公开(公告)号：US11104910B2

公开(公告)日：2021-08-31

申请号：US16108402

申请日：2018-08-22

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Asaph Aharoni ,  Samuel Bocobza ,  Tal Dahan ,  Avraham A. Levy

IPC: C12N15/82 ,  C12N15/86 ,  C07K14/08

Abstract: Disclosed herein are methods for gene targeting in a plant cell, as well as recombinant nucleic acid molecules used in these methods. Further disclosed are recombinant nucleic acid molecules comprising a target gene operably linked to a regulatory region of the UBQ10 gene.

公开(公告)号：US20210253998A1

公开(公告)日：2021-08-19

申请号：US17117157

申请日：2020-12-10

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yaqub HANNA ,  Noa NOVERSHTERN ,  Yoach RAIS

IPC: C12N5/0735 ,  C12N5/074

Abstract: Provided is an isolated human naive pluripotent stem cell (PSC), wherein: (i) when the naive PSC is a female PSC, then said naive female PSC has two unmethylated alleles of an X-inactive specific transcript (XIST) gene; and (ii) when said naive PSC is a male PSC, then said naive male PSC has an unmethylated allele of said XIST gene. Also provided is a culture medium which comprises an ERK1/2 inhibitor, a GSK3beta inhibitor, a p38 inhibitor, a JNK inhibitor, a STAT3 activator and at least one agent selected from the group consisting of: bFGF, TGFbeta 1, a PKC inhibitor, a ROCK inhibitor and a NOTCH inhibitor; or at least agent selected from the group consisting of: a TGFR inhibitor, a FGFR inhibitor, a PKC inhibitor, a ROCK inhibitor and a NOTCH inhibitor.

公开(公告)号：US20210236638A1

公开(公告)日：2021-08-05

申请号：US17188988

申请日：2021-03-01

Applicant: Memorial Sloan Kettering Cancer Center ,  Yeda Research and Development Co., Ltd.

Inventor： Jonathan COLEMAN ,  Phillip A. WATSON ,  Kwanghee KIM ,  Avigdor SCHERZ

IPC: A61K41/00 ,  A61P35/00 ,  A61K31/4166 ,  A61K38/08 ,  A61K47/64

Abstract: A method for treatment of prostate cancer or benign prostate hyperplasia by combination therapy comprising administering to a patient an androgen-deprivation therapy agent and a bacteriochlorophyll derivative followed by photodynamic therapy (PDT) or vascular-targeted photodynamic therapy (VTP).

公开(公告)号：US20210214687A1

公开(公告)日：2021-07-15

申请号：US17211863

申请日：2021-03-25

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair REISNER ,  Noga OR-GEVA ,  Rotem GIDRON BUDOVSKY ,  Esther BACHAR-LUSTIG ,  Assaf LASK ,  Sivan KAGAN

IPC: C12N5/0783 ,  A61K35/17 ,  A61K39/00 ,  C12N5/00

Abstract: A method of generating an isolated population of non graft versus host disease (GvHD) inducing cells comprising a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance inducing cells and/or endowed with anti-disease activity, and capable of homing to the lymph nodes following transplantation is disclosed. The method comprising: (a) providing a population of at least 70% memory T cells; (b) contacting the population of memory T cells with an antigen or antigens so as to allow enrichment of antigen reactive cells; and (c) culturing the cells resulting from step (b) in the presence of cytokines so as to allow proliferation of cells comprising the Tcm phenotype. Cells generated by the method, pharmaceutical compositions and methods of treatment are also disclosed.

公开(公告)号：US11062794B2

公开(公告)日：2021-07-13

申请号：US15965930

申请日：2018-04-29

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Noam Sobel ,  Tali Weiss ,  Kobi Snitz ,  Adi Yablonka-Barak ,  Elad Schneidman ,  Rehan Mahmood Khan

IPC: G16C20/90 ,  G16C20/30 ,  G01N33/00 ,  C11B9/00 ,  C11B9/02 ,  G06F16/245 ,  G16C20/40

Abstract: An odorant mixture is disclosed. The odorant mixture comprises N odorant components wherein N equals at least 20. Each odorant component is characterized by a multidimensional vector of attributes. A z score of an average of characteristic distances between vectors corresponding to odorant components in the mixture and vectors corresponding to odorant components in a group of M odorant components but not in the mixture is less than 2.

公开(公告)号：US11041928B2

公开(公告)日：2021-06-22

申请号：US16891437

申请日：2020-06-03

Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Aharon Blank ,  Itai Katz ,  Akiva Feintuch

IPC: G01R33/62 ,  A61B5/055 ,  G01R33/56 ,  A61K49/20 ,  G01R33/28 ,  A61M5/00 ,  G01R33/48

Abstract: A method tor the preparation of a highly polarized nuclear spins containing sample of an organic or inorganic material, containing H or OH groups or adsorbed water molecules. Such highly polarized nuclear spins containing samples can be subjected to nuclear magnetic resonance (NMR) measurement and/or can be thawed and immediately administered to an individual undergoing a magnetic resonance imaging (MRI) scan. The method is based on generating unstable radicals on the surface of the sample in the presence of ionized environment followed by cooling the sample to cryogenic temperatures. A device for carrying out a particular step of said method is also discloses.

公开(公告)号：US20210162025A1

公开(公告)日：2021-06-03

申请号：US17166060

申请日：2021-02-03

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irit SAGI ,  Eitan WONG ,  Ran AFIK

IPC: A61K38/48 ,  C12N9/64

Abstract: A method of treating an inflammatory disease is disclosed. The method comprises administering to the subject a therapeutically effective amount of a polypeptide comprising a pro-domain of TNF-alpha converting enzyme (TACE), said polypeptide being devoid of a catalytic domain of said TACE, said polypeptide comprising a modification at a site selected from the group consisting of R58, R56 and K57 which renders said polypeptide resistant to furin degradation said polypeptide being capable of downregulating an activity of TACE, thereby treating the inflammatory disease.

公开(公告)号：US20210156867A1

公开(公告)日：2021-05-27

申请号：US17140075

申请日：2021-01-03

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： David MARGULIES ,  Leila MOTIEI ,  Pragati PRASAD ,  Tom GRANOT ,  Ohad SUSS

IPC: G01N33/58 ,  G01N33/68 ,  G01N21/64 ,  G01N33/50

Abstract: This invention is directed to a turn-on fluorescent probe, wherein said probe comprises a quinoline based cyanine dye derivative (QBC) and a specific protein binder covalently attached thereto directly or via a linker. This invention is further directed to His-tag binding compounds and uses thereof in the preparation of genetically targeted detectable molecules and sensors which can specifically bind tag-labeled proteins. This invention further describes methods for using these turn-on probes and compounds for detecting and labelling a wide range of proteins in their native environment.

公开(公告)号：US20210144999A1

公开(公告)日：2021-05-20

申请号：US16629572

申请日：2018-07-09

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  THE NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV LTD.

Inventor： Ilana KOLODKIN-GAL ,  Yaara OPPENHEIMER-SHAANAN ,  Ariel OGRAN-NACHMAN ,  Michael MEIJLER ,  Eliane Hadas YARDENI

IPC: A01N43/16 ,  A01N37/38 ,  A01N33/04 ,  C07C231/24 ,  C12N1/38

Abstract: The present invention provides anti-microbial compositions comprising a hydroxycinnamic acid and related conjugates, analogues and derivatives, and methods of use thereof for enhancing production of anti-microbial agents in bacteria as well as for protecting plants from microbial infection.

公开(公告)号：US10975373B2

公开(公告)日：2021-04-13

申请号：US16180083

申请日：2018-11-05

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Alon Chen ,  Orna Issler

IPC: C12N15/11 ,  C12Q1/6883 ,  C12N15/113

Abstract: A method of treating a bipolar disorder in a subject in need thereof is disclosed. The method comprising administering to the subject sa therapeutically effective amount of a miR-135, a precursor thereof or a nucleic acid molecule encoding said miR-135 or said precursor thereof, thereby treating the bipolar disorder. Methods of diagnosing a mood disorder in a human subject and of monitoring treatment of an anti-depressant drug or a medicament for the treatment of a mood disorder are also disclosed.