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    MICROORGANISMS FOR THE PRODUCTION OF ADIPIC ACID AND OTHER COMPOUNDS
    62.
    发明申请
    MICROORGANISMS FOR THE PRODUCTION OF ADIPIC ACID AND OTHER COMPOUNDS 有权
    用于生产对苯二酸和其他化合物的微生物

    公开(公告)号：US20120115194A1

    公开(公告)日：2012-05-10

    申请号：US13288699

    申请日：2011-11-03

    Applicant: Anthony P. Burgard ,  Priti Pharkya ,  Robin E. Osterhout

    Inventor： Anthony P. Burgard ,  Priti Pharkya ,  Robin E. Osterhout

    IPC: C12P7/44 ,  C12N1/19 ,  C12N1/15 ,  C12N1/21

    CPC classification number: C12N15/52 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/80 ,  C12N9/88 ,  C12P7/44 ,  C12P7/46 ,  C12P7/62 ,  C12P13/001 ,  C12P13/005 ,  C12P13/02 ,  C12P17/10 ,  C12Y101/01035 ,  C12Y102/0101 ,  C12Y103/01031 ,  C12Y206/01 ,  C12Y402/01

    Abstract: The invention provides a non-naturally occurring microbial organism having an adipate, 6-aminocaproic acid or caprolactam pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective adipate, 6-aminocaproic acid or caprolactam pathway. The invention additionally provides a method for producing adipate, 6-aminocaproic acid or caprolactam. The method can include culturing an adipate, 6-aminocaproic acid or caprolactam producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an adipate, 6-aminocaproic acid or caprolactam pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce adipate, 6-aminocaproic acid or caprolactam.

    Abstract translation: 本发明提供了具有己二酸，6-氨基己酸或己内酰胺途径的非天然存在的微生物。 微生物生物体含有至少一种编码相应己二酸，6-氨基己酸或己内酰胺途径中的酶的外源核酸。 本发明另外提供了生产己二酸，6-氨基己酸或己内酰胺的方法。 该方法可以包括培养己二酸，6-氨基己酸或己内酰胺生产微生物，其中微生物生物体表达至少一种编码己二酸，6-氨基己酸或己内酰胺途径酶的外源核酸，其量足以产生相应的产物 在条件下和足够的时间内生产己二酸，6-氨基己酸或己内酰胺。

    Methods and organisms for the growth-coupled production of 1,4-Butanediol
    64.
    发明申请
    Methods and organisms for the growth-coupled production of 1,4-Butanediol 有权
    用于1,4-丁二醇生长偶联生产的方法和生物

    公开(公告)号：US20110201071A1

    公开(公告)日：2011-08-18

    申请号：US13065303

    申请日：2011-03-18

    Applicant: Anthony P. Burgard ,  Stephen J. Van Dien ,  Mark Burk

    Inventor： Anthony P. Burgard ,  Stephen J. Van Dien ,  Mark Burk

    IPC: C12P7/18 ,  C12N1/00

    CPC classification number: C12P7/18 ,  B01D3/002 ,  C12N9/0006

    Abstract: The invention provides a non-naturally occurring microorganism comprising one or more gene disruptions, the one or more gene disruptions occurring in genes encoding an enzyme obligatory to coupling 1,4-butanediol production to growth of the microorganism when the gene disruption reduces an activity of the enzyme, whereby theone or more gene disruptions confers stable growth-coupled production of 1,4-butanediol onto the non-naturally occurring microorganism. The microorganism can further comprise a gene encoding an enzyme in a 1,4-butanediol (BDO) biosynthetic pathway. The invention additionally relates to methods of using microorganisms to produce BDO.

    Abstract translation: 本发明提供了包含一种或多种基因破坏的非天然存在的微生物，所述一个或多个基因破坏发生在编码需要将1,4-丁二醇生产偶联以生产微生物的酶的基因发生在基因破坏时降低活性 该酶，其中一种或多种基因破坏赋予非天然存在的微生物上1,4-丁二醇稳定的生长偶联产生。 微生物还可以包含编码1,4-丁二醇（BDO）生物合成途径中的酶的基因。 本发明还涉及使用微生物来生产BDO的方法。

    ORGANISMS FOR THE PRODUCTION OF ISOPROPANOL, n-BUTANOL, AND ISOBUTANOL
    67.
    发明申请
    ORGANISMS FOR THE PRODUCTION OF ISOPROPANOL, n-BUTANOL, AND ISOBUTANOL 有权
    生产异丙酚，正丁醇和异丁醇的有机体

    公开(公告)号：US20100323418A1

    公开(公告)日：2010-12-23

    申请号：US12772094

    申请日：2010-04-30

    Applicant: Anthony P. Burgard

    Inventor： Anthony P. Burgard

    IPC: C12P7/16 ,  C12N1/21 ,  C12P7/04

    CPC classification number: C12P17/16 ,  C12N9/0006 ,  C12N9/1025 ,  C12N9/16 ,  C12N9/88 ,  C12N9/93 ,  C12P7/04

    Abstract: A non-naturally occurring microbial organism having an isopropanol pathway includes at least one exogenous nucleic acid encoding an isopropanol pathway enzyme. The pathway includes an enzyme selected from a 4-hydroxybutyryl-CoA dehydratase, a crotonase, a 3-hydroxybutyryl-CoA dehydrogenase, an acetoacetyl-CoA synthetase, an acetyl-CoA:acetoacetate-CoA transferase, an acetoacetyl-CoA hydrolase, an acetoacetate decarboxylase, and an acetone reductase. A non-naturally occurring microbial organism having an n-butanol pathway includes at least one exogenous nucleic acid encoding an n-butanol pathway enzyme. Other non-naturally occurring microbial organism have n-butanol or isobutanol pathways. The organisms are cultured to produce isopropanol, n-butanol, or isobutanol.

    Abstract translation: 具有异丙醇途径的非天然存在的微生物生物体包括至少一种编码异丙醇途径酶的外源核酸。 该途径包括选自4-羟基丁酰辅酶A脱水酶，巴豆酸酶，3-羟基丁酰辅酶A脱氢酶，乙酰乙酰辅酶A合成酶，乙酰辅酶A：乙酰乙酸酯-CoA转移酶，乙酰乙酰辅酶A水解酶，乙酰乙酸酯 脱羧酶和丙酮还原酶。 具有正丁醇途径的非天然存在的微生物包括至少一种编码正丁醇途径酶的外源核酸。 其他非天然存在的微生物生物体具有正丁醇或异丁醇途径。 培养生物体以产生异丙醇，正丁醇或异丁醇。

    Microorganisms for the production of adipic acid and other compounds
    68.
    发明授权
    Microorganisms for the production of adipic acid and other compounds 有权
    用于生产己二酸等化合物的微生物

    公开(公告)号：US07799545B2

    公开(公告)日：2010-09-21

    申请号：US12413355

    申请日：2009-03-27

    Applicant: Anthony P. Burgard ,  Priti Pharkya ,  Robin E. Osterhout

    Inventor： Anthony P. Burgard ,  Priti Pharkya ,  Robin E. Osterhout

    IPC: C12P7/40 ,  C12N1/20

    CPC classification number: C12N15/52 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/80 ,  C12N9/88 ,  C12P7/44 ,  C12P7/46 ,  C12P7/62 ,  C12P13/001 ,  C12P13/005 ,  C12P13/02 ,  C12P17/10 ,  C12Y101/01035 ,  C12Y102/0101 ,  C12Y103/01031 ,  C12Y206/01 ,  C12Y402/01

    Abstract: The invention provides a non-naturally occurring microbial organism having an adipate, 6-aminocaproic acid or caprolactam pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective adipate, 6-aminocaproic acid or caprolactam pathway. The invention additionally provides a method for producing adipate, 6-aminocaproic acid or caprolactam. The method can include culturing an adipate, 6-aminocaproic acid or caprolactam producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an adipate, 6-aminocaproic acid or caprolactam pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce adipate, 6-aminocaproic acid or caprolactam.

    Abstract translation: 本发明提供了具有己二酸，6-氨基己酸或己内酰胺途径的非天然存在的微生物。 微生物生物体含有至少一种编码相应己二酸，6-氨基己酸或己内酰胺途径中的酶的外源核酸。 本发明另外提供了生产己二酸，6-氨基己酸或己内酰胺的方法。 该方法可以包括培养己二酸，6-氨基己酸或己内酰胺生产微生物，其中微生物生物体表达至少一种编码己二酸，6-氨基己酸或己内酰胺途径酶的外源核酸，其量足以产生相应的产物 在条件下和足够的时间内生产己二酸，6-氨基己酸或己内酰胺。

    MICROORGANISMS FOR THE PRODUCTION OF METHYL ETHYL KETONE AND 2-BUTANOL
    69.
    发明申请
    MICROORGANISMS FOR THE PRODUCTION OF METHYL ETHYL KETONE AND 2-BUTANOL 审中-公开
    用于生产甲基乙基酮和2-丁醇的微生物

    公开(公告)号：US20100184173A1

    公开(公告)日：2010-07-22

    申请号：US12618545

    申请日：2009-11-13

    Applicant: Mark J. Burk ,  Priti Pharkya ,  Anthony P. Burgard

    Inventor： Mark J. Burk ,  Priti Pharkya ,  Anthony P. Burgard

    IPC: C12P7/26 ,  C12N1/00 ,  C12P7/16

    CPC classification number: C12P7/16 ,  C12N15/52 ,  C12P7/26 ,  Y02E50/10

    Abstract: A non-naturally occurring microbial organism having a methyl ethyl ketone pathway includes at least one exogenous nucleic acid encoding a methyl ethyl ketone pathway enzyme expressed in a sufficient amount to produce methyl ethyl ketone. The methyl ethyl ketone pathway includes a β-ketothiolase, a β-ketovalerate decarboxylase and an enzyme selected from the group consisting of a β-ketovaleryl-CoA hydrolase and a β-ketovaleryl-CoA transferase. Alternatively, the methyl ethyl ketone pathway includes a 2-methylacetoacetyl-CoA thiolase, a 2-methylacetoacetate decarboxylase and an enzyme selected from the group consisting of a 2-methylacetoacetyl-CoA hydrolase and a 2-methylacetoacetyl-CoA transferase. Either pathway can further include a methyl ethyl ketone reductase to produce 2-BuOH. A method for producing methyl ethyl ketone or 2-BuOH includes culturing these non-naturally occurring microbial organisms under conditions, and for a sufficient period of time, to produce methyl ethyl ketone or 2-BuOH.

    Abstract translation: 具有甲基乙基酮途径的非天然存在的微生物包括至少一种编码甲基乙基酮途径酶的外源核酸，其以足以产生甲基乙基酮的量表达。 甲基乙基酮途径包括α-酮硫解酶，α-酮戊二酸脱羧酶和选自α-酮戊酰基-CoA水解酶和一种α-酮戊酰基-CoA转移酶的酶。 或者，甲基乙基酮途径包括2-甲基乙酰乙酰辅酶A硫解酶，2-甲基乙酰乙酸脱羧酶和选自2-甲基乙酰乙酰辅酶A水解酶和2-甲基乙酰乙酰辅酶A转移酶的酶。 任一途径还可以包括甲基乙基酮还原酶以产生2-BuOH。 一种生产甲基乙基酮或2-BuOH的方法包括在条件和足够的时间内培养这些非天然存在的微生物生产甲基乙基酮或2-BuOH。

    METHODS AND ORGANISMS FOR PRODUCTION OF 3-HYDROXYPROPIONIC ACID
    70.
    发明申请
    METHODS AND ORGANISMS FOR PRODUCTION OF 3-HYDROXYPROPIONIC ACID 审中-公开
    用于生产3-羟基丙酸的方法和有机体

    公开(公告)号：US20100021978A1

    公开(公告)日：2010-01-28

    申请号：US12508547

    申请日：2009-07-23

    Applicant: Mark J. Burk ,  Robin E. Osterhout

    Inventor： Mark J. Burk ,  Robin E. Osterhout

    IPC: C12P7/42 ,  C12N1/21

    CPC classification number: C12P7/42

    Abstract: A non-naturally occurring microbial organism having a 3-hydroxypropanoic acid (3-HP) pathway includes at least one exogenous nucleic acid encoding 3-HP pathway enzyme expressed in a sufficient amount to produce 3-HP. The 3-HP pathway includes a 2-keto acid decarboxylase, a CoA-dependent oxaloacetate dehydrogenase, or a malate decarboxylase. A method for producing 3-HP includes culturing a non-naturally occurring microbial organism having a 3-HP pathway that includes at least one exogenous nucleic acid encoding a 3-HP pathway enzyme expressed in a sufficient amount to produce 3-HP under conditions and for a sufficient period of time to produce 3-HP. The 3-HP pathway includes a 2-keto acid decarboxylase, a CoA-dependent oxaloacetate dehydrogenase, or a malate decarboxylase.

    Abstract translation: 具有3-羟基丙酸（3-HP）途径的非天然存在的微生物包含至少一种编码3-HP途径酶的外源核酸，其以足以产生3-HP的量表达。 3-HP途径包括2-酮酸脱羧酶，辅酶A依赖性草酰乙酸脱氢酶或苹果酸脱羧酶。 制备3-HP的方法包括培养具有3-HP途径的非天然存在的微生物，其包括至少一种编码以足够量表达的3-HP途径酶的外源核酸以在条件下产生3-HP， 足够的时间来生产3-HP。 3-HP途径包括2-酮酸脱羧酶，辅酶A依赖性草酰乙酸脱氢酶或苹果酸脱羧酶。

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