公开(公告)号：US20090048641A1

公开(公告)日：2009-02-19

申请号：US12257079

申请日：2008-10-23

申请人： Imad Libbus

发明人： Imad Libbus

IPC分类号： A61N1/36

CPC分类号： A61N1/3627 ,  A61N1/36117 ,  A61N1/36564

摘要： An aspect of the present subject relates to an implantable medical system. An embodiment of the system includes a baroreflex stimulator, a myocardial infarction detector, and a controller. The baroreflex stimulator applies a baroreflex stimulation signal through an electrode. The myocardial infarction detector detects an event indicative of myocardial infarction. The controller is connected to the baroreflex stimulator and to the myocardial infarction detector, and is adapted to apply a baroreflex therapy in response to a detected event indicative of myocardial infarction. Other aspects are provided herein.

摘要翻译： 本发明的一个方面涉及可植入医疗系统。 系统的一个实施例包括压力反射刺激器，心肌梗死检测器和控制器。 压力反射刺激器通过电极施加压力反射刺激信号。 心肌梗塞检测器检测到指示心肌梗死的事件。 控制器连接到压力反射刺激器和心肌梗塞检测器，并且适于对检测到的指示心肌梗塞的事件应用压力反射疗法。 本文提供了其他方面。

公开(公告)号：US20080243212A1

公开(公告)日：2008-10-02

申请号：US11693001

申请日：2007-03-29

申请人： Eric G. Lovett ,  Imad Libbus ,  Joseph Walker

发明人： Eric G. Lovett ,  Imad Libbus ,  Joseph Walker

IPC分类号： A61F7/00

CPC分类号： A61F7/12 ,  A61F7/10 ,  A61F2007/0056

摘要： Disclosed herein, among other things, is system for thermal neuroinhibition. According to an embodiment, the system includes at least one implantable fluid-filled conduit adapted to be placed adjacent to a neural target. The system also includes an implantable housing including a power source, a heat pump deriving power from the source and connected to the conduit, and a controller within the housing. The controller is connected to the heat pump, and is adapted to control the heat pump to effect fluid flow in the conduit to cool the neural target using electromechanical refrigeration to reversibly inhibit neural activity as part of a medical treatment.

摘要翻译： 本文公开了除了其它之外，是用于热神经抑制的系统。 根据一个实施例，该系统包括适于邻近神经靶标放置的至少一个可植入流体填充导管。 该系统还包括可植入壳体，该可植入壳体包括电源，源自源并连接到导管的热泵以及壳体内的控制器。 控制器连接到热泵，并且适于控制热泵来实现管道中的流体流动，以使用机电制冷来冷却神经靶标，以可逆地抑制作为医疗治疗的一部分的神经活动。

公开(公告)号：US20080195188A1

公开(公告)日：2008-08-14

申请号：US11673186

申请日：2007-02-09

申请人： Imad Libbus ,  Randy Westlund

发明人： Imad Libbus ,  Randy Westlund

IPC分类号： A61N1/05

CPC分类号： A61N1/0558 ,  A61N1/36114 ,  A61N1/372 ,  A61N1/37205 ,  A61N1/3756

摘要： Miniature implantable medical devices each include a fixation mechanism to prevent the device from migrating in the body of a patient after implantation. The fixation mechanism is activated after the device is positioned in the body. In one embodiment, the miniature implantable medical devices each include a circuit to deliver neurostimulation. In one embodiment, the fixation mechanism includes one or more externally activated anchoring devices each configured to switch from a substantially non-anchoring state to a substantially anchoring state in response to an externally applied energy. In another embodiment, implantable medical devices are magnetically attracted to each other to prevent the devices from migrating in the body after implantation.

摘要翻译： 微型可植入医疗装置各自包括固定机构，以防止装置在植入后在患者体内迁移。 在装置定位在体内后，固定机构被激活。 在一个实施例中，微型可植入医疗装置各自包括用于递送神经刺激的电路。 在一个实施例中，固定机构包括一个或多个外部激活的锚固装置，其各自被配置为响应于外部施加的能量而从基本上非锚定状态转换到基本锚定状态。 在另一个实施例中，可植入医疗装置彼此磁吸引以防止装置在植入后在体内迁移。

公开(公告)号：US20080086185A1

公开(公告)日：2008-04-10

申请号：US11539301

申请日：2006-10-06

申请人： Badri Amurthur ,  Steven D. Girouard ,  Imad Libbus

发明人： Badri Amurthur ,  Steven D. Girouard ,  Imad Libbus

IPC分类号： A61N1/00

CPC分类号： A61N1/37288 ,  A61N1/36114 ,  A61N1/37247 ,  A61N1/3787

摘要： A distributed system is described that employs electrical neural stimulation to modulate autonomic activity and which allows titration of the neural stimulation therapy in accordance with physiological measurements reflective of autonomic activity and/or physiological variables affected by the neural stimulation. Such a system may include a plurality of implantable neuromodulation units that communicate with one another over a network.

摘要翻译： 描述了一种使用电神经刺激来调节自主活动的分布式系统，并且其允许根据反映受神经刺激影响的自主活动和/或生理变量的生理测量来滴定神经刺激疗法。 这样的系统可以包括通过网络彼此通信的多个可植入神经调节单元。

公开(公告)号：US20080086181A1

公开(公告)日：2008-04-10

申请号：US11539289

申请日：2006-10-06

申请人： Badri Amurthur ,  Imad Libbus

发明人： Badri Amurthur ,  Imad Libbus

IPC分类号： A61N1/00

CPC分类号： A61N1/36114 ,  A61N1/3627 ,  A61N1/36521

摘要： Described herein are methods and devices that utilize electrical neural stimulation to treat heart failure by modulating a patient's autonomic balance in a manner that inhibits sympathetic activity and/or augments parasympathetic activity. In one embodiment, the duty cycle for delivering neural stimulation is adjusted in accordance with one or more measured physiological variables.

摘要翻译： 本文描述了利用电神经刺激来以抑制交感神经活动和/或增加副交感神经活动的方式调节患者的自主神经平衡来治疗心力衰竭的方法和装置。 在一个实施例中，根据一个或多个测量的生理变量来调整用于递送神经刺激的占空比。

公开(公告)号：US20080058871A1

公开(公告)日：2008-03-06

申请号：US11468135

申请日：2006-08-29

申请人： Imad Libbus ,  Andrew P. Kramer ,  Anthony V. Caparso ,  Kristofer J. James ,  Stephen Ruble ,  Weiying Zhoa

发明人： Imad Libbus ,  Andrew P. Kramer ,  Anthony V. Caparso ,  Kristofer J. James ,  Stephen Ruble ,  Weiying Zhoa

IPC分类号： A61N1/00

CPC分类号： A61N1/365 ,  A61N1/36053 ,  A61N1/36114

摘要： Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.

摘要翻译： 各种方面提供可植入装置。 在各种实施例中，该装置包括至少一个端口，其中每个端口适于将引线与电极连接到该装置。 所述装置还包括刺激平台，包括连接到所述至少一个端口以感测固有心脏信号的感测电路和经由刺激通道连接到所述至少一个端口的刺激电路，以将刺激信号通过所述刺激通道传递到 电极。 刺激电路适于通过刺激通道递送刺激信号用于神经刺激治疗和CRM治疗。 感测和刺激电路适用于执行CRM功能。 该装置还包括连接到感测电路和刺激电路的控制器，以控制神经刺激疗法和CRM治疗。 本文提供了其它方面和实施例。

公开(公告)号：US20080015648A1

公开(公告)日：2008-01-17

申请号：US11777394

申请日：2007-07-13

申请人： Imad Libbus ,  Bruce KenKnight ,  Julia Moffitt ,  Yatheendhar Manicka

发明人： Imad Libbus ,  Bruce KenKnight ,  Julia Moffitt ,  Yatheendhar Manicka

IPC分类号： A61N1/05

CPC分类号： A61N1/362 ,  A61N1/36114 ,  A61N1/3627

摘要： A method and device for delivering ventricular resynchronization pacing therapy in conjunction with electrical stimulation of nerves which alter the activity of the autonomic nervous system is disclosed. Such therapies may be delivered by an implantable device and are useful in preventing the deleterious ventricular remodeling which occurs as a result of a heart attack or heart failure. The device may perform an assessment of cardiac function in order to individually modulate the delivery of the two types of therapy.

摘要翻译： 公开了一种用于将脑室再同步起搏治疗与神经改变自主神经系统的活动的电刺激结合的方法和装置。 这样的治疗可以由可植入装置递送，并且可用于防止由于心脏病发作或心力衰竭而发生的有害心室重构。 该装置可以执行心脏功能的评估，以便单独地调节两种类型的治疗的递送。

公开(公告)号：US20070260285A1

公开(公告)日：2007-11-08

申请号：US11382128

申请日：2006-05-08

申请人： Imad Libbus ,  Krzysztof Siejko ,  Marina Brockway ,  Robert Sweeney

发明人： Imad Libbus ,  Krzysztof Siejko ,  Marina Brockway ,  Robert Sweeney

IPC分类号： A61N1/00

CPC分类号： A61B5/0205 ,  A61B5/0031 ,  A61B5/0215 ,  A61B5/02158 ,  A61B5/0402 ,  A61B5/0488 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/36128 ,  A61N1/36139 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/36521 ,  A61N1/36542 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/36585 ,  A61N1/36592 ,  A61N1/372 ,  A61N1/37288

摘要： Various system embodiments comprise a stimulator adapted to deliver a stimulation signal for a heart failure therapy, a number of sensors adapted to provide at least a first measurement of a heart failure status and a second measurement of the heart failure status, and a controller. The controller is connected to the stimulator and to the number of sensors. The controller is adapted to use the first and second measurements to create a heart failure status index, and control the stimulator to modulate the signal using the index. Other aspects and embodiments are provided herein.

摘要翻译： 各种系统实施例包括适于递送用于心力衰竭治疗的刺激信号的刺激器，适于提供心力衰竭状态的至少第一测量和心力衰竭状态的第二测量的多个传感器以及控制器。 控制器连接到刺激器和传感器的数量。 控制器适于使用第一和第二测量来创建心力衰竭状态指数，并且使用该索引来控制刺激器来调制信号。 本文提供了其它方面和实施例。

公开(公告)号：US07260431B2

公开(公告)日：2007-08-21

申请号：US10850341

申请日：2004-05-20

申请人： Imad Libbus ,  Bruce H. KenKnight ,  Julia Moffitt ,  Yatheendhar D. Manicka

发明人： Imad Libbus ,  Bruce H. KenKnight ,  Julia Moffitt ,  Yatheendhar D. Manicka

IPC分类号： A61N1/18

CPC分类号： A61N1/362 ,  A61N1/36114 ,  A61N1/3627

摘要： A method and device for delivering ventricular resynchronization pacing therapy in conjunction with electrical stimulation of nerves which alter the activity of the autonomic nervous system is disclosed. Such therapies may be delivered by an implantable device and are useful in preventing the deleterious ventricular remodeling which occurs as a result of a heart attack or heart failure. The device may perform an assessment of cardiac function in order to individually modulate the delivery of the two types of therapy.

摘要翻译： 公开了一种用于将脑室再同步起搏治疗与神经改变自主神经系统的活动的电刺激结合的方法和装置。 这样的治疗可以由可植入装置递送，并且可用于防止由于心脏病发作或心力衰竭而发生的有害心室重构。 该装置可以执行心脏功能的评估，以便单独地调节两种类型的治疗的递送。

公开(公告)号：US20070150006A1

公开(公告)日：2007-06-28

申请号：US11320500

申请日：2005-12-28

申请人： Imad Libbus ,  Anthony Caparso ,  M. Brooke ,  Jonathan Kwok ,  Kent Lee ,  Yachuan Pu

发明人： Imad Libbus ,  Anthony Caparso ,  M. Brooke ,  Jonathan Kwok ,  Kent Lee ,  Yachuan Pu

IPC分类号： A61N1/32

CPC分类号： A61N1/36185 ,  A61N1/3611

摘要： Various aspects relate to an implantable device. Various device embodiments include at least one sensor for use in detecting sleep disordered breathing, a pulse generator adapted to deliver a first electrical signal through at least one electrode to stimulate a neural target, and a controller adapted to communicate with the at least one sensor and with the pulse generator. The controller is adapted to detect sleep disordered breathing using the at least one sensor and provide a therapy for sleep disordered breathing in response to a detected apneic event. The therapy for sleep disordered breathing is adapted to deliver the first electrical signal through the at least one electrode to induce a cough reflex to terminate the apneic event. Various embodiments stimulate a superior laryngeal nerve, various embodiments stimulate a recurrent laryngeal nerve, and various embodiments stimulate a vagus nerve. Other aspects and embodiments are provided herein.

摘要翻译： 各种方面涉及可植入装置。 各种装置实施例包括用于检测睡眠无序呼吸的至少一个传感器，适于通过至少一个电极传递第一电信号以刺激神经靶的脉冲发生器，以及适于与至少一个传感器和 与脉冲发生器。 所述控制器适于使用所述至少一个传感器检测睡眠呼吸障碍，并响应于检测到的呼吸暂停事件提供针对睡眠呼吸障碍的治疗。 用于睡眠呼吸紊乱的治疗适于通过至少一个电极传递第一电信号以引起咳嗽反射以终止呼吸暂停事件。 各种实施方案刺激上喉神经，各种实施方案刺激复发性喉神经，并且各种实施方案刺激迷走神经。 本文提供了其它方面和实施例。