公开(公告)号：US06723535B2

公开(公告)日：2004-04-20

申请号：US09906700

申请日：2001-07-16

申请人： Avi Ashkenazi ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Jennie P. Mather ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

发明人： Avi Ashkenazi ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Jennie P. Mather ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

IPC分类号： C12N1512

CPC分类号： C07K16/18

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US06686451B1

公开(公告)日：2004-02-03

申请号：US09902775

申请日：2001-07-10

申请人： Luc Desnoyers ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Jennie P. Mather ,  P. Mickey Williams ,  William I. Wood

发明人： Luc Desnoyers ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Jennie P. Mather ,  P. Mickey Williams ,  William I. Wood

IPC分类号： C07K1600

CPC分类号： C07K14/47 ,  C07K14/705 ,  C07K2319/00

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US06664376B2

公开(公告)日：2003-12-16

申请号：US09905125

申请日：2001-07-12

申请人： Avi Ashkenazi ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Jennie P. Mather ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

发明人： Avi Ashkenazi ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Jennie P. Mather ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

IPC分类号： C07K14435

CPC分类号： C07K14/47 ,  C07K14/705 ,  C07K2319/00

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US06232117B1

公开(公告)日：2001-05-15

申请号：US08843434

申请日：1997-04-15

申请人： Jennie P. Mather

发明人： Jennie P. Mather

IPC分类号： C12N1572

CPC分类号： C07K14/59 ,  C07K14/79

摘要： A method for culturing a recombinant host cell comprising: determining a polypeptide factor for a polypeptide factor-dependent host cell; transforming said host cell with nucleic acid encoding said polypeptide factor; transforming the host cell with nucleic acid encoding a desired protein; and, culturing the transformed host cells in a medium lacking the polypeptide factor.

公开(公告)号：US5830685A

公开(公告)日：1998-11-03

申请号：US910260

申请日：1992-07-16

申请人： Jennie P. Mather ,  Penelope E. Roberts

发明人： Jennie P. Mather ,  Penelope E. Roberts

IPC分类号： C07K14/475 ,  C07K14/785 ,  C12N5/071 ,  C12N15/85 ,  C12N15/63 ,  C07K1/00 ,  C12N5/06 ,  C12P21/00

CPC分类号： C12N5/0688 ,  C07K14/475 ,  C07K14/785 ,  C12N15/85 ,  C12N2500/25 ,  C12N2500/84 ,  C12N2501/01 ,  C12N2501/11 ,  C12N2501/385 ,  C12N2501/39 ,  C12N2501/392 ,  C12N2501/395 ,  C12N2503/02

摘要： A novel bronchial or bronchiolar epithelial cell from normal neonatal mammalian lung has been isolated, established and maintained for multiple passages in the absence of serum, without undergoing crisis or senescence. By careful manipulation of the nutritional/hormonal microenvironment we have been able to select, from a heterogeneous population, a single epithelial cell type which can maintain highly differentiated features in vitro. This cell type has characteristics of bronchiolar epithelial cells. A clonal line, RL-65, has been selected and observed for more than 3 years in continuous culture. It has been characterized by ultrastructural, morphological and biochemical criteria.

摘要翻译： PCT No.PCT / US91 / 00878 Sec。 371日期：1992年7月16日 102（e）日期1992年7月16日PCT 1991年2月8日PCT公布。 公开号WO91 / 12317 日期1991年8月22日已经分离了来自正常新生儿哺乳动物肺的新型支气管或细支气管上皮细胞，在不存在血清的情况下建立并维持多次传代，而不经历危机或衰老。 通过仔细操纵营养/激素微环境，我们已经能够从异质群体中选择能在体外保持高度分化特征的单一上皮细胞类型。 该细胞类型具有细支气管上皮细胞的特征。 克隆系RL-65在连续培养中被选择并观察3年以上。 其特征在于超微结构，形态和生化标准。

公开(公告)号：US5166190A

公开(公告)日：1992-11-24

申请号：US461714

申请日：1990-01-08

申请人： Jennie P. Mather ,  Kenneth M. Attie

发明人： Jennie P. Mather ,  Kenneth M. Attie

IPC分类号： A61K38/04 ,  A61K38/22 ,  A61P13/02 ,  A61P15/00

CPC分类号： A61K38/22

摘要： A method is provided for increasing fertility in a male mammal exhibiting germinal epithelium failure comprising administering to the mammal an effective amount of activin. Preferably, the administration is to the testis of the mammal.

摘要翻译： 提供一种用于增加表现生发上皮细胞衰竭的雄性哺乳动物的生殖力的方法，包括向哺乳动物施用有效量的激活素。 优选地，给药是哺乳动物的睾丸。

公开(公告)号：US5102868A

公开(公告)日：1992-04-07

申请号：US461705

申请日：1990-01-08

申请人： Teresa K. Woodruff ,  Jennie P. Mather

发明人： Teresa K. Woodruff ,  Jennie P. Mather

IPC分类号： A61K38/04 ,  A61K38/22 ,  A61P13/02 ,  A61P15/00

CPC分类号： A61K38/22

摘要： A method is provided for inhibiting the maturation of follicles in the ovary of a femal mammal comprising administering to the ovary of the mammal an effective amount of activin. This method is particularly effective in treating polycystic ovarian disease.

摘要翻译： 提供了一种用于抑制雌性哺乳动物卵巢中卵泡成熟的方法，包括向哺乳动物的卵巢施用有效量的激活素。 这种方法在治疗多囊卵巢疾病方面特别有效。