：1992-06-17

申请人： Richard D. Moss

发明人： Richard D. Moss

IPC分类号： E05F15/16 ,  E05F15/20 ,  H01H3/16 ,  H01H36/00

CPC分类号： H01H3/16 ,  E05F15/668 ,  E05F15/75 ,  E05Y2900/106 ,  H01H36/00

摘要： A control panel includes a first switch to effect selective actuation of a garage door opener motor, with a second on/off switch arranged to effect selective locking engagement and disengagement of the motor relative to the first switch. An indicator light is arranged to indicate separation of a garage door from a garage door framework. An abutment switch is arranged also for engagement with a vehicular windshield for actuation of the garage door motor.

摘要翻译： 控制面板包括第一开关，用于实现车库门开启电机的选择性致动，第二开/关开关被布置成实现电动机相对于第一开关的选择性锁定接合和分离。 布置指示灯以指示车库门与车库门框架的分离。 桥台开关还布置成与车辆挡风玻璃接合以致动车库门马达。

公开(公告)号：US20080189828A1

公开(公告)日：2008-08-14

申请号：US12069087

申请日：2008-02-07

申请人： Richard D. Moss

发明人： Richard D. Moss

IPC分类号： A42B1/24 ,  A42B1/00 ,  A42B1/04

CPC分类号： A42B1/24

摘要： A flexible hat or cap-like assembly having a compressible doughnut shape memory substance or padding disposed within and is worn on a person's head for cushioning an object or load such as sheetrock which is carried or supported on the head during drywall installation of a ceiling. The doughnut style padding places the pivot area of the object off the crown of the person's head and places the pivot area around the outer parameter of the head. This increases the pivot area of the load to equal the circumference of the compressible substance. The larger pivot area increases balance and stability of the load and reduces side loading and thrust on the person's neck which is associated with prior art devices having a centralized load pivot point.

摘要翻译： 具有可压缩环形形状记忆物质或填充物的柔性帽或帽状组件，其设置在人的头部内并佩戴在人的头部上，用于缓冲在天花板的墙壁安装期间承载或支撑在头部上的物体或负载物体或负载。 甜甜圈风格衬垫使物体的枢轴区域离开人头部的冠顶，并将枢轴区域放置在头部的外部参数周围。 这增加了负载的枢转面积等于可压缩物质的周长。 较大的枢轴区域增加了负载的平衡和稳定性，并且减小了与具有集中式负载枢转点的现有技术装置相关联的人的颈部的侧向负载和推力。

公开(公告)号：US06346889B1

公开(公告)日：2002-02-12

申请号：US09610013

申请日：2000-07-01

申请人： Richard D. Moss

发明人： Richard D. Moss

IPC分类号： G08B2100

CPC分类号： G08B13/08 ,  E05F15/00 ,  E05F15/668 ,  E05F15/71 ,  E05F15/79 ,  E05Y2400/324 ,  E05Y2400/326 ,  E05Y2400/354 ,  E05Y2400/452 ,  E05Y2400/51 ,  E05Y2400/61 ,  E05Y2400/65 ,  E05Y2400/66 ,  E05Y2400/812 ,  E05Y2400/818 ,  E05Y2600/46 ,  E05Y2800/426 ,  E05Y2800/75 ,  E05Y2900/106

摘要： A system and device for insuring the integrity of an automatic garage door has a sensor to determine the status of the door with respect to a predetermined position and a programable actuator which provides a positive signal for automatically activating a warning or alert system when the door is in predetermined position when the programmable actuator is activated and the sensor indicates that the door is at other than the predetermined position. Preferably the programmable actuator is a timer and the predetermined position is closed. The timer can be remotely programmable. The actuator can also be triggered by a sensor of an event such as darkness. Remote means are provided for manually activating the door to return to the desired position by an RF frequency transmitter.

摘要翻译： 用于确保自动车库门的完整性的系统和装置具有用于确定门相对于预定位置的状态的传感器和可编程致动器，该致动器提供用于当门是自动启动警告或警报系统时的自动启动信号 在可编程致动器被激活并且传感器指示门处于除了预定位置之外时在预定位置。 优选地，可编程致动器是定时器并且预定位置被关闭。 定时器可以远程编程。 致动器也可以由诸如黑暗的事件的传感器触发。 提供遥控装置用于手动地启动门以由RF频率发射器返回到期望的位置。