公开(公告)号：US20200257805A1

公开(公告)日：2020-08-13

申请号：US16603786

申请日：2018-03-20

申请人： COMMISSARIAT A L'ENERGIE ATGMIGUE ET AUX ENERGIES ALTERNATIVES ,  SORBONNE UNIVERSITE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： Damien COUROUSSE ,  Karine HEYDEMANN ,  Thierno BARRY

IPC分类号： G06F21/60 ,  G06F9/30 ,  G06F9/32

摘要： This execution method comprises the supplying of the machine code, this machine code being formed by a succession of base blocks, each base block being associated with a signature and comprising instructions to be protected, each instruction to be protected being immediately preceded or followed by an instruction for constructing the value of the signature associated with this base block, wherein: each construction instruction is coded on strictly less than N bits, and each word of the machine code which comprises at least one portion of one of said instructions to be protected also comprises one of said construction instructions so that it is not possible to load an instruction to be protected into an execution file, without at the same time loading a construction instruction which modifies the value of the signature associated with this base block when it is executed.

公开(公告)号：US20200247046A1

公开(公告)日：2020-08-06

申请号：US16635126

申请日：2018-08-03

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT CURIE ,  SORBONNE UNIVERSITE

发明人： Laurent Malaquin ,  Jean Louis Viovy ,  Sandrine Souleille ,  Xavier Dollat ,  Victor Fournie

IPC分类号： B29C64/209 ,  B29C64/106 ,  B33Y10/00 ,  B33Y30/00 ,  B41J2/175 ,  C12M1/26

摘要： A microfluidic print head of a printer has a distal face, an injection channel, a suction channel, a groove, and a light source or an optical waveguide. The injection channel is configured to inject an ink onto a substrate and leads onto the distal face by an injection opening The suction channel is configured to suck up the ink and leads onto the distal face by a suction opening. The groove is defined on the distal face and into which the suction opening leads.

公开(公告)号：US10732484B2

公开(公告)日：2020-08-04

申请号：US16472162

申请日：2017-12-22

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  SORBONNE UNIVERSITE ,  OBSERVATOIRE DE PARIS

发明人： Mohand Ouali Acef

IPC分类号： G02F1/35 ,  H01S3/00

摘要： A THz laser source includes a first generator suitable for emitting at least one first light emission and one second light emission of frequencies that are multiples of a first reference frequency; a second generator suitable for emitting at least one first light emission and one second light emission of frequencies that are multiples of a second reference frequency different from the first reference frequency; the THz laser source furthermore comprises a nonlinear crystal suitable for forming, from the first light emissions emitted by each of the first and second generators, a THz light emission generated by difference-frequency generation, of frequency comprised between 0.3 THz and 10 THz; and at least one first frequency-stabilizing module allowing the frequency of one of the second emissions emitted by one of the first and second generators to be stabilized to an atomic transition.

公开(公告)号：US20200037870A1

公开(公告)日：2020-02-06

申请号：US16499782

申请日：2018-03-29

申请人： INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE (ICM) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (AP-HP) ,  SORBONNE UNIVERSITE

发明人： Pierre Pouget ,  Alexis Genin

IPC分类号： A61B3/06 ,  A61B3/032 ,  A61B3/00 ,  A61B5/117

摘要： A method for generating an indicator or biomarker of colour perception in a mammalian subject, where the method may include submitting the mammalian subject to a multicoloured dynamic stimulus comprising displaying, on a display device. The method may include controlling a change over time of at least one of the two colours of the multicolour pattern when displaying the dynamic multicolour stimulus, to vary the displayed luminance of this colour (usually several times). The method may include acquiring, by using an image acquisition device, an oscillatory response of a pupil of the mammalian subject. The method may include generating, from the acquired response, a signal representative of the power of the pupil's oscillatory response as a function of the change over time of at least one of the two colours when displaying the dynamic multicoloured stimulus.

公开(公告)号：US20190351023A1

公开(公告)日：2019-11-21

申请号：US16361902

申请日：2019-03-22

申请人： INSERM (Institut National de la Sante et de la Recherche Medicale) ,  Assistance Publique - Hopitaux De Paris ,  SORBONNE UNIVERSITE

发明人： David Klatzmann ,  David Saadoun ,  Patrice Cacoub ,  Michèle Rosenzwajg ,  Eliane Piaggio ,  Gilbert Bensimon ,  Claude Bernard

IPC分类号： A61K38/20

摘要： The present invention relates to novel therapies for treating autoimmune and inflammatory diseases. More specifically, the present invention relates to a use of low dose interleukin-2 for the treatment of type I diabetes and other autoimmune and/or inflammatory diseases.

公开(公告)号：US10376564B2

公开(公告)日：2019-08-13

申请号：US15124734

申请日：2015-03-10

申请人： SORBONNE UNIVERSITE ,  ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： David Klatzmann ,  Bertrand Bellier

IPC分类号： A61K38/16 ,  A61K38/20 ,  A61K9/00 ,  A61K39/35 ,  A61K39/00

摘要： The present invention relates to the use of interleukin-2 (IL-2) for treating a food allergy, either by inducing non-specific tolerance against food allergens, or in a desensitization protocol in combination with a food allergen.

公开(公告)号：US20190135865A1

公开(公告)日：2019-05-09

申请号：US16099997

申请日：2017-05-10

申请人： SORBONNE UNIVERSITE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： Philippe Karoyan

IPC分类号： C07K7/50 ,  C07K7/64 ,  A61P37/06 ,  A61P29/00

摘要： The present invention relates to cyclic peptides mimetics of the C-terminal binding domain of TSP-1. The present invention also relates to the use of these cyclic peptides as agonists of CD47 and their ability to trigger programmed cell death (PCD). The present invention further relate to a pharmaceutical composition for use in the treatment of diseases associated with defects in PCD such as cancers and immunological disorders (including chronic inflammation) and comprising at least one cyclic peptide according to the invention.

公开(公告)号：US10196683B2

公开(公告)日：2019-02-05

申请号：US15570070

申请日：2016-05-04

申请人： PARIS SCIENCES ET LETTRES—QUARTIER LATIN ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  SORBONNE UNIVERSITE ,  UNIVERSITE PARIS DIDEROT PARIS 7

发明人： Vincent Croquette ,  Jimmy Ouellet

IPC分类号： C12Q1/68 ,  C12Q1/6834 ,  C12Q1/6806 ,  C12Q1/6874 ,  C12Q1/6816 ,  C12Q1/6832

摘要： The present invention relates to a method of preparation of substrates for nucleic acid sequencing reactions. More specifically, the present invention provides a new method of preparing hairpins using force-induced strand invasion. Hairpins prepared by this method and methods of nucleic acid analysis using these hairpins are also part of the present invention.

公开(公告)号：US20190030089A1

公开(公告)日：2019-01-31

申请号：US16072319

申请日：2017-01-23

申请人： Institut National De La Researche Agronomique (INRA) ,  Sorbonne Universite ,  Assistance Publique - Hopitaux de Paris

发明人： Philippe Langella ,  Rebeca Martin Rosique ,  Luis Bermudez Humaran ,  Florian Chain ,  Harry Sokol

IPC分类号： A61K35/74 ,  A61P1/00 ,  A23L33/135

摘要： The invention relates to a bacterial strain of species Faecalibacterium prausnitzii deposited at the CNCM under access number CNCM I-4573, for use in the treatment and/or prevention of an inflammatory gastrointestinal illness in an individual.

公开(公告)号：US20190002832A1

公开(公告)日：2019-01-03

申请号：US16065155

申请日：2016-12-23

申请人： ASSOCIATION INSTITUT DE MYOLOGIE ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE ,  SORBONNE UNIVERSITE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： SONIA BERRIH-AKNIN ,  MURIEL SUDRES

IPC分类号： C12N5/0775 ,  A61K35/28 ,  A01K67/027

摘要： The present invention relates to an animal model of myasthenia gravis, and to uses thereof.