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公开(公告)号：US08101372B2
公开(公告)日：2012-01-24
申请号：US12343170
申请日：2008-12-23
申请人： Rene S. Hubert , Arthur B. Raitano , Daniel E. H. Afar , Steve Chappell Mitchell , Mary Faris , Aya Jakobovits
发明人： Rene S. Hubert , Arthur B. Raitano , Daniel E. H. Afar , Steve Chappell Mitchell , Mary Faris , Aya Jakobovits
IPC分类号： G01N33/574
CPC分类号： G01N33/57434 , A01K2217/05 , A61K39/00 , C07K14/47 , C07K16/18 , C07K16/3069 , C07K2319/00 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/154 , C12Q2600/158
摘要： The present invention relates to methods and compositions for the diagnosis and therapy of prostate cancer which utilize isolated polynucleotides corresponding to the human SGP28 gene, proteins encoded by the SGP28 gene and fragments thereof, and antibodies capable of specifically recognizing and binding to SGP28 proteins.
摘要翻译： 本发明涉及用于诊断和治疗前列腺癌的方法和组合物，其利用对应于人SGP28基因的分离的多核苷酸，由SGP28基因及其片段编码的蛋白质，以及能够特异性识别和结合SGP28蛋白质的抗体。
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62.发明授权Nucleic acid and corresponding protein entitled 161P5C5 useful in treatment and detection of cancer 失效核酸和相应的标题为161P5C5的蛋白质可用于治疗和检测癌症公开(公告)号：US07982004B2
公开(公告)日：2011-07-19
申请号：US12646863
申请日：2009-12-23
申请人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
发明人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
IPC分类号： C07K1/00
CPC分类号： C07K14/4748 , A61K39/00 , Y02A50/466 , Y10T436/143333
摘要： A novel gene (designated 161P5C5) and its encoded protein, and variants thereof, are described wherein 161P5C5 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P5C5 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P5C5 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P5C5 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为161P5C5）及其编码的蛋白及其变体，其中161P5C5在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，161P5C5提供诊断，预后， 癌症的预防和/或治疗靶标。 161P5C5基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与161P5C5反应的抗体或T细胞可用于主动或被动免疫。
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63.发明申请NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 151P3D4 USEFUL IN TREATMENT AND DETECTION OF CANCER 审中-公开核酸和相关蛋白151P3D4用于治疗和检测癌症公开(公告)号：US20110123539A1
公开(公告)日：2011-05-26
申请号：US13016639
申请日：2011-01-28
申请人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
发明人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
IPC分类号： A61K39/395 , C07K16/18 , C12N5/071 , C12P21/02
CPC分类号： C07K14/47 , A61K38/00 , C12N9/78 , Y10T436/25
摘要： A novel gene (designated 151P3D4) and its encoded protein, and variants thereof, are described wherein 151P3D4 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 151P3D4 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 151P3D4 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 151P3D4 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为151P3D4）及其编码的蛋白及其变体，其中151P3D4在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，151P3D4提供诊断，预后， 癌症的预防和/或治疗靶标。 151P3D4基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与151P3D4反应的抗体或T细胞可用于主动或被动免疫。
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64.发明授权Nucleic acid and corresponding protein entitled 125P5C8 useful in treatment and detection of cancer 失效核酸和相应的蛋白质125P5C8可用于治疗和检测癌症公开(公告)号：US07928196B2
公开(公告)日：2011-04-19
申请号：US12820083
申请日：2010-06-21
申请人： Mary Faris , Pia M. Challita-Eid , Rene S. Hubert , Daniel E. H. Afar , Arthur B. Raitano , Wangmao Ge , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Aya Jakobovits
发明人： Mary Faris , Pia M. Challita-Eid , Rene S. Hubert , Daniel E. H. Afar , Arthur B. Raitano , Wangmao Ge , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Aya Jakobovits
IPC分类号： C07K14/00
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , Y02A50/466
摘要： A novel gene (designated 125P5C8) and its encoded protein, and variants thereof, are described wherein 125P5C8 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 125P5C8 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 125P5C8 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 125P5C8 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为125P5C8）及其编码的蛋白及其变体，其中125P5C8在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，125P5C8提供诊断，预后， 癌症的预防和/或治疗靶标。 125P5C8基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与125P5C8反应的抗体或T细胞可用于主动或被动免疫。
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65.发明授权Nucleic acid and corresponding protein entitled 162P1E6 useful in treatment and detection of cancer 失效核酸和相应的蛋白质162P1E6可用于治疗和检测癌症公开(公告)号：US07923543B1
公开(公告)日：2011-04-12
申请号：US11841126
申请日：2007-08-20
申请人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
发明人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
CPC分类号： C07K14/4748 , A61K39/00 , Y02A50/466 , Y10T436/143333
摘要： A novel gene (designated 162P1E6) and its encoded protein, and variants thereof, are described wherein 162P1E6 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 162P1E6 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 162P1E6 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 162P1E6 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（命名为162P1E6）及其编码的蛋白质及其变体，其中162P1E6在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，162P1E6提供诊断，预后， 癌症的预防和/或治疗靶标。 162P1E6基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与162P1E6反应的抗体或T细胞可用于主动或被动免疫。
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66.发明授权Nucleic acid and corresponding protein entitled 125P5C8 useful in treatment and detection of cancer 失效核酸和相应的蛋白质125P5C8可用于治疗和检测癌症公开(公告)号：US07759474B2
公开(公告)日：2010-07-20
申请号：US12235444
申请日：2008-09-22
申请人： Mary Faris , Pia M. Challita-Eid , Rene S. Hubert , Daniel E. H. Afar , Arthur B. Raitano , Wangmao Ge , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Aya Jakobovits
发明人： Mary Faris , Pia M. Challita-Eid , Rene S. Hubert , Daniel E. H. Afar , Arthur B. Raitano , Wangmao Ge , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Aya Jakobovits
IPC分类号： C07H21/02
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , Y02A50/466
摘要： A novel gene (designated 125P5C8) and its encoded protein, and variants thereof, are described wherein 125P5C8 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 125P5C8 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 125P5C8 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 125P5C8 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为125P5C8）及其编码的蛋白及其变体，其中125P5C8在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，125P5C8提供诊断，预后， 癌症的预防和/或治疗靶标。 125P5C8基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与125P5C8反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US07749746B2
公开(公告)日：2010-07-06
申请号：US12429012
申请日：2009-04-23
申请人： Arthur B. Raitano , Pia M. Challita-Eid , Mary Faris , Rene S. Hubert , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
发明人： Arthur B. Raitano , Pia M. Challita-Eid , Mary Faris , Rene S. Hubert , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
CPC分类号： C07K16/30 , A61K39/395 , A61K2039/505 , C07K14/47 , C07K2317/34 , A61K2300/00
摘要： A novel gene (designated 238P1B2) and its encoded protein, and variants thereof, are described wherein 238P1B2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 238P1B2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 238P1B2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 238P1B2 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为238P1B2）及其编码的蛋白及其变体，其中238P1B2在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，238P1B2提供诊断，预后， 癌症的预防和/或治疗靶标。 238P1B2基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与238P1B2反应的抗体或T细胞可用于主动或被动免疫。
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68.发明授权Nucleic acid and corresponding protein entitled 193P1E1B useful in treatment and detection of cancer 失效核酸和相应的标题为193P1E1B的蛋白质可用于治疗和检测癌症公开(公告)号：US07732584B2
公开(公告)日：2010-06-08
申请号：US12434526
申请日：2009-05-01
申请人： Arthur B. Raitano , Pia M. Challita-Eid , Mary Faris , Rene S. Hubert , Wangmao Ge , Aya Jakobovits
发明人： Arthur B. Raitano , Pia M. Challita-Eid , Mary Faris , Rene S. Hubert , Wangmao Ge , Aya Jakobovits
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/34 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , Y02A50/466
摘要： A novel gene 0193P1E1B (also designated 193P1E1B) and its encoded protein, and variants thereof, are described wherein 193P1E1B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 193P1E1B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 193P1E1B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 193P1E1B can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因0193P1E1B（也称为193P1E1B）及其编码的蛋白质及其变体，其中193P1E1B在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，193P1E1B提供诊断， 癌症的预后，预防和/或治疗靶标。 193P1E1B基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与193P1E1B反应的抗体或T细胞可用于主动或被动免疫。
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69.发明授权Nucleic acid and corresponding protein entitled 205P1B5 useful in treatment and detection of cancer 失效核酸和相应的蛋白质205P1B5可用于治疗和检测癌症公开(公告)号：US07700749B2
公开(公告)日：2010-04-20
申请号：US10415014
申请日：2002-08-30
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K14/47 , G01N33/57484 , Y02A50/466
摘要： A novel gene (designated 205P1B5) and its encoded protein are described. While 205P1B5 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in prostrate cancer. Consequently, 205P1B5 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 205P1B5 gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit an immune response.
摘要翻译： 描述了一种新型基因（命名为205P1B5）及其编码的蛋白质。 虽然205P1B5在正常成人组织中表现出组织特异性表达，但是在前列腺癌中异常表达。 因此，205P1B5提供了癌症的诊断，预后，预防和/或治疗靶点。 205P1B5基因或其片段或其编码的蛋白质或其片段可用于引发免疫应答。
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70.发明申请NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 238P1B2 USEFUL IN TREATMENT AND DETECTION OF CANCER 失效核酸和相关蛋白实现238P1B2有效治疗和检测癌症公开(公告)号：US20090311274A1
公开(公告)日：2009-12-17
申请号：US12429012
申请日：2009-04-23
申请人： Arthur B. Raitano , Pia M. Challita-Eid , Mary Faris , Rene S. Hubert , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
发明人： Arthur B. Raitano , Pia M. Challita-Eid , Mary Faris , Rene S. Hubert , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
IPC分类号： A61K39/395 , C07H21/04 , C12N15/63 , C12N1/21 , C12N1/19 , C12N5/10 , C07K14/435 , C07K16/40 , C12N9/96 , C12N5/00
CPC分类号： C07K16/30 , A61K39/395 , A61K2039/505 , C07K14/47 , C07K2317/34 , A61K2300/00
摘要： A novel gene (designated 238P1B2) and its encoded protein, and variants thereof, are described wherein 238P1B2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 238P1B2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 238P1B2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 238P1B2 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（命名为238P1B2）及其编码的蛋白及其变体，其中238P1B2在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，238P1B2提供诊断，预后， 癌症的预防和/或治疗靶标。 238P1B2基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与238P1B2反应的抗体或T细胞可用于主动或被动免疫。
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