公开(公告)号：US20210332322A1

公开(公告)日：2021-10-28

申请号：US17367231

申请日：2021-07-02

申请人： Huvepharma Inc.

发明人： Mary Ann Pfannenstiel ,  Jennifer Albrecht ,  Glen M. Wilkinson

IPC分类号： C12N1/10 ,  A61K39/012 ,  C12N1/04

摘要： Compositions are provided that contain sporulated coccidial oocysts, wherein the compositions are free of antibiotics and comprise formalin at a concentration sufficient to inhibit microbial growth for at least 12 months while maintaining oocyst viability. Methods of preparing such compositions are also provided.

公开(公告)号：US20210290761A1

公开(公告)日：2021-09-23

申请号：US17275892

申请日：2019-09-13

申请人： Prommune, Inc. ,  Board of Regents of the University of Nebraska

发明人： Paul Davis ,  Samer Al-Murrani

IPC分类号： A61K39/39 ,  A61K39/015 ,  A61K39/018 ,  A61K39/005 ,  A61K39/008 ,  A61K39/012 ,  A61K39/002 ,  A61P33/02

摘要： Anti-parasitic compounds and uses thereof. Compounds comprising a C-terminal peptide adjuvant conjugated to an N-terminal peptide antigen via a protease-cleavable linker, said peptide adjuvant comprising a peptide analog of C5a, wherein said peptide antigen comprises an antigenic epitope of a parasitic organism, such as T. gondii. Methods of therapeutic or prophylactic treatment of a parasitic infections.

公开(公告)号：US20210213129A1

公开(公告)日：2021-07-15

申请号：US17216819

申请日：2021-03-30

申请人： Immugen Pharma LLC

发明人： Craig Travis

IPC分类号： A61K39/39 ,  A61K39/04 ,  A61K39/02 ,  A61K39/05 ,  A61K39/118 ,  A61K39/085 ,  A61K39/095 ,  A61K39/08 ,  A61K39/104 ,  A61K39/112 ,  A61K39/29 ,  A61K39/225 ,  A61K39/215 ,  A61K39/145 ,  A61K39/13 ,  A61K39/165 ,  A61K39/20 ,  A61K39/205 ,  A61K39/25 ,  A61K39/00 ,  A61K39/015 ,  A61K39/008 ,  A61K39/005 ,  A61K39/002 ,  A61K39/012

摘要： Disclosed are methods and compositions related to the use cannabinoids as adjuvants for the accelerated induction and production of an antibody based immune response.

公开(公告)号：US10792351B2

公开(公告)日：2020-10-06

申请号：US16439511

申请日：2019-06-12

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS ,  THE TEXAS A&M UNIVERSITY SYSTEM

发明人： John R. Barta ,  Luc Berghman ,  Srichaitanya Shivaramaiah ,  Olivia B. Faulkner ,  Lisa Bielke ,  Billy Hargis

IPC分类号： A61K39/002 ,  C07K14/445 ,  A61K39/012 ,  A61K39/015 ,  A61K39/00

摘要： Vaccine vectors and methods of using the vaccine vectors to enhance the immune response to an Apicomplexan parasite and reduce the morbidity or mortality associated with subsequent infection are provided herein. The vaccine vectors include a polynucleotide encoding a Rhomboid polypeptide and optionally include an immune-stimulatory polypeptide suitably expressed on the surface of the vaccine vector.

公开(公告)号：US10744192B2

公开(公告)日：2020-08-18

申请号：US15074689

申请日：2016-03-18

申请人： Moredun Research Institute

发明人： Michael Christopher Fontaine ,  David George Emslie Smith ,  Julie Lydia Fitzpatrick ,  William Donachie ,  Anita Dorota Jaglarz

IPC分类号： A61K39/09 ,  A61K39/00 ,  A61K39/012 ,  A61K39/108 ,  A61K39/05 ,  A61K39/08 ,  A61K39/118 ,  A61K39/39 ,  A61K39/002 ,  A61K39/085 ,  A61K39/12 ,  G01N33/569

摘要： The invention is based upon the identification of a number of antigens derived from a species of the genus Streptococcus, which are cross reactive and which may serve as the basis of useful compositions and tests and procedures capable of identifying and/or detecting Streptococcus sp in samples.

公开(公告)号：US20190298815A1

公开(公告)日：2019-10-03

申请号：US16439511

申请日：2019-06-12

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS ,  THE TEXAS A&M UNIVERSITY SYSTEM

发明人： John R. Barta ,  Luc Berghman ,  Srichaitanya Shivaramaiah ,  Olivia B. Faulkner ,  Lisa Bielke ,  Billy Hargis

IPC分类号： A61K39/002 ,  C07K14/445 ,  A61K39/012 ,  A61K39/015

摘要： Vaccine vectors and methods of using the vaccine vectors to enhance the immune response to an Apicomplexan parasite and reduce the morbidity or mortality associated with subsequent infection are provided herein. The vaccine vectors include a polynucleotide encoding a Rhomboid polypeptide and optionally include an immune-stimulatory polypeptide suitably expressed on the surface of the vaccine vector.

公开(公告)号：US10294483B2

公开(公告)日：2019-05-21

申请号：US15887130

申请日：2018-02-02

申请人： The United States of America, as represented by the Secretary of Agriculture

发明人： Hyun S. Lillehoj ,  Sungtaek Oh ,  Alfredo Panebra

IPC分类号： C07K14/44 ,  A61K39/002 ,  C12N15/70 ,  A61P33/02 ,  A61K39/012 ,  C07K14/455 ,  A61K39/00

摘要： Provided herein are immunogenic compositions containing recombinant proteins capable of presenting all, or antigenic portions of, the Eimeria tenella Elongation Factor 1 alpha, or EF-1α, protein in the development of active immunity to, and control of, coccidiosis. Also provided are methodologies of using the immunogenic compositions for administration to poultry and other animals in the control of coccidiosis. In some instances, the EF-1α protein utilized in the immunogenic composition presented herein is molecularly manipulated or combined with adjuvants to increase effectiveness.

公开(公告)号：US10011815B2

公开(公告)日：2018-07-03

申请号：US15300522

申请日：2015-04-02

申请人： Intervet Inc.

发明人： Theodorus Petrus Maria Schetters ,  Koen Gevers

IPC分类号： A61K39/00 ,  A61K39/002 ,  A61K45/00 ,  C12N3/00 ,  A61K39/012 ,  C12M1/26 ,  C12M3/04

CPC分类号： C12N3/00 ,  A61K39/012 ,  C12M27/10 ,  C12M33/14 ,  C12N1/10

摘要： The invention pertains to a method to sporulate coccidial oocysts purified from animal faeces (5), the method comprising providing the purified oocysts as a layer (40) on a supporting surface (22), maintaining the layer at least intermittently in an oxygen containing gaseous environment (60) having a relative humidity of at least 15% and maintaining the temperature of the oocysts between 19° C. and 37° C. The invention also pertains to sporulated oocysts obtained with this method and to a vaccine containing such sporulated oocysts.

公开(公告)号：US09802974B2

公开(公告)日：2017-10-31

申请号：US14416052

申请日：2013-07-23

申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

发明人： Nahid Azzouz ,  Sebastian Götze ,  Peter H. Seeberger ,  Daniel Varon Silva ,  Yu-Hsuan Tsai

IPC分类号： C07H1/02 ,  C07H15/207 ,  A61K39/002 ,  A61K47/48 ,  G01N33/569 ,  A61K39/012 ,  C08B37/00 ,  A61K39/00

CPC分类号： C07H15/207 ,  A61K39/002 ,  A61K39/012 ,  A61K47/6415 ,  A61K2039/55544 ,  A61K2039/64 ,  C07H1/02 ,  C08B37/006 ,  G01N33/56905 ,  G01N2333/45

摘要： The present invention relates to the synthesis of GPI-related surface antigens of the parasite Toxoplasma gondii (T. gondii) and the resulting products obtained. These synthetic compounds are suitable for diagnosis of toxoplasmosis, as well as vaccine against toxoplasmosis, a diseases caused by infection with T. gondii.

公开(公告)号：US20150182564A1

公开(公告)日：2015-07-02

申请号：US14417067

申请日：2013-07-31

申请人： PACIFIC VET GROUP-USA, INC.

发明人： Ross Wolfenden

IPC分类号： A61K35/742 ,  C12Q1/02 ,  A61K35/744 ,  A61K39/012 ,  A61K35/741

CPC分类号： A61K35/742 ,  A61K35/74 ,  A61K35/741 ,  A61K35/744 ,  A61K39/012 ,  A61K2035/115 ,  A61K2039/552 ,  C12Q1/02 ,  A61K2300/00

摘要： Methods for improving the health of agricultural poultry are provided. For example, methods including selecting specific bacteria to form a probiotic for the administration with coccidiosis vaccines for the reduction of adverse effects associated with the coccidiosis vaccines are disclosed. In accordance with various aspects of the present disclosure, a bacterial isolate, probiotic and or treatment may be obtained by novel screening methods resulting in products that are advantageously administered with or about the same time as a coccidiosis vaccine.

摘要翻译： 提供了改善农业家禽健康的方法。 例如，公开了包括选择特定细菌以形成益生菌用于用球虫病疫苗施用以减少与球虫病疫苗相关的不利影响的方法。 根据本公开的各个方面，可以通过新的筛选方法获得细菌分离物，益生菌和/或治疗，所述筛选方法有利地与球虫病疫苗一起或大约同时施用。