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    TRANSGENIC NON-HUMAN VERTEBRATE FOR THE IN VIVO PRODUCTION OF DUAL SPECIFICITY IMMUNOGLOBULINS OR HYPERMUTATED HEAVY CHAIN ONLY IMMUNOGLOBULINS
    63.
    发明申请
    TRANSGENIC NON-HUMAN VERTEBRATE FOR THE IN VIVO PRODUCTION OF DUAL SPECIFICITY IMMUNOGLOBULINS OR HYPERMUTATED HEAVY CHAIN ONLY IMMUNOGLOBULINS 审中-公开
    用于生产双重特异性免疫球蛋白或超重型重链的转基因非人类VERTEBRATE仅限免疫球蛋白

    公开(公告)号：US20150133641A1

    公开(公告)日：2015-05-14

    申请号：US14543359

    申请日：2014-11-17

    申请人： KYMAB LIMITED

    发明人： Volker Germaschewski ,  E-Chiang Lee ,  Hanif Ali ,  Jasper Clube

    IPC分类号： A01K67/027 ,  C07K16/46 ,  C12N15/85

    摘要： The invention relates, in one aspect, generally to novel concept of guided selection of antibody variable domains, combination and expression entirely in vivo. An application is to produce multivalent polypeptides. The present invention relates to multivalent (eg, multispecific) antibodies, antibody chains and polypeptides, as well as heavy chain-only antibodies (H2 antibodies) that are devoid of light chains. The invention further relates to the selection, maturation and production of these in vivo in non-human vertebrates and non-human vertebrate cells. To this end the invention also relates to such non-human vertebrates and cells. The invention also relates to the provision of means to produce and select heavy chain-only antibodies and heavy chains comprising variable domains that have undergone affinity maturation.

    摘要翻译： 本发明在一个方面涉及抗体可变域的引导选择，完全在体内的组合和表达的新概念。 应用是产生多价多肽。 本发明涉及多价（例如，多特异性）抗体，抗体链和多肽，以及没有轻链的重链抗体（H2抗体）。 本发明还涉及这些体内在非人类脊椎动物和非人类脊椎动物细胞中的选择，成熟和产生。 为此，本发明还涉及这种非人类脊椎动物和细胞。 本发明还涉及提供产生和选择仅含重链的抗体和重链的手段，所述重链和重链包含经过亲和力成熟的可变结构域。

    Chimaeric Surrogate Light Chains (SLC) Comprising Human VpreB
    64.
    发明申请
    Chimaeric Surrogate Light Chains (SLC) Comprising Human VpreB 有权
    包括人类VpreB的Chimaeric替代轻链（SLC）

    公开(公告)号：US20140359797A1

    公开(公告)日：2014-12-04

    申请号：US14226698

    申请日：2014-03-26

    申请人： Kymab Limited

    发明人： Allan Bradley ,  E-Chiang Lee ,  Qi Liang ,  Dominik Spensberger ,  Nicholas England

    IPC分类号： C12N15/85 ,  A01K67/02 ,  A01K67/027

    CPC分类号： C12N15/85 ,  A01K67/02 ,  A01K67/0278 ,  A01K2217/07 ,  A01K2217/077 ,  A01K2227/10 ,  A01K2227/105 ,  A01K2267/01 ,  C12N5/10 ,  C12N15/8509 ,  C12N2015/8518

    摘要： The present invention relates inter alia to improvements in the production of chimaeric antibodies in non-human transgenic vertebrates such as mice and rats bearing one or more chimaeric antibody transgenes. In particular, the invention provides for improved non-human vertebrates and cells in which VpreB has been species-matched with the variable region of the chimaeric antibodies. Also, embodiments also provide for species-matching of the entire surrogate light chain for efficient pairing with chimaeric heavy chains during B-cell development in vivo in a non-human transgenic vertebrate setting.

    摘要翻译： 本发明特别涉及非人转基因脊椎动物（例如携带一个或多个嵌合抗体转基因的小鼠和大鼠）中嵌合抗体的产生的改进。 特别地，本发明提供了改良的非人脊椎动物和细胞，其中VpreB已经与嵌合抗体的可变区物种匹配。 此外，实施方案还提供整个替代轻链的物种匹配，用于在非人转基因脊椎动物环境中体内B细胞发育期间与嵌合重链进行有效配对。