公开(公告)号：US20140193434A1

公开(公告)日：2014-07-10

申请号：US14236795

申请日：2012-08-03

申请人： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Yoshitaka Minamida ,  Takanori Saito

发明人： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Yoshitaka Minamida ,  Takanori Saito

IPC分类号： A61K39/395 ,  C07K16/28

CPC分类号： A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/732 ,  A61K2300/00

摘要： It is intended to identify a cancer antigenic protein specifically expressed on the surface of cancer cells and to provide an antibody targeting the antigenic protein and use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody comprising a heavy chain variable region comprising amino acid sequences of SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences of SEQ ID NOs: 9, 10, and 11, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising this antibody or fragment as an active ingredient.

摘要翻译： 旨在鉴定在癌细胞表面上特异性表达的癌抗原蛋白，并提供靶向抗原蛋白的抗体和使用抗体作为癌症的治疗和/或预防剂。 本发明提供了与CAPRIN-1蛋白具有免疫反应性的抗体或其片段，所述抗体包含包含SEQ ID NO：5,6和7的氨基酸序列的重链可变区和轻链可变区 包含SEQ ID NO：9,10和11的氨基酸序列，和包含该抗体或片段作为活性成分的用于治疗和/或预防癌症的药物组合物。

公开(公告)号：US08454968B2

公开(公告)日：2013-06-04

申请号：US13056122

申请日：2009-08-05

申请人： Fumiyoshi Okano ,  Masaki Shimizu ,  Takanori Saito

发明人： Fumiyoshi Okano ,  Masaki Shimizu ,  Takanori Saito

IPC分类号： A61K39/00 ,  A61K38/00 ,  A61K38/04 ,  C12N15/00

CPC分类号： A61K39/0011 ,  A61K38/00 ,  A61K38/19 ,  A61K2039/53 ,  C07K14/47 ,  C07K14/4748 ,  C12N5/0634 ,  C12N5/0636 ,  A61K2300/00

摘要： The invention relates to an immunity-inducing agent comprising, as an active ingredient, at least one polypeptide having immunity-inducing activity that is selected from among polypeptides (a), (b), and (c): (a) a polypeptide of at least seven contiguous amino acids of the amino acid sequence shown by any even SEQ ID number selected from SEQ ID NOs: 2 to 30 listed in the Sequence Listing; (b) a polypeptide of at least seven amino acids having 90% or more sequence identity with the polypeptide (a); and (c) a polypeptide comprising the polypeptide (a) or (b) as a partial sequence thereof, or a recombinant vector comprising a polynucleotide encoding said polypeptide and capable of expressing said polypeptide in vivo.

摘要翻译： 本发明涉及一种免疫诱导剂，其包含作为活性成分的至少一种具有免疫诱导活性的多肽，其选自多肽（a），（b）和（c）：（a）多肽 氨基酸序列的至少七个连续氨基酸由选自序列表中所列的SEQ ID NO：2至30的任何偶数SEQ ID号表示; （b）与多肽（a）具有90％或更多序列同一性的至少7个氨基酸的多肽; 以及（c）包含多肽（a）或（b）作为其部分序列的多肽，或包含编码所述多肽并能够在体内表达所述多肽的多核苷酸的重组载体。

公开(公告)号：US20130045210A1

公开(公告)日：2013-02-21

申请号：US13577212

申请日：2011-02-04

申请人： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Takanori Saito

发明人： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Takanori Saito

IPC分类号： A61K39/395 ,  A61P35/00 ,  A61P35/02 ,  C07K16/28

CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/34 ,  C07K2317/732

摘要： According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen protein as an agent for treating and/or preventing a cancer is provided. Specifically, the present invention provides a pharmaceutical composition for treating and/or preventing a cancer, which comprises an antibody or a fragment thereof as an active ingredient having immunological reactivity with a partial polypeptide of CAPRIN-1, wherein CAPRIN-1 is represented by any of the even-numbered sequences of SEQ ID NOS: 2 to 30, and wherein the partial polypeptide comprises the amino acid sequence represented by SEQ ID NO: 37 or an amino acid sequence having 80% or more sequence identity with the amino acid sequence.

摘要翻译： 根据本发明，鉴定在癌细胞表面特异性表达的癌抗原蛋白，因此提供了靶向癌抗原蛋白的抗体作为治疗和/或预防癌症的药剂的用途。 具体地说，本发明提供了用于治疗和/或预防癌症的药物组合物，其包含抗体或其片段作为与CAPRIN-1的部分多肽具有免疫反应性的活性成分，其中CAPRIN-1由任何 的SEQ ID NO：2至30的偶数序列，并且其中所述部分多肽包含由SEQ ID NO：37表示的氨基酸序列或与氨基酸序列具有80％或更多序列同一性的氨基酸序列。

公开(公告)号：US20130037534A1

公开(公告)日：2013-02-14

申请号：US13571011

申请日：2012-08-09

申请人： Koji YOSHII ,  Tatsuya Yamaguchi ,  Wenling Wang ,  Takanori Saito

发明人： Koji YOSHII ,  Tatsuya Yamaguchi ,  Wenling Wang ,  Takanori Saito

IPC分类号： H05B1/02 ,  F27D11/00

CPC分类号： H01L21/67781 ,  H01L21/67248

摘要： Provided is a method of controlling temperatures of objects to be heated in a heating unit by adjusting a heating rate of each of a plurality of heating elements, based on temperature detection values detected at a plurality of temperature detection elements, wherein the plurality of temperature detection elements are positioned at different positions and the plurality of heating elements are positioned at different positions. The method includes estimating a temperature of each of the plurality of temperature detection elements by using a first estimation algorithm when one of the plurality of temperature detection elements is broken, based on the temperature detection values of the temperature detection elements excluding the broken temperature detection element, and controlling the temperatures of the objects to be heated based on the estimated temperatures.

摘要翻译： 提供了一种通过基于在多个温度检测元件检测到的温度检测值来调节多个加热元件的加热速度来控制加热单元中待加热物体的温度的方法，其中多个温度检测 元件位于不同的位置，并且多个加热元件位于不同的位置。 该方法包括：基于除了断开的温度检测元件之外的温度检测元件的温度检测值，通过使用第一估计算法来估计多个温度检测元件中的每一个的温度， 并且基于估计的温度来控制被加热物体的温度。

公开(公告)号：US20120301476A1

公开(公告)日：2012-11-29

申请号：US13576969

申请日：2011-02-04

申请人： Fumiyoshi Okano ,  Takanori Saito ,  Shinichi Kobayashi ,  Takayoshi Ido ,  Yoshinori Narita

发明人： Fumiyoshi Okano ,  Takanori Saito ,  Shinichi Kobayashi ,  Takayoshi Ido ,  Yoshinori Narita

IPC分类号： A61K39/395 ,  A61P35/00 ,  C07K16/30

CPC分类号： C07K16/3053 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/3015 ,  C07K2317/34

摘要： According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen protein as an agent for treating and/or preventing a cancer is provided. Specifically, the present invention provides a pharmaceutical composition for treating and/or preventing a cancer, which comprises an antibody or a fragment thereof as an active ingredient having immunological reactivity to a partial polypeptide of CAPRIN-1, which is represented by any of even-numbered sequences of SEQ ID NOS: 2 to 30, wherein the polypeptide has the amino acid sequence represented by SEQ ID NO: 37 or an amino acid sequence having 80% or more sequence identity with the amino acid sequence.

摘要翻译： 根据本发明，鉴定在癌细胞表面特异性表达的癌抗原蛋白，因此提供了靶向癌抗原蛋白的抗体作为治疗和/或预防癌症的药剂的用途。 具体地说，本发明提供了一种用于治疗和/或预防癌症的药物组合物，其包含抗体或其片段作为对CAPRIN-1的部分多肽具有免疫反应性的活性成分， SEQ ID NO：2至30的编号序列，其中所述多肽具有由SEQ ID NO：37表示的氨基酸序列或与氨基酸序列具有80％或更高序列同一性的氨基酸序列。

公开(公告)号：US20120251966A1

公开(公告)日：2012-10-04

申请号：US13429845

申请日：2012-03-26

申请人： Koji YOSHII ,  Tatsuya Yamaguchi ,  Wenling Wang ,  Takanori Saito

发明人： Koji YOSHII ,  Tatsuya Yamaguchi ,  Wenling Wang ,  Takanori Saito

IPC分类号： F27D19/00

CPC分类号： H01L21/67109 ,  G05D23/1931 ,  H01L21/324 ,  H01L21/67248

摘要： There is provided a heat treatment control system and method which can accurately estimate the temperatures of wafers upon loading of the wafers, enabling quick heat treatment of the wafers. The heat treatment control system includes: a processing container for processing wafers held in a boat; a lid for hermetically closing the processing container; heaters for heating the processing container; and a controller for controlling the heaters. A profile temperature sensor holding tool is installed on the lid. To the sensor holding tool are mounted profile temperature sensors which are connected to a temperature estimation section. The temperature estimation section estimates the temperature of a wafer by applying a first-order lag filter to a detection signal from a profile temperature sensor. The controller controls the heaters based on the temperatures of wafers thus determined by the temperature estimation section.

摘要翻译： 提供了一种热处理控制系统和方法，其可以在加载晶片时准确地估计晶片的温度，从而能够快速地对晶片进行热处理。 热处理控制系统包括：处理容器，用于处理保存在船上的晶片; 用于气密地关闭处理容器的盖子; 用于加热处理容器的加热器; 以及用于控制加热器的控制器。 外壳温度传感器固定工具安装在盖子上。 传感器保持工具是连接到温度估计部分的安装型材温度传感器。 温度估计部通过对来自轮廓温度传感器的检测信号应用一阶滞后滤波器来估计晶片的温度。 控制器基于由温度估计部确定的晶片的温度来控制加热器。

公开(公告)号：US08253075B2

公开(公告)日：2012-08-28

申请号：US12223162

申请日：2007-02-07

申请人： Makoto Kobayashi ,  Kenichi Yamaga ,  Takanori Saito

发明人： Makoto Kobayashi ,  Kenichi Yamaga ,  Takanori Saito

IPC分类号： F27B5/08 ,  F27B5/16 ,  F27D1/12

CPC分类号： H01L21/67109 ,  H01L21/425 ,  Y10T29/49083

摘要： A heat treatment apparatus with a process chamber, a tubular heater, a heat exhaust system and a cooling section. The heater surrounds an outer circumference of the process chamber. The heat exhaust system exhausts an atmosphere in a space between the heater and the process chamber. The cooling section blows a cooling fluid into the space to cool the atmosphere. The heater includes a tubular heat insulator, a heat generating resistor on an inner circumference of the heat insulator, and an outer shell provided on an outer circumference of the heat insulator. The cooling section includes at least one annular flow path between the heat insulator and the outer shell, and an outlet in the heat insulator. The outlet blows cooling fluid toward a vertical central axis of the heat insulator, or in a direction oblique to the direction toward vertical central axis of the heat insulator.

摘要翻译： 一种具有处理室，管状加热器，散热系统和冷却部分的热处理设备。 加热器围绕处理室的外周。 排热系统排出加热器和处理室之间的空间中的气氛。 冷却部分将冷却液吹入空间以冷却大气。 加热器包括管状隔热件，隔热件的内周上的发热电阻器和设置在隔热件外周上的外壳。 冷却部分包括在绝热器和外壳之间的至少一个环形流动路径以及隔热件中的出口。 出口将冷却流体吹向绝热体的垂直中心轴线，或者朝向与绝热体垂直中心轴方向倾斜的方向。

公开(公告)号：US07528347B2

公开(公告)日：2009-05-05

申请号：US10505900

申请日：2003-02-28

申请人： Takanori Saito ,  Kenichi Yamaga

发明人： Takanori Saito ,  Kenichi Yamaga

IPC分类号： F27B5/14

CPC分类号： H01L21/67109

摘要： A heat treating device (50) has a cooling sleeve that covers a treating vessel (56) and a heater (100). The cooling sleeve has a cylindrical base member (110) and a cooling pipe (112) spirally wound on the outer peripheral surface hereof. The cooling pipe (112) is brazed to the base member (110).

摘要翻译： 热处理装置（50）具有覆盖处理容器（56）和加热器（100）的冷却套筒。 冷却套筒具有圆筒形的基座部件（110）和螺旋地卷绕在其外周面上的冷却管道（112）。 冷却管（112）钎焊到基体（110）上。

公开(公告)号：US07479619B2

公开(公告)日：2009-01-20

申请号：US11487434

申请日：2006-07-17

申请人： Takanori Saito ,  Toshiyuki Makiya ,  Hisaei Osanai ,  Tsuyoshi Takizawa ,  Tomohisa Shimazu ,  Kazuhide Hasebe ,  Hiroyuki Yamamoto ,  Yukimasa Saito ,  Kenichi Yamaga

发明人： Takanori Saito ,  Toshiyuki Makiya ,  Hisaei Osanai ,  Tsuyoshi Takizawa ,  Tomohisa Shimazu ,  Kazuhide Hasebe ,  Hiroyuki Yamamoto ,  Yukimasa Saito ,  Kenichi Yamaga

IPC分类号： F27B5/14 ,  F27D11/00

CPC分类号： H01L21/67109 ,  H01L21/67098

摘要： The present invention is a thermal processing unit including: a heating-furnace body whose upper end has an opening; a heating unit provided on an inside wall of the heating-furnace body; a reaction container consisting of a single tube contained in the heating-furnace body; a gas-discharging-pipe connecting portion formed at an upper portion of the reaction container; and a first temperature controlling unit provided around the gas-discharging-pipe connecting portion.

摘要翻译： 本发明是一种热处理单元，包括：上端具有开口的加热炉体; 设置在所述加热炉体的内壁上的加热单元; 由包含在加热炉体内的单个管构成的反应容器; 形成在反应容器的上部的气体排出管连接部; 以及设置在气体排出管连接部周围的第一温度控制单元。

公开(公告)号：US07072578B2

公开(公告)日：2006-07-04

申请号：US11038283

申请日：2005-01-21

申请人： Norihiko Saito ,  Hiroyuki Honma ,  Hiroshi Mori ,  Eiichi Toya ,  Tomio Konn ,  Tomohiro Nagata ,  Sunao Seko ,  Akira Otsu ,  Takanori Saito ,  Ken Nakao ,  Kazutoshi Miura ,  Harunari Hasegawa ,  George Hoshi ,  Katsutoshi Ishi

发明人： Norihiko Saito ,  Hiroyuki Honma ,  Hiroshi Mori ,  Eiichi Toya ,  Tomio Konn ,  Tomohiro Nagata ,  Sunao Seko ,  Akira Otsu ,  Takanori Saito ,  Ken Nakao ,  Kazutoshi Miura ,  Harunari Hasegawa ,  George Hoshi ,  Katsutoshi Ishi

IPC分类号： H05B3/00

CPC分类号： H05B3/145 ,  H01L2924/0002 ,  H01L2924/00

摘要： A carbon wire heating element sealing heater is provided. Therein, a carbon wire heating element using carbon fibers is sealed in a quartz glass member, wherein absorption water quantity of the carbon wire heating element is 2×10−3 g/cm3 or less.

摘要翻译： 提供碳丝加热元件密封加热器。 其中，使用碳纤维的碳丝加热元件密封在石英玻璃构件中，其中碳线加热元件的吸收水量为2×10 -3 / cm 3 或更少。