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公开(公告)号：US20220002296A1
公开(公告)日：2022-01-06
申请号：US17297397
申请日：2019-11-26
发明人： David J. AUGERI , Hatem SABAAWY , John A. GILLERAN
IPC分类号： C07D471/04 , A61P35/00
摘要： The invention provides compounds of formula (16) and (17); and salts thereof, as well as compositions comprising such compounds and salts, complexes comprising such compounds and salts, and methods for treating cancer, inhibiting BMI1 expression, or treating Huntington's disease using such compounds, salts, and complexes. The compounds, salts, and complexes have potency, permeability, and oral bioavailability that make them particularly useful, for example, for the treatment of glioblastoma.
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公开(公告)号：US20210398425A1
公开(公告)日：2021-12-23
申请号：US17465011
申请日：2021-09-02
发明人： Marco Gruteser , Suhas Mathur
摘要： Disclosed is a method and system that receives sensor information from each of a plurality of sensors. Each sensor in the plurality is associated with a vehicle. The sensor information includes location coordinates of each vehicle in the plurality. The sensor information associated with each vehicle in the plurality then is translated to parking statistics information. In one embodiment, the translation is based on an aggregate of sensor information corresponding to the plurality of vehicles. The system then communicates parking statistics information to the vehicle.
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公开(公告)号：US20210371606A1
公开(公告)日：2021-12-02
申请号：US17305499
申请日：2021-07-08
摘要： A method for forming a carbon fiber-reinforced polymer matrix composite by distributing carbon fibers or nanotubes into a molten polymer phase comprising one or more molten polymers; and applying a succession of shear strain events to the molten polymer phase so that the molten polymer phase breaks the carbon fibers successively with each event, producing reactive edges on the broken carbon fibers that react with and cross-link the one or more polymers. The composite shows improvements in mechanical properties, such as stiffness, strength and impact energy absorption.
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公开(公告)号：US11186549B2
公开(公告)日：2021-11-30
申请号：US16642817
申请日：2018-08-29
发明人： Joel S. Freundlich , David Alland , Matthew B. Neiditch , Pradeep Kumar , Glenn Capodagli , Divya Awasthi , Sean Ekins
IPC分类号： C07D231/56 , A61P31/06 , A61K31/4409
摘要： The invention provides compounds of formula (I): and salts thereof wherein R1-R5 have any of the meanings described in the specification. The compounds are useful for treating bacterial infections (e.g. tuberculosis).
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公开(公告)号：US20210349127A1
公开(公告)日：2021-11-11
申请号：US17313743
申请日：2021-05-06
发明人： Angela Coe , Guohong Li , Eva Y. Andrei
摘要： An apparatus, including: a scanning probe microscope head with a frame configured to fit within an insert of a cryostat, and a scanner, a probe and a sample holder all disposed within the frame; and a coarse motor assembly disposed within the frame and comprising: a positionable component; and coarse motors. The coarse motors are configured to move the positionable component relative to the frame along an X axis, a Y axis, and a Z axis. The apparatus further includes a universal electrical base connection with half of a plug/socket arrangement. The plug/socket arrangement is configured to provide electrical communication between the scanning probe microscope head and a base which has a second half of the plug/socket arrangement when the scanning probe microscope head is lowered onto the base.
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公开(公告)号：US20210346462A1
公开(公告)日：2021-11-11
申请号：US17282883
申请日：2019-10-03
摘要： Methods are provided for reducing type 2 cytokine-mediated inflammation, for example by reducing IL-5 and Il-13 activity, using native and variant neuromedin B (Nmb) peptides or coding sequences. Such methods can be used to treat an inflammatory disorder, such as asthma, COPD or an allergic reaction. Also provided are modified Nmb peptides.
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公开(公告)号：US20210339186A1
公开(公告)日：2021-11-04
申请号：US17274388
申请日：2019-09-13
摘要： The present disclosure relates to novel metal-organic frameworks (MOFs) comprising tetratopic ligands with small pore apertures. The present disclosure further relates to methods of utilizing the MOFs of the disclosure to separate hydrocarbons through adsorptive processes.
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公开(公告)号：US11147847B2
公开(公告)日：2021-10-19
申请号：US14683730
申请日：2015-04-10
发明人： Ilya Raskin , Carrie Waterman
IPC分类号： A61K36/185 , A23L33/125 , A23L33/105 , A23L33/00 , A61K8/97 , A61Q19/00 , A23K20/10 , A61K31/7034
摘要： The present application is directed to materials and methods for producing extracts from a plant of the Moringaceae family having high concentrations of moringa isothiocyanates.
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公开(公告)号：US20210310017A1
公开(公告)日：2021-10-07
申请号：US16636565
申请日：2018-08-03
摘要： Endophytic bacteria, compositions comprising the same, and methods of use thereof are disclosed which increase the root and shoot growth of cotton host plants, suppress growth of soil borne fungal pathogens of host plants, and increase resistance of the plant to salt stress and other abiotic stressors.
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公开(公告)号：US20210300910A1
公开(公告)日：2021-09-30
申请号：US17209850
申请日：2021-03-23
发明人： Alan S. Goldman , Thomas R. Dugan
IPC分类号： C07D413/10
摘要： The present disclosure provides compounds which are useful for a number of catalytic transformations of organic molecules, non-limiting examples including dehydrogenation of alkanes. The present disclosure further relates to methods of preparing the compounds of the present disclosure.
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