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    PRODRUGS OF CC-1065 ANALOGS
    63.
    发明申请
    PRODRUGS OF CC-1065 ANALOGS 审中-公开
    CC-1065模拟的产品

    公开(公告)号：US20110280890A1

    公开(公告)日：2011-11-17

    申请号：US13184255

    申请日：2011-07-15

    申请人： Robert ZHAO ,  Ravi V. J. CHARI

    发明人： Robert ZHAO ,  Ravi V. J. CHARI

    IPC分类号： A61K39/395 ,  C07K16/00 ,  A61P35/00 ,  C07D209/56

    CPC分类号： C07D401/14 ,  C07D209/60 ,  Y02P20/55

    摘要： The present invention provides prodrugs of analogs of the anti-tumor antibiotic CC-1065 having a cleavable protective group containing a sulfonic acid containing phenyl carbamate, in which the protecting group confers enhanced water solubility upon the prodrug, and in which the prodrug also has a moiety, such as a sulfide or a disulfide, that can conjugate to a cell binding reagent such as an antibody, and for the therapeutic use of such prodrug and conjugates, and for processes for preparing such prodrugs and conjugates.

    摘要翻译： 本发明提供抗肿瘤抗生素CC-1065类似物的前药，其具有含可含有磺酸的苯基氨基甲酸酯的可切割保护基，其中保护基赋予前药上的水溶性增强，其中前药还具有 可以与细胞结合试剂如抗体结合的部分，例如硫化物或二硫化物，以及用于治疗用途的这种前药和缀合物，以及用于制备这些前药和缀合物的方法。

    Prodrugs of CC-A1065 analogs
    64.
    发明授权
    Prodrugs of CC-A1065 analogs 失效
    CC-A1065类似物的前药

    公开(公告)号：US08012978B2

    公开(公告)日：2011-09-06

    申请号：US12204082

    申请日：2008-09-04

    申请人： Robert Zhao ,  Ravi V. J. Chari

    发明人： Robert Zhao ,  Ravi V. J. Chari

    IPC分类号： A61K31/497 ,  C07F9/02

    CPC分类号： C07D401/14 ,  C07D209/60 ,  Y02P20/55

    摘要： The present invention provides prodrugs of analogs of the anti-tumor antibiotic CC-1065 having a cleavable protective group containing a sulfonic acid containing phenyl carbamate, in which the protecting group confers enhanced water solubility upon the prodrug, and in which the prodrug also has a moiety, such as a sulfide or a disulfide, that can conjugate to a cell binding reagent such as an antibody, and for the therapeutic use of such prodrug and conjugates, and for processes for preparing such prodrugs and conjugates.

    摘要翻译： 本发明提供抗肿瘤抗生素CC-1065类似物的前药，其具有含可含有磺酸的苯基氨基甲酸酯的可切割保护基，其中保护基赋予前药上的水溶性增强，其中前药还具有 可以与细胞结合试剂如抗体结合的部分，例如硫化物或二硫化物，以及用于治疗用途的这种前药和缀合物，以及用于制备这些前药和缀合物的方法。

    CC-1065 analog synthesis
    67.
    发明授权
    CC-1065 analog synthesis 失效
    CC-1065模拟合成

    公开(公告)号：US07329760B2

    公开(公告)日：2008-02-12

    申请号：US10265452

    申请日：2002-10-07

    申请人： Robert Yongxin Zhao ,  Ravi V. J. Chari

    发明人： Robert Yongxin Zhao ,  Ravi V. J. Chari

    IPC分类号： C07D209/56 ,  C07D487/02

    CPC分类号： C07D209/60 ,  Y02P20/55

    摘要： Improved synthesis of seco(−)CBI (5-hydroxy-3-amino-1-[S]-(chloromethyl)-1,2-dihydro-3H-benz(e)indole): and improved syntheses therefrom of a wide variety of CC-1065 analogs that comprise a cyclopropabenzidole (CBI) alkylating moiety, and which are collectively DC1 and its derivatives, for the synthesis of cell-targeted therapeutic agents.

    摘要翻译： （ - ）CBI（5-羟基-3-氨基-1- [S] - （氯甲基）-1,2-二氢-3H-苯并（e）吲哚）的改进的合成： 的CC-1065类似物，其包含环丙烷苯偶姻（CBI）烷基化部分，并且它们共同为DC1及其衍生物，用于合成细胞靶向治疗剂。

    Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
    68.
    发明授权
    Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents 有权
    使用免疫缀合物和化学治疗剂治疗癌症的组合物和方法

    公开(公告)号：US07303749B1

    公开(公告)日：2007-12-04

    申请号：US09671995

    申请日：2000-09-29

    申请人： Ravi V. J. Chari

    发明人： Ravi V. J. Chari

    IPC分类号： A61K39/00

    CPC分类号： C07K16/2803 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6857 ,  A61K2039/505 ,  C07K16/3023 ,  C07K2317/24 ,  C07K2319/55

    摘要： The present invention is based on the discovery that the administration of at least one immunoconjugate and at least one chemotherapeutic agent provides an unexpectedly superior treatment for cancer. The present invention is directed to compositions comprising at least one immunoconjugate and at least one chemotherapeutic agent and to methods of treating cancer using at least one immunoconjugate and at least one chemotherapeutic agent. The present invention also provides methods of modulating the growth of selected cell populations, such as cancer cells, by administering a therapeutically effective amount of at least one chemotherapeutic agent and at least one immunoconjugate.

    摘要翻译： 本发明基于这样的发现，即至少一种免疫缀合物和至少一种化学治疗剂的施用提供了对于癌症的意想不到的优异治疗。 本发明涉及包含至少一种免疫缀合物和至少一种化学治疗剂的组合物以及使用至少一种免疫缀合物和至少一种化学治疗剂治疗癌症的方法。 本发明还提供了通过施用治疗有效量的至少一种化学治疗剂和至少一种免疫缀合物来调节所选细胞群体如癌细胞的生长的方法。