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    Methods for limiting spread of pulmonary infections
    1.
    发明授权
    Methods for limiting spread of pulmonary infections 有权
    限制肺部感染传播的方法

    公开(公告)号：US08858917B2

    公开(公告)日：2014-10-14

    申请号：US12351328

    申请日：2009-01-09

    申请人： David A. Edwards ,  Howard A. Stone

    发明人： David A. Edwards ,  Howard A. Stone

    IPC分类号： A61K9/00 ,  A61K31/685 ,  A61K9/14 ,  A61K31/74 ,  A61K31/355 ,  A61K31/715

    CPC分类号： A61K9/0075 ,  A61K9/0078 ,  A61K31/355 ,  A61K31/685 ,  A61K31/715

    摘要： Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as vital infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be a surfactant and, optionally, a carrier. The formulation may be administered as a powder where the particles consist basically of the material altering surface tension. The carrier may be a solution, such as an alcohol, although an aqueous solution may be utilized, or a material mixed with the material altering surface tension to form particles. These may include proteins such as albumin or polysaccharides such as dextran, which also has surface active properties, or polymers such as polyethylene oxide (PEO) or biodegradable synthetic polymers which can be used to encapsulate or deliver the materials to be delivered. Drugs, especially antivirals or antibiotics, may optionally be included with the formulation. These may be administered with or incorporated into the formulation.

    摘要翻译： 已经开发了用于肺部输送以治疗或减少诸如人体中的重要感染，特别是结核病，SARS，流感和呼吸道合成病毒以及动物蹄和口蹄疫的疾病的感染性的制剂。 用于肺部给药的制剂包括显着改变诸如表面活性剂和任选的载体的肺粘液衬里液体的表面张力和表面弹性的物理性质的材料。 制剂可以粉末施用，其中颗粒基本上由改变表面张力的材料组成。 载体可以是溶液，例如醇，尽管可以使用水溶液，或与材料混合的材料改变表面张力以形成颗粒。 这些可以包括诸如白蛋白或多糖的蛋白质，例如还具有表面活性的葡聚糖，或聚合物如聚环氧乙烷（PEO）或可生物降解的合成聚合物，其可用于封装或递送待递送材料。 药物，特别是抗病毒剂或抗生素，可以任选地包括在制剂中。 这些可以与制剂一起施用或掺入制剂中。

    FORMULATIONS LIMITING SPREAD OF PULMONARY INFECTIONS
    2.
    发明申请
    FORMULATIONS LIMITING SPREAD OF PULMONARY INFECTIONS 有权
    限制肺部感染蔓延的制剂

    公开(公告)号：US20090208581A1

    公开(公告)日：2009-08-20

    申请号：US12351328

    申请日：2009-01-09

    申请人： David A. Edwards ,  Howard A. Stone

    发明人： David A. Edwards ,  Howard A. Stone

    IPC分类号： A61K9/14 ,  C08B37/00 ,  C07K14/00 ,  A61K31/74 ,  A61K38/16 ,  A61K31/715 ,  C08B37/02 ,  C08G65/34 ,  C07K14/76 ,  A61K31/721 ,  A61K31/765 ,  A61K38/38 ,  A61P31/12 ,  A01K29/00 ,  A61D7/00

    CPC分类号： A61K9/0075 ,  A61K9/0078 ,  A61K31/355 ,  A61K31/685 ,  A61K31/715

    摘要： Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as vital infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be a surfactant and, optionally, a carrier. The formulation may be administered as a powder where the particles consist basically of the material altering surface tension. The carrier may be a solution, such as an alcohol, although an aqueous solution may be utilized, or a material mixed with the material altering surface tension to form particles. These may include proteins such as albumin or polysaccharides such as dextran, which also has surface active properties, or polymers such as polyethylene oxide (PEO) or biodegradable synthetic polymers which can be used to encapsulate or deliver the materials to be delivered. Drugs, especially antivirals or antibiotics, may optionally be included with the formulation. These may be administered with or incorporated into the formulation.

    摘要翻译： 已经开发了用于肺部输送以治疗或减少诸如人体中的重要感染，特别是结核病，SARS，流感和呼吸道合成病毒以及动物蹄和口蹄疫的疾病的感染性的制剂。 用于肺部给药的制剂包括显着改变诸如表面活性剂和任选的载体的肺粘液衬里液体的表面张力和表面弹性的物理性质的材料。 制剂可以粉末施用，其中颗粒基本上由改变表面张力的材料组成。 载体可以是溶液，例如醇，尽管可以使用水溶液，或与材料混合的材料改变表面张力以形成颗粒。 这些可以包括诸如白蛋白或多糖的蛋白质，例如还具有表面活性的葡聚糖，或聚合物如聚环氧乙烷（PEO）或可生物降解的合成聚合物，其可用于封装或递送待递送材料。 药物，特别是抗病毒剂或抗生素，可以任选地包括在制剂中。 这些可以与制剂一起施用或掺入制剂中。

    MANIPULATION OF PARTICLES IN CHANNELS
    6.
    发明申请
    MANIPULATION OF PARTICLES IN CHANNELS 有权
    管道中的颗粒的操作

    公开(公告)号：US20120080360A1

    公开(公告)日：2012-04-05

    申请号：US13262079

    申请日：2010-04-08

    申请人： Howard A. Stone ,  Mara G. Prentiss ,  Pierre Striehl ,  Efraim Feinstein

    发明人： Howard A. Stone ,  Mara G. Prentiss ,  Pierre Striehl ,  Efraim Feinstein

    IPC分类号： B03C1/32 ,  B81B7/00 ,  B03C1/00

    CPC分类号： B03C1/288 ,  B03C1/01

    摘要： Systems and methods for the manipulation of particles within channels such as microfluidic channels are provided. In one set of embodiments, magnets are positioned around a channel. As a fluid containing magnetic and non-magnetic particles flows through the channel, the magnetic field created by the magnets can be used to transport the magnetic and/or non-magnetic particles to desired locations within the channel, which may useful in some cases for causing some separation of the particles. For example, the magnetic field may be used to transport magnetic or non-magnetic particles from a core fluid to a surrounding sheath fluid. In some cases, the magnetic field is used to transport non-magnetic particles to a small volume within the channel (e.g., a single-file row within the channel). The systems and methods described herein may find application in a variety of fields including, for example, continuous sorting of cells, removal of targeted cells from a stream of blood, or the arrangement of non-magnetic particles in channels for analysis.

    摘要翻译： 提供了用于操纵诸如微流体通道的通道内的颗粒的系统和方法。 在一组实施例中，磁体围绕通道定位。 当含有磁性和非磁性颗粒的流体流过通道时，由磁体产生的磁场可用于将磁性和/或非磁性颗粒传输到通道内的所需位置，这在某些情况下可能有用 导致颗粒的一些分离。 例如，磁场可以用于将磁性或非磁性颗粒从芯流体输送到周围的鞘液。 在一些情况下，磁场用于将非磁性颗粒传输到通道内的小体积（例如，通道内的单个文件行）。 本文所述的系统和方法可以应用于各种领域，包括例如细胞的连续分选，从血液流中去除靶细胞，或者在通道中排列非磁性粒子进行分析。

    Systems And Methods For Forming Fluidic Droplets Encapsulated In Particles Such As Colloidal Particles
    8.
    发明申请
    Systems And Methods For Forming Fluidic Droplets Encapsulated In Particles Such As Colloidal Particles 审中-公开
    用于形成包封在诸如胶体颗粒的颗粒中的液滴的系统和方法

    公开(公告)号：US20080213593A1

    公开(公告)日：2008-09-04

    申请号：US11794940

    申请日：2006-01-20

    申请人： Anand Bala Subramaniam ,  Manouk Abkarian ,  Howard A. Stone

    发明人： Anand Bala Subramaniam ,  Manouk Abkarian ,  Howard A. Stone

    IPC分类号： B32B5/16 ,  B01J13/02

    CPC分类号： B01F13/0062 ,  B01F3/0807 ,  Y10T428/2984

    摘要： The present invention generally relates to systems and methods for forming fluidic droplets comprising particles such as colloidal particles, which may be distributed on the surfaces of the fluidic droplets in some cases, thereby encapsulating the fluidic droplets. The particles at least partially surrounding the fluidic droplet may be colloidal particles in some cases, i.e., forming a “colloidal capsule.” In one set of embodiments, the particles may be positioned on the surface of a fluidic droplet such that the fluidic droplet is able to maintain a shape that, when left undisturbed, is not achievable by an undisturbed fluidic droplet free of discrete particles, for example, elongated or prolate ellipsoid fluidic droplets. Such fluidic droplets may also exhibit unusual properties, for example, plasticity, isolation from electromagnetic fields, certain electrical and/or magnetic properties, and/or mechanical resistance. In certain embodiments, multiple fluidic droplets may be prevented from fusing or coalescing into one droplet when coming into physical contact, due to the presence of particles on the fluidic droplets. However, the fluidic droplets may be induced into fusing or coalescing by initially deforming one or more of the fluidic droplets, e.g., mechanically.

    摘要翻译： 本发明一般涉及用于形成流体液滴的系统和方法，其包括诸如胶体颗粒的颗粒，其在一些情况下可以分布在流体液滴的表面上，从而封装流体液滴。 至少部分围绕流体液滴的颗粒在某些情况下可能是胶体颗粒，即形成“胶体胶囊”。 在一组实施例中，颗粒可以定位在流体液滴的表面上，使得流体液滴能够保持一种形状，当不受干扰时，不能通过不受干扰的不含离散颗粒的流体液滴来实现，例如 ，细长或长椭圆形流体液滴。 这种流体液滴也可能表现出不寻常的特性，例如可塑性，与电磁场的隔离，某些电和/或磁特性和/或机械阻力。 在某些实施例中，由于流体液滴上存在颗粒，可以防止多个流体液滴在进入物理接触时熔融或聚结成一个液滴。 然而，流体液滴可以通过首先使一个或多个流体液滴变形（例如机械地）而被引入融合或聚结。

    NANO-OTOLOGIC PROTECTIVE EQUIPMENT FOR IMPACT NOISE TOXICITY AND/OR BLAST OVERPRESSURE EXPOSURE
    10.
    发明申请
    NANO-OTOLOGIC PROTECTIVE EQUIPMENT FOR IMPACT NOISE TOXICITY AND/OR BLAST OVERPRESSURE EXPOSURE 审中-公开
    影响噪声和/或爆发过度暴露的纳米生物防护设备

    公开(公告)号：US20120033823A1

    公开(公告)日：2012-02-09

    申请号：US11722287

    申请日：2007-01-10

    申请人： Rick Rogers ,  Brendan Clifford ,  Robert M. Westervelt ,  John W. Hutchinson ,  Howard A. Stone ,  Eben Oldmixon

    发明人： Rick Rogers ,  Brendan Clifford ,  Robert M. Westervelt ,  John W. Hutchinson ,  Howard A. Stone ,  Eben Oldmixon

    IPC分类号： A61F11/06

    CPC分类号： A61F11/08 ,  A61N1/36036

    摘要： An apparatus for preventing hearing loss having a body made of a soft compliant material having first and second ends and a channel extending therethrough, an acoustically limp material adjacent one of the ends of the body with the acoustically limp material having a hole therein aligned with the channel extending through the body, and a component film, disc or other structure covering or sealing the opening in the acoustically limp material. The film or disc may be formed of a high-strength polymer material and may be less than 10 micrometers in thickness. Rather than having a single channel extending through the body, a plurality of channels may extend therethrough and a plurality of corresponding holes may be provided in the acoustically limp material. The film, disc or other structure covers or seals the plurality of holes in the acoustically limp material. The film, disc or other structure may be attached in such a fashion as to behave like a flap whose operation is to close in response to high energy sound waves. The flap is pressed shut from the high intensity shock wave itself. The body may cylindrical in shape or may have another shape to fit snugly in a human ear canal.

    摘要翻译： 一种用于防止听力损失的装置，具有由具有第一和第二端的柔性柔性材料制成的主体和延伸穿过其中的通道，与身体的一个端部相邻的声学瑕疵材料，其中具有孔的声lim材料与 通道延伸穿过身体，以及覆盖或密封声学柔软材料中的开口的部件膜，盘或其他结构。 膜或盘可以由高强度聚合物材料形成，并且厚度可以小于10微米。 不是具有延伸穿过主体的单个通道，而是可以在多个通道中延伸通过，并且可以在声学柔软的材料中设置多个对应的孔。 胶片，碟片或其他结构覆盖或密封声lim材料中的多个孔。 胶片，碟片或其他结构可以以与其操作以响应于高能量声波而关闭的片状的方式附接。 从高强度冲击波本身关闭襟翼。 身体可以是圆柱形的或者可以具有另一形状以适合贴合在人耳道中。