公开(公告)号：US09385895B2

公开(公告)日：2016-07-05

申请号：US12016629

申请日：2008-01-18

Applicant: Carlo Luschi ,  Simon Walker ,  Steve Allpress ,  Philip Jones

Inventor： Carlo Luschi ,  Simon Walker ,  Steve Allpress ,  Philip Jones

IPC: H04L25/03 ,  H04L25/02

CPC classification number: H04L25/03114 ,  H04L25/0212 ,  H04L25/0222 ,  H04L2025/03566 ,  H04L2025/03726

Abstract: Techniques are described for optimizing the processing facilities of a receiver in a wireless communication environment, taking into account processing performance set against the computing resources and/or power consumption required to obtain that processing performance. A radio receiver for a wireless communications system can include channel equalization means arranged to receive samples of an incoming signal and to generate an equalized output, said channel equalization means including means for processing said digital samples in accordance with an equalizer algorithm. The receiver includes means for estimating parameters of a channel over which the incoming signal has been transmitted. The receiver can also include means for selecting from a plurality of equalizer algorithms an equalizer algorithm for execution by the processing means based on at least one said estimated channel parameter. Related methods and algorithms are described. Related computer program products are also described.

Abstract translation: 描述了在无线通信环境中优化接收机的处理设施的技术，考虑到针对计算资源设置的处理性能和/或获得该处理性能所需的功耗。 用于无线通信系统的无线电接收机可以包括被设置为接收输入信号的采样并产生均衡输出的信道均衡装置，所述信道均衡装置包括用于根据均衡器算法处理所述数字样本的装置。 接收机包括用于估计传入信号已被发送的信道的参数的装置。 接收机还可以包括用于从多个均衡器算法中选择用于由处理装置基于至少一个所述估计的信道参数执行的均衡器算法的装置。 描述相关的方法和算法。 还描述了相关的计算机程序产品。

公开(公告)号：US08937077B2

公开(公告)日：2015-01-20

申请号：US13880767

申请日：2011-10-17

Applicant: David Joseph Guerin ,  Jason D. Brubaker ,  Michelle Martinez ,  Joon O. Jung ,  Neville J. Anthony ,  Mark E. Scott ,  Carolyn Michele Cammarano ,  Dawn Marie Mampreian Hoffman ,  Hyun Chong Woo ,  Christopher J. Dinsmore ,  Philip Jones

Inventor： David Joseph Guerin ,  Jason D. Brubaker ,  Michelle Martinez ,  Joon O. Jung ,  Neville J. Anthony ,  Mark E. Scott ,  Carolyn Michele Cammarano ,  Dawn Marie Mampreian Hoffman ,  Hyun Chong Woo ,  Christopher J. Dinsmore ,  Philip Jones

IPC: A01N43/90 ,  A61K31/519 ,  C07D487/00 ,  C07D471/04 ,  C07D519/00

CPC classification number: C07D471/04 ,  A61K31/519 ,  C07D519/00

Abstract: The instant invention provides compounds of formula I which are Jak inhibitors, and as such are useful for the treatment of Jak-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Abstract translation: 本发明提供了作为Jak抑制剂的式I化合物，因此可用于治疗Jak介导的疾病如类风湿性关节炎，哮喘，COPD和癌症。

公开(公告)号：US08856802B2

公开(公告)日：2014-10-07

申请号：US13462820

申请日：2012-05-03

Applicant: Michael R. Croft ,  Philip Jones ,  Adam R. Rice ,  Matthew D. Whitbourne

Inventor： Michael R. Croft ,  Philip Jones ,  Adam R. Rice ,  Matthew D. Whitbourne

IPC: G06F9/46 ,  G06F9/48

CPC classification number: G06F8/4451 ,  G06F9/4451 ,  G06F9/485 ,  G06F2209/482

Abstract: Operating a data processing system comprises defining a plurality of profiles, each profile comprising a list of one or more applications; receiving a defined user input requesting a switch from a first profile to a second profile; hibernating the (or each) application listed in the first profile; and recalling from hibernation the (or each) application listed in the second profile. Preferably, a graphical user interface is adjusted to reflect a change in status of each application that has been hibernated or recalled from hibernation.

公开(公告)号：US20130225577A1

公开(公告)日：2013-08-29

申请号：US13880767

申请日：2011-10-17

Applicant: David Joseph Guerin ,  Jason D. Brubaker ,  Michelle Martinez ,  Joon O. Jung ,  Neville J. Anthony ,  Mark E. Scott ,  Carolyn Michele Cammarano ,  Dawn Marie Mampreian Hoffman ,  Hyun Chong Woo ,  Christopher J. Dinsmore ,  Philip Jones

Inventor： David Joseph Guerin ,  Jason D. Brubaker ,  Michelle Martinez ,  Joon O. Jung ,  Neville J. Anthony ,  Mark E. Scott ,  Carolyn Michele Cammarano ,  Dawn Marie Mampreian Hoffman ,  Hyun Chong Woo ,  Christopher J. Dinsmore ,  Philip Jones

IPC: C07D471/04

CPC classification number: C07D471/04 ,  A61K31/519 ,  C07D519/00

Abstract: The instant invention provides compounds of formula I which are Jak inhibitors, and as such are useful for the treatment of Jak-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Abstract translation: 本发明提供了作为Jak抑制剂的式I化合物，因此可用于治疗Jak介导的疾病如类风湿性关节炎，哮喘，COPD和癌症。

公开(公告)号：US20130080452A1

公开(公告)日：2013-03-28

申请号：US13243298

申请日：2011-09-23

Applicant: John Hosie ,  Philip Jones ,  Gregory Lubel ,  Anthony H. Phillips ,  Brian Stewart ,  Dominic J. Storey

Inventor： John Hosie ,  Philip Jones ,  Gregory Lubel ,  Anthony H. Phillips ,  Brian Stewart ,  Dominic J. Storey

IPC: G06F17/30

CPC classification number: G06F17/30345 ,  G06F17/30289 ,  G06F17/3041 ,  G06F17/30424 ,  G06F17/30557

Abstract: At least one message flow file that stores a message flow is read by a processor. The message flow stored within the at least one message flow file is parsed. The message flow is organized within a memory as a message flow database structure. Entries within the message flow database structure represent nodes, connections, and properties used by the message flow. The message flow database structure is edited in response to receipt of a structured query language (SQL) statement that specifies a change to the message flow database structure.

Abstract translation: 存储消息流的至少一个消息流文件由处理器读取。 存储在至少一个消息流文件中的消息流被解析。 消息流作为消息流数据库结构组织在内存中。 消息流数据库结构中的条目表示消息流使用的节点，连接和属性。 响应于接收到指定消息流数据库结构的改变的结构化查询语言（SQL）语句来编辑消息流数据库结构。

公开(公告)号：US20120297386A1

公开(公告)日：2012-11-22

申请号：US13420524

申请日：2012-03-14

Applicant: Michael R. Croft ,  Philip Jones ,  Adam R. Rice ,  Matthew Whitbourne

Inventor： Michael R. Croft ,  Philip Jones ,  Adam R. Rice ,  Matthew Whitbourne

IPC: G06F9/46

CPC classification number: G06F8/4451 ,  G06F9/4451 ,  G06F9/485 ,  G06F2209/482

Abstract: Operating a data processing system comprises defining a plurality of profiles, each profile comprising a list of one or more applications; receiving a defined user input requesting a switch from a first profile to a second profile; hibernating the (or each) application listed in the first profile; and recalling from hibernation the (or each) application listed in the second profile. Preferably, a graphical user interface is adjusted to reflect a change in status of each application that has been hibernated or recalled from hibernation.

Abstract translation: 操作数据处理系统包括定义多个简档，每个简档包括一个或多个应用的​​列表; 接收将切换从第一简档请求到第二简档的定义的用户输入; 休眠第一个配置文件中列出的（或每个）应用程序; 并从休眠状态回忆第二个配置文件中列出的（或每个）应用程序。 优选地，调整图形用户界面以反映已经从休眠状态休眠或召回的每个应用程序的状态的变化。

公开(公告)号：US20110201657A1

公开(公告)日：2011-08-18

申请号：US13091427

申请日：2011-04-21

Applicant: Julia Boueres ,  Danila Branca ,  Federica Ferrigno ,  Philip Jones ,  Ester Muraglia ,  Jesus Maria Ontoria Ontoria ,  Federica Orvieto ,  Rita Scarpelli ,  Carsten Schultz-Fademrecht

Inventor： Julia Boueres ,  Danila Branca ,  Federica Ferrigno ,  Philip Jones ,  Ester Muraglia ,  Jesus Maria Ontoria Ontoria ,  Federica Orvieto ,  Rita Scarpelli ,  Carsten Schultz-Fademrecht

IPC: A61K31/4192 ,  C07D249/20 ,  A61P9/10 ,  A61P35/00 ,  A61P29/00 ,  A61P3/10 ,  A61P25/28 ,  A61P17/00 ,  A61P27/02 ,  A61P31/14

CPC classification number: C07D231/56 ,  C07D249/20 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D409/12 ,  C07D413/10 ,  C07D417/12 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10 ,  C07D491/08 ,  C07D491/10

Abstract: The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly (ADP-ribose) polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes, neurodegenerative diseases, retroviral infection, retinal damage or skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.

Abstract translation: 本发明涉及作为聚（ADP-核糖）聚合酶（PARP）的抑制剂的式（I）化合物及其药学上可接受的盐或互变异构体，因此可用于治疗癌症，炎性疾病，再灌注损伤，缺血状况， 中风，肾衰竭，心血管疾病，心血管疾病以外的血管疾病，糖尿病，神经变性疾病，逆转录病毒感染，视网膜损伤或皮肤衰老以及紫外线诱发的皮肤损伤，以及用于癌症治疗的化学或放射增敏剂。

公开(公告)号：US20110183974A1

公开(公告)日：2011-07-28

申请号：US13056027

申请日：2009-07-27

Applicant: Gabriella Dessole ,  Philip Jones ,  Laura Llauger Bufi ,  Ester Muraglia ,  Jesus Maria Ontoria Ontoria ,  Caterina Torrisi

Inventor： Gabriella Dessole ,  Philip Jones ,  Laura Llauger Bufi ,  Ester Muraglia ,  Jesus Maria Ontoria Ontoria ,  Caterina Torrisi

IPC: A61K31/5355 ,  C07D413/14 ,  A61K31/4709 ,  A61P35/00 ,  A61K31/4545 ,  A61K31/454 ,  A61K31/496

CPC classification number: C07D413/14 ,  C07D417/14

Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts, stereoisomers or tautomers thereof which are inhibitors of the Sonic Hedgehog pathway, in particular Smo antagonists. Thus the compounds of this invention are useful for the treatment of diseases associated with abnormal hedgehog pathway activation, including cancer, for example basal cell carcinoma, medulloblastoma, prostate, pancreatic, breast, colon, bone and small cell lung cancers, and cancers of the upper GI tract.

Abstract translation: 本发明涉及式（I）的化合物及其药学上可接受的盐，立体异构体或互变异构体，其是Sonic Hedgehog途径的抑制剂，特别是Smo拮抗剂。 因此，本发明的化合物可用于治疗与异常hedgehog途径活化相关的疾病，包括癌症，例如基底细胞癌，成神经管细胞瘤，前列腺，胰腺癌，乳腺癌，结肠癌，骨细胞和小细胞肺癌，以及癌症 上胃肠道

公开(公告)号：US07863294B2

公开(公告)日：2011-01-04

申请号：US11792294

申请日：2005-12-09

Applicant: Barbara Attenni ,  Federica Ferrigno ,  Philip Jones ,  Raffaele Ingenito ,  Olaf Kinzel ,  Laura Llauger Bufi ,  Jesus Maria Ontoria ,  Giovanna Pescatore ,  Michael Rowley ,  Rita Scarpelli ,  Carsten Schultz

Inventor： Barbara Attenni ,  Federica Ferrigno ,  Philip Jones ,  Raffaele Ingenito ,  Olaf Kinzel ,  Laura Llauger Bufi ,  Jesus Maria Ontoria ,  Giovanna Pescatore ,  Michael Rowley ,  Rita Scarpelli ,  Carsten Schultz

IPC: A61K31/4709 ,  C07D215/227

CPC classification number: C07D405/12 ,  C07D231/10 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

Abstract: The present invention relates to compounds of formula I: or pharmaceutically acceptable salts or tautomers thereof, which are inhibitors of histone deacetylase (HDAC). The compounds of the present invention are useful for treating cellular proliferative diseases, including cancer. Further, the compounds of the present invention are useful for treating neurodegenerative diseases, schizophrenia and stroke among other diseases.

Abstract translation: 本发明涉及式I化合物或其药学上可接受的盐或互变异构体，其是组蛋白脱乙酰酶（HDAC）的抑制剂。 本发明的化合物可用于治疗包括癌症在内的细胞增殖性疾病。 此外，本发明的化合物可用于治疗神经变性疾病，精神分裂症和中风等疾病。

公开(公告)号：US20100234374A1

公开(公告)日：2010-09-16

申请号：US12086812

申请日：2006-12-21

Applicant: Philip Jones ,  Jesus Maria Ontoria Ontoria ,  Rita Scarpelli ,  Raffaele Ingenito ,  Carsten Schultz-Fademrecht

Inventor： Philip Jones ,  Jesus Maria Ontoria Ontoria ,  Rita Scarpelli ,  Raffaele Ingenito ,  Carsten Schultz-Fademrecht

IPC: A61K31/4164 ,  C07D233/64 ,  A61K31/4172 ,  C07D401/06 ,  A61K31/4439 ,  C07D403/06 ,  A61K31/496 ,  C07D401/12 ,  A61K31/4709 ,  A61K31/454 ,  C07D417/12 ,  A61K31/427 ,  C07D413/12 ,  A61K31/5377 ,  C07D403/12 ,  A61K31/4196 ,  A61P35/00 ,  A61P25/28 ,  A61P25/00 ,  A61P25/18 ,  A61P29/00 ,  A61P37/02 ,  A61P9/10 ,  A61P9/00 ,  A61P11/06 ,  A61P3/10

CPC classification number: C07D233/64 ,  C07D401/12

Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts and tautomers thereof. Compounds of the present invention are inhibitors of histone deacetylase (HDAC) and are useful for treating cellular proliferative diseases, including cancer. They are also useful for treating neurodegenerative diseases, mental retardation, schizophrenia, inflammatory diseases, restenosis, immune disorders, diabetes, cardiovascular disorders and asthma.

Abstract translation: 本发明涉及式（I）的化合物及其药学上可接受的盐和互变异构体。 本发明化合物是组蛋白脱乙酰酶（HDAC）的抑制剂，可用于治疗包括癌症在内的细胞增殖性疾病。 它们也可用于治疗神经变性疾病，精神发育迟滞，精神分裂症，炎性疾病，再狭窄，免疫疾病，糖尿病，心血管疾病和哮喘。