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    Amphiphilic compounds and vesicles liposomes for organ-specified drug targeting
    62.
    发明授权
    Amphiphilic compounds and vesicles liposomes for organ-specified drug targeting 有权
    两性化合物和囊泡脂质体用于器官特异性药物靶向

    公开(公告)号：US07887833B2

    公开(公告)日：2011-02-15

    申请号：US10497705

    申请日：2002-12-04

    申请人： Eliahu Heldman ,  Charles Linder ,  Sarina Grinberg ,  Victoria Kolot ,  Eleonora Shaubi

    发明人： Eliahu Heldman ,  Charles Linder ,  Sarina Grinberg ,  Victoria Kolot ,  Eleonora Shaubi

    IPC分类号： A61K9/127 ,  C07C231/00 ,  C07C229/00

    CPC分类号： C07D401/04 ,  A61K9/1272 ,  C07C219/06 ,  C07C233/36 ,  C07C235/28 ,  C07C237/10 ,  C07D303/46 ,  C07H7/00 ,  C07H15/10 ,  C07H15/26

    摘要： An amphiphilic compound is provided capable of forming vesicles or liposomes, said amphiphilic compound having at least one headgroup containing a selectively cleavable group or moiety such as a residue of a choline or phenylalanine derivative, and at least one hydrogen-bonding group located either within said headgroup and/or in close proximity thereto. The cleavable group or moiety is cleaved under selective conditions including change of chemical, physical or biological environment and is preferably cleaved enzymatically in a biological environment such as the brain or the blood. Vesicles or liposomes made from said amphiphilic compounds are suitable for delivery of a therapeutic substance or a diagnostic agent specifically to a target organ or tissue, or for delivery of a nucleic acid for gene therapy.

    摘要翻译： 提供能够形成囊泡或脂质体的两亲化合物，所述两亲化合物具有至少一个含有选择性可切割基团或部分的头基，例如胆碱或苯丙氨酸衍生物的残基，以及至少一个位于所述 头组和/或其附近。 可切割基团或部分在选择性条件下被切割，包括化学，物理或生物环境的变化，并且优选在诸如脑或血液的生物环境中酶促切割。 由所述两亲性化合物制成的囊泡或脂质体适于将治疗物质或诊断剂特异性递送至靶器官或组织，或用于递送用于基因治疗的核酸。

    Process for improving membranes
    63.
    发明授权
    Process for improving membranes 失效
    改进膜的方法

    公开(公告)号：US07677398B2

    公开(公告)日：2010-03-16

    申请号：US11574643

    申请日：2005-09-04

    申请人： Sophia Belfer ,  Rosalia Fainstein ,  Luba Kesselman ,  Charles Linder

    发明人： Sophia Belfer ,  Rosalia Fainstein ,  Luba Kesselman ,  Charles Linder

    IPC分类号： B01D39/00 ,  B01D39/14 ,  B01D71/28 ,  B01D67/00 ,  B05D5/00

    CPC分类号： B01D67/0093 ,  B01D71/56 ,  B01D2323/38 ,  C02F1/441

    摘要： The invention provides a process for improving the antifouling properties and for increasing the selectivity of commercial composite polyamide nanofiltration (NF) and reverse osmosis (RO) membranes comprising circulating a low concentration of water soluble monomers and an initiating redox couple in an aqueous solvent, without transverse pressure over the surface of the membrane thereby effecting a free-radical graft polymerization on the surface of the membrane.

    摘要翻译： 本发明提供了一种改善防污性能和提高市售复合聚酰胺纳滤（NF）和反渗透（RO）膜的选择性的方法，其包括在水性溶剂中循环低浓度的水溶性单体和引发氧化还原对，而没有 在膜的表面上的横向压力，从而在膜的表面上实现自由基接枝聚合。

    Nano - and Mesosized Particles Comprising an Inorganic Core, Process and Applications Thereof
    64.
    发明申请
    Nano - and Mesosized Particles Comprising an Inorganic Core, Process and Applications Thereof 有权
    包含无机核的纳米和中尺寸颗粒，其工艺和应用

    公开(公告)号：US20090011002A1

    公开(公告)日：2009-01-08

    申请号：US11813311

    申请日：2006-01-02

    申请人： Jacob Zabicky ,  Charles Linder ,  Sarina Grinberg ,  Eliahu Heldman

    发明人： Jacob Zabicky ,  Charles Linder ,  Sarina Grinberg ,  Eliahu Heldman

    IPC分类号： A61K9/127 ,  A61K9/14

    CPC分类号： A61K9/1272 ,  A61K9/127 ,  A61K9/1277

    摘要： Method for the preparation of nano- and mesosized particles consisting of a lipid layer comprising at least one amphiphile and a core of an inorganic compound and/or a metal, comprising: (i) dissolving in a common solvent at least one self-aggregating amphiphile with at least one inorganic, organometallic or metallorganic precursor of said inorganic compound or metal; and (ii) either injecting the resulting solution into an aqueous solution or drying the resulting solution and re-hydrating it, so as to form particles in which the precursor is encapsulated by the amphiphile(s) and is converted therein to said inorganic compound and/or metallic solid form.

    摘要翻译： 由包含至少一种无机化合物和/或金属的两亲物和核心的脂质层组成的纳米和中尺寸颗粒的制备方法，包括：（i）在普通溶剂中溶解至少一种自聚集的两亲物 与所述无机化合物或金属的至少一种无机，有机金属或金属有机前体; 和（ii）将所得溶液注入水溶液中或干燥所得溶液并对其进行再水化，以形成其中前体被两亲物包封并在其中转化为所述无机化合物的颗粒， /或金属固体形式。

    Process for Improving Membranes
    65.
    发明申请
    Process for Improving Membranes 失效
    改进膜的方法

    公开(公告)号：US20080269417A1

    公开(公告)日：2008-10-30

    申请号：US11574643

    申请日：2005-09-04

    申请人： Sophia Belfer ,  Rosalia Fainstein ,  Luba Kesselman ,  Charles Linder

    发明人： Sophia Belfer ,  Rosalia Fainstein ,  Luba Kesselman ,  Charles Linder

    IPC分类号： C08F8/00 ,  C08G73/00

    CPC分类号： B01D67/0093 ,  B01D71/56 ,  B01D2323/38 ,  C02F1/441

    摘要： The invention provides a process for improving the antifouling properties and for increasing the selectivity of commercial composite polyamide nanofiltration (NF) and reverse osmosis (RO) membranes comprising circulating a low concentration of water soluble monomers and an initiating redox couple in an aqueous solvent, without transverse pressure over the surface of the membrane thereby effecting a free-radical graft polymerization on the surface of the membrane.

    摘要翻译： 本发明提供了一种改善防污性能和提高市售复合聚酰胺纳滤（NF）和反渗透（RO）膜的选择性的方法，其包括在水性溶剂中循环低浓度的水溶性单体和引发氧化还原对，而没有 在膜的表面上的横向压力，从而在膜的表面上实现自由基接枝聚合。

    Process for producing a tubular membrane assembly
    66.
    发明授权
    Process for producing a tubular membrane assembly 失效
    用于生产管状膜组件的方法

    公开(公告)号：US6077376A

    公开(公告)日：2000-06-20

    申请号：US954938

    申请日：1997-10-22

    申请人： Reuven Katraro ,  Charles Linder ,  Mara Nemas

    发明人： Reuven Katraro ,  Charles Linder ,  Mara Nemas

    IPC分类号： B01D69/04 ,  B01D69/10 ,  B29C53/60 ,  B29C65/08 ,  B65H81/00

    CPC分类号： B01D69/10 ,  B29C53/60 ,  B29C65/08 ,  B29C66/1122 ,  B29C66/4322 ,  B29C66/49 ,  B29K2105/0854

    摘要： The invention provides a process for producing a tubular membrane assembly comprising helically winding at least one strip of fibrous material on a mandrel to produce at least a single ply tubular support member for a semi-permeable membrane, characterized by passing the strip through a heated section of the mandrel during the helical winding thereof to flatten and smooth fibers protruding along the cross-sectional width of the strip, whereby a tube with a smooth inner bore along its entire length is formed.

    摘要翻译： 本发明提供了一种用于生产管状膜组件的方法，其包括在心轴上螺旋地缠绕至少一条纤维材料条，以产生至少一个用于半透膜的单层管状支撑构件，其特征在于，将带穿过加热段 在其螺旋形卷绕期间将心轴沿着带的横截面宽度平坦化并且光滑，从而形成具有沿其整个长度的平滑内孔的管。

    Multi-stage membrane system and process
    67.
    发明授权
    Multi-stage membrane system and process 失效
    多级膜系统和工艺

    公开(公告)号：US5676832A

    公开(公告)日：1997-10-14

    申请号：US745050

    申请日：1996-11-07

    申请人： Reuven Katraro ,  Charles Linder ,  Mara Nemas

    发明人： Reuven Katraro ,  Charles Linder ,  Mara Nemas

    IPC分类号： G01N30/26 ,  B01D15/08 ,  B01D61/02 ,  B01D61/58 ,  B01D69/02 ,  B01D69/04 ,  B01D69/08 ,  B01D69/10

    CPC分类号： B01D61/022

    摘要： The invention provides a multistage membrane system for the recovery of solvents and solutes from chromatographic systems, including first means for directing a first fluid stream of a main eluting fraction, containing target molecules to be concentrated and solvent, to a first filtration membrane unit for concentration and recovery of the target molecules at the feed side of the first membrane; second means for directing fluid streams of other eluting fractions of the chromatographic process, containing contaminants and solvent, to a second filtration membrane unit for concentration and collection of the contaminant solutes at the feed side of the second membrane unit; and third means for directing filtered solvent coming from the permeate side of the first filtration unit to the feed side of the second filtration membrane unit, whereby the filtered solvent intermixes with the fluid stream of other eluting fractions.

    摘要翻译： 本发明提供了一种用于从色谱系统回收溶剂和溶质的多级膜系统，包括用于将含有待浓缩的目标分子和溶剂的主要洗脱级分的第一流体流引导到用于浓缩的第一过滤膜单元的第一装置 并在第一膜的进料侧回收靶分子; 将含有污染物和溶剂的色谱法的其它洗脱级分的流体流引导到第二过滤膜单元的第二装置，用于在第二膜单元的进料侧浓缩和收集污染物溶质; 以及将来自第一过滤单元的渗透侧的过滤溶剂引导到第二过滤膜单元的进料侧的第三装置，由此过滤的溶剂与其它洗脱级分的流体流混合。

    Silicone-derived solvent stable membranes
    69.
    发明授权
    Silicone-derived solvent stable membranes 失效
    有机硅溶剂稳定膜

    公开(公告)号：US5205934A

    公开(公告)日：1993-04-27

    申请号：US929464

    申请日：1992-08-13

    申请人： Charles Linder ,  Mara Nemas ,  Mordechai Perry ,  Reuven Katraro

    发明人： Charles Linder ,  Mara Nemas ,  Mordechai Perry ,  Reuven Katraro

    IPC分类号： B01D69/02 ,  B01D69/12 ,  B01D71/42 ,  B01D71/70

    CPC分类号： B01D69/125 ,  B01D69/02 ,  B01D71/42 ,  B01D71/70

    摘要： A composite membrane which is substantially insoluble (and preferably swells no more than 10%) in acetonitrile, ethanol, hexane, toluene, N-methylpyrrolidone, dimethylsulfoxide, dimethylformamide, dimethylacetamide, and their mixtures with each other and/or with water, comprises a substrate made from copolymers or homopolymers of ethylenically unsaturated nitriles, the substrate having been subjected to the steps of: (1) insolubilizing the polymer by crosslinking; (2) coating with a silicone layer; and (3) crosslinking the silicone layer. Prior to step (2), the substrate is preferably treated with a pore protector in absence of curing agents and catalysts. The pore protector is e.g. a hydroxy-terminated polysiloxane, particularly a silanol-terminated polysiloxane; it prevents the pores from collapsing, when the support is dried during step (3), and prevents passage of the coating material deeply into the pores, thus also preventing an undue reduction of the flux of the finished membrane.

    摘要翻译： 在乙腈，乙醇，己烷，甲苯，N-甲基吡咯烷酮，二甲基亚砜，二甲基甲酰胺，二甲基乙酰胺及其彼此和/或与水的混合物中基本不溶（优选不超过10％）的复合膜包括： 由烯键式不饱和腈的共聚物或均聚物制成的基材，所述基材已经经过以下步骤：（1）通过交联使聚合物不溶; （2）用硅树脂涂层; 和（3）交联硅氧烷层。 在步骤（2）之前，优选在没有固化剂和催化剂的情况下用孔保护剂处理基材。 孔保护剂是例如。 羟基封端的聚硅氧烷，特别是硅烷醇封端的聚硅氧烷; 当在步骤（3）期间支撑件被干燥时，防止孔隙塌陷，并且防止涂层材料深深地渗入孔中，从而也防止成品膜的通量过度减少。