-
公开(公告)号：US20210330597A1
公开(公告)日：2021-10-28
申请号：US17240405
申请日：2021-04-26
发明人： Xiaoyang Xu , Zhongyu Li , William Ho
摘要： One aspect of the disclosure describes a lipid conjugated cationic molecule. Other aspects of the disclosure describes nanoparticle delivery systems and methods of making the systems are disclosed. An embodiment of the nanoparticle delivery system has sustained gene delivery properties, the nanoparticle delivery system can be synthesized using biodegradable and biocompatible polymers via self-assembly. The nanoparticle delivery system comprises a plurality of nanoparticle depots, each of which has a particle-in-particle structure, and is composed of a polymeric nanoparticle, which encapsulates cationic molecule/nucleic acid complexes, facilitating enhanced retention and prolonged release of the gene payload. The polymeric nanoparticle comprises a shell, and a nanocomplex of the cationic molecule and a polynucleotide, the nanocomplexes are distributed within the shell and/or embedded in the shell. Another embodiment of the nanoparticle delivery system has one or more nanocomplexes. The one or more nanocomplexes includes a lipid conjugated cationic molecule and a polynucleotide.
-
62.发明申请公开(公告)号：US20210275013A1
公开(公告)日：2021-09-09
申请号：US17253300
申请日：2019-06-18
摘要： Exemplary embodiments of the present disclosure relate to systems, methods, and apparatus to objectively assess binocular dysfunction for screening, diagnoses, and evaluation of vision/oculomotor function before, during, and after various forms of therapeutic interventions. Systems and methods of the present disclosure diagnose and assess binocular dysfunction objectively and automatically, can render a visual stimulus on one or more displays, and can control accommodative and proximal vergence stimulation of a user's eyes.
-
63.发明授权公开(公告)号：US10918602B2
公开(公告)日：2021-02-16
申请号：US16150931
申请日：2018-10-03
IPC分类号： A61K9/16 , A61K9/70 , A61K45/06 , A61K47/10 , A61K47/20 , A61K31/343 , A61K9/00 , A61K31/216 , A61K47/38 , A61K9/50
摘要： The present disclosure provides improved film based pharmaceutical products containing uniformly distributed drug or active agent particles (e.g., to achieve improved/excellent dissolution control including enhancing dissolution and bioavailability and/or product uniformity). More particularly, the present disclosure provides improved systems/methods for fabricating film based pharmaceutical products by utilizing higher surface modified micronized drug or active agent powders and film forming precursors and drying methods that accomplish improved/efficient drying and provide improved/excellent content uniformity of active pharmaceutical agents in the fabricated film based pharmaceutical products. In exemplary embodiments, the present disclosure provides for an easier means of directly incorporating dry micronized poorly water-soluble drugs or active agent particles (e.g., fenofibrate (“FNB”)) into films. The present disclosure demonstrates some advantages of direct incorporation of surface modified-micronized poorly water-soluble drug or active agent powders in film manufacturing.
-
公开(公告)号：US20200182864A1
公开(公告)日：2020-06-11
申请号：US16471419
申请日：2018-02-15
发明人： Eon Soo Lee , Bharath Babu Nunna
IPC分类号： G01N33/543 , B01L3/00 , G01N27/02
摘要： An apparatus and method to detect disease-specific antigens assists in disease diagnosis. Point-of-care (POC) micro biochip incorporates at least one hydrophilic microchannel for controlled and self-driven flow of body fluid. Metallic nano-interdigitated electrodes disposed within the channels give enhanced sensitivity detection. Microchannel controls flow and amplifies a capillary effect. Electrodes are fabricated on microchannel surface to detect biomolecular interactions. When a sample flows through microchannel, disease-specific antigens from the sample form antigen-antibody complex with antibodies immobilized on electrodes. Antigen-antibody interaction is detected via an electrical change in the biochip's nano circuit. Each electrode may include a different antibody to detect different antigens. Capacitance during antigen-antibody interaction without microfluidic flow is higher than with microfluidic flow due to immobilized antibodies instability on sensing surface caused by shear stress. POC biochip provides nano level detection of many disease-specific antigens of any type based on micro volume or single drop sized sample.
-
65.发明授权公开(公告)号：US10603701B2
公开(公告)日：2020-03-31
申请号：US16241547
申请日：2019-01-07
发明人： Mengyan Li , Daiyong Deng
IPC分类号： B09C1/10 , B09C1/00 , C02F3/34 , B09C1/08 , C02F101/36 , C02F101/34 , C02F103/06
摘要： Methods of removing dioxane and optionally one or more CAHs such as 1,1-DCE, cis-1,2-DCE, trans-1,2-DCE, 1,2-DCA, 1,1-DCA, VC, and TCE from a liquid medium contaminated therewith include applying a feedstream of propane to the liquid medium in the presence of at least one propanotrophic bacteria strain selected from Azoarcus sp. DD4 (DD4) and Mycobacterium sp. DT1 (DT1). Propane, 1-propanol and/or 1-butanol may be employed as substrates in the bioaugmentation of the propanotrophic bacteria strain.
-
公开(公告)号：US20200087621A1
公开(公告)日：2020-03-19
申请号：US16573206
申请日：2019-09-17
IPC分类号： C12N5/079
摘要： Sodium cellulose sulfate (NaCS) is employed as a novel GAG mimetic. Schwann cells (SCs) could be used in combination with a scaffold because the SCs can secrete neurotrophic factors stimulating neuron survival and extension of axons. Furthermore, the conduit may be used alone or combination with Schwann cells for spinal cord repair. In addition, the conduit also can be used for peripheral nerve repair. Also described herein are compositions and methods useful for promoting the growth and/or differentiation and/or repair of a cell and/or tissue in the peripheral nervous system, central nervous system, and specifically the spinal cord. In certain aspects, the present disclosure includes a scaffold supporting and promoting growth, differentiation, and/or regeneration and repair. The scaffold in one embodiment closely mimics the natural extracellular matrix (ECM) of the spinal cord.
-
公开(公告)号：US20200047399A1
公开(公告)日：2020-02-13
申请号：US16533216
申请日：2019-08-06
发明人： Murat Guvendiren , Shen Ji
IPC分类号： B29C64/106 , B29C64/40 , A61L27/52 , A61L27/50
摘要： A method is disclosed for 3D printing of soft polymeric material such as a hydrogel or elastomer for scaffolds or devices with embedded channels with tunable shape and size such as a channel inner diameter). The method utilizes extrusion based printing of polymer solutions usually referred as direct ink writing (DIW) or BioPlotting, and requires sequential printing of a photocurable polymer solution, herein, referred as the matrix material, and a sacrificial polymer solution that may dissolve in an aqueous media.
-
公开(公告)号：US20200000875A1
公开(公告)日：2020-01-02
申请号：US16438872
申请日：2019-06-12
摘要： A set of cationic amphiphilic self-assembled peptides (CASPs) is presented that employ high-charge density at fiber edges to disrupt bacterial membranes. CASP nanofibers are effective against Pseudomonas biofilms. There is an inherent trade-off between the ability of the peptides to undergo nanofibrous self-assembly and having a high terminal charge density required for effective bactericidal efficacy. The self-assembled peptide hydrogel presented achieves a balance of these opposing factors. Also demonstrated is the applicability of the new composition in an injectable hydrogel formulation. A CASP platform may be useful for topical application and integration into medical coatings, grafts, devices, and prostheses, thereby reducing risk of bacterial infection and related failure.
-
公开(公告)号：US20190201892A1
公开(公告)日：2019-07-04
申请号：US16312091
申请日：2017-06-21
发明人： Eon Soo Lee , Bharath Babu Nunna , K. Stephen Suh
IPC分类号： B01L3/00 , G01N33/543 , G01N21/00
CPC分类号： B01L3/502707 , B01L2300/0645 , B01L2300/0816 , B01L2300/0883 , B01L2300/0887 , G01N21/00 , G01N33/54366
摘要： Improved diagnostic assemblies are provided. More particularly, the present disclosure provides improved and highly advantageous chip based diagnostic assemblies configured to detect human diseases (e.g., cancer) and/or pathogens, and related methods of use. In exemplary embodiments, the present disclosure provides for consumable micro- or nano-fluidic chip based diagnostic assemblies having visual biosensors, with the diagnostic assemblies using continuous flow-based micro- or nano-fluidic channels and antibody-based immuno-complex designs. In certain embodiments, the diagnostic assembly includes a self-sustainable and operable chip (e.g., thumb-sized chip) that is configured to be deployed as a single use consumable with a direct all-or-none readout as an output to satisfy a point of screening method to screen a population.
-
公开(公告)号：US20190083945A1
公开(公告)日：2019-03-21
申请号：US16135716
申请日：2018-09-19
IPC分类号： B01F3/04
摘要： Systems, devices, and methods for manufacturing nanobubbles are disclosed herein. In an embodiment, a nanobubble generator system includes a medium, wherein in the medium is a liquid medium or a semi-liquid medium. A device is immersed in the medium. The device includes a ceramic membrane having a first surface and an opposing second surface, and pores extending through the membrane from the first surface to the second surface, and a hydrophobic porous coating layer disposed on the first surface of the membrane. The system includes a gas source for providing a gas to the medium. In operation, the gas enters pores on the second surface of the membrane and exits the coating layer in the form of nanobubbles.
-
-
-
-
-
-
-
-
-
搜索结果
261 条记录 (耗时 0.026 秒)
