公开(公告)号：US20210022638A1

公开(公告)日：2021-01-28

申请号：US16982174

申请日：2019-03-22

申请人： PARIS SCIENCES ET LETTRES - QUARTIER LATIN ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  ASSISTANCE PUBLIQUE HOPITAUX DE PARIS ,  ÉCOLE NORMALE SUPÉRIEURE ,  UNIVERSITÉ DE PARIS ,  INSERM (INSTITUTE NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)

发明人： David HOLCMAN ,  Adrien DOUMERGUE ,  Nathalie KUBIS ,  Alexandra RICHARD ,  Aymeric FLOYRAC

IPC分类号： A61B5/0484 ,  A61B5/04 ,  A61B5/00

摘要： This method for generating an indicator of the state of a patient in coma includes: generating at least one auditory stimulation by generating a sequence of auditory stimuli, the sequence producing evoked potentials in the patient; acquiring a first electroencephalographic signal produced by patient from at least one electrode; estimating at least one pair of values corresponding to a first parameter and a second parameter extracted from the first acquired signal, including estimating a first pair of values such that calculating the first parameter includes an estimation of the amplitude variance of the first signal within a predefined time window and the calculation of the second parameter includes an estimation of the correlation of two segments of the first signal; generating a state indicator for the or each pair of values of the first and second parameters, the values defining coordinates of a point in a reference base.

公开(公告)号：US20200308686A1

公开(公告)日：2020-10-01

申请号：US16765569

申请日：2018-11-22

申请人： PARIS SCIENCES ET LETTRES - QUARTIER LATIN ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  BIOTECH DENTAL

发明人： Frédéric PRIMA ,  Stéphanie DELANNOY

IPC分类号： C22F1/18 ,  C22C14/00

摘要： The invention relates to a ternary Titanium-Zirconium-Oxygen (Ti—Zr—O) alloy, characterized in that it comprises from 83% to 95.15 mass % of titanium, from 4.5% to 15 mass % of zirconium and from 0.35% to 2 mass % of oxygen, with said alloy being capable of forming a single-phase material consisting of a stable and homogeneous a solid solution of Hexagonal Close Packed (HCP) structure at room temperature. The invention further relates to a method for producing such alloy as well as preferred applications and utilizations thereof.

公开(公告)号：US20190119822A1

公开(公告)日：2019-04-25

申请号：US16096740

申请日：2017-03-31

申请人： Paris Sciences et Lettres - Quartier Latin ,  Centre National de la Recherche Scientifique (CNRS) ,  SORBONNE UNIVERSITE

发明人： Marc Fontecave ,  Victor Mougel ,  Ngoc Huan Tran

IPC分类号： C25B11/04 ,  C25B1/04 ,  C25D3/38 ,  C25D5/48 ,  C25D7/00

摘要： The present invention relates to an electrode comprising an electrically conductive substrate of which at least one portion of the surface is covered with a metal deposit of copper, the surface of said deposit being in an oxidised, sulphurised, selenised and/or tellurised form and the deposit having a specific surface area of more than 1 m2/g; a method for preparing such an electrode; and a method for oxygenising water with dioxygen involving such an electrode.

公开(公告)号：US20180369778A1

公开(公告)日：2018-12-27

申请号：US16060605

申请日：2016-12-09

申请人： Paris Sciences et Lettres - Quartier Latin ,  Centre National de la Recherche Scientifique (CNRS)

发明人： Michael Tatoulian ,  Stéphanie Ognier ,  Mengxue Zhang

IPC分类号： B01J19/00 ,  B01J19/08 ,  B01J19/24

摘要： The present invention relates to a microfluidic or millifluidic device (1) comprising: —a support (2) made at least partially of a dielectric material, the support (2) comprising a first inlet (21a) adapted to be connected to a first reservoir containing gas, a second inlet (21b) adapted to be connected to a second reservoir containing liquid, an outlet (22) adapted to be connected to a receiver container containing gas and/or liquid, and a main microchannel or millichannel (3) present in the dielectric material allowing the liquid and the gas to flow from the inlets towards the outlet, —one or several ground electrode(s) (4) embedded in said dielectric material and extending along the main microchannel or millichannel (3), and —one or several high-voltage electrode(s) (5) embedded fi in said dielectric material and extending along the main microchannel or millichannel (3), wherein the high-voltage electrode(s) (5) and the ground electrode(s) (4) are located on opposite sides of the main microchannel or millichannel (3) so as to be able to generate an electric field inside the main microchannel or millichannel (3). The present invention relates also to a method for generating a plasma in a continuous manner using such a microfluidic or millifluidic device (1).

公开(公告)号：US20180172974A1

公开(公告)日：2018-06-21

申请号：US15897335

申请日：2018-02-15

申请人： Paris Sciences Et Lettres - Quartier Latin ,  Centre National de la Recherche Scientifique (CNRS) ,  Universite Pierre Et Marie Curie (Paris 6) ,  Universite Paris Diderot Paris 7

发明人： Vincent Croquette ,  Jean-François Allemand ,  Thibault Vielle

IPC分类号： G02B21/36 ,  H04N5/225 ,  G02B21/24 ,  G02B21/18 ,  G02B21/10 ,  G02B21/08 ,  G06T7/70 ,  G02B21/00 ,  G02B5/04 ,  G02B5/00 ,  G01B11/00 ,  C12Q1/6816 ,  G02B21/02

CPC分类号： G02B21/365 ,  C12Q1/6816 ,  G01B11/002 ,  G02B5/005 ,  G02B5/04 ,  G02B21/0032 ,  G02B21/0052 ,  G02B21/02 ,  G02B21/086 ,  G02B21/10 ,  G02B21/18 ,  G02B21/241 ,  G02B21/361 ,  G06T7/70 ,  H04N5/2256

摘要： The invention relates to an optical device for measuring the position of an object along a first axis, the object being subjected to light radiations emitted by a light source. The optical device comprises: an imaging system comprising an objective for collecting light radiations diffused by the object, the imaging system having an optical axis extending parallel to the first axis; a transmission mask having at least a first aperture and a second aperture, the first aperture and second aperture being spaced from each other along a second axis, perpendicular to the first axis, the transmission mask being arranged so as to let a first part of the radiations and a second part of the radiations which are diffused by the object pass through the first aperture and the second aperture respectively, while blocking a part of the radiations emitted by the light source which is not diffused by the object; and a detector adapted for generating an image including a first spot and a second spot representative of the first part and second part of the radiations impacting the detector plane, wherein variation of the position of the object relative to the object plane of the imaging system along the first axis causes variation of a position of the first spot and of the second spot relative to each other along the second axis.

公开(公告)号：US20160376441A1

公开(公告)日：2016-12-29

申请号：US15039681

申请日：2014-11-27

申请人： PARIS SCIENCES ET LETTRES - QUARTIER LATIN

发明人： Jean-Maurice MALLET ,  Mayeul COLLOT

IPC分类号： C09B11/24 ,  G01N33/84 ,  C07D491/22

CPC分类号： C07D491/22 ,  C09B11/24 ,  G01N31/22 ,  G01N33/84

摘要： Compounds of formula I and a process for manufacturing the compounds. A method of using the compounds for the detection of calcium ions and a method of detecting intracellular calcium are also described.

摘要翻译： 和该化合物的制造方法。 还描述了使用该化合物检测钙离子的方法和检测细胞内钙的方法。

公开(公告)号：US20210345873A1

公开(公告)日：2021-11-11

申请号：US17280646

申请日：2019-09-27

申请人： PARIS SCIENCES ET LETTRES - QUARTIER LATIN ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS

发明人： Viacheslav Mazlin ,  Peng Xiao ,  Mathias Fink ,  Albert Claude Boccara

IPC分类号： A61B3/10 ,  A61B3/13

摘要： According to one aspect, the invention relates to a system (101) for in vivo, full-field interference microscopy imaging of a scattering three-dimensional sample. It comprises a full-field OCT imaging system (130) for providing en face images of the sample, wherein said full-field OCT system comprises an interference device (145) with an object arm (147) intended to receive the sample and a reference arm (146) comprising an optical lens (134) and a first reflection surface (133), and an acquisition device (138) configured to acquire a temporal succession of two-dimensional interferometric signals (I1, I2) resulting from interferences produced at each point of an imaging field; an OCT imaging system (110) for providing at the same times of acquisition of said two-dimensional interferometric signals, cross-sectional images of both the sample and a first reflection surface (133) of said full-field OCT imaging system (130); a processing unit (160) configured to determine a plurality of en face images (X-Y) of a plurality of slices of the sample, each en face image being determined from at least two two-dimensional interferometric signals (I1, I2) having a given phase shift; determine from the cross-sectional images provided by the OCT imaging system (110) at the times of acquisition of each of said two two-dimensional interferometric signals (I1, I2) a depth (z) for each en face image (X-Y) of said plurality of slices; determine a 3D image of the sample from said plurality of en face images of said plurality of slices of the sample and depths.

公开(公告)号：US11040083B2

公开(公告)日：2021-06-22

申请号：US15764621

申请日：2016-09-29

申请人： PARIS SCIENCES ET LETTRES—QUARTIER LATIN ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)

发明人： Guy Tran Van Nhieu ,  Cesar Valencia-Gallardo ,  Nicole Quenech'Du

IPC分类号： C07K14/25 ,  C07K4/04 ,  A61K38/06 ,  A61P35/04 ,  A61K48/00

摘要： Disclosed are polypeptides including at least one vinculin binding sites, to nucleic acid sequences encoding thereof and to their use for treating a proliferation and/or adhesion related disease.

公开(公告)号：US20210178384A1

公开(公告)日：2021-06-17

申请号：US17186954

申请日：2021-02-26

申请人： Paris Sciences Et Lettres - Quartier Latin ,  Centre National de la Recherche Scientifique (CNRS) ,  Universite Paris Diderot Paris 7 ,  Sorbonne Universite

发明人： Vincent Croquette ,  David Bensimon ,  Jimmy Ouellet ,  Jean-François Allemand ,  Charles Andre ,  Gordon Hamilton

IPC分类号： B01L3/00 ,  C12Q1/6825 ,  G01N27/327

摘要： The invention proposes a device for analyzing nucleic acid molecules (M), comprising: —a bead (20), on which one molecule can be anchored at one end, —a surface (520), on which the molecule can be anchored at the other end, —an actuator (30), adapted to cause the bead to move relative to said surface in one direction, —a sensor (50), adapted to measure a distance between the bead and the surface, the device further comprising a well (11), having an axis (X-X) extending along the direction of motion of the bead and a bottom (110) formed by said surface, said well being filled with electrically conductive solution (40), and receiving the bead, the sensor being adapted to measure an impedance of the well, depending on a distance between the bead and the surface, to determine, the distance between the bead and the surface.

公开(公告)号：US20210153485A1

公开(公告)日：2021-05-27

申请号：US16625999

申请日：2018-06-29

申请人： PARIS SCIENCES ET LETTRES - QUARTIER LATIN ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)

发明人： Piotr TOPILKO ,  Patrick CHARNAY ,  Fanny COULPIER ,  Aurélie GRESSET ,  Katarzyna RADOMSKA

IPC分类号： A01K67/027 ,  C12N5/09 ,  G01N33/50 ,  A61K49/00

摘要： A transgenic non-human animal model for Neurofibromatosis type 1, wherein the Nf1 gene is specifically inactivated in BC cells and derivatives thereof. Also, an in vitro method of producing cutaneous and plexiform Neurofibromas (NFBs) and/or for studying the development and composition of plexiform NFBs, including culturing in vitro Prss56-expressing cells and-derivatives thereof obtained from the transgenic non-human animal model. Further, a method for screening a candidate compound for use as a drug to treat Neurofibromatosis type 1, cutaneous NFBs and/or plexiform NFBs including contacting the candidate compound Prss56-expressing cells and-derivatives thereof obtained from the transgenic non-human animal model or administering the candidate compound to the transgenic non-human animal model.