公开(公告)号：US20230068893A1

公开(公告)日：2023-03-02

申请号：US18046473

申请日：2022-10-13

Applicant: Edwards Lifesciences Corporation

Inventor： Salvador Marquez ,  Da-Yu Chang ,  Cindy Woo ,  Hao-Chung Yang ,  Lynn T. Dang ,  Javier A. Sanguinetti ,  Alexander H. Siemons ,  Yaron Keidar ,  Virginia Qi Lin ,  Brian S. Conklin ,  Donald E. Bobo, Jr.

IPC: A61F2/24 ,  A61B5/026 ,  A61B5/00

Abstract: Sensor-integrated prosthetic valves that can comprise a variety of features, including a plurality of valve leaflets, a frame assembly configured to support the plurality of valve leaflets and define a plurality of commissure supports terminating at an outflow end of the prosthetic valve, a sensor device associated with the frame assembly and configured to generate a sensor signal, for example, a sensor signal indicating deflection of one or more of the plurality of commissure supports, and a transmitter assembly configured to receive the sensor signal from the sensor device and wirelessly transmit a transmission signal that is based at least in part on the sensor signal.

公开(公告)号：US11576784B2

公开(公告)日：2023-02-14

申请号：US17100381

申请日：2020-11-20

Applicant: Edwards Lifesciences Corporation

Inventor： Yaron Keidar ,  W. Vaso Adzich ,  Dan Rottenberg ,  Boaz Manash ,  Alon Nahshon

IPC: A61F2/24

Abstract: An active annuloplasty ring holder having a template that can be folded or pivoted to the side allowing the template to align longitudinally with the handle and enter the patient's chest through a small incision. The holder may include a mechanism to remotely detach sutures fastening the ring to the holder, thereby detaching the ring while avoiding the risk associated with introducing a scalpel into the operating field. A detachment mechanism may include a movable pin actuated by a pull wire that releases a plurality of holding sutures, or a hot wire, knives, or pull wire that severs the sutures. The holder may have a built-in light source for better visualization of the ring inside the heart. The holder may also have an optical means of visualizing the inside of the heart from the proximal end of the handle.

公开(公告)号：US11224507B2

公开(公告)日：2022-01-18

申请号：US16506886

申请日：2019-07-09

Applicant: Edwards Lifesciences Corporation

Inventor： Matthew A. Peterson ,  Seung-Beom Yi ,  Siddharth Vad ,  Travis Zenyo Oba ,  Lauren R. Freschauf ,  Amanda French ,  Yaron Keidar ,  Yuanlong Du ,  Gregory Bak-Boychuk ,  Kevin M. Golemo ,  Alexander H. Cooper

IPC: A61F2/24

Abstract: A heart valve prosthesis for replacing a native mitral valve includes a self-expanding frame with a plurality of anchoring members disposed along the lower region. A valve body is positioned within the self-expanding frame and includes a plurality of leaflets configured to allow blood flow through the self-expanding frame in only one direction. A skirt surrounds the self-expanding frame and is spaced apart therefrom for contacting surrounding tissue and impeding blood flow around the self-expanding frame. The skirt may be reinforced with wires to help maintain a desired shape. The leaflets in the valve body are preferably connected to the self-expanding frame through one or more intermediate components such that the valve body is spaced radially inwardly from an inner surface of the self-expanding frame.

公开(公告)号：US20190142363A1

公开(公告)日：2019-05-16

申请号：US16177609

申请日：2018-11-01

Applicant: Edwards Lifesciences Corporation

Inventor： Yaron Keidar

IPC: A61B8/06 ,  A61B5/00 ,  A61B8/08

Abstract: The invention is a device, system, and method for providing an initial assessment of potential heart valve disease and recommending and/or providing follow-up assessments for heart valve disease. The invention includes a simple ECHO device which uses ultrasonic signals to detect and determine maximum blood flow velocities, and compares the maximum blood flow velocities to set thresholds to determine if it is appropriate for the patient to be subjected to additional and more detailed assessments for heart valve disease.

公开(公告)号：US10226338B1

公开(公告)日：2019-03-12

申请号：US16197280

申请日：2018-11-20

Applicant: Edwards Lifesciences Corporation

Inventor： Stanton J. Rowe ,  Larry L. Wood ,  Henry Bourang ,  George Bakis ,  Benjamin Spenser ,  Netanel Benichou ,  Assaf Bash ,  Yaron Keidar

IPC: A61F2/24 ,  A61F2/90 ,  A61L27/36

Abstract: A two-stage or component-based valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve comprises a support structure that is deployed at a treatment site. The prosthetic valve further comprises a valve member configured to be quickly connected to the support structure. The support structure may take the form of a stent that is expanded at the site of a native valve. If desired, the native leaflets may remain and the stent may be used to hold the native valve open. In this case, the stent may be balloon expandable and configured to resist the powerful recoil force of the native leaflets. The support structure is provided with a coupling means for attachment to the valve member, thereby fixing the position of the valve member in the body. The valve member may be a non-expandable type, or may be expandable from a compressed state to an expanded state. The system is particularly suited for rapid deployment of heart valves in a conventional open-heart surgical environment.

公开(公告)号：US20160302922A1

公开(公告)日：2016-10-20

申请号：US15130521

申请日：2016-04-15

Applicant: Edwards Lifesciences Corporation

Inventor： Yaron Keidar

IPC: A61F2/24

CPC classification number: A61F2/2433 ,  A61F2/2418 ,  A61F2220/0008 ,  A61F2250/0063

Abstract: In one representative embodiment, a prosthetic valve assembly comprises a valve component comprising a radially compressible and expandable frame and a valve structure supported inside of the frame. The valve structure is configured to allow blood to flow through the valve component in one direction and block the flow of blood in the opposite direction. The assembly further comprises a radially compressible and expandable anchor comprising an annular base and a plurality of cantilevered fixation members extending from the base. The fixation members are configured to pivot inwardly toward the valve component when the valve component is radially expanded within the anchor.

公开(公告)号：US20150328403A1

公开(公告)日：2015-11-19

申请号：US14409393

申请日：2013-07-02

Applicant: Edwards Lifesciences Corporation

Inventor： John M. Dobbles ,  Yaron Keidar ,  Amanda L. DePalma

IPC: A61M5/172 ,  A61B5/02 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1495

CPC classification number: A61B5/14532 ,  A61B5/02 ,  A61B5/14542 ,  A61B5/1495 ,  A61B5/4064 ,  A61B5/4839 ,  A61B5/6876 ,  A61B5/7278 ,  A61B5/7435 ,  A61M5/1723 ,  A61M2205/3334 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2205/70 ,  A61M2205/702 ,  A61M2230/005 ,  A61M2230/201 ,  A61M2230/202 ,  A61M2230/205

Abstract: Apparatus and methods for monitoring and indexing glucose consumption are disclosed. Embodiments of the present invention provide for accurate measurement of small differences in blood glucose values at various points in the body. These accurate measurements can be used to monitor glucose uptake in specific organs of the body such as the brain or heart. The apparatus includes an upstream intravascular glucose sensor and a downstream intravascular glucose sensor. In some embodiments, substantially simultaneous fluid communication of a calibration fluid to both glucose sensors reduces bias between the sensors. A processor is used to calculate and optionally display blood glucose consumption. Oxygen consumption can also be determined and used to determine and display an index value that is indicative of any mismatch between the two. In some embodiments, insulin and/or glucose infusion can be controlled by the system.

Abstract translation: 公开了用于监测和分配葡萄糖消耗的装置和方法。 本发明的实施例提供了对身体各个点的血糖值的差异的精确测量。 这些精确的测量可用于监测身体的特定器官（如大脑或心脏）中的葡萄糖摄取。 该装置包括上游血管内葡萄糖传感器和下游血管内葡萄糖传感器。 在一些实施例中，校准流体与两个葡萄糖传感器的基本上同时的流体连通减少了传感器之间的偏差。 处理器用于计算和可选地显示血糖消耗。 也可以确定氧消耗并用于确定和显示指示两者之间任何不匹配的指数值。 在一些实施方案中，胰岛素和/或葡萄糖输注可由系统控制。

公开(公告)号：US09101472B2

公开(公告)日：2015-08-11

申请号：US13762236

申请日：2013-02-07

Applicant: Edwards Lifesciences Corporation

Inventor： Yaron Keidar ,  W. Vaso Adzich ,  Dan Rottenberg ,  Boaz Manash ,  Alon Nahshon

IPC: A61F2/24

CPC classification number: A61F2/2466 ,  A61F2/2427 ,  A61F2/2448

Abstract: An active annuloplasty ring holder having a template that can be folded or pivoted to the side allowing the template to align longitudinally with the handle and enter the patient's chest through a small incision. The holder may include a mechanism to remotely detach sutures fastening the ring to the holder, thereby detaching the ring while avoiding the risk associated with introducing a scalpel into the operating field. A detachment mechanism may include a movable pin actuated by a pull wire that releases a plurality of holding sutures, or a hot wire, knives, or pull wire that severs the sutures. The holder may have a built-in light source for better visualization of the ring inside the heart. The holder may also have an optical means of visualizing the inside of the heart from the proximal end of the handle.

Abstract translation: 活动的瓣膜成形术环形支架具有可以折叠或枢转到侧面的模板，允许模板与手柄纵向对准并通过小切口进入患者的胸部。 保持器可以包括用于将紧固环的缝合线远程地分离到保持器的机构，从而分离环，同时避免与将手术刀引入操作区域相关联的风险。 脱离机构可以包括由释放多个保持缝合线的拉线致动的可动销，或者切断缝线的热丝，刀或拉丝。 保持器可以具有内置的光源，用于更好地可视化心脏内的环。 保持器还可以具有从手柄的近端可视化心脏内部的光学装置。

公开(公告)号：US20140031930A1

公开(公告)日：2014-01-30

申请号：US14038357

申请日：2013-09-26

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Yaron Keidar ,  Mark A. Konno

IPC: A61F2/24

CPC classification number: A61F2/2409 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/2427 ,  A61F2/2433 ,  A61F2/2442 ,  A61F2/2445 ,  A61F2/958 ,  A61F2220/0075 ,  A61F2250/001 ,  A61F2250/0071

Abstract: The invention is a cardiac implant, and associated methods therefore, configured to repair and/or replace a native heart valve, and having a support frame configured to be reshaped into an expanded/changed form in order to receive and/or support an expandable prosthetic heart valve therein. The implant may be configured to have a generally rigid and/or expansion-resistant configuration when initially implanted to replace/repair a native valve (or other prosthetic heart valve), but to assume a generally non-rigid and/or expanded/expandable form when subjected to an outward force such as that provided by a dilation balloon. The implant may be configured to have a generally D-shaped configuration when initially implanted, but to assume a generally circular form when subjected to an outward force such as that provided by a dilation balloon.

Abstract translation: 本发明是一种心脏植入物，因此，相关方法被配置为修复和/或替换天然心脏瓣膜，并且具有被配置成重新成形为扩张/改变形式的支撑框架，以便接收和/或支撑可扩张的假体 心脏瓣膜。 当最初植入以替换/修复天然瓣膜（或其他假体心脏瓣膜）时，植入物可构造成具有通常刚性和/或抗膨胀的构造，但是假设通常为非刚性和/或膨胀/可扩张形式 当受到由膨胀气球提供的向外的力时。 植入物可以被配置为在最初植入时具有大致D形构造，但是当经受例如由膨胀气球提供的向外的力时呈现大致圆形形状。

公开(公告)号：US20130150955A1

公开(公告)日：2013-06-13

申请号：US13762236

申请日：2013-02-07

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Yaron Keidar ,  W. Vaso Adzich ,  Dan Rottenberg ,  Boaz Manash ,  Alon Nahshon

IPC: A61F2/24

CPC classification number: A61F2/2466 ,  A61F2/2427 ,  A61F2/2448

Abstract: An active annuloplasty ring holder having a template that can be folded or pivoted to the side allowing the template to align longitudinally with the handle and enter the patient's chest through a small incision. The holder may include a mechanism to remotely detach sutures fastening the ring to the holder, thereby detaching the ring while avoiding the risk associated with introducing a scalpel into the operating field. A detachment mechanism may include a movable pin actuated by a pull wire that releases a plurality of holding sutures, or a hot wire, knives, or pull wire that severs the sutures. The holder may have a built-in light source for better visualization of the ring inside the heart. The holder may also have an optical means of visualizing the inside of the heart from the proximal end of the handle.