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1.发明申请COMBINED REMODELING CONTROL THERAPY AND ANTI-REMODELING THERAPY BY IMPLANTABLE CARDIAC DEVICE 有权可重构心脏器械组合重组控制治疗与抗再感染治疗公开(公告)号：US20110015692A1
公开(公告)日：2011-01-20
申请号：US12891674
申请日：2010-09-27
IPC分类号： A61N1/365
CPC分类号： A61N1/362 , A61N1/36114 , A61N1/3627
摘要： A method and device for delivering ventricular resynchronization pacing therapy in conjunction with electrical stimulation of nerves which alter the activity of the autonomic nervous system is disclosed. Such therapies may be delivered by an implantable device and are useful in preventing the deleterious ventricular remodeling which occurs as a result of a heart attack or heart failure. The device may perform an assessment of cardiac function in order to individually modulate the delivery of the two types of therapy.
摘要翻译： 公开了一种用于将脑室再同步起搏治疗与神经改变自主神经系统的活动的电刺激结合的方法和装置。 这样的治疗可以由可植入装置递送，并且可用于防止由于心脏病发作或心力衰竭而发生的有害心室重构。 该装置可以执行心脏功能的评估，以便单独地调节两种类型的治疗的递送。
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2.发明授权Combined remodeling control therapy and anti-remodeling therapy by implantable cardiac device 有权通过可植入心脏装置的联合重塑控制治疗和抗重塑治疗公开(公告)号：US08483828B2
公开(公告)日：2013-07-09
申请号：US12891674
申请日：2010-09-27
CPC分类号： A61N1/362 , A61N1/36114 , A61N1/3627
摘要： A method and device for delivering ventricular resynchronization pacing therapy in conjunction with electrical stimulation of nerves which alter the activity of the autonomic nervous system is disclosed. Such therapies may be delivered by an implantable device and are useful in preventing the deleterious ventricular remodeling which occurs as a result of a heart attack or heart failure. The device may perform an assessment of cardiac function in order to individually modulate the delivery of the two types of therapy.
摘要翻译： 公开了一种用于将脑室再同步起搏治疗与神经改变自主神经系统的活动的电刺激结合的方法和装置。 这样的治疗可以由可植入装置递送，并且可用于防止由于心脏病发作或心力衰竭而发生的有害心室重构。 该装置可以执行心脏功能的评估，以便单独地调节两种类型的治疗的递送。
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3.发明授权Combined remodeling control therapy and anti-remodeling therapy by implantable cardiac device 有权通过可植入心脏装置的联合重塑控制治疗和抗重塑治疗公开(公告)号：US07260431B2
公开(公告)日：2007-08-21
申请号：US10850341
申请日：2004-05-20
IPC分类号： A61N1/18
CPC分类号： A61N1/362 , A61N1/36114 , A61N1/3627
摘要： A method and device for delivering ventricular resynchronization pacing therapy in conjunction with electrical stimulation of nerves which alter the activity of the autonomic nervous system is disclosed. Such therapies may be delivered by an implantable device and are useful in preventing the deleterious ventricular remodeling which occurs as a result of a heart attack or heart failure. The device may perform an assessment of cardiac function in order to individually modulate the delivery of the two types of therapy.
摘要翻译： 公开了一种用于将脑室再同步起搏治疗与神经改变自主神经系统的活动的电刺激结合的方法和装置。 这样的治疗可以由可植入装置递送，并且可用于防止由于心脏病发作或心力衰竭而发生的有害心室重构。 该装置可以执行心脏功能的评估，以便单独地调节两种类型的治疗的递送。
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4.发明授权Combined remodeling control therapy and anti-remodeling therapy by implantable cardiac device 有权通过可植入心脏装置的联合重塑控制治疗和抗重塑治疗公开(公告)号：US07805193B2
公开(公告)日：2010-09-28
申请号：US11777394
申请日：2007-07-13
IPC分类号： A61N1/368
CPC分类号： A61N1/362 , A61N1/36114 , A61N1/3627
摘要： A method and device for delivering ventricular resynchronization pacing therapy in conjunction with electrical stimulation of nerves which alter the activity of the autonomic nervous system is disclosed. Such therapies may be delivered by an implantable device and are useful in preventing the deleterious ventricular remodeling which occurs as a result of a heart attack or heart failure. The device may perform an assessment of cardiac function in order to individually modulate the delivery of the two types of therapy.
摘要翻译： 公开了一种用于将脑室再同步起搏治疗与神经改变自主神经系统的活动的电刺激结合的方法和装置。 这样的治疗可以由可植入装置递送，并且可用于防止由于心脏病发作或心力衰竭而发生的有害心室重构。 该装置可以执行心脏功能的评估，以便单独地调节两种类型的治疗的递送。
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公开(公告)号：US08131362B2
公开(公告)日：2012-03-06
申请号：US12543654
申请日：2009-08-19
申请人： Julia Moffitt , Sophia Wang , Bruce H. KenKnight , Imad Libbus
发明人： Julia Moffitt , Sophia Wang , Bruce H. KenKnight , Imad Libbus
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/056 , A61N1/0587 , A61N1/36114 , A61N1/3962
摘要： Methods and devices for delivering cardiac therapy to a patient are provided. Various implantable device embodiments comprise a plurality of leads and a controller. The leads include at least one lead to be positioned within a lead path to deliver ventricular pacing pulses and to deliver neural stimulation at a site proximate to the heart to inhibit sympathetic nerve activity. The controller controls delivery of the ventricular pacing pulses in accordance with a programmed pacing mode and controls delivery of the neural stimulation. The controller is programmed to deliver remodeling control therapy (RCT) by delivering ventricular pacing to pre-excite a ventricular myocardium region to mechanically unload that region during systole, and further is programmed to deliver anti-remodeling therapy (ART) by delivering neural stimulation to inhibit sympathetic nerve activity in conjunction with RCT. Other embodiments are provided herein.
摘要翻译： 提供了向患者输送心脏治疗的方法和装置。 各种可植入装置实施例包括多个引线和控制器。 引线包括至少一个引线定位在引导路径内以提供心室起搏脉冲并且在靠近心脏的部位输送神经刺激以抑制交感神经活动。 控制器根据编程的起搏模式控制心室起搏脉冲的传递并控制神经刺激的传递。 控制器被编程为通过提供心室起搏来预先激发心室心肌区域以在心脏收缩期间机械地卸载该区域来递送重建控制治疗（RCT），并且进一步被编程以通过递送神经刺激来递送抗重塑疗法（ART） 与RCT结合抑制交感神经活动。 本文提供了其他实施例。
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公开(公告)号：US20090306734A1
公开(公告)日：2009-12-10
申请号：US12543654
申请日：2009-08-19
申请人： Julia Moffitt , Sophia Wang , Bruce H. Kenknight , Imad Libbus
发明人： Julia Moffitt , Sophia Wang , Bruce H. Kenknight , Imad Libbus
CPC分类号： A61N1/3627 , A61N1/056 , A61N1/0587 , A61N1/36114 , A61N1/3962
摘要： Methods and devices for delivering cardiac therapy to a patient are provided. Various implantable device embodiments comprise a plurality of leads and a controller. The leads include at least one lead to be positioned within a lead path to deliver ventricular pacing pulses and to deliver neural stimulation at a site proximate to the heart to inhibit sympathetic nerve activity. The controller controls delivery of the ventricular pacing pulses in accordance with a programmed pacing mode and controls delivery of the neural stimulation. The controller is programmed to deliver remodeling control therapy (RCT) by delivering ventricular pacing to pre-excite a ventricular myocardium region to mechanically unload that region during systole, and further is programmed to deliver anti-remodeling therapy (ART) by delivering neural stimulation to inhibit sympathetic nerve activity in conjunction with RCT. Other embodiments are provided herein.
摘要翻译： 提供了向患者输送心脏治疗的方法和装置。 各种可植入装置实施例包括多个引线和控制器。 引线包括至少一个引线定位在引导路径内以提供心室起搏脉冲并且在靠近心脏的部位输送神经刺激以抑制交感神经活动。 控制器根据编程的起搏模式控制心室起搏脉冲的传递并控制神经刺激的传递。 控制器被编程为通过提供心室起搏来预先激发心室心肌区域以在心脏收缩期间机械地卸载该区域来递送重建控制治疗（RCT），并且进一步被编程以通过递送神经刺激来递送抗重塑疗法（ART） 与RCT结合抑制交感神经活动。 本文提供了其他实施例。
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公开(公告)号：US07587238B2
公开(公告)日：2009-09-08
申请号：US11078460
申请日：2005-03-11
申请人： Julia Moffitt , Sophia Wang , Bruce H. KenKnight , Imad Libbus
发明人： Julia Moffitt , Sophia Wang , Bruce H. KenKnight , Imad Libbus
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/056 , A61N1/0587 , A61N1/36114 , A61N1/3962
摘要： Methods and devices for delivering cardiac therapy to a patient are provided. Various implantable device embodiments comprise a plurality of leads and a controller. The leads include at least one lead to be positioned within a lead path to deliver ventricular pacing pulses and to deliver neural stimulation at a site proximate to the heart to inhibit sympathetic nerve activity. The controller controls delivery of the ventricular pacing pulses in accordance with a programmed pacing mode and controls delivery of the neural stimulation. The controller is programmed to deliver remodeling control therapy (RCT) by delivering ventricular pacing to pre-excite a ventricular myocardium region to mechanically unload that region during systole, and further is programmed to deliver anti-remodeling therapy (ART) by delivering neural stimulation to inhibit sympathetic nerve activity in conjunction with RCT. Other embodiments are provided herein.
摘要翻译： 提供了向患者输送心脏治疗的方法和装置。 各种可植入装置实施例包括多个引线和控制器。 引线包括至少一个引线定位在引导路径内以提供心室起搏脉冲并且在靠近心脏的部位输送神经刺激以抑制交感神经活动。 控制器根据编程的起搏模式控制心室起搏脉冲的传递并控制神经刺激的传递。 控制器被编程为通过提供心室起搏来预先激发心室心肌区域以在心脏收缩期间机械地卸载该区域来递送重建控制治疗（RCT），并且进一步被编程以通过递送神经刺激来递送抗重塑疗法（ART） 与RCT结合抑制交感神经活动。 本文提供了其他实施例。
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公开(公告)号：US08823490B2
公开(公告)日：2014-09-02
申请号：US13139996
申请日：2009-12-15
申请人： Imad Libbus , Badri Amurthur , Yatheendhar D. Manicka , Scott T. Mazar , Matt Merkert , Brett A. Landrum
发明人： Imad Libbus , Badri Amurthur , Yatheendhar D. Manicka , Scott T. Mazar , Matt Merkert , Brett A. Landrum
IPC分类号： G08B25/00
CPC分类号： A61B5/0002 , A61B5/0006 , A61B5/002 , A61B5/01 , A61B5/02055 , A61B5/04085 , A61B5/0537 , A61B5/085 , A61B5/1115 , A61B5/1117 , A61B5/1455 , A61B5/4818 , A61B5/6833 , A61B2562/0219 , G06F19/00 , G06Q50/22 , Y10S128/903
摘要： An adherent patient device is configured to adhere to the skin of the patient and measure electrocardiogram data, impedance data, accelerometer data, blood oxygen data and temperature data. The adherent device can communicate wirelessly with gateways and a local processor system, such that the patient can wander about the hospital and update the monitoring station with the patient data when the patient is ambulatory. The local processor system can be configured to customize alerts for the patient, for example to notify automatically a specialist in response to a special condition of the patient. The adherent device may comprise a unique adherent device identifier such that the customized alert can be sent based on the unique device identifier. Each of the gateways can be carried and may comprise a unique gateway identifier, such that the unique device identifier and the unique gateway identifier can be used to locate the ambulatory patient.
摘要翻译： 附着的患者装置被配置为粘附到患者的皮肤并测量心电图数据，阻抗数据，加速度计数据，血氧数据和温度数据。 附着设备可以与网关和本地处理器系统进行无线通信，使得当患者走动时，患者可以在医院周围漫游并且利用患者数据更新监测站。 本地处理器系统可以被配置为为患者定制警报，例如，以响应患者的特殊状况自动通知专家。 附着设备可以包括唯一的附着设备标识符，使得可以基于唯一的设备标识符来发送定制的警报。 可以携带每个网关，并且可以包括唯一的网关标识符，使得可以使用唯一的设备标识符和唯一的网关标识符来定位移动患者。
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公开(公告)号：US08718752B2
公开(公告)日：2014-05-06
申请号：US12402318
申请日：2009-03-11
CPC分类号： A61B5/7275 , A61B5/0006 , A61B5/0022 , A61B5/0031 , A61B5/0205 , A61B5/02055 , A61B5/04085 , A61B5/046 , A61B5/0464 , A61B5/053 , A61B5/6833 , A61B5/7246 , A61B7/04 , A61B2560/0412 , G06F19/00
摘要： Systems and methods of detecting an impending cardiac decompensation of a patient measure an electrocardiogram signal of the patient. An incidence of cardiac arrhythmias is determined from the electrocardiogram signal. A risk of impending decompensation is determined in response to the incidence of cardiac arrhythmias. In many embodiments, the impending decompensation can be detected early enough to avoid, or at least delay, the impending decompensation, such that patient trauma and/or expensive ICU care can be avoided. Although embodiments make specific reference to monitoring electrocardiogram and other physiological signals with an adherent patch, the system methods and devices are applicable to many applications in which physiological monitoring is used, for example wireless physiological monitoring with implanted sensors for extended periods.
摘要翻译： 检测患者即将到来的心脏代偿失调的系统和方法测量患者的心电图信号。 由心电图信号确定心律失常的发生率。 随着心律失常的发生，确定即将失代偿的风险。 在许多实施方案中，可以提前检测即将发生的代偿失调，以避免或至少延迟即将发生的代偿失调，使得可以避免患者创伤和/或昂贵的ICU护理。 尽管实施例特别参考了使用粘附贴片监测心电图和其他生理信号，但是系统方法和装置可应用于其中使用生理监测的许多应用，例如用植入式传感器进行长时间的无线生理监测。
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公开(公告)号：US08688190B2
公开(公告)日：2014-04-01
申请号：US13543660
申请日：2012-07-06
申请人： Imad Libbus , Yatheendhar D. Manicka , Mark J. Bly
发明人： Imad Libbus , Yatheendhar D. Manicka , Mark J. Bly
CPC分类号： A61B5/4818 , A61B5/0002 , A61B5/0205 , A61B5/02055 , A61B5/04085 , A61B5/0809 , A61B5/11 , A61B5/14551 , A61B5/6832 , A61B5/6833 , A61B5/7282 , A61B2560/0412 , A61B2562/164
摘要： An adherent device is configured to adhere to the skin of the patient with an adherent patch, for example breathable tape, coupled to at least four electrodes. The device comprises impedance circuitry coupled to the at least four electrodes and configured to measure respiration of the patient to detect sleep apnea and/or hypopnea. The impedance circuitry may be used to measure hydration of the patient. An accelerometer can be mechanically coupled to the adherent patch such that the accelerometer can be coupled to and move with the skin of the patient. Electrocardiogram circuitry to generate an electrocardiogram signal may be coupled to at least two of the at least four electrodes to detect the sleep apnea and/or hypopnea.
摘要翻译： 贴附装置被配置为使用与至少四个电极耦合的粘附贴片（例如透气带）粘附到患者的皮肤。 该装置包括耦合到至少四个电极的阻抗电路，并且被配置为测量患者的呼吸以检测睡眠呼吸暂停和/或呼吸不足。 阻抗电路可以用于测量患者的水合。 加速度计可以机械耦合到粘附贴片，使得加速度计可以耦合到患者皮肤并与患者的皮肤一起移动。 用于产生心电图信号的心电图电路可以耦合到至少四个电极中的至少两个，以检测睡眠呼吸暂停和/或呼吸不足。
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