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2159 条记录 (耗时 0.042 秒)

    METHODS AND SYSTEMS FOR PHYSICAL EXPANSION AND IMAGING OF BIOLOGICAL SAMPLES
    61.
    发明申请
    METHODS AND SYSTEMS FOR PHYSICAL EXPANSION AND IMAGING OF BIOLOGICAL SAMPLES 有权

    公开(公告)号：US20230132184A1

    公开(公告)日：2023-04-27

    申请号：US17905864

    申请日：2021-03-12

    申请人： Yale University

    发明人： Ons M'Saad

    IPC分类号： G01N33/483 ,  G01N1/04 ,  G01N21/17

    摘要： Methods and systems for physical expansion and imaging of biological samples are described herein. In one aspect of the disclosure, a method for preparing a biological sample for the purpose of generating images of its ultrastructure with an imaging instrument includes a) physically expanding the sample by at least a factor of two in at least one dimension; and b) bulk labeling a plurality of components of the sample with at least one reagent to introduce contrast.

    COMPOSITIONS AND METHODS FOR DELIVERY OF NUCLEIC ACIDS TO CELLS
    62.
    发明申请
    COMPOSITIONS AND METHODS FOR DELIVERY OF NUCLEIC ACIDS TO CELLS 有权

    公开(公告)号：US20230093888A1

    公开(公告)日：2023-03-30

    申请号：US17823494

    申请日：2022-08-30

    申请人： Yale University

    发明人： Elias QUIJANO ,  Peter GLAZER

    IPC分类号： C07K16/44 ,  C07K14/52 ,  C07K14/47

    摘要： Compositions and methods of use thereof for delivering nucleic acid cargo into cells are provided. The compositions typically include (a) a 3E10 monoclonal antibody or an antigen binding, cell-penetrating fragment thereof; a monovalent, divalent, or multivalent single chain variable fragment (scFv); or a diabody; or humanized form or variant thereof, and (b) a nucleic acid cargo including, for example, a nucleic acid encoding a polypeptide, a functional nucleic acid, a nucleic acid encoding a functional nucleic acid, or a combination thereof. Elements (a) and (b) are typically non-covalently linked to form a complex.

    System and Method for Heart Pump Interrogation and Inspection
    63.
    发明申请
    System and Method for Heart Pump Interrogation and Inspection 有权

    公开(公告)号：US20230078176A1

    公开(公告)日：2023-03-16

    申请号：US18051190

    申请日：2022-10-31

    申请人： YALE UNIVERSITY

    发明人： Pramod Bonde

    IPC分类号： A61M25/10 ,  A61M60/232 ,  A61M60/237 ,  A61M60/538 ,  A61M60/178

    摘要： The present invention relates to systems and methods for in situ inspection, interrogation, and maintenance of heart pump function in subjects with an implanted heart pump. In certain embodiments, the system comprises a catheter assembly deliverable to the inflow port and outflow port of the implanted heart pump. The system comprises additional components used to examine pump function and prevent malfunction. In certain embodiments, the invention allows for temporary, mid-term, or permanent exclusion of the implanted heart pump from cardiac function without surgically removing the pump.

    COMPOSITIONS AND METHODS OF USING TYROSINE KINASE INHIBITORS
    67.
    发明申请
    COMPOSITIONS AND METHODS OF USING TYROSINE KINASE INHIBITORS 有权

    公开(公告)号：US20230036788A1

    公开(公告)日：2023-02-02

    申请号：US17823439

    申请日：2022-08-30

    申请人： YALE UNIVERSITY

    发明人： Anton BENNETT ,  Jae-Sung YI

    IPC分类号： A61K31/506 ,  A61P9/00

    摘要： The present invention provides compositions and methods of inhibiting tyrosine phosphorylation. In one aspect, a composition comprising a low-dosage tyrosine kinase inhibitor, where the low-dosage tyrosine kinase inhibitor decreases tyrosine phosphorylation, is provided. In another aspect, a method for treating cardiovascular disease or condition associated with a RASopathy having aberrant protein tyrosine phosphorylation is described. Methods for treating congenital heart disease associated with Noonan or Noonan syndrome with multiple lentigines and decreasing aberrant levels of Protein Zero-Related (PZR) tyrosyl phosphorylation are also described.

    TREATMENT FOR CHEMOBRAIN
    69.
    发明申请
    TREATMENT FOR CHEMOBRAIN 有权

    公开(公告)号：US20230031009A1

    公开(公告)日：2023-02-02

    申请号：US17801486

    申请日：2021-02-11

    申请人： YALE UNIVERSITY

    发明人： Barbara Ehrlich ,  Lien Nguyen

    IPC分类号： A61K31/4741 ,  A61K31/337 ,  A61K31/437 ,  A61K31/675 ,  A61K31/704 ,  A61P25/28 ,  A61K33/14

    摘要： The present invention is directed to a method of treatment, including prevention or reducing the likelihood of adverse effects of chemotherapy comprising reducing and/or inhibiting chemotherapy-induced adverse effects (CIAE), especially central nervous system adverse effects, such as cognitive effects (especially chemotherapy induced cognitive impairment or CICI, also referred to as reduced cognition, cognitive impairment or chemobrain) by administering to the patient in need, including co-administering to the subject in need a pharmaceutically effective amount of a protein kinase C (PKC, often, PKC α and/or β) inhibitor, alone or in combination with a lithium salt. Related pharmaceutical compositions are also provided by the present invention.