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公开(公告)号：US20200054450A1
公开(公告)日：2020-02-20
申请号：US16666099
申请日：2019-10-28
发明人： Stanton J. Rowe , Larry L. Wood , Henry Bourang , George Bakis , Benjamin Spenser , Netanel Benichou , Assaf Bash , Yaron Keidar
摘要： A two-stage or component-based valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve comprises a support structure that is deployed at a treatment site. The prosthetic valve further comprises a valve member configured to be quickly connected to the support structure. The support structure may take the form of a stent that is expanded at the site of a native valve. If desired, the native leaflets may remain and the stent may be used to hold the native valve open. In this case, the stent may be balloon expandable and configured to resist the powerful recoil force of the native leaflets. The support structure is provided with a coupling means for attachment to the valve member, thereby fixing the position of the valve member in the body. The valve member may be a non-expandable type, or may be expandable from a compressed state to an expanded state. The system is particularly suited for rapid deployment of heart valves in a conventional open-heart surgical environment.
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公开(公告)号：US10456251B2
公开(公告)日：2019-10-29
申请号：US16298616
申请日：2019-03-11
发明人： Stanton J. Rowe , Larry L. Wood , Henry Bourang , George Bakis , Benjamin Spenser , Netanel Benichou , Assaf Bash , Yaron Keidar
摘要： A two-stage or component-based valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve comprises a support structure that is deployed at a treatment site. The prosthetic valve further comprises a valve member configured to be quickly connected to the support structure. The support structure may take the form of a stent that is expanded at the site of a native valve. If desired, the native leaflets may remain and the stent may be used to hold the native valve open. In this case, the stent may be balloon expandable and configured to resist the powerful recoil force of the native leaflets. The support structure is provided with a coupling means for attachment to the valve member, thereby fixing the position of the valve member in the body. The valve member may be a non-expandable type, or may be expandable from a compressed state to an expanded state. The system is particularly suited for rapid deployment of heart valves in a conventional open-heart surgical environment.
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公开(公告)号：US20180125643A1
公开(公告)日：2018-05-10
申请号：US15833853
申请日：2017-12-06
发明人： Henry Bourang , Thanh Huy Le , David M. Taylor , Sam Sok , Mario M. Gabriel Iobbi , David J. Evans , Rajesh A. Khanna
CPC分类号： A61F2/243 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2002/9517 , A61F2002/9583
摘要： An assembly for treating a native valve in a human heart includes a prosthetic heart valve having an expandable frame and a valvular structure. The assembly also includes a tubular sleeve and a valve catheter disposed within the sleeve. A plurality of metal extension arms are coupled to the valve catheter for holding the prosthetic heart valve. The extension arms are configured to radially expand with the prosthetic heart valve during expansion of the prosthetic heart valve at a treatment site. A plurality of metal rods extend distally from the valve catheter. The rods are axially movable relative to the extension arms. A plurality of release members are provided for releasing the prosthetic heart valve from the extension arms upon movement of the metal rods.
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公开(公告)号：US20150105856A1
公开(公告)日：2015-04-16
申请号：US14571141
申请日：2014-12-15
发明人： Stanton J. Rowe , Larry L. Wood , Henry Bourang , George Bakis , Benjamin Spenser , Netanel Benichou , Assaf Bash , Yaron Keidar
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2412 , A61F2/2445 , A61F2/90 , A61F2220/0008 , A61F2220/0016 , A61F2220/0025 , A61F2220/0041 , A61F2220/0066 , A61F2220/0075 , A61F2220/0083 , A61F2230/0078 , A61F2250/006 , A61F2250/0098 , A61L27/3625
摘要： A heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve comprises a support structure that is deployed at a treatment site. The prosthetic valve further comprises a valve member configured to be quickly connected to the support structure. The support structure may take the form of a stent that is expanded at the site of a native valve. If desired, the native leaflets may remain and the stent may be used to hold the native valve open. In this case, the stent may be balloon expandable and configured to resist the powerful recoil force of the native leaflets. The support structure is provided with a coupling means for attachment to the valve member, thereby fixing the position of the valve member in the body. The valve member may be expandable or a non-expandable type.
摘要翻译： 提供了可以在手术过程中快速且容易地植入的心脏瓣膜假体。 假体瓣膜包括部署在治疗部位的支撑结构。 假体瓣膜还包括构造成快速连接到支撑结构的阀构件。 支撑结构可以采取在天然瓣膜部位扩张的支架的形式。 如果需要，天然传单可以保留，并且支架可以用于保持天然瓣膜打开。 在这种情况下，支架可以是球囊可扩张的并且被配置为抵抗天然传单的强大后坐力。 支撑结构设置有用于附接到阀构件的联接装置，从而将阀构件的位置固定在主体中。 阀构件可以是可膨胀型或不可膨胀型。
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公开(公告)号：US20130317598A1
公开(公告)日：2013-11-28
申请号：US13954822
申请日：2013-07-30
发明人： Stanton J. Rowe , Larry L. Wood , Henry Bourang , George Bakis , Benjamin Spenser , Netanel Benichou , Assaf Bash , Yaron Keidar
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2412 , A61F2/2445 , A61F2/90 , A61F2220/0008 , A61F2220/0016 , A61F2220/0025 , A61F2220/0041 , A61F2220/0066 , A61F2220/0075 , A61F2220/0083 , A61F2230/0078 , A61F2250/006 , A61F2250/0098 , A61L27/3625
摘要： A heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve comprises a support structure that is deployed at a treatment site. The prosthetic valve further comprises a valve member configured to be quickly connected to the support structure. The support structure may take the form of a stent that is expanded at the site of a native valve. If desired, the native leaflets may remain and the stent may be used to hold the native valve open. In this case, the stent may be balloon expandable and configured to resist the powerful recoil force of the native leaflets. The support structure is provided with a coupling means for attachment to the valve member, thereby fixing the position of the valve member in the body. The valve member may be expandable or a non-expandable type.
摘要翻译： 提供了可以在手术过程中快速且容易地植入的心脏瓣膜假体。 假体瓣膜包括部署在治疗部位的支撑结构。 假体瓣膜还包括构造成快速连接到支撑结构的阀构件。 支撑结构可以采取在天然瓣膜部位扩张的支架的形式。 如果需要，天然传单可以保留，并且支架可以用于保持天然瓣膜打开。 在这种情况下，支架可以是球囊可扩张的并且被配置为抵抗天然传单的强大后坐力。 支撑结构设置有用于附接到阀构件的联接装置，从而将阀构件的位置固定在主体中。 阀构件可以是可膨胀型或不可膨胀型。
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公开(公告)号：US20170119525A1
公开(公告)日：2017-05-04
申请号：US15403458
申请日：2017-01-11
发明人： Stanton J. Rowe , Larry L. Wood , Henry Bourang , George Bakis , Benjamin Spenser , Netanel Benichou , Assaf Bash , Yaron Keidar
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2412 , A61F2/2445 , A61F2/90 , A61F2220/0008 , A61F2220/0016 , A61F2220/0025 , A61F2220/0041 , A61F2220/0066 , A61F2220/0075 , A61F2220/0083 , A61F2230/0078 , A61F2250/006 , A61F2250/0098 , A61L27/3625
摘要： A two-stage or component-based valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve comprises a support structure that is deployed at a treatment site. The prosthetic valve further comprises a valve member configured to be quickly connected to the support structure. The support structure may take the form of a stent that is expanded at the site of a native valve. If desired, the native leaflets may remain and the stent may be used to hold the native valve open. In this case, the stent may be balloon expandable and configured to resist the powerful recoil force of the native leaflets. The support structure is provided with a coupling means for attachment to the valve member, thereby fixing the position of the valve member in the body. The valve member may be a non-expandable type, or may be expandable from a compressed state to an expanded state. The system is particularly suited for rapid deployment of heart valves in a conventional open-heart surgical environment.
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公开(公告)号：US20170056161A1
公开(公告)日：2017-03-02
申请号：US15347505
申请日：2016-11-09
发明人： Henry Bourang , Thanh Huy Le , David M. Taylor , Sam Sok , Mario Gabriel Iobbi , David J. Evans , Rajesh A. Khanna
IPC分类号： A61F2/24
CPC分类号： A61F2/243 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2002/9583
摘要： An assembly for treating a native heart valve can include a prosthetic valve and a delivery apparatus. The prosthetic valve can include an expandable frame, a valve structure, a first end with apertures formed therein, and a second end. The delivery apparatus can include a valve catheter, flexible extension arms, slidable wires, and release members. First ends of the arms can be coupled to a cylindrical coupling element, second ends of the arms can be releasably coupled to the prosthetic valve, and the coupling element can be connected to the distal end of the valve catheter. The slidable wires can extend distally from the distal end of the valve catheter. The release members can be coupled to the distal end of the valve catheter and can extend through a respective aperture of the prosthetic valve, thereby forming a releasable connection between the prosthetic valve and the slidable wires.
摘要翻译： 用于治疗天然心脏瓣膜的组件可以包括人造瓣膜和输送装置。 假体瓣膜可以包括可扩张框架，阀结构，其中形成有孔的第一端和第二端。 输送装置可以包括阀导管，柔性延伸臂，可滑动导线和释放构件。 臂的第一端可以联接到圆柱形联接元件，臂的第二端可以可释放地联接到人工瓣膜，并且联接元件可以连接到瓣膜导管的远端。 滑动导线可以从阀导管的远端向远侧延伸。 释放构件可以联接到瓣膜导管的远端并且可以延伸穿过人造瓣膜的相应孔，从而在假体瓣膜和可滑动线之间形成可释放的连接。
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公开(公告)号：US09539092B2
公开(公告)日：2017-01-10
申请号：US14561113
申请日：2014-12-04
发明人： Henry Bourang , Thanh Huy Le , David M. Taylor , Sam Sok , Mario Gabriel Iobbi , David J. Evans , Rajesh A. Khanna
CPC分类号： A61F2/243 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2002/9583
摘要： A heart valve delivery system is provided wherein a prosthetic valve is carried on a valve catheter inside a delivery sleeve. A step balloon protrudes from the delivery sleeve and provides a tapered surface for facilitating advancement through a body vessel. The step balloon also aids in crossing the leaflets of a native valve. After the prosthetic valve is positioned within the native valve, the delivery sleeve is retracted to expose the prosthetic valve. If necessary, the step balloon may be expanded to securely seat the prosthetic valve at the site of the native valve. The prosthetic valve is preferably coupled to the valve catheter by a plurality of flexible extension arms which allow the prosthetic valve to be collapsed after initial deployment such that the prosthetic valve may be repositioned if necessary.
摘要翻译： 提供心脏瓣膜输送系统，其中人造瓣膜被携带在输送套筒内的阀导管上。 步进气球从输送套筒突出并提供锥形表面，以便于通过身体血管进入。 阶梯气球还有助于穿过天然瓣膜的小叶。 在人工瓣膜定位在天然瓣膜内之后，输送套筒缩回以露出假体瓣膜。 如果需要，可以扩展踏板气囊以将人工瓣膜牢固地安置在天然瓣膜的位置。 假体瓣膜优选地通过多个柔性延伸臂联接到瓣膜导管，所述多个柔性延伸臂允许假肢瓣膜在初始部署之后被折叠，使得如果必要，可以重新定位假体瓣膜。
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公开(公告)号：US12011351B2
公开(公告)日：2024-06-18
申请号：US16849243
申请日：2020-04-15
发明人： Henry Bourang , Thanh Huy Le , David M. Taylor , Sam Sok , Mario Iobbi , David J. Evans , Rajesh A. Khanna
CPC分类号： A61F2/243 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2002/9583
摘要： A valve catheter is advanced through a patient's vasculature while a prosthetic heart valve is attached to flexible extensions along a distal end thereof. The valve catheter is advanced through a tubular sleeve for exposing the prosthetic heart valve and allowing the prosthetic heart valve to self-expand while the extensions remain attached to the prosthetic heart valve. A release mechanism on a handle portion is actuated for releasing the prosthetic heart valve from the extensions, thereby implanting the prosthetic heart in a native heart valve. If the operator is not satisfied with the initial expansion, the prosthetic heart valve may be reoriented before release from the extensions by retracting the prosthetic heart valve back into the tubular sleeve, adjusting the orientation of the prosthetic heart valve and then re-advancing the valve catheter from the tubular sleeve for allowing the prosthetic heart valve to re-self-expand at a more desirable location.
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公开(公告)号：US10130468B2
公开(公告)日：2018-11-20
申请号：US15403458
申请日：2017-01-11
发明人： Stanton J. Rowe , Larry L. Wood , Henry Bourang , George Bakis , Benjamin Spenser , Netanel Benichou , Assaf Bash , Yaron Keidar
摘要： A two-stage or component-based valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve comprises a support structure that is deployed at a treatment site. The prosthetic valve further comprises a valve member configured to be quickly connected to the support structure. The support structure may take the form of a stent that is expanded at the site of a native valve. If desired, the native leaflets may remain and the stent may be used to hold the native valve open. In this case, the stent may be balloon expandable and configured to resist the powerful recoil force of the native leaflets. The support structure is provided with a coupling means for attachment to the valve member, thereby fixing the position of the valve member in the body. The valve member may be a non-expandable type, or may be expandable from a compressed state to an expanded state. The system is particularly suited for rapid deployment of heart valves in a conventional open-heart surgical environment.
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