公开(公告)号：US10208113B2

公开(公告)日：2019-02-19

申请号：US14745939

申请日：2015-06-22

Applicant: Janssen Biotech, Inc.

Inventor： Ellen Chi ,  Judith Connor ,  Chichi Huang ,  Jarrat Jordan ,  Xiefan Lin-Schmidt ,  Jinquan Luo ,  Lu Lu ,  Christian Martinez ,  Galina Obmolova ,  Ronald Swanson

IPC: C07K16/24 ,  A61K45/06 ,  A61K38/13

Abstract: The present invention relates to antibodies that broady neutralize interferon-α and interferon-ω, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.

公开(公告)号：US20180355061A1

公开(公告)日：2018-12-13

申请号：US15997148

申请日：2018-06-04

Applicant: Janssen Biotech, Inc.

Inventor： Qiang Chen ,  Suzanne Cole ,  Karen Duffy ,  Yanxia Guo ,  Debra Gardner ,  Damon Hamel ,  Shannon Hitchcock ,  Ann Lacombe ,  Jinquan Luo ,  Ravi Malaviya ,  Yavegniya Orlovsky ,  Pejman Soroosh ,  Melissa Swiecki ,  Deepti Wilkinson

IPC: C07K16/40 ,  A61P37/06 ,  C07K16/18 ,  C07K16/06 ,  A61K39/395

CPC classification number: C07K16/40 ,  A61K39/3955 ,  A61K2039/57 ,  A61P37/06 ,  C07K16/065 ,  C07K16/18

Abstract: Antibodies that specifically bind PD-1 or antigen binding fragments thereof, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing are useful in the treatment of an inflammatory or immune disorder.

公开(公告)号：US09902770B2

公开(公告)日：2018-02-27

申请号：US14208861

申请日：2014-03-13

Applicant: Janssen Biotech, Inc.

Inventor： Ellen Chi ,  Judith Connor ,  Chichi Huang ,  Jarrat Jordan ,  Xiefan Lin-Schmidt ,  Jinquan Luo ,  Lu Lu ,  Christian Martinez ,  Galina Obmolova ,  Ronald Swanson

IPC: C07K16/24 ,  C07K16/46 ,  A61K39/395

CPC classification number: C07K16/249 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92

Abstract: Broadly neutralizing interferon-α and interferon-ω antibody antagonists, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing are useful in the treatment of diseases associated with increased production of IFNα and IFNω.

公开(公告)号：US09862766B2

公开(公告)日：2018-01-09

申请号：US15432636

申请日：2017-02-14

Applicant: Janssen Biotech, Inc.

Inventor： Jill Giles-Komar ,  George Heavner ,  David Knight ,  Jinquan Luo ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: A61K38/20 ,  C07K16/24 ,  C07K14/54 ,  A61K31/137 ,  A61K31/56 ,  A61K38/27 ,  A61K39/395 ,  A61K45/06 ,  A61K51/00 ,  C12Q1/68 ,  A61K39/00

CPC classification number: C07K16/244 ,  A61K31/137 ,  A61K31/56 ,  A61K38/27 ,  A61K39/3955 ,  A61K45/06 ,  A61K51/00 ,  A61K2039/505 ,  C07K14/54 ,  C07K14/5434 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76 ,  C12Q1/6876

Abstract: An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

公开(公告)号：US20150368338A1

公开(公告)日：2015-12-24

申请号：US14745939

申请日：2015-06-22

Applicant: Janssen Biotech, Inc.

Inventor： Ellen Chi ,  Judith Connor ,  Chichi Huang ,  Jarrat Jordan ,  Xiefan Lin-Schmidt ,  Jinquan Luo ,  Lu Lu ,  Christian Martinez ,  Galina Obmolova ,  Ronald Swanson

IPC: C07K16/24 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/249 ,  A61K38/13 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  A61K2300/00

Abstract: The present invention relates to antibodies that broady neutralize interferon-α and interferon-ω, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.

Abstract translation: 本发明涉及广泛中和干扰素-α和干扰素-ω，编码抗体或片段的多核苷酸的抗体，以及制备和使用前述物质的方法。

公开(公告)号：US09212227B2

公开(公告)日：2015-12-15

申请号：US13798226

申请日：2013-03-13

Applicant: Janssen Biotech, Inc.

Inventor： Karen Duffy ,  Natalie Fursov ,  LeRoy Hall ,  Catherine Healy ,  Roberta Lamb ,  Jinquan Luo ,  Ravi Malaviya ,  Michael Naso ,  Michael Pratta ,  Mark Tornetta ,  John Wheeler ,  Sheng-Jiun Wu

IPC: A61K39/395 ,  C07K16/28 ,  A61K38/01 ,  C07K16/44 ,  C07K16/18 ,  A61K39/00

CPC classification number: C07K16/2866 ,  A61K38/012 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/44 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to ST2L antagonists, polynucleotides encoding the antagonists or fragments thereof, and methods of making and using the foregoing.

Abstract translation: 本发明涉及ST2L拮抗剂，编码拮抗剂或其片段的多核苷酸，以及制备和使用上述物质的方法。

公开(公告)号：US09096667B2

公开(公告)日：2015-08-04

申请号：US13968942

申请日：2013-08-16

Applicant: Janssen Biotech, Inc.

Inventor： Jacqueline Benson ,  Mark Cunningham ,  Cynthia Duchala ,  Jill M. Giles-Komar ,  Jinquan Luo ,  Michael A. Rycyzyn ,  Raymond Sweet

IPC: C07K16/24 ,  G01N33/68 ,  A61K39/00

CPC classification number: A61K39/3955 ,  A61K39/00 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/55527 ,  A61K2039/55544 ,  C07K16/244 ,  C07K2317/30 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/55 ,  G01N33/6869 ,  G01N2333/54 ,  Y02A50/386 ,  Y02A50/401 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/55 ,  Y02A50/57 ,  Y02A50/58

Abstract: An anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

公开(公告)号：US20130336980A1

公开(公告)日：2013-12-19

申请号：US13798204

申请日：2013-03-13

Applicant: Janssen Biotech, Inc.

Inventor： Karen Duffy ,  Natalie Fursov ,  LeRoy Hall ,  Catherine Healy ,  Roberta Lamb ,  Jinquan Luo ,  Ravi Malaviya ,  Michael Naso ,  Michael Pratta ,  Mark Tornetta ,  John Wheeler ,  Sheng-Jiu Wu

IPC: C07K16/28

CPC classification number: C07K16/2866 ,  A61K38/012 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/44 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to ST2L antagonists, polynucleotides encoding the antagonists or fragments thereof, and methods of making and using the foregoing.

Abstract translation: 本发明涉及ST2L拮抗剂，编码拮抗剂或其片段的多核苷酸，以及制备和使用上述物质的方法。

公开(公告)号：US20130129617A1

公开(公告)日：2013-05-23

申请号：US13669894

申请日：2012-11-06

Applicant: Janssen Biotech, Inc.

Inventor： Jill Giles-Komar ,  George Heavner ,  David Knight ,  Jinquan Luo ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: C07K16/24 ,  A61K45/06 ,  A61K38/19 ,  A61K38/27 ,  A61K51/00 ,  A61K31/137 ,  A61K39/395 ,  A61K31/56

CPC classification number: C07K16/244 ,  A61K31/137 ,  A61K31/56 ,  A61K38/27 ,  A61K39/3955 ,  A61K45/06 ,  A61K51/00 ,  A61K2039/505 ,  C07K14/54 ,  C07K14/5434 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76 ,  C12Q1/6876

Abstract: An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in treating IL-12-related disorders, such as psoriatic arthritis.

Abstract translation: 结合IL-12蛋白的一部分对应于至少一个氨基酸残基的抗IL-12抗体，其选自残基15,17-21,23,40-43,45-47,54 -56和58-62的IL-12的p40亚基的氨基酸序列，包括编码至少一种抗IL-12抗体，载体，宿主细胞，转基因动物或植物的分离的核酸，以及制备方法 并且其应用具有治疗IL-12相关疾病如牛皮癣关节炎的应用。