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公开(公告)号：US08858917B2
公开(公告)日：2014-10-14
申请号：US12351328
申请日：2009-01-09
申请人： David A. Edwards , Howard A. Stone
发明人： David A. Edwards , Howard A. Stone
IPC分类号： A61K9/00 , A61K31/685 , A61K9/14 , A61K31/74 , A61K31/355 , A61K31/715
CPC分类号： A61K9/0075 , A61K9/0078 , A61K31/355 , A61K31/685 , A61K31/715
摘要： Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as vital infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be a surfactant and, optionally, a carrier. The formulation may be administered as a powder where the particles consist basically of the material altering surface tension. The carrier may be a solution, such as an alcohol, although an aqueous solution may be utilized, or a material mixed with the material altering surface tension to form particles. These may include proteins such as albumin or polysaccharides such as dextran, which also has surface active properties, or polymers such as polyethylene oxide (PEO) or biodegradable synthetic polymers which can be used to encapsulate or deliver the materials to be delivered. Drugs, especially antivirals or antibiotics, may optionally be included with the formulation. These may be administered with or incorporated into the formulation.
摘要翻译： 已经开发了用于肺部输送以治疗或减少诸如人体中的重要感染，特别是结核病，SARS，流感和呼吸道合成病毒以及动物蹄和口蹄疫的疾病的感染性的制剂。 用于肺部给药的制剂包括显着改变诸如表面活性剂和任选的载体的肺粘液衬里液体的表面张力和表面弹性的物理性质的材料。 制剂可以粉末施用，其中颗粒基本上由改变表面张力的材料组成。 载体可以是溶液，例如醇，尽管可以使用水溶液，或与材料混合的材料改变表面张力以形成颗粒。 这些可以包括诸如白蛋白或多糖的蛋白质，例如还具有表面活性的葡聚糖，或聚合物如聚环氧乙烷（PEO）或可生物降解的合成聚合物，其可用于封装或递送待递送材料。 药物，特别是抗病毒剂或抗生素，可以任选地包括在制剂中。 这些可以与制剂一起施用或掺入制剂中。
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公开(公告)号：US08707619B2
公开(公告)日：2014-04-29
申请号：US12682353
申请日：2008-10-08
IPC分类号： A01G9/02
CPC分类号： A01G9/02 , A01G7/00 , B01D53/85 , B01D2257/2064 , B01D2257/502 , B01D2257/70 , B01D2257/7027 , B01D2259/4508 , F24F2003/1653 , F24F2006/005 , Y02A50/2359
摘要： A novel apparatus for the treatment, e.g., cleaning, humidifying, filtration and/or detoxifying, of ambient air incorporates a plant, soil, roots and a water reservoir to allow for effective filtration of air over an extended period of time. In particular, the device is designed with an air impeller system such that external “dirty” air is circulated within the device in the proximity of the plant, soil, roots and/or water reservoir, thereby removing impurities, toxins and other undesirable chemicals from the air. The apparatus and methods of the present invention are readily applicable to a number of applications where air treatment is desired, e.g., household use. Moreover, by incorporating a plant system, the apparatus serves not only a functional but an aesthetic purpose as well.
摘要翻译： 用于治疗，例如清洁，加湿，过滤和/或解毒环境空气的新型装置包括植物，土壤，根部和水贮存器，以允许在长时间内有效地过滤空气。 特别地，该装置设计有空气叶轮系统，使得外部“脏”空气在装置内在植物，土壤，根部和/或水储存器附近循环，从而从杂质，毒素和其他不期望的化学物质中除去 空气。 本发明的装置和方法可以容易地应用于需要空气处理的许多应用，例如家用。 此外，通过结合植物系统，该装置不仅起到功能性的作用，而且起到美学的作用。
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公开(公告)号：US20120093893A1
公开(公告)日：2012-04-19
申请号：US13334236
申请日：2011-12-22
IPC分类号： A61K9/14 , A61P11/00 , A61K31/192 , A61K31/137 , A61K31/138 , A61K31/198
CPC分类号： A61K9/14 , A61K9/0075 , A61K9/1617 , A61K31/198
摘要： A method for delivering an agent to the pulmonary system, in a single, breath-activated step or a single breath, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. The particles are capable of carrying agents. The agent is (1) part of the spray-drying pre-mixture and thereby incorporated into the particles, (2) added to separately-prepared particles so that the agent is in chemical association with the particles or (3) blended so that the agent is mixed with, and co-delivered with the particles.Respirable compositions comprising carrier particles having a tap density of less than 0.4 g/cm3 and a composition comprising an agent are also disclosed. Methods of delivering these respirable compositions are also included.
摘要翻译： 用于在单个呼吸激活步骤或单次呼吸中将药物递送至肺部系统的方法包括从包围大量颗粒的容器向受试者的呼吸道施用具有小于 0.4克/厘米3，并输送至少约50％的颗粒。 颗粒能够携带。 试剂是（1）部分喷雾干燥预混合物，由此加入到颗粒中，（2）加入到单独制备的颗粒中，使得试剂与颗粒化学缔合，或（3）混合 试剂与颗粒混合并与颗粒共同传送。 还公开了包含振实密度小于0.4g / cm 3的载体颗粒和包含试剂的组合物的可吸入组合物。 还包括递送这些可呼吸组合物的方法。
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64.发明申请METHOD AND APPARATUS FOR SECURE SCAN OF DATA STORAGE DEVICE FROM REMOTE SERVER 有权用于从远程服务器安全数据存储设备扫描的方法和装置公开(公告)号：US20110289306A1
公开(公告)日：2011-11-24
申请号：US12785146
申请日：2010-05-21
IPC分类号： G06F15/177 , H04L9/32
CPC分类号： G06F21/64 , G06F21/567 , G06F21/606 , G06F21/85 , G06F2213/0038
摘要： A method and device for providing a secure scan of a data storage device from a remote server are disclosed. In some embodiments, a computing device may include an in-band processor configured to execute an operating system and at least one host driver, communication circuitry configured to communicate with a remote server, and an out-of-band (OOB) processor capable of communicating with the remote server using the communication circuitry irrespective of the state of the operating system. The OOB processor may be configured to receive a block read request from the remote server, instruct the at least one host driver to send a storage command to a data storage device, receive data retrieved from the data storage device and authentication metadata generated by the data storage device, and transmit the data and the authentication metadata to the remote server.
摘要翻译： 公开了一种从远程服务器提供数据存储设备的安全扫描的方法和设备。 在一些实施例中，计算设备可以包括带内处理器，其被配置为执行操作系统和至少一个主机驱动器，被配置为与远程服务器通信的通信电路和能够与远程服务器通信的带外（OOB） 使用通信电路与远程服务器通信，而与操作系统的状态无关。 OOB处理器可以被配置为从远程服务器接收块读取请求，指示至少一个主机驱动程序向数据存储设备发送存储命令，接收从数据存储设备检索的数据和由数据生成的认证元数据 存储设备，并将数据和认证元数据传输到远程服务器。
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公开(公告)号：US20110153725A1
公开(公告)日：2011-06-23
申请号：US12646692
申请日：2009-12-23
申请人： David A. Edwards , Hormuzd M. Khosravi , Yasser Rasheed , Divya Naidu Kolar Sunder , Joseph E. Clark
发明人： David A. Edwards , Hormuzd M. Khosravi , Yasser Rasheed , Divya Naidu Kolar Sunder , Joseph E. Clark
IPC分类号： G06F15/16 , G06F15/173
CPC分类号： H04L67/1097
摘要： Embodiments of the present disclosure provide methods and computing devices configured to establish secure out-of-band storage control. In various embodiments, a management module in a client device may be used to communicate with a server device independent of an operating system of the client device, to facilitate remote storage services. Other embodiments may be disclosed and claimed.
摘要翻译： 本公开的实施例提供了被配置为建立安全的带外存储控制的方法和计算设备。 在各种实施例中，客户端设备中的管理模块可用于与独立于客户端设备的操作系统的服务器设备通信，以便于远程存储服务。 可以公开和要求保护其他实施例。
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公开(公告)号：US20110094156A1
公开(公告)日：2011-04-28
申请号：US12682353
申请日：2008-10-08
CPC分类号： A01G9/02 , A01G7/00 , B01D53/85 , B01D2257/2064 , B01D2257/502 , B01D2257/70 , B01D2257/7027 , B01D2259/4508 , F24F2003/1653 , F24F2006/005 , Y02A50/2359
摘要： A novel apparatus for the treatment, e.g., cleaning, humidifying, filtration and/or detoxifying, of ambient air incorporates a plant, soil, roots and a water reservoir to allow for effective filtration of air over an extended period of time. In particular, the device is designed with an air impeller system such that external ‘dirty’ air is circulated within the device in the proximity of the plant, soil, roots and/or water reservoir, thereby removing impurities, toxins and other undesirable chemicals from the air. The apparatus and methods of the present invention are readily applicable to a number of applications where air treatment is desired, e.g., household use. Moreover, by incorporating a plant system, the apparatus serves not only a functional but an aesthetic purpose as well.
摘要翻译： 用于治疗，例如清洁，加湿，过滤和/或解毒环境空气的新型装置包括植物，土壤，根部和水贮存器，以允许在长时间内有效地过滤空气。 特别地，该装置设计有空气叶轮系统，使得外部“脏”空气在装置内在植物，土壤，根部和/或水储存器附近循环，从而从杂质，毒素和其他不期望的化学物质中除去 空气。 本发明的装置和方法可以容易地应用于需要空气处理的许多应用，例如家用。 此外，通过结合植物系统，该装置不仅起到功能性的作用，而且起到美学的作用。
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公开(公告)号：USD636177S1
公开(公告)日：2011-04-19
申请号：US29363655
申请日：2010-06-11
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公开(公告)号：US07678364B2
公开(公告)日：2010-03-16
申请号：US09822716
申请日：2001-03-30
CPC分类号： A61K9/0075 , A61K9/1611 , A61K9/1617 , A61K38/28
摘要： The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a multivalent metal cation which is complexed with a therapeutic, prophylactic or diagnostic agent or any combination thereof having a charge capable of complexing with the cation upon association with the agent, a pharmaceutically acceptable carrier and optionally, a multivalent metal cation-containing component wherein the total amount of multivalent metal cation present in the particles is more than 1% weight/weight of the total weight of the agent (% w/w). Release of the agent from the administered particles occurs in a sustained fashion.
摘要翻译： 本发明一般涉及将治疗性预防和诊断试剂肺部递送给患者，其中药剂以持续方式释放，以及适用于该方法的颗粒。 特别地，本发明涉及用于肺部递送治疗性，预防性或诊断性药物的方法，其包括对需要治疗，预防或诊断的患者的呼吸道施用有效量的包含多价金属阳离子的颗粒，所述多价金属阳离子是 与治疗性，预防性或诊断剂或其任何组合复合，其具有能够与该药物结合时与阳离子络合的电荷，药学上可接受的载体和任选的多价金属阳离子组分，其中多价金属阳离子的总量 颗粒中存在的重量比重大于重量的1％（％w / w）。 药剂从给药颗粒中的释放以持续的方式发生。
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公开(公告)号：US20080039366A1
公开(公告)日：2008-02-14
申请号：US11436404
申请日：2006-05-18
CPC分类号： A61K9/0075 , A61K9/1617 , A61K38/28 , A61K47/544 , Y10S514/958
摘要： The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.
摘要翻译： 本发明一般涉及将治疗性预防和诊断试剂肺部递送给患者，其中药剂以持续方式释放，以及适用于该方法的颗粒。 特别地，本发明涉及用于肺部递送治疗性，预防性或诊断性药物的方法，其包括对需要治疗，预防或诊断的患者的呼吸道施用有效量的包含治疗性，预防性或诊断性的颗粒 药剂或其任何组合与带电脂质相结合，其中带电脂质具有与药剂相关的与药剂相反的总净电荷。 药剂从给药颗粒中的释放以持续的方式发生。
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公开(公告)号：US07266728B1
公开(公告)日：2007-09-04
申请号：US09410646
申请日：1999-10-01
IPC分类号： G06F11/00
CPC分类号： G06F11/3636 , G06F11/364 , G06F11/3648
摘要： A circuit for monitoring information put onto an interconnect by one or more modules, said circuit comprising circuitry for determining if the information on the interconnect matches one or more conditions; and circuitry for preventing a module from putting further information onto said interconnect if it is determined that information on the interconnect matches said one or more conditions.
摘要翻译： 一种用于监视由一个或多个模块放在互连上的信息的电路，所述电路包括用于确定所述互连上的信息是否匹配一个或多个条件的电路; 以及用于如果确定互连上的信息匹配所述一个或多个条件，则用于防止模块将更多信息放入所述互连的电路。
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