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61.发明授权Nucleotide sequence of the Haemophilus influenzae Rd genome, fragments thereof, and uses thereof 失效流感嗜血杆菌Rd基因组的核苷酸序列，其片段及其用途公开(公告)号：US06506581B1
公开(公告)日：2003-01-14
申请号：US09557884
申请日：2000-04-25
IPC分类号： C12N121
CPC分类号： C07K14/285 , Y10S435/851
摘要： The present invention provides the sequencing of the entire genome of Haemophilus influenzae Rd, SEQ ID NO:1. The present invention further provides the sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use. In addition to the entire genomic sequence, the present invention identifies over 1700 protein encoding fragments of the genome and identifies, by position relative to a unique Not I restriction endonuclease site, any regulatory elements which modulate the expression of the protein encoding fragments of the Haemophilus genome.
摘要翻译： 本发明提供了流感嗜血杆菌Rd，SEQ ID NO：1的整个基因组的测序。 本发明还提供存储在计算机可读介质上的序列信息，以及便于其使用的基于计算机的系统和方法。 除了整个基因组序列之外，本发明鉴定了基因组的超过1700个蛋白质编码片段，并且通过相对于独特的Not I限制性内切核酸酶位点的位置鉴定调节嗜血杆菌蛋白编码片段的表达的任何调节元件 基因组
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公开(公告)号：US06391589B1
公开(公告)日：2002-05-21
申请号：US09479729
申请日：2000-01-07
申请人： Henrik S. Olsen , Haodong Li , Mark D. Adams , Solange H. L. Gentz , Ralph Alderson , Yuling Li , David Parmelee , John R. White , Edward R. Appelbaum
发明人： Henrik S. Olsen , Haodong Li , Mark D. Adams , Solange H. L. Gentz , Ralph Alderson , Yuling Li , David Parmelee , John R. White , Edward R. Appelbaum
IPC分类号： C12N510
CPC分类号： C07K14/523 , A61K38/00 , C07K2319/00
摘要： Human chemokine Beta-10 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.
摘要翻译： 公开了人趋化因子β-10多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种趋化因子多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化因子多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧和骨髓衰竭的治疗剂的用途。
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63.发明授权Computer readable genomic sequence of Haemophilus influenzae Rd, fragments thereof, and uses thereof 失效流感嗜血杆菌Rd的计算机可读基因组序列及其用途及其用途公开(公告)号：US06355450B1
公开(公告)日：2002-03-12
申请号：US08476102
申请日：1995-06-07
IPC分类号： C12P2106
CPC分类号： C07K14/285 , Y10S435/851
摘要： The present invention provides the sequencing of the entire genome of Haemophilus influenzae Rd, SEQ ID NO: 1. The present invention further provides the sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use. In addition to the entire genomic sequence, the present invention identifies over 1700 protein encoding fragments of the genome and identifies, by position relative to a unique Not I restriction endonuclease site, any regulatory elements which modulate the expression of the protein encoding fragments of the Haemophilus genome.
摘要翻译： 本发明提供了流感嗜血杆菌Rd，SEQ ID NO：1的整个基因组的测序。本发明还提供存储在计算机可读介质上的序列信息以及便于其使用的基于计算机的系统和方法。 除了整个基因组序列之外，本发明鉴定了基因组的超过1700个蛋白质编码片段，并且通过相对于独特的Not I限制性内切核酸酶位点的位置鉴定调节嗜血杆菌蛋白编码片段的表达的任何调节元件 基因组
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公开(公告)号：US06265543B1
公开(公告)日：2001-07-24
申请号：US08915096
申请日：1997-08-20
IPC分类号： C07K14495
CPC分类号： C07K14/495 , A61K38/00 , A61K48/00 , C12N2799/026
摘要： The present invention discloses transforming growth factor alpha HI polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.
摘要翻译： 本发明公开了转化生长因子αHI多肽和编码这种多肽的多核苷酸。 还提供了通过重组技术和多肽的治疗用途产生此类多肽的方法，其包括刺激伤口愈合，治疗神经障碍，治疗眼部疾病，治疗肾脏和肝脏疾病以及刺激胚胎发生和血管发生。 还公开了抗这种多肽的拮抗剂及其作为治疗瘤形成的治疗剂的用途。 还公开了用于检测本发明多肽的改变水平的诊断测定和编码本发明多肽的核酸序列中的突变。
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公开(公告)号：US5994506A
公开(公告)日：1999-11-30
申请号：US30582
申请日：1998-02-25
申请人： Daniel R. Soppet , Yi Li , Mark D. Adams
发明人： Daniel R. Soppet , Yi Li , Mark D. Adams
IPC分类号： A61K38/00 , C07K14/705 , C07K14/72 , C12N15/12
CPC分类号： C07K14/70571 , C07K14/723 , A61K38/00 , C12N2799/026
摘要： A human adrenergic receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are agonists for the adrenergic receptor polypeptide which may be used therapeutically to stimulate the adrenergic receptor and antagonist inhibitors against such adrenergic receptor polypeptides and their use therapeutically to antagonize the adrenergic receptor. Also disclosed are diagnostic methods for detecting mutations in the polynucleotides of the present invention and for detecting levels of the soluble polypeptides in samples derived from a host.
摘要翻译： 公开了人类肾上腺素能受体多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了肾上腺素能受体多肽的激动剂，其可以用于治疗性地刺激肾上腺素能受体和拮抗剂对抗这些肾上腺素能受体多肽的抑制剂及其用于拮抗肾上腺素能受体的用途。 还公开了用于检测本发明的多核苷酸中的突变并用于检测衍生自宿主的样品中可溶性多肽的水平的诊断方法。
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公开(公告)号：US5966049A
公开(公告)日：1999-10-12
申请号：US203257
申请日：1998-12-01
CPC分类号： H03F1/3276 , H03F1/3252
摘要： A broadband linearizer for use with a power amplifier. The broadband linearizer includes a broadband linearizer bridge, a preamplifier/attenuator, a post amplifier/attenuator, and a control circuit. The broadband linearizer bridge includes a power divider and a power combiner interconnected by linear and nonlinear arms. The linear arm has a phase shifter, a passive equalizer, and a first delay line that are serially coupled together. The nonlinear arm has a distortion generator, an attenuator and a second delay line that are serially coupled together. The control circuit controls respective settings of the broadband linearizer bridge, preamplifier/attenuator and post amplifier/attenuator. The control circuit provides bias circuitry and sends command and telemetry signals to control operation of the broadband linearizer. The broadband linearizer provides for independent, flexible gain and phase control that can mate with different kinds of power amplifiers having various gain and phase performance.
摘要翻译： 用于功率放大器的宽带线性化电路。 宽带线性化器包括宽带线性化电桥，前置放大器/衰减器，后置放大器/衰减器和控制电路。 宽带线性化电路桥包括功率分配器和通过线性和非线性臂互连的功率组合器。 线性臂具有串联连接在一起的移相器，无源均衡器和第一延迟线。 非线性臂具有串联耦合的失真发生器，衰减器和第二延迟线。 控制电路控制宽带线性化电路桥，前置放大器/衰减器和后置放大器/衰减器的各个设置。 控制电路提供偏置电路并发送命令和遥测信号以控制宽带线性化电路的工作。 宽带线性化电路提供独立，灵活的增益和相位控制，可以与具有各种增益和相位性能的不同种类的功率放大器配合使用。
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公开(公告)号：US5962411A
公开(公告)日：1999-10-05
申请号：US710324
申请日：1996-09-16
IPC分类号： G01N33/53 , A61K31/70 , A61K35/76 , A61K38/00 , A61K38/27 , A61K39/395 , A61K48/00 , A61P3/00 , A61P3/04 , A61P5/00 , A61P13/12 , A61P19/00 , A61P31/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P43/00 , C07H21/04 , C07K14/61 , C07K16/26 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/09 , C12N15/18 , C12P21/02 , C12R1/19 , C07K14/00 , A61K38/16
摘要： There is provided a DNA (or RNA) polynucleotide sequences encoding naturally occurring splice variants of human growth hormone, hGHV-2(88) and hGHV-3(53) as well as analogs and derivatives thereof, which both lack nucleotide sequences normally present in the gene which codes for wild-type hGH. The growth hormone variants of the present invention are of human origin and are useful for diagnostic preventative and therapeutic purposes with respect to certain human diseases. The present invention is also related to a method for producing the human growth hormone variants by recombinant DNA techniques. A method of generating an antibody directed against and therefore inhibiting the activity of wild-type growth hormone is also provided.
摘要翻译： 提供了编码人生长激素，hGHV-2（88）和hGHV-3（53）的天然存在的剪接变体的DNA（或RNA）多核苷酸序列以及其类似物和衍生物，其缺乏通常存在于 编码野生型hGH的基因。 本发明的生长激素变体是人源的，并且对于某些人类疾病的诊断预防和治疗目的是有用的。 本发明还涉及通过重组DNA技术生产人生长激素变体的方法。 还提供了产生针对并因此抑制野生型生长激素的活性的抗体的方法。
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公开(公告)号：US5723311A
公开(公告)日：1998-03-03
申请号：US458477
申请日：1995-06-02
摘要： Disclosed is a human is a hTopI-.alpha. polypeptide and DNA (RNA) encoding such hTopI-.alpha. polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonists against such polypeptide. Also provided are methods of using the antibodies and antagonist inhibitors to inhibit the action of hTopI-.alpha. for therapeutic purposes such as an antitumor agent, to detect an autoimmune disease, or retroviral infections and to treat adenocarcinoma of the colon. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.
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公开(公告)号：US5641657A
公开(公告)日：1997-06-24
申请号：US246427
申请日：1994-05-19
申请人： Steven Ruben , Haodong Li , Mark D. Adams
发明人： Steven Ruben , Haodong Li , Mark D. Adams
IPC分类号： G01N33/50 , A61K31/70 , A61K31/7088 , A61K38/00 , A61K45/00 , A61K48/00 , A61P3/10 , A61P7/00 , A61P7/04 , A61P9/00 , A61P29/00 , A61P31/00 , A61P31/12 , A61P35/00 , A61P35/02 , A61P37/02 , A61P43/00 , C07H21/04 , C07K14/54 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/68 , C12R1/19 , G01N33/15 , G01N33/566 , C12N15/24
CPC分类号： C07K14/5412 , A61K38/00 , A61K48/00
摘要： Polynucleotides which encode the polypeptide IL-6SV, as well as such polypeptides, antibodies and antagonist inhibitors against the polypeptide and the use of the polypeptide as a pharmaceutical for treating cancer, auto-immune diseases, platelet reducing conditions, anemias, bone marrow and organ transplantation.
摘要翻译： 编码多肽IL-6SV的多核苷酸，以及针对多肽的多肽，抗体和拮抗剂抑制剂以及多肽作为治疗癌症的药物，自身免疫疾病，血小板减少病症，贫血，骨髓和器官的用途 移植。
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公开(公告)号：US07851596B2
公开(公告)日：2010-12-14
申请号：US12111079
申请日：2008-04-28
申请人： Reiner L. Gentz , Brent L. Kreider , Jun Zhang , Michael Antonaccio , Donna Mendrick , Pablo Jimenez , Vikram Patel , Craig A. Rosen , Mark D. Adams , Haodong Li , Steven M. Ruben
发明人： Reiner L. Gentz , Brent L. Kreider , Jun Zhang , Michael Antonaccio , Donna Mendrick , Pablo Jimenez , Vikram Patel , Craig A. Rosen , Mark D. Adams , Haodong Li , Steven M. Ruben
IPC分类号： C07K14/52
CPC分类号： G01N33/6863 , A61K38/00 , A61K48/00 , C07K1/113 , C07K1/36 , C07K14/50 , C07K14/521 , C07K14/523 , C07K16/24 , C07K2319/00 , C12N15/72 , C12N2799/026 , G01N2333/52
摘要： There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine β8 (CKβ8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-γ and chemokine β1 (CKβ1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.
摘要翻译： 公开了使用编码人骨髓祖细胞抑制因子-1（MPIF-1）多肽（以前称为MIP-3和趋化因子8（CK＆bgr; 8或ckb-8））的分离的核酸分子的治疗组合物和方法; 人类单核细胞集落抑制因子（M-CIF）多肽（以前称为MIP1-γ和趋化因子1（CK＆bgr; 1或ckb-1））和巨噬细胞抑制蛋白-4（MIP-4） 作为MPIF-1，M-CIF和/或MIP-4多肽本身，载体，宿主细胞和用于制备它们的重组方法也是如此。
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