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354 条记录 (耗时 0.024 秒)

    Process for producing de(mycinosyloxy)tylosin
    52.
    发明授权
    Process for producing de(mycinosyloxy)tylosin 失效
    生产de（霉素氧基）泰乐菌素的方法

    公开(公告)号：US4334019A

    公开(公告)日：1982-06-08

    申请号：US261826

    申请日：1981-05-08

    申请人： Richard H. Baltz ,  Gene M. Wild ,  Eugene T. Seno

    发明人： Richard H. Baltz ,  Gene M. Wild ,  Eugene T. Seno

    IPC分类号： C07H17/08 ,  C12P19/62 ,  C12N1/20

    CPC分类号： C07H17/08 ,  C12P19/62 ,  C12R1/54 ,  Y10S435/896

    摘要： 23-De(mycinosyloxy)tylosin (DMOT) which has the formula: ##STR1## 20-dihydro-DMOT, specified acyl ester derivatives, and the acid addition salts thereof are useful antibacterial agents. New methods of making 23-deoxy-5-O-mycaminosyltylonolide (DOMT) and 20-dihydro-DOMT by mild acid hydrolysis of DMOT and 20-dihydro-DMOT, respectively, are included.

    摘要翻译： 具有下式的23-De（霉素氧基）泰乐菌素（DMOT）及其酸加成盐是有用的抗菌剂，其具有下式：20-dihydro-DMOT，特定的酰基酯衍生物及其酸加成盐。 包括分别通过DMOT和20-dihydro-DMOT的温和酸解来制备23-脱氧-5-O-碳霉糖基太乐内酯（DOMT）和20-二氢-NDTT的新方法。

    Selective hydrogenation products of C-076 compounds and derivatives thereof
    55.
    发明授权
    Selective hydrogenation products of C-076 compounds and derivatives thereof 失效
    C-076化合物及其衍生物的选择性氢化产物

    公开(公告)号：US4199569A

    公开(公告)日：1980-04-22

    申请号：US928111

    申请日：1978-07-31

    申请人： John C. Chabala ,  Michael H. Fisher

    发明人： John C. Chabala ,  Michael H. Fisher

    IPC分类号： A01N43/90 ,  C07D493/22 ,  C07H17/08 ,  C12P19/62 ,  A61K31/70

    CPC分类号： C07D493/22 ,  A01N43/90 ,  C07H17/08 ,  C12P19/623

    摘要： Derivatives of C-076 are described in which the C-076 molecule, as series of macrolides, has a specific unsaturation, at the 22,23-position, catalytically reduced. Further reaction of the reduced C-076 compounds are also possible. The compounds thus produced have profound anthelmintic, insecticidal, ectoparasiticidal and acaracidal activity. Compositions containing the described C-076 derivatives as the active ingredient thereof are also disclosed.

    摘要翻译： 描述了C-076的衍生物，其中作为大环内酯类的一系列的C-076分子在22,23位具有特异性不饱和键，被催化还原。 还原的C-076化合物的进一步反应也是可能的。 由此产生的化合物具有深远的驱肠虫，杀虫，外寄生虫杀螨和杀螨活性。 还公开了含有所述C-076衍生物作为其活性成分的组合物。

    Purification of C-076 compounds by single column chromatography
    57.
    发明授权
    Purification of C-076 compounds by single column chromatography 失效
    通过单柱色谱法纯化C-076化合物

    公开(公告)号：US4172940A

    公开(公告)日：1979-10-30

    申请号：US838693

    申请日：1977-10-03

    申请人： Louis Chaiet

    发明人： Louis Chaiet

    IPC分类号： C07H19/01 ,  C12P19/62 ,  C07H17/08

    CPC分类号： C07H19/01 ,  C12P19/623 ,  C12R1/465

    摘要： This case relates to a novel process for aiding in the isolation and purification of novel compounds which are produced by the microorganism, Streptomyces avermitilis. The process described herein utilizes a bed of activated alumina and a bed of activated carbon, respectively. The compounds which are isolated and purified are described generically as C-076 and have significant parasiticidal activity.

    摘要翻译： 这种情况涉及一种用于帮助分离和纯化由微生物阿维链霉菌（Streptomyces avermitilis）产生的新化合物的新方法。 本文所述的方法分别使用活性氧化铝床和活性炭床。 分离和纯化的化合物一般被描述为C-076并且具有显着的杀寄生虫活性。

    Tylosin derivatives and their manufacturing process
    58.
    发明授权
    Tylosin derivatives and their manufacturing process 失效
    泰乐菌素衍生物及其制造工艺

    公开(公告)号：US4092473A

    公开(公告)日：1978-05-30

    申请号：US708151

    申请日：1976-07-23

    申请人： Rokuro Okamoto ,  Tsumoru Fukumoto ,  Akira Takamatsu ,  Tomio Takeuchi

    发明人： Rokuro Okamoto ,  Tsumoru Fukumoto ,  Akira Takamatsu ,  Tomio Takeuchi

    IPC分类号： C07H17/08 ,  C12P19/62 ,  A61K31/71

    CPC分类号： C07H17/08 ,  C12P19/62 ,  Y10S435/886

    摘要： New tylosin derivatives having at least one acyl group at the 3- and 4"-positions of tylosin, and the acid addition salts thereof, which inhibit the growth of various microorganisms including drug-resistant bacterial isolants and which produce high blood levels through oral administration are produced by a biochemical reaction using the microorganisms of the genus Streptomyces which are selected for their newly-found ability to acylate at least one of the 3- and 4"-positions of macrolide antibiotics; they are recovered from the reacted mixture by conventional methods for recovering macrolide antibiotics.

    摘要翻译： 在泰乐菌素的3和4“位具有至少一个酰基的新泰乐菌素衍生物及其酸加成盐，其抑制各种微生物生长，包括耐药性细菌分离物，并通过口服产生高血药浓度 通过使用由链霉菌属（Streptomyces）属的微生物生物化学反应来产生施用，所述微生物被选择用于其新发现的能够酰化大环内酯类抗生素的3-和4-位中的至少一个的能力; 它们通过用于回收大环内酯类抗生素的常规方法从反应混合物中回收。