-
61.
公开(公告)号:US20210293643A1
公开(公告)日:2021-09-23
申请号:US17257715
申请日:2019-07-05
发明人: Nikolaus Correll , Radhen Patel , Jacob Segil , John Klingner , Richard F. Weir
摘要: Various embodiments of the present technology generally relate to robotics and prosthetics. More specifically, some embodiments of the present technology relate to multi-modal fingertip sensors with proximity, contact, and for localization capabilities. Various embodiments of the present technology provide for a novel multi-modal tactile sensor which comprises an infrared proximity sensor and a barometric pressure sensor embedded in an elastomer layer. Signals from both of these sensors can be fused to measure proximity (0-10 mm), contact (0N), force (0-50N) and localize impact at five spatial locations and three angles of incidence. Gaussian processes in a regression setting can be used to obtain calibrated force measurements with an R-squared value of 0.99. Supervised machine learning approaches can be used to localize the position and direction of probing with classification accuracies of 96% and 89% respectively.
-
公开(公告)号:US20210275659A1
公开(公告)日:2021-09-09
申请号:US17125422
申请日:2020-12-17
IPC分类号: A61K39/04 , A61K35/741
摘要: Methods of treating or preventing stress, anxiety, or postoperative cognitive dysfunction. Also provided are methods of improving resilience in a subject by administering a therapeutically effective amount of isolated Mycobacterium.
-
公开(公告)号:US20210272771A1
公开(公告)日:2021-09-02
申请号:US17186835
申请日:2021-02-26
发明人: Kieran Wilson , Miles Bengtson , Hanspeter Schaub , Dalton Turpen
IPC分类号: H01J37/305 , H01J37/065
摘要: Various embodiments of the present technology generally relate to devices and methods for generating and directing energetic electrons toward a target. More specifically, some embodiments relate to devices, systems, and methods for generating and directing energetic electrons based in the photoelectric effect and directing electric field-focused beams of the energetic electrons toward a target. Electron guns according to the present technology include one or more light sources to stimulate electron transmission, and a series of differentially charged stages to provide a hollow path allowing electrons generated by the photoelectric effect of the light irradiated on interior surfaces defining the path through the stages to travel to an exit of the electron gun. Each of the differentially charged stages have a different potential, thereby providing electrons having two or more different and tunable energy levels exiting as a beam from the electron gun.
-
公开(公告)号:US20210255356A1
公开(公告)日:2021-08-19
申请号:US16003201
申请日:2018-06-08
发明人: Tam Vu , Richard Han , Phuc Nguyen , Hoang Truong , Mahesh Kumar Ravindranathan
摘要: One aspect of the invention provides a device for passive detection of the presence of a drone. The device includes: an antenna; a receiver in communication with the antenna to passively receive wireless signals; and a processor in communication with the receiver and programmed to determine whether a drone is present based on a pattern in the wireless signals emitted from the drone that is correlated with a physical movement of the drone. Another aspect of the invention provides a method for passively detecting the presence of a drone. The method includes: receiving a wireless signal at a device comprising an antenna, a receiver and a processor; and analyzing the wireless signal to determine whether the wireless signal includes a pattern in the signal that is indicative of a physical movement of a drone.
-
公开(公告)号:US11078498B2
公开(公告)日:2021-08-03
申请号:US16938739
申请日:2020-07-24
发明人: Andrew Garst , Ryan T Gill
摘要: Described herein are method for generating a vector for editing a cell. The method comprises ligating into a vector that encodes a portion of a gRNA a cassette comprising at least one editing cassette, a promoter, and a gene encoding another portion of the gRNA. Upon ligation, the portion of the gRNA from the editing cassette and the other portion of the gRNA are ligated and form a functional gRNA.
-
公开(公告)号:US11076948B2
公开(公告)日:2021-08-03
申请号:US16017295
申请日:2018-06-25
发明人: Malik Y. Kahook , Glenn Sussman , Rudolph F. Zacher , Paul J. McLean , Harvey Uy , Robert Cionni , Kerry Solomon
摘要: Modular IOL systems including a base and a lens, wherein the lens includes tabs for connection to the base. The modular IOL allows for the lens to be adjusted or exchanged while leaving the base in place, either intra-operatively or post-operatively.
-
公开(公告)号:US20210213673A1
公开(公告)日:2021-07-15
申请号:US16967395
申请日:2019-02-11
发明人: Kambez Benam , Alexander Kaiser
IPC分类号: B29C64/106 , C12M1/26 , C12M3/00 , B29C64/245 , B29C64/209 , B29C64/232 , B29C64/236 , B29C64/393 , B33Y10/00 , B33Y30/00 , B33Y50/02 , B33Y70/00
摘要: A bioprinter for manufacturing an organomimetic device includes at least one extruder configured to extrude a material, a three-dimensional movement assembly, and a build-plate mounted to the three-dimensional movement assembly. The build-plate may be configured to support the organomimetic device being manufactured. The bioprinter may further include a controller operably coupled to and configured to control the at least one extruder, the three-dimensional movement assembly, and the build-plate. The at least one extruder may be non-movably fixed to the cabinet.
-
公开(公告)号:US20210206813A1
公开(公告)日:2021-07-08
申请号:US17141321
申请日:2021-01-05
发明人: Jerome Fox , Ankur Sarkar , Akarawin Hongdusit , Edward Kim
IPC分类号: C07K14/005 , C07K14/47 , C12N1/20
摘要: This invention relates to the field of genetic engineering. Specifically, the invention relates to the construction of operons to produce biologically active agents. For example, operons may be constructed to produce agents that control the function of biochemical pathway proteins (e.g., protein phosphatases, kinases and/or proteases). Such agents may include inhibitors and modulators that may be used in studying or controlling phosphatase function associated with abnormalities in a phosphatase pathway or expression level. Fusion proteins, such as light activated protein phosphatases, may be genetically encoded and expressed as photoswitchable phosphatases. Systems are provided for use in controlling phosphatase function within living cells or in identifying small molecule inhibitors/activator/modulator molecules of protein phosphatases associated with cell signaling.
-
公开(公告)号:US20210204922A1
公开(公告)日:2021-07-08
申请号:US17198000
申请日:2021-03-10
发明人: Amir Tehrani , Edward A. Jasion
IPC分类号: A61B10/04 , A61B5/00 , A61B17/34 , A61B90/11 , A61B1/00 , A61B1/04 , A61B1/06 , A61B1/07 , A61B5/06 , A61B6/12 , A61B8/08 , A61B8/12 , A61B8/00 , A61B10/02
摘要: A surgical method including positioning an optical probe within a tissue at a target location in a body of a patient; emitting electromagnetic radiation from the optical probe toward the tissue; and receiving a spectra at the optical probe; generating, based on the spectra, by a tissue classification system, a diagnosis classification indicative of a condition of the tissue and treating the tissue with a treatment modality selected based on the diagnosis classification. The spectra is generated by the tissue in response to the emitted electromagnetic radiation.
-
公开(公告)号:US11052060B2
公开(公告)日:2021-07-06
申请号:US16357397
申请日:2019-03-19
申请人: ImmunoMolecular Therapeutics, INC. , The Regents of the University of Colorado, a body corporate
发明人: Steve Orndorff , Aaron Michels
IPC分类号: A61K31/216 , A61K45/06 , A61P37/00 , A61P3/10 , A61K31/198
摘要: Compounds and compositions useful in methods of treating, ameliorating, or inhibiting the development of autoimmune diseases or Celiac disease by modulating the binding of DQ8 MHC class II molecules to antigenic peptides or fragments of antigenic peptides.
-
-
-
-
-
-
-
-
-