公开(公告)号：US20030211092A1

公开(公告)日：2003-11-13

申请号：US10162521

申请日：2001-10-19

Applicant: Genentech, Inc.

Inventor： Avi J. Ashkenazi ,  Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Sophia S. Kuo ,  Mary A. Napier ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  David L. Shelton ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

IPC: C12P021/02 ,  C12N005/06 ,  C07K014/47 ,  C07H021/04 ,  A61K038/43 ,  C12N009/00

CPC classification number: C07K14/47 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4702 ,  C07K14/4703 ,  C07K14/475 ,  C07K14/52 ,  C07K14/521 ,  C07K14/54 ,  C07K14/705 ,  C07K14/70503 ,  C07K14/70578 ,  C07K16/18 ,  C07K16/28 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/30 ,  C12N9/00 ,  C12N2799/026 ,  C12N2799/027 ,  G01N33/573 ,  G01N33/57484 ,  G01N33/68 ,  G01N2333/99 ,  G01N2800/042

Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20030211091A1

公开(公告)日：2003-11-13

申请号：US10013918

申请日：2001-10-25

Applicant: Genentech, Inc.

Inventor： Avi J. Ashkenazi ,  Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Sophia S. Kuo ,  Mary A. Napier ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  David L. Shelton ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

IPC: G01N033/53 ,  A61K038/43 ,  C12N009/00 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06 ,  C07K014/435 ,  C07K016/40

CPC classification number: G11B5/022 ,  C07K2317/24 ,  C07K2319/30 ,  H04B10/508

Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20030203451A1

公开(公告)日：2003-10-30

申请号：US10458442

申请日：2003-06-10

Applicant: Genentech, Inc.

Inventor： Jian Chen ,  Ellen Filvaroff ,  Sherman Fong ,  Audrey Goddard ,  Paul Godowski ,  J. Christopher Grimaldi ,  Austin Gurney ,  Hanzhong Li ,  Kenneth Hillan ,  Sarah G. Hymowitz ,  Daniel Tumas ,  Melissa A. Starovasnik ,  Menno VanLookeren ,  Richard Vandlen ,  Colin Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Daniel Yansura

IPC: C12P021/02 ,  C12N005/06 ,  C07K014/47 ,  C07K016/18 ,  C07H021/04 ,  C12N009/00

CPC classification number: A61K38/20 ,  C07K14/54 ,  C07K14/7155 ,  C07K2319/30 ,  C12N15/1136 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/15

Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

公开(公告)号：US20030203446A1

公开(公告)日：2003-10-30

申请号：US10210028

申请日：2001-10-18

Applicant: Genentech, Inc.

Inventor： Avi J. Ashkenazi ,  Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Sophia S. Kuo ,  Mary A. Napier ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  David L. Shelton ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

IPC: C12P021/02 ,  C12N005/06 ,  C07K014/435 ,  C07H021/04 ,  C12N009/00

CPC classification number: C07K14/705

Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20030199436A1

公开(公告)日：2003-10-23

申请号：US09978544

申请日：2001-10-16

Applicant: Genentech, Inc.

Inventor： Avi J. Ashkenazi ,  Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Sophia S. Kuo ,  Mary A. Napier ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  David L. Shelton ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

IPC: C07K014/435 ,  A61K038/17 ,  C12P021/02 ,  C12N005/06 ,  C07K016/40 ,  G01N033/53 ,  C07H021/04 ,  C12N009/00

CPC classification number: G11B5/022 ,  C07K2317/24 ,  C07K2319/30 ,  H04B10/508

Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20030199435A1

公开(公告)日：2003-10-23

申请号：US09978299

申请日：2001-10-15

Applicant: Genentech, Inc.

Inventor： Avi J. Ashkenazi ,  Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Sophia S. Kuo ,  Mary A. Napier ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  David L. Shelton ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

IPC: A61K038/17 ,  G01N033/53 ,  C07H021/04 ,  C12N009/00 ,  C12P021/02 ,  C12N005/06 ,  C07K014/435 ,  C07K016/40

CPC classification number: C07K14/47 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4702 ,  C07K14/4703 ,  C07K14/475 ,  C07K14/52 ,  C07K14/521 ,  C07K14/54 ,  C07K14/705 ,  C07K14/70503 ,  C07K14/70578 ,  C07K16/18 ,  C07K16/28 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/30 ,  C12N9/00 ,  C12N2799/026 ,  C12N2799/027 ,  G01N33/573 ,  G01N33/57484 ,  G01N33/68 ,  G01N2333/99 ,  G01N2800/042

Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20030195347A1

公开(公告)日：2003-10-16

申请号：US10015385

申请日：2001-12-12

Applicant: Genentech, Inc.

Inventor： Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Sherman Fong ,  Wei-Qiang Gao ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood

IPC: C07H021/04 ,  C12N009/00 ,  C12P021/02 ,  C12N005/06 ,  C07K014/435 ,  C07K016/40

CPC classification number: C07K14/47 ,  C07K14/575 ,  C07K2319/30 ,  C07K2319/40

Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20030194744A1

公开(公告)日：2003-10-16

申请号：US10017086

申请日：2001-10-24

Applicant: Genentech, Inc.

Inventor： Avi J. Ashkenazi ,  Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Sophia S. Kuo ,  Mary A. Napier ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  David L. Shelton ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

IPC: G01N033/53 ,  C07H021/04 ,  C12N009/00 ,  C12P021/02 ,  C12N005/06

CPC classification number: G11B5/022 ,  C07K2317/24 ,  C07K2319/30 ,  H04B10/508

Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20030191299A1

公开(公告)日：2003-10-09

申请号：US10015388

申请日：2001-12-12

Applicant: Genentech, Inc.

Inventor： Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Sherman Fong ,  Wei-Qiang Gao ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood

IPC: G01N033/53 ,  C07H021/04 ,  C12N009/00 ,  C12P021/02 ,  C12N005/06 ,  C07K014/435 ,  C07K016/40

CPC classification number: C07H21/04 ,  C07K14/435 ,  C07K16/40 ,  C12N5/06 ,  C12N9/00 ,  C12P21/02 ,  G01N33/53

Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20030190321A1

公开(公告)日：2003-10-09

申请号：US10165247

申请日：2001-10-19

Applicant: Genentech, Inc.

Inventor： Avi J. Ashkenazi ,  Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Sophia S. Kuo ,  Mary A. Napier ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  David L. Shelton ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

IPC: A61K039/00 ,  C12N009/00 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06 ,  C07K014/435

CPC classification number: C07K14/705

Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.