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61.发明申请Variants And Compositions Comprising Variants With High Stability In Presence Of A Chelating Agent 有权含有高度稳定性的变体和组合物在螯合剂存在下公开(公告)号：US20110195481A1
公开(公告)日：2011-08-11
申请号：US13024770
申请日：2011-02-10
申请人： Allan Svendsen , Annette Helle Johansen , Mads Bjoernvad , Frank W. Rasmussen , Michael Skjoet , Signe Eskildsen Larsen , Jens Oebro , Svend Kaasgaard , Lars Beier
发明人： Allan Svendsen , Annette Helle Johansen , Mads Bjoernvad , Frank W. Rasmussen , Michael Skjoet , Signe Eskildsen Larsen , Jens Oebro , Svend Kaasgaard , Lars Beier
CPC分类号： C12N9/2417
摘要： The present invention relates to variants of an alpha-amylase having improved stability to chelating agents relative to its parent enzyme, compositions comprising the variants, nucleic acids encoding the variants, methods of producing the variants, and methods for using the variants.
摘要翻译： 本发明涉及具有相对于其母体酶对螯合剂具有改善的稳定性的α-淀粉酶的变体，包含变体的组合物，编码变体的核酸，产生变体的方法以及使用该变体的方法。
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公开(公告)号：US20110158976A1
公开(公告)日：2011-06-30
申请号：US11597273
申请日：2005-05-24
申请人： Allan Svendsen , Svend Kaasgaard , Kim Borch , Morten Fischer , Dan Pettersson , Peter Colin Gregory
发明人： Allan Svendsen , Svend Kaasgaard , Kim Borch , Morten Fischer , Dan Pettersson , Peter Colin Gregory
CPC分类号： A61K38/482 , A61K38/465 , A61K38/47 , A61K2300/00
摘要： The pharmaceutical use of proteases related to a protease derived from Nocardiopsis sp. NRRL 18262 (SEQ ID NO: 1), optionally in combination with a lipase and/or an amylase. Examples of medical indications are: Treatment of digestive disorders, pancreatic exocrine insufficiency (PEI), pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II.
摘要翻译： 与来自诺卡氏菌属的蛋白酶有关的蛋白酶的药物用途 NRRL 18262（SEQ ID NO：1），任选与脂肪酶和/或淀粉酶组合。 医学适应症的例子有：消化系统疾病，胰腺外分泌功能不全（PEI），胰腺炎，囊性纤维化，I型糖尿病和/或II型糖尿病的治疗。
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63.发明授权公开(公告)号：US07919298B2
公开(公告)日：2011-04-05
申请号：US12393283
申请日：2009-02-26
申请人： Jesper Vind , Jurgen Carsten Franz Knotzel , Kim Borch , Allan Svendsen , Thomas Hoenger Callisen , Debbie Yaver , Mads Eskelund Bjoernvad , Peter Kamp Hansen
发明人： Jesper Vind , Jurgen Carsten Franz Knotzel , Kim Borch , Allan Svendsen , Thomas Hoenger Callisen , Debbie Yaver , Mads Eskelund Bjoernvad , Peter Kamp Hansen
CPC分类号： C12N9/20
摘要： The invention provides polypeptides obtained by introducing mutations in one or more regions identified in a parent lipase. The polypeptides of the present invention have surprisingly been found to have a low specific activity towards short chain fatty acids leading to a reduced odor generation and an increased BR over the lipases known in the art.
摘要翻译： 本发明提供通过在母体脂肪酶中鉴定的一个或多个区域中引入突变获得的多肽。 令人惊奇地发现本发明的多肽对短链脂肪酸具有低比活性，导致气味产生减少，并且在本领域已知的脂肪酶上增加BR。
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64.发明授权Pullulanase variants and methods for preparing such variants with predetermined properties 失效支链淀粉酶变体和用于制备具有预定性质的这种变体的方法公开(公告)号：US07906306B2
公开(公告)日：2011-03-15
申请号：US12202808
申请日：2008-09-02
申请人： Allan Svendsen
发明人： Allan Svendsen
CPC分类号： C12N9/2457 , C12N9/246 , C12Y302/01041 , C12Y302/01068
摘要： The present invention relates to pullulanase variants, wherein the variants have improved properties, for example, altered pH optimum, improved thermostability, altered substrate specificity, increased specific activity or altered cleavage pattern.
摘要翻译： 本发明涉及支链淀粉酶变体，其中变体具有改善的性质，例如改变的pH最佳，改善的热稳定性，改变的底物特异性，增加的比活性或改变的切割模式。
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公开(公告)号：US07833772B2
公开(公告)日：2010-11-16
申请号：US11524693
申请日：2006-09-21
申请人： Bjarne Roenfeldt Nielsen , Allan Svendsen , Henrik Pedersen , Jesper Vind , Hanne Vang Hendriksen , Torben Peter Frandsen
发明人： Bjarne Roenfeldt Nielsen , Allan Svendsen , Henrik Pedersen , Jesper Vind , Hanne Vang Hendriksen , Torben Peter Frandsen
CPC分类号： C12N9/2428 , C12P19/14 , C12P19/20 , Y02E50/17
摘要： The invention relates to a variant of a parent fungal glucoamylase, which exhibits improved thermal stability and/or increased specific activity using saccharide substrates.
摘要翻译： 本发明涉及亲本真菌葡糖淀粉酶的变体，其使用糖基底显示出改善的热稳定性和/或增加的比活性。
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公开(公告)号：US20100135978A1
公开(公告)日：2010-06-03
申请号：US12693947
申请日：2010-01-26
CPC分类号： C12N9/54
摘要： The pharmaceutical use of proteases related to amino acids 1-274 of SEQ ID NO: 2, the serine protease derived from Bacillus licheniformis, which is also designated subtilisin Carlsberg, optionally in combination with a lipase and/or an amylase. Examples of medical indications are: Treatment of digestive disorders, pancreatic exocrine insufficiency (PEI), pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II.
摘要翻译： 与SEQ ID NO：2的氨基酸1-274相关的蛋白酶的药物用途，来自地衣芽孢杆菌的丝氨酸蛋白酶，其也被指定为枯草杆菌蛋白酶卡尔斯伯格，任选与脂肪酶和/或淀粉酶组合。 医学适应症的例子有：消化系统疾病，胰腺外分泌功能不全（PEI），胰腺炎，囊性纤维化，I型糖尿病和/或II型糖尿病的治疗。
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公开(公告)号：US20090203108A1
公开(公告)日：2009-08-13
申请号：US12413758
申请日：2009-03-30
IPC分类号： C12N9/28
CPC分类号： C12N9/2417 , A21D2/26 , A21D8/042
摘要： The inventors have modified the amino acid sequence of a maltogenic alpha-amylase to obtain variants with improved properties, based on the three-dimensional structure of the maltogenic alpha-amylase Novamyl. The variants have altered physicochemical properties., e.g. an altered pH optimum, improved thermostability, increased specific activity, an altered cleavage pattern or an increased ability to reduce retrogradation of starch or staling of bread.
摘要翻译： 基于麦芽糖α-淀粉酶Novamyl的三维结构，本发明人已经修饰了产麦芽糖α-淀粉酶的氨基酸序列以获得具有改进性质的变体。 这些变体具有改变的物理化学性质。 改变的pH最佳，改善的热稳定性，增加的比活性，改变的切割模式或增加降低淀粉退化或面包陈化的能力。
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公开(公告)号：US20090148893A1
公开(公告)日：2009-06-11
申请号：US11928576
申请日：2007-10-30
申请人： Allan Svendsen , Henriette Draborg
发明人： Allan Svendsen , Henriette Draborg
CPC分类号： C12N9/54 , C11D3/386 , C12Y304/21062
摘要： The present invention relates to methods for producing variants of a parent TY145 subtilase and of a parent BPN′ subtilase and to TY145 and BPN′ variants having altered properties as compared to the parent TY145/BPN′ subtilase.
摘要翻译： 本发明涉及用于产生亲本TY145脱落酶和亲本BPN'脱羧酶的变体的方法，并且与亲本TY145 / BPN'脱羧酶相比具有改变的性质的TY145和BPN'变体的方法。
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公开(公告)号：US07465570B2
公开(公告)日：2008-12-16
申请号：US10556511
申请日：2004-04-29
CPC分类号： A21D8/042 , C12N9/18 , C12N9/20 , C12Y301/01032
摘要： The inventors have developed improved polypeptides by substituting or deleting specified amino acids in fungal lipolytic enzymes. More particularly, the polypeptides result in a reduction of dough stickiness when they are added to a dough. The polypeptides may particularly have activity on polar lipids.
摘要翻译： 本发明人通过在真菌脂肪分解酶中取代或缺失特定的氨基酸而开发了改进的多肽。 更具体地说，当将多肽加入面团时，多肽导致面团粘性降低。 多肽可以特别地对极性脂质具有活性。
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公开(公告)号：US20080293120A1
公开(公告)日：2008-11-27
申请号：US12169679
申请日：2008-07-09
IPC分类号： C12N9/20
CPC分类号： A21D8/042 , C12N9/18 , C12N9/20 , C12Y301/01032
摘要： The inventors have developed improved polypeptides by substituting or deleting specified amino acids in fungal lipolytic enzymes. More particularly, the polypeptides result in a reduction of dough stickiness when they are added to a dough. The polypeptides may particularly have activity on polar lipids.
摘要翻译： 本发明人通过在真菌脂肪分解酶中取代或缺失特定的氨基酸而开发了改进的多肽。 更具体地说，当将多肽加入面团时，多肽导致面团粘性降低。 多肽可以特别地对极性脂质具有活性。
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